 Spheroids, Cellular
"Spheroids, Cellular" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Spherical, heterogeneous aggregates of proliferating, quiescent, and necrotic cells in culture that retain three-dimensional architecture and tissue-specific functions. The ability to form spheroids is a characteristic trait of CULTURED TUMOR CELLS derived from solid TUMORS. Cells from normal tissues can also form spheroids. They represent an in-vitro model for studies of the biology of both normal and malignant cells. (From Bjerkvig, Spheroid Culture in Cancer Research, 1992, p4)
| Descriptor ID |
D018874
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| MeSH Number(s) |
A11.251.800
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| Concept/Terms |
Spheroids, Cellular- Spheroids, Cellular
- Cellular Spheroid
- Cellular Spheroids
- Spheroid, Cellular
- Multicellular Spheroids
- Multicellular Spheroid
- Spheroid, Multicellular
- Spheroids, Multicellular
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Below are MeSH descriptors whose meaning is more general than "Spheroids, Cellular".
Below are MeSH descriptors whose meaning is more specific than "Spheroids, Cellular".
This graph shows the total number of publications written about "Spheroids, Cellular" by people in this website by year, and whether "Spheroids, Cellular" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 2 | 2 | | 2012 | 1 | 2 | 3 | | 2013 | 1 | 1 | 2 | | 2014 | 1 | 1 | 2 | | 2015 | 1 | 3 | 4 | | 2016 | 0 | 1 | 1 | | 2017 | 3 | 5 | 8 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 3 | 3 | | 2020 | 1 | 1 | 2 | | 2021 | 3 | 1 | 4 | | 2022 | 0 | 3 | 3 | | 2023 | 1 | 0 | 1 | | 2024 | 3 | 2 | 5 | | 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Spheroids, Cellular" by people in Profiles.
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Tajpara P, Sobkowiak MJ, Healy K, Naud S, G?ndel B, Halimi A, Khan ZA, Gabarrini G, Le Guyader S, Imreh G, Reisz JA, Del Chiaro M, D'Alessandro A, Heuchel R, L?hr JM, ?zenci V, S?llberg Chen M. Patient-derived pancreatic tumor bacteria exhibit oncogenic properties and are recognized by MAIT cells in tumor spheroids. Front Immunol. 2025; 16:1553034.
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Di Caprio N, Hughes AJ, Burdick JA. Programmed shape transformations in cell-laden granular composites. Sci Adv. 2025 Jan 17; 11(3):eadq5011.
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Bower BM, Curry SD, Goodwin AP, Cha JN. Photocrosslinkable, Low-Affinity Affibodies Show Improved Transport and Retention in 3D Tumor Spheroids. Biomacromolecules. 2024 Nov 11; 25(11):7511-7517.
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Saemundsson SA, Curry SD, Bower BM, DeBoo EJ, Goodwin AP, Cha JN. Controlling cellular packing and hypoxia in 3D tumor spheroids via DNA interactions. Biomater Sci. 2024 Sep 10; 12(18):4759-4769.
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Zanetti M, Braidotti N, Khumar M, Montelongo E, Lombardi R, Sbaizero O, Mestroni L, Taylor MRG, Baj G, Lazzarino M, Pe?a B, Andolfi L. Investigations of cardiac fibrosis rheology by in vitro cardiac tissue modeling with 3D cellular spheroids. J Mech Behav Biomed Mater. 2024 Jul; 155:106571.
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Xu KL, Di Caprio N, Fallahi H, Dehghany M, Davidson MD, Laforest L, Cheung BCH, Zhang Y, Wu M, Shenoy V, Han L, Mauck RL, Burdick JA. Microinterfaces in biopolymer-based bicontinuous hydrogels guide rapid 3D cell migration. Nat Commun. 2024 Mar 29; 15(1):2766.
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Caprio ND, Davidson MD, Daly AC, Burdick JA. Injectable MSC Spheroid and Microgel Granular Composites for Engineering Tissue. Adv Mater. 2024 Apr; 36(14):e2312226.
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Saemundsson SA, Ganguly S, Curry SD, Goodwin AP, Cha JN. Controlling Cell Organization in 3D Coculture Spheroids Using DNA Interactions. ACS Biomater Sci Eng. 2023 06 12; 9(6):3185-3192.
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Bera K, Kiepas A, Godet I, Li Y, Mehta P, Ifemembi B, Paul CD, Sen A, Serra SA, Stoletov K, Tao J, Shatkin G, Lee SJ, Zhang Y, Boen A, Mistriotis P, Gilkes DM, Lewis JD, Fan CM, Feinberg AP, Valverde MA, Sun SX, Konstantopoulos K. Extracellular fluid viscosity enhances cell migration and cancer dissemination. Nature. 2022 Nov; 611(7935):365-373.
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Caprio ND, Burdick JA. Engineered biomaterials to guide spheroid formation, function, and fabrication into 3D tissue constructs. Acta Biomater. 2023 Jul 15; 165:4-18.
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