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Matthew Jeremy Wortham

TitleAssistant Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BDC Basic Research

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jones JA, Zhou J, Dong J, Huitron-Resendiz S, Boussaty E, Chavez E, Wei N, Dumitru CD, Morodomi Y, Kanaji T, Ryan AF, Friedman R, Zhou T, Kanaji S, Wortham M, Schenk S, Roberts AJ, Yang XL. Murine nuclear tyrosyl-tRNA synthetase deficiency leads to fat storage deficiency and hearing loss. J Biol Chem. 2024 Oct; 300(10):107756. PMID: 39260699.
      View in: PubMed
    2. Wortham M, Ramms B, Zeng C, Benthuysen JR, Sai S, Pollow DP, Liu F, Schlichting M, Harrington AR, Liu B, Prakash TP, Pirie EC, Zhu H, Baghdasarian S, Auwerx J, Shirihai OS, Sander M. Metabolic control of adaptive ?-cell proliferation by the protein deacetylase SIRT2. bioRxiv. 2024 Feb 28. PMID: 38464227.
      View in: PubMed
    3. Bender RHF, O'Donnell BT, Shergill B, Pham BQ, Tahmouresie S, Sanchez CN, Juat DJ, Hatch MMS, Shirure VS, Wortham M, Nguyen-Ngoc KV, Jun Y, Gaetani R, Christman KL, Teyton L, George SC, Sander M, Hughes CCW. A vascularized 3D model of the human pancreatic islet forex vivostudy of immune cell-islet interaction. Biofabrication. 2024 01 11; 16(2). PMID: 38128127.
      View in: PubMed
    4. Urizar AI, Prause M, Ingerslev LR, Wortham M, Sui Y, Sander M, Williams K, Barr?s R, Larsen MR, Christensen GL, Billestrup N. Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding. Cell Death Dis. 2023 07 05; 14(7):399. PMID: 37407581.
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    5. Wortham M, Liu F, Harrington AR, Fleischman JY, Wallace M, Mulas F, Mallick M, Vinckier NK, Cross BR, Chiou J, Patel NA, Sui Y, McGrail C, Jun Y, Wang G, Jhala US, Sch?le R, Shirihai OS, Huising MO, Gaulton KJ, Metallo CM, Sander M. Nutrient regulation of the islet epigenome controls adaptive insulin secretion. J Clin Invest. 2023 04 17; 133(8). PMID: 36821378.
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    6. Ramms B, Pollow DP, Zhu H, Nora C, Harrington AR, Omar I, Gordts PLSM, Wortham M, Sander M. Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity. Diabetes. 2022 12 01; 71(12):2513-2529. PMID: 36162056.
      View in: PubMed
    7. Nguyen-Ngoc KV, Wortham M, Sander M. Sizing up beta cells made from stem cells. Nat Biotechnol. 2022 07; 40(7):1006-1008. PMID: 35288669.
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    8. Shum M, Segawa M, Gharakhanian R, Vi?uela A, Wortham M, Baghdasarian S, Wolf DM, Sereda SB, Nocito L, Stiles L, Zhou Z, Gutierrez V, Sander M, Shirihai OS, Liesa M. Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance. Mol Metab. 2022 01; 55:101403. PMID: 34823065.
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    9. Parashar S, Chidambaram R, Chen S, Liem CR, Griffis E, Lambert GG, Shaner NC, Wortham M, Hay JC, Ferro-Novick S. Endoplasmic reticulum tubules limit the size of misfolded protein condensates. Elife. 2021 09 01; 10. PMID: 34467852.
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    10. Wortham M, Sander M. Transcriptional mechanisms of pancreatic ?-cell maturation and functional adaptation. Trends Endocrinol Metab. 2021 07; 32(7):474-487. PMID: 34030925.
      View in: PubMed
    11. Vinckier NK, Patel NA, Geusz RJ, Wang A, Wang J, Matta I, Harrington AR, Wortham M, Wetton N, Wang J, Jhala US, Rosenfeld MG, Benner CW, Shih HP, Sander M. LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. Nat Commun. 2020 04 29; 11(1):2082. PMID: 32350257.
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    12. Ibarra Urizar A, Prause M, Wortham M, Sui Y, Thams P, Sander M, Christensen GL, Billestrup N. Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1? is associated with changes in expression of beta-cell maturity genes and associated histone modifications. Mol Cell Endocrinol. 2019 10 01; 496:110524. PMID: 31362031.
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    13. Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR, Metallo CM, Sander M. Integrated In?Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic ? Cell Function. Cell Rep. 2018 12 04; 25(10):2904-2918.e8. PMID: 30517875.
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    14. Gaetani R, Aude S, DeMaddalena LL, Strassle H, Dzieciatkowska M, Wortham M, Bender RHF, Nguyen-Ngoc KV, Schmid-Sch?enbein GW, George SC, Hughes CCW, Sander M, Hansen KC, Christman KL. Evaluation of Different Decellularization Protocols on the Generation of Pancreas-Derived Hydrogels. Tissue Eng Part C Methods. 2018 12; 24(12):697-708. PMID: 30398401.
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    15. Wortham M, Sander M. Mechanisms of ?-cell functional adaptation to changes in workload. Diabetes Obes Metab. 2016 09; 18 Suppl 1:78-86. PMID: 27615135.
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    16. Wortham M, Sander M. High T Gives ? Cells a Boost. Cell Metab. 2016 May 10; 23(5):761-3. PMID: 27166938.
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    17. Wortham M, Guo C, Zhang M, Song L, Lee BK, Iyer VR, Furey TS, Crawford GE, Yan H, He Y. Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma. PLoS One. 2014; 9(9):e107156. PMID: 25198066.
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    18. Guo C, Chang CC, Wortham M, Chen LH, Kernagis DN, Qin X, Cho YW, Chi JT, Grant GA, McLendon RE, Yan H, Ge K, Papadopoulos N, Bigner DD, He Y. Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17603-8. PMID: 23045699.
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    19. Shibata Y, Sheffield NC, Fedrigo O, Babbitt CC, Wortham M, Tewari AK, London D, Song L, Lee BK, Iyer VR, Parker SC, Margulies EH, Wray GA, Furey TS, Crawford GE. Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection. PLoS Genet. 2012 Jun; 8(6):e1002789. PMID: 22761590.
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    20. Wortham M, Yan H. Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells. Cancer Discov. 2012 Jun; 2(6):492-4. PMID: 22684456.
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    21. Wortham M, Jin G, Sun JL, Bigner DD, He Y, Yan H. Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells. PLoS One. 2012; 7(4):e36211. PMID: 22558385.
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    22. Adamson DC, Shi Q, Wortham M, Northcott PA, Di C, Duncan CG, Li J, McLendon RE, Bigner DD, Taylor MD, Yan H. OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas. Cancer Res. 2010 Jan 01; 70(1):181-91. PMID: 20028867.
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    23. Wortham M, He L, Gyamfi M, Copple BL, Wan YJ. The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet. Dig Dis Sci. 2008 Oct; 53(10):2761-74. PMID: 18299981.
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    24. Wortham M, Czerwinski M, He L, Parkinson A, Wan YJ. Expression of constitutive androstane receptor, hepatic nuclear factor 4 alpha, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver. Drug Metab Dispos. 2007 Sep; 35(9):1700-10. PMID: 17576804.
      View in: PubMed
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