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Mia Smith

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BDC Basic Research
Phone303/724-8708

    Collapse Research 
    Collapse research activities and funding
    F30OD021477     (SMITH, MIA)Jul 1, 2016 - Jun 30, 2018
    NIH
    Genetic risk alleles as drivers of loss of anergic B cells in autoimmunity
    Role: Principal Investigator

    K01OD028759     (SMITH, MIA)Jul 1, 2020 - Jun 30, 2025
    NIH
    Genetic contribution to loss of B cell anergy during development of type 1 diabetes
    Role: Principal Investigator

    R03DK129925     (SMITH, MIA)Jul 1, 2021 - Jun 30, 2023
    NIH
    Decoding the B cell endotype in early onset type 1 diabetes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Stensland ZC, Cambier JC, Smith MJ. Therapeutic Targeting of Autoreactive B Cells: Why, How, and When? Biomedicines. 2021 Jan 16; 9(1). PMID: 33467130.
      View in: PubMed
    2. Smith MJ, Cambier JC, Gottlieb PA. Endotypes in T1D: B lymphocytes and early onset. Curr Opin Endocrinol Diabetes Obes. 2020 08; 27(4):225-230. PMID: 32618634.
      View in: PubMed
    3. Smith MJ, Ford BR, Rihanek M, Coleman BM, Getahun A, Sarapura VD, Gottlieb PA, Cambier JC. Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity. JCI Insight. 2019 Feb 07; 4(3). PMID: 30728334.
      View in: PubMed
    4. Smith MJ, Hinman RM, Getahun A, Kim S, Packard TA, Cambier JC. Silencing of high-affinity insulin-reactive B lymphocytes by anergy and impact of the NOD genetic background in mice. Diabetologia. 2018 12; 61(12):2621-2632. PMID: 30255377.
      View in: PubMed
    5. Takeda K, Webb TL, Ning F, Shiraishi Y, Regan DP, Chow L, Smith MJ, Ashino S, Guth AM, Hopkins S, Gelfand EW, Dow S. Mesenchymal Stem Cells Recruit CCR2+ Monocytes To Suppress Allergic Airway Inflammation. J Immunol. 2018 02 15; 200(4):1261-1269. PMID: 29352000.
      View in: PubMed
    6. Smith MJ, Rihanek M, Wasserfall C, Mathews CE, Atkinson MA, Gottlieb PA, Cambier JC. Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles. Diabetes. 2018 04; 67(4):697-703. PMID: 29343548.
      View in: PubMed
    7. Smith MJ, Rihanek M, Coleman BM, Gottlieb PA, Sarapura VD, Cambier JC. Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients. J Autoimmun. 2018 05; 89:82-89. PMID: 29233566.
      View in: PubMed
    8. Smith MJ, Simmons KM, Cambier JC. B cells in type 1 diabetes mellitus and diabetic kidney disease. Nat Rev Nephrol. 2017 Oct 17; 13(11):712-720. PMID: 29038537.
      View in: PubMed
    9. Smith MJ, Packard TA, O'Neill SK, Hinman RM, Rihanek M, Gottlieb PA, Cambier JC. Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function. J Vis Exp. 2017 02 16; (120). PMID: 28287549.
      View in: PubMed
    10. Seay HR, Yusko E, Rothweiler SJ, Zhang L, Posgai AL, Campbell-Thompson M, Vignali M, Emerson RO, Kaddis JS, Ko D, Nakayama M, Smith MJ, Cambier JC, Pugliese A, Atkinson MA, Robins HS, Brusko TM. Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes. JCI Insight. 2016 12 08; 1(20):e88242. PMID: 27942583.
      View in: PubMed
    11. Packard TA, Smith MJ, Conrad FJ, Johnson SA, Getahun A, Lindsay RS, Hinman RM, Friedman RS, Thomas JW, Cambier JC. B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes. J Clin Med. 2016 Nov 08; 5(11). PMID: 27834793.
      View in: PubMed
    12. Smith MJ, Packard TA, O'Neill SK, Henry Dunand CJ, Huang M, Fitzgerald-Miller L, Stowell D, Hinman RM, Wilson PC, Gottlieb PA, Cambier JC. Loss of anergic B cells in prediabetic and new-onset type 1 diabetic patients. Diabetes. 2015 May; 64(5):1703-12. PMID: 25524915.
      View in: PubMed
    13. Hinman RM, Smith MJ, Cambier JC. B cells and type 1 diabetes ...in mice and men. Immunol Lett. 2014 Aug; 160(2):128-32. PMID: 24472603.
      View in: PubMed
    14. Hardy IR, Anceriz N, Rousseau F, Seefeldt MB, Hatterer E, Irla M, Buatois V, Chatel LE, Getahun A, Fletcher A, Cons L, Pontini G, Hertzberg NA, Magistrelli G, Malinge P, Smith MJ, Reith W, Kosco-Vilbois MH, Ferlin WG, Cambier JC. Anti-CD79 antibody induces B cell anergy that protects against autoimmunity. J Immunol. 2014 Feb 15; 192(4):1641-50. PMID: 24442438.
      View in: PubMed
    15. Getahun A, Smith MJ, Kogut I, van Dyk LF, Cambier JC. Retention of anergy and inhibition of antibody responses during acute ? herpesvirus 68 infection. J Immunol. 2012 Sep 15; 189(6):2965-74. PMID: 22904300.
      View in: PubMed
    16. O'Neill SK, Getahun A, Gauld SB, Merrell KT, Tamir I, Smith MJ, Dal Porto JM, Li QZ, Cambier JC. Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity. 2011 Nov 23; 35(5):746-56. PMID: 22078222.
      View in: PubMed
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