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Daniel LaBarbera

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-4116
    Other Positions
    TitleDirector-Faculty
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOP-Administration


    Collapse Research 
    Collapse research activities and funding
    R01EY021498     (PETRASH, JONATHAN MARK)Sep 30, 2011 - Aug 31, 2016
    NIH/NEI
    Novel Therapeutics Against Diabetic Eye Disease
    Role: Co-Principal Investigator

    R01AI120365     (CHEN, CHAOPING)Sep 1, 2016 - Aug 31, 2019
    NIH/NIAID
    Assay Development for Identification of HIV-1 Protease Autoprocessing Specific Inhibitors
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Bashyal B, Li L, Bains T, Debnath A, LaBarbera DV. Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri. PLoS Negl Trop Dis. 2017 Aug 09; 11(8):e0005832. PMID: 28793307.
      View in: PubMed
    2. Fettig LM, McGinn O, Finlay-Schultz J, LaBarbera DV, Nordeen SK, Sartorius CA. Cross talk between progesterone receptors and retinoic acid receptors in regulation of cytokeratin 5-positive breast cancer cells. Oncogene. 2017 Jul 10. PMID: 28692043.
      View in: PubMed
    3. Hoffman AF, Simpson KJ, Horvath P, Lovitt C, Silver S, Easton E, LaBarbera DV, Mendez M, Rothenberg ME, Seldin J, Wardwell-Swanson J, Fennell M. SBI2 HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium. Assay Drug Dev Technol. 2017 Jan; 15(1):1-7. PMID: 28092461.
      View in: PubMed
    4. Chang KC, Li L, Sanborn TM, Shieh B, Lenhart P, Ammar D, LaBarbera DV, Petrash JM. Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract. J Nat Prod. 2016 May 27; 79(5):1439-44. PMID: 27140653.
      View in: PubMed
    5. Zhou Q, Abraham AD, Li L, Babalmorad A, Bagby S, Arcaroli JJ, Hansen RJ, Valeriote FA, Gustafson DL, Schaack J, Messersmith WA, LaBarbera DV. Topoisomerase IIa mediates TCF-dependent epithelial-mesenchymal transition in colon cancer. Oncogene. 2016 Sep 22; 35(38):4990-9. PMID: 26947016.
      View in: PubMed
    6. Medellin DC, Zhou Q, Scott R, Hill RM, Frail SK, Dasari R, Ontiveros SJ, Pelly SC, van Otterlo WA, Betancourt T, Shuster CB, Hamel E, Bai R, LaBarbera DV, Rogelj S, Frolova LV, Kornienko A. Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities. J Med Chem. 2016 Jan 14; 59(1):480-5. PMID: 26641132; PMCID: PMC4950951 [Available on 01/14/17].
    7. Li L, Zhou Q, Voss TC, Quick KL, LaBarbera DV. High-throughput imaging: Focusing in on drug discovery in 3D. Methods. 2016 Mar 01; 96:97-102. PMID: 26608110; PMCID: PMC4766031 [Available on 03/01/17].
    8. Chang KC, Snow A, LaBarbera DV, Petrash JM. Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells. Chem Biol Interact. 2015 Jun 05; 234:254-60. PMID: 25451566; PMCID: PMC4402120.
    9. Li L, Abraham AD, Zhou Q, Ali H, O'Brien JV, Hamill BD, Arcaroli JJ, Messersmith WA, LaBarbera DV. An improved high yield total synthesis and cytotoxicity study of the marine alkaloid neoamphimedine: an ATP-competitive inhibitor of topoisomerase IIa and potent anticancer agent. Mar Drugs. 2014 Sep 19; 12(9):4833-50. PMID: 25244109; PMCID: PMC4178486.
    10. Chang KC, Ponder J, Labarbera DV, Petrash JM. Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia. Invest Ophthalmol Vis Sci. 2014 May 02; 55(5):2853-61. PMID: 24677107; PMCID: PMC4010364.
    11. Reid BG, Jerjian T, Patel P, Zhou Q, Yoo BH, Kabos P, Sartorius CA, Labarbera DV. Live multicellular tumor spheroid models for high-content imaging and screening in cancer drug discovery. Curr Chem Genom Transl Med. 2014; 8(Suppl 1):27-35. PMID: 24596682; PMCID: PMC3941083.
    12. Li L, Chang KC, Zhou Y, Shieh B, Ponder J, Abraham AD, Ali H, Snow A, Petrash JM, LaBarbera DV. Design of an amide N-glycoside derivative of ß-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. J Med Chem. 2014 Jan 09; 57(1):71-7. PMID: 24341381; PMCID: PMC3956592.
    13. LaBarbera DV, Skibo EB. The synthesis of vinylogous amidine heterocycles. J Org Chem. 2013 Dec 06; 78(23):11887-95. PMID: 24228868.
      View in: PubMed
    14. Chang KC, Laffin B, Ponder J, Enzsöly A, Németh J, LaBarbera DV, Petrash JM. Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues. Chem Biol Interact. 2013 Feb 25; 202(1-3):283-7. PMID: 23247009; PMCID: PMC3656825.
    15. Axlund SD, Yoo BH, Rosen RB, Schaack J, Kabos P, Labarbera DV, Sartorius CA. Progesterone-inducible cytokeratin 5-positive cells in luminal breast cancer exhibit progenitor properties. Horm Cancer. 2013 Feb; 4(1):36-49. PMID: 23184698; PMCID: PMC3549640.
    16. LaBarbera DV, Reid BG, Yoo BH. The multicellular tumor spheroid model for high-throughput cancer drug discovery. Expert Opin Drug Discov. 2012 Sep; 7(9):819-30. PMID: 22788761.
      View in: PubMed
    17. Yoo BH, Axlund SD, Kabos P, Reid BG, Schaack J, Sartorius CA, LaBarbera DV. A high-content assay to identify small-molecule modulators of a cancer stem cell population in luminal breast cancer. J Biomol Screen. 2012 Oct; 17(9):1211-20. PMID: 22751729; PMCID: PMC4158006.
    18. Puppala M, Ponder J, Suryanarayana P, Reddy GB, Petrash JM, LaBarbera DV. The isolation and characterization of ß-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis. PLoS One. 2012; 7(4):e31399. PMID: 22485126; PMCID: PMC3317655.
    19. Ponder J, Yoo BH, Abraham AD, Li Q, Ashley AK, Amerin CL, Zhou Q, Reid BG, Reigan P, Hromas R, Nickoloff JA, LaBarbera DV. Neoamphimedine circumvents metnase-enhanced DNA topoisomerase IIa activity through ATP-competitive inhibition. Mar Drugs. 2011; 9(11):2397-408. PMID: 22163192; PMCID: PMC3229241.
    20. Li Q, Chen C, Kapadia A, Zhou Q, Harper MK, Schaack J, LaBarbera DV. 3D models of epithelial-mesenchymal transition in breast cancer metastasis: high-throughput screening assay development, validation, and pilot screen. J Biomol Screen. 2011 Feb; 16(2):141-54. PMID: 21297102.
      View in: PubMed
    21. LaBarbera DV, Modzelewska K, Glazar AI, Gray PD, Kaur M, Liu T, Grossman D, Harper MK, Kuwada SK, Moghal N, Ireland CM. The marine alkaloid naamidine A promotes caspase-dependent apoptosis in tumor cells. Anticancer Drugs. 2009 Jul; 20(6):425-36. PMID: 19369860.
      View in: PubMed
    22. Hargreaves RH, David CL, Whitesell LJ, Labarbera DV, Jamil A, Chapuis JC, Skibo EB. Discovery of quinolinediones exhibiting a heat shock response and angiogenesis inhibition. J Med Chem. 2008 Apr 24; 51(8):2492-501. PMID: 18363347.
      View in: PubMed
    23. LaBarbera DV, Bugni TS, Ireland CM. The total synthesis of neoamphimedine. J Org Chem. 2007 Oct 26; 72(22):8501-5. PMID: 17900144; PMCID: PMC2547140.
    24. Hoang H, LaBarbera DV, Mohammed KA, Ireland CM, Skibo EB. Synthesis and biological evaluation of imidazoquinoxalinones, imidazole analogues of pyrroloiminoquinone marine natural products. J Med Chem. 2007 Sep 20; 50(19):4561-71. PMID: 17705462.
      View in: PubMed
    25. Laird DW, LaBarbera DV, Feng X, Bugni TS, Harper MK, Ireland CM. Halogenated cyclic peptides isolated from the sponge Corticium sp. J Nat Prod. 2007 May; 70(5):741-6. PMID: 17391049; PMCID: PMC2533844.
    26. Lira SP, Vita-Marques AM, Seleghim MH, Bugni TS, LaBarbera DV, Sette LD, Sponchiado SR, Ireland CM, Berlinck RG. New destruxins from the marine-derived fungus Beauveria felina. J Antibiot (Tokyo). 2006 Sep; 59(9):553-63. PMID: 17136888.
      View in: PubMed
    27. LaBarbera DV, Skibo EB. Solution kinetics of CC-1065 A-ring opening: substituent effects and general acid/base catalysis. J Am Chem Soc. 2006 Mar 22; 128(11):3722-7. PMID: 16536546.
      View in: PubMed
    28. Labarbera DV, Skibo EB. Synthesis of imidazo[1,5,4-de]quinoxalin-9-ones, benzimidazole analogues of pyrroloiminoquinone marine natural products. Bioorg Med Chem. 2005 Jan 17; 13(2):387-95. PMID: 15598560.
      View in: PubMed
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