 Spheroids, Cellular
"Spheroids, Cellular" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Spherical, heterogeneous aggregates of proliferating, quiescent, and necrotic cells in culture that retain three-dimensional architecture and tissue-specific functions. The ability to form spheroids is a characteristic trait of CULTURED TUMOR CELLS derived from solid TUMORS. Cells from normal tissues can also form spheroids. They represent an in-vitro model for studies of the biology of both normal and malignant cells. (From Bjerkvig, Spheroid Culture in Cancer Research, 1992, p4)
| Descriptor ID |
D018874
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| MeSH Number(s) |
A11.251.800
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| Concept/Terms |
Spheroids, Cellular- Spheroids, Cellular
- Cellular Spheroid
- Cellular Spheroids
- Spheroid, Cellular
- Multicellular Spheroids
- Multicellular Spheroid
- Spheroid, Multicellular
- Spheroids, Multicellular
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Below are MeSH descriptors whose meaning is more general than "Spheroids, Cellular".
Below are MeSH descriptors whose meaning is more specific than "Spheroids, Cellular".
This graph shows the total number of publications written about "Spheroids, Cellular" by people in this website by year, and whether "Spheroids, Cellular" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1999 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 2 | 2 | | 2012 | 1 | 2 | 3 | | 2013 | 1 | 1 | 2 | | 2014 | 1 | 2 | 3 | | 2015 | 1 | 3 | 4 | | 2016 | 0 | 2 | 2 | | 2017 | 2 | 4 | 6 | | 2019 | 0 | 4 | 4 | | 2020 | 1 | 1 | 2 | | 2021 | 3 | 1 | 4 | | 2022 | 0 | 3 | 3 | | 2023 | 1 | 0 | 1 | | 2024 | 3 | 2 | 5 | | 2025 | 3 | 0 | 3 | | 2026 | 2 | 2 | 4 |
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Below are the most recent publications written about "Spheroids, Cellular" by people in Profiles.
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Saemundsson SA, Ausec TR, Bower BM, Curry SD, Shields Iv CW, Goodwin AP, Cha JN. Engineered Deoxyribonucleic Acid-Tunable Spheroid Platform for Analysis of Tumor-Macrophage Interactions. ACS Biomater Sci Eng. 2026 Sep 14; 12(9):4734-4745.
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Bower BM, Ho GM, Saemundsson SA, Goodwin AP, Cha JN. Optimization of Affibody Affinity to Improve Distribution in Tumor Models. Biomacromolecules. 2026 Sep 14; 27(9):6134-6142.
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Gaikwad H, Angarita D, Carter N, Reichardt N, Siegel D, Mattanovich H, De Melo DM, Anchordoquy TJ, Aguado J, Graner A, Graner M, Balyasnikova IV, Simberg D. Physicochemical and molecular determinants of lipid migration through multicellular assemblies. J Control Release. 2026 Nov 10; 399(Pt A):115326.
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Schiavon A, Evaristo C, Saba L, Petiti J, Pignochino Y, Puglisi S, Perotti P, Messina E, Giachino C, Terzolo M, Lo Iacono M. Targeting ER stress in adrenocortical carcinoma: Celastrol as a novel therapeutic candidate. Biomed Pharmacother. 2026 Apr; 197:119156.
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Cooke ME, Caprio ND, Killgore J, Burdick JA. Tailoring agarose fluid gels for use in suspension bath bioprinting and culture of spheroid-based bioinks. Biofabrication. 2025 10 10; 17(4).
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Tajpara P, Sobkowiak MJ, Healy K, Naud S, Gündel B, Halimi A, Khan ZA, Gabarrini G, Le Guyader S, Imreh G, Reisz JA, Del Chiaro M, D'Alessandro A, Heuchel R, Löhr JM, Özenci V, Sällberg Chen M. Patient-derived pancreatic tumor bacteria exhibit oncogenic properties and are recognized by MAIT cells in tumor spheroids. Front Immunol. 2025; 16:1553034.
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Di Caprio N, Hughes AJ, Burdick JA. Programmed shape transformations in cell-laden granular composites. Sci Adv. 2025 Jan 17; 11(3):eadq5011.
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Bower BM, Curry SD, Goodwin AP, Cha JN. Photocrosslinkable, Low-Affinity Affibodies Show Improved Transport and Retention in 3D Tumor Spheroids. Biomacromolecules. 2024 11 11; 25(11):7511-7517.
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Saemundsson SA, Curry SD, Bower BM, DeBoo EJ, Goodwin AP, Cha JN. Controlling cellular packing and hypoxia in 3D tumor spheroids via DNA interactions. Biomater Sci. 2024 Sep 10; 12(18):4759-4769.
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Zanetti M, Braidotti N, Khumar M, Montelongo E, Lombardi R, Sbaizero O, Mestroni L, Taylor MRG, Baj G, Lazzarino M, Peña B, Andolfi L. Investigations of cardiac fibrosis rheology by in vitro cardiac tissue modeling with 3D cellular spheroids. J Mech Behav Biomed Mater. 2024 07; 155:106571.
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