Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Wendy Macklin

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Cell and Devopmental Bio
Phone303/724-3426
    Other Positions
    TitleChair
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-Cell and Devopmental Bio


     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Liu Y, Given KS, Harlow DE, Matschulat AM, Macklin WB, Bennett JL, Owens GP. Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination. Acta Neuropathol Commun. 2017 Mar 24; 5(1):25.
      View in: PubMed
    2. Hussain R, Macklin WB. Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle. J Neurosci. 2017 Jan 11; 37(2):397-412.
      View in: PubMed
    3. Liu Y, Harlow DE, Given KS, Owens GP, Macklin WB, Bennett JL. Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica. J Neuroinflammation. 2016 Dec 01; 13(1):301.
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    4. Verden D, Macklin WB. Neuroprotection by central nervous system remyelination: Molecular, cellular, and functional considerations. J Neurosci Res. 2016 Dec; 94(12):1411-1420.
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    5. Turcotte R, Rutledge DJ, Bélanger E, Dill D, Macklin WB, Côté DC. Intravital assessment of myelin molecular order with polarimetric multiphoton microscopy. Sci Rep. 2016 Aug 19; 6:31685.
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    6. Ahrendsen JT, Grewal HS, Hickey SP, Culp CM, Gould EA, Shimizu T, Strnad FA, Traystman RJ, Herson PS, Macklin WB. Juvenile striatal white matter is resistant to ischemia-induced damage. Glia. 2016 Nov; 64(11):1972-86.
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    7. Bai CB, Sun S, Roholt A, Benson E, Edberg D, Medicetty S, Dutta R, Kidd G, Macklin WB, Trapp B. A mouse model for testing remyelinating therapies. Exp Neurol. 2016 Sep; 283(Pt A):330-40.
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    8. Li Y, Dunphy JM, Pedraza CE, Lynch CR, Cardona SM, Macklin WB, Lynch WP. Ecotropic Murine Leukemia Virus Infection of Glial Progenitors Interferes with Oligodendrocyte Differentiation: Implications for Neurovirulence. J Virol. 2016 Jan 13; 90(7):3385-99.
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    9. Dai J, Bercury KK, Jin W, Macklin WB. Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development. J Neurosci. 2015 Dec 02; 35(48):15875-93.
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    10. Novgorodov SA, Riley CL, Keffler JA, Yu J, Kindy MS, Macklin WB, Lombard DB, Gudz TI. SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY. J Biol Chem. 2016 Jan 22; 291(4):1957-73.
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    11. Harlow DE, Saul KE, Komuro H, Macklin WB. Myelin Proteolipid Protein Complexes with av Integrin and AMPA Receptors In Vivo and Regulates AMPA-Dependent Oligodendrocyte Progenitor Cell Migration through the Modulation of Cell-Surface GluR2 Expression. J Neurosci. 2015 Aug 26; 35(34):12018-32.
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    12. Dai J, Bercury KK, Ahrendsen JT, Macklin WB. Olig1 function is required for oligodendrocyte differentiation in the mouse brain. J Neurosci. 2015 Mar 11; 35(10):4386-402.
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    13. Bercury KK, Macklin WB. Dynamics and mechanisms of CNS myelination. Dev Cell. 2015 Feb 23; 32(4):447-58.
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    14. Sachs HH, Bercury KK, Popescu DC, Narayanan SP, Macklin WB. A new model of cuprizone-mediated demyelination/remyelination. ASN Neuro. 2014; 6(5).
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    15. Preston MA, Macklin WB. Zebrafish as a model to investigate CNS myelination. Glia. 2015 Feb; 63(2):177-93.
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    16. Dai J, Bercury KK, Macklin WB. Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation. Glia. 2014 Dec; 62(12):2096-109.
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    17. Greenberg ML, Weinger JG, Matheu MP, Carbajal KS, Parker I, Macklin WB, Lane TE, Cahalan MD. Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):E2349-55.
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    18. Chen L, Coleman R, Leang R, Tran H, Kopf A, Walsh CM, Sears-Kraxberger I, Steward O, Macklin WB, Loring JF, Lane TE. Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis. Stem Cell Reports. 2014 Jun 03; 2(6):825-37.
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    19. Bercury KK, Dai J, Sachs HH, Ahrendsen JT, Wood TL, Macklin WB. Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination. J Neurosci. 2014 Mar 26; 34(13):4466-80.
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    20. Wahl SE, McLane LE, Bercury KK, Macklin WB, Wood TL. Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination. J Neurosci. 2014 Mar 26; 34(13):4453-65.
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    21. Zhao X, Dai J, Ma Y, Mi Y, Cui D, Ju G, Macklin WB, Jin W. Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation. Glia. 2014 Jun; 62(6):914-26.
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    22. Harlow DE, Saul KE, Culp CM, Vesely EM, Macklin WB. Expression of proteolipid protein gene in spinal cord stem cells and early oligodendrocyte progenitor cells is dispensable for normal cell migration and myelination. J Neurosci. 2014 Jan 22; 34(4):1333-43.
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    23. Harlow DE, Macklin WB. Inhibitors of myelination: ECM changes, CSPGs and PTPs. Exp Neurol. 2014 Jan; 251:39-46.
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    24. Jaini R, Popescu DC, Flask CA, Macklin WB, Tuohy VK. Myelin antigen load influences antigen presentation and severity of central nervous system autoimmunity. J Neuroimmunol. 2013 Jun 15; 259(1-2):37-46.
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    25. Dutta R, Chomyk AM, Chang A, Ribaudo MV, Deckard SA, Doud MK, Edberg DD, Bai B, Li M, Baranzini SE, Fox RJ, Staugaitis SM, Macklin WB, Trapp BD. Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors. Ann Neurol. 2013 May; 73(5):637-45.
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    26. Ahrendsen JT, Macklin W. Signaling mechanisms regulating myelination in the central nervous system. Neurosci Bull. 2013 Apr; 29(2):199-215.
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    27. Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB. mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development. ASN Neuro. 2013 Mar 19; 5(1):e00108.
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    28. Hu X, Schlanger R, He W, Macklin WB, Yan R. Reversing hypomyelination in BACE1-null mice with Akt-DD overexpression. FASEB J. 2013 May; 27(5):1868-73.
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    29. Hussain R, Ghoumari AM, Bielecki B, Steibel J, Boehm N, Liere P, Macklin WB, Kumar N, Habert R, Mhaouty-Kodja S, Tronche F, Sitruk-Ware R, Schumacher M, Ghandour MS. The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination. Brain. 2013 Jan; 136(Pt 1):132-46.
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    30. Inamura N, Sugio S, Macklin WB, Tomita K, Tanaka KF, Ikenaka K. Gene induction in mature oligodendrocytes with a PLP-tTA mouse line. Genesis. 2012 May; 50(5):424-8.
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    31. Hussain R, El-Etr M, Gaci O, Rakotomamonjy J, Macklin WB, Kumar N, Sitruk-Ware R, Schumacher M, Ghoumari AM. Progesterone and Nestorone facilitate axon remyelination: a role for progesterone receptors. Endocrinology. 2011 Oct; 152(10):3820-31.
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    32. Zhao L, Spassieva SD, Jucius TJ, Shultz LD, Shick HE, Macklin WB, Hannun YA, Obeid LM, Ackerman SL. A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet. 2011 May; 7(5):e1002063.
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    33. Wang C, Wu C, Popescu DC, Zhu J, Macklin WB, Miller RH, Wang Y. Longitudinal near-infrared imaging of myelination. J Neurosci. 2011 Feb 16; 31(7):2382-90.
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    34. Yu M, Narayanan SP, Wang F, Morse E, Macklin WB, Peachey NS. Visual abnormalities associated with enhanced optic nerve myelination. Brain Res. 2011 Feb 16; 1374:36-42.
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    35. Wu C, Wang C, Popescu DC, Zhu W, Somoza EA, Zhu J, Condie AG, Flask CA, Miller RH, Macklin W, Wang Y. A novel PET marker for in vivo quantification of myelination. Bioorg Med Chem. 2010 Dec 15; 18(24):8592-9.
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    36. Macklin WB. The myelin brake: when enough is enough. Sci Signal. 2010 Sep 21; 3(140):pe32.
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    37. Wang C, Popescu DC, Wu C, Zhu J, Macklin W, Wang Y. In situ fluorescence imaging of myelination. J Histochem Cytochem. 2010 Jul; 58(7):611-21.
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    38. Rasband M, Bansal R, Macklin W, de Vellis J. Editorial. J Neurosci Res. 2009 Nov 15; 87(15):3239-40.
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    39. Tsai HH, Macklin WB, Miller RH. Distinct modes of migration position oligodendrocyte precursors for localized cell division in the developing spinal cord. J Neurosci Res. 2009 Nov 15; 87(15):3320-30.
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    40. Mayer CA, Macklin WB, Avishai N, Balan K, Wilson CG, Miller MJ. Mutation in the myelin proteolipid protein gene alters BK and SK channel function in the caudal medulla. Respir Physiol Neurobiol. 2009 Dec 31; 169(3):303-14.
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    41. Miller MJ, Kangas CD, Macklin WB. Neuronal expression of the proteolipid protein gene in the medulla of the mouse. J Neurosci Res. 2009 Oct; 87(13):2842-53.
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    42. Jacobs EC, Reyes SD, Campagnoni CW, Irene Givogri M, Kampf K, Handley V, Spreuer V, Fisher R, Macklin W, Campagnoni AT. Targeted overexpression of a golli-myelin basic protein isoform to oligodendrocytes results in aberrant oligodendrocyte maturation and myelination. ASN Neuro. 2009 Sep 23; 1(4).
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    43. Narayanan SP, Flores AI, Wang F, Macklin WB. Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination. J Neurosci. 2009 May 27; 29(21):6860-70.
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    44. Paez PM, Fulton DJ, Spreuer V, Handley V, Campagnoni CW, Macklin WB, Colwell C, Campagnoni AT. Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca2+ influx. J Neurosci. 2009 May 20; 29(20):6663-76.
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    45. Pedraza CE, Monk R, Lei J, Hao Q, Macklin WB. Production, characterization, and efficient transfection of highly pure oligodendrocyte precursor cultures from mouse embryonic neural progenitors. Glia. 2008 Sep; 56(12):1339-52.
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    46. Flores AI, Narayanan SP, Morse EN, Shick HE, Yin X, Kidd G, Avila RL, Kirschner DA, Macklin WB. Constitutively active Akt induces enhanced myelination in the CNS. J Neurosci. 2008 Jul 09; 28(28):7174-83.
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    47. Duncan ID, Goldman S, Macklin WB, Rao M, Weiner LP, Reingold SC. Stem cell therapy in multiple sclerosis: promise and controversy. Mult Scler. 2008 May; 14(4):541-6.
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    48. Hu X, He W, Diaconu C, Tang X, Kidd GJ, Macklin WB, Trapp BD, Yan R. Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves. FASEB J. 2008 Aug; 22(8):2970-80.
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    49. Dy P, Penzo-Méndez A, Wang H, Pedraza CE, Macklin WB, Lefebvre V. The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties. Nucleic Acids Res. 2008 May; 36(9):3101-17.
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    50. Malone KE, Stohlman SA, Ramakrishna C, Macklin W, Bergmann CC. Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitis. Glia. 2008 Mar; 56(4):426-35.
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    51. Murtie JC, Macklin WB, Corfas G. Morphometric analysis of oligodendrocytes in the adult mouse frontal cortex. J Neurosci Res. 2007 Aug 01; 85(10):2080-6.
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    52. Wight PA, Duchala CS, Shick HE, Gudz TI, Macklin WB. Expression of a myelin proteolipid protein (Plp)-lacZ transgene is reduced in both the CNS and PNS of Plp(jp) mice. Neurochem Res. 2007 Feb; 32(2):343-51.
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    53. Hu X, Hicks CW, He W, Wong P, Macklin WB, Trapp BD, Yan R. Bace1 modulates myelination in the central and peripheral nervous system. Nat Neurosci. 2006 Dec; 9(12):1520-5.
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    54. Zhao L, Tian D, Xia M, Macklin WB, Feng Y. Rescuing qkV dysmyelination by a single isoform of the selective RNA-binding protein QKI. J Neurosci. 2006 Nov 01; 26(44):11278-86.
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    55. Lee KK, de Repentigny Y, Saulnier R, Rippstein P, Macklin WB, Kothary R. Dominant-negative beta1 integrin mice have region-specific myelin defects accompanied by alterations in MAPK activity. Glia. 2006 Jun; 53(8):836-44.
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    56. Morris JK, Maklad A, Hansen LA, Feng F, Sorensen C, Lee KF, Macklin WB, Fritzsch B. A disorganized innervation of the inner ear persists in the absence of ErbB2. Brain Res. 2006 May 26; 1091(1):186-99.
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    57. Dutta R, McDonough J, Yin X, Peterson J, Chang A, Torres T, Gudz T, Macklin WB, Lewis DA, Fox RJ, Rudick R, Mirnics K, Trapp BD. Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Ann Neurol. 2006 Mar; 59(3):478-89.
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    58. Gudz TI, Komuro H, Macklin WB. Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex. J Neurosci. 2006 Mar 01; 26(9):2458-66.
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    59. González JM, Bergmann CC, Ramakrishna C, Hinton DR, Atkinson R, Hoskin J, Macklin WB, Stohlman SA. Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination. Am J Pathol. 2006 Mar; 168(3):796-804.
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    60. Tsai HH, Macklin WB, Miller RH. Netrin-1 is required for the normal development of spinal cord oligodendrocytes. J Neurosci. 2006 Feb 15; 26(7):1913-22.
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    61. Yin X, Baek RC, Kirschner DA, Peterson A, Fujii Y, Nave KA, Macklin WB, Trapp BD. Evolution of a neuroprotective function of central nervous system myelin. J Cell Biol. 2006 Jan 30; 172(3):469-78.
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    62. Gao L, Macklin W, Gerson J, Miller RH. Intrinsic and extrinsic inhibition of oligodendrocyte development by rat retina. Dev Biol. 2006 Feb 15; 290(2):277-86.
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    63. Sherman DL, Tait S, Melrose S, Johnson R, Zonta B, Court FA, Macklin WB, Meek S, Smith AJ, Cottrell DF, Brophy PJ. Neurofascins are required to establish axonal domains for saltatory conduction. Neuron. 2005 Dec 08; 48(5):737-42.
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    64. Hindinger C, Gonzalez JM, Bergmann CC, Fuss B, Hinton DR, Atkinson RD, Macklin WB, Stohlman SA. Astrocyte expression of a dominant-negative interferon-gamma receptor. J Neurosci Res. 2005 Oct 01; 82(1):20-31.
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    65. Yoshida M, Macklin WB. Oligodendrocyte development and myelination in GFP-transgenic zebrafish. J Neurosci Res. 2005 Jul 01; 81(1):1-8.
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    66. González JM, Bergmann CC, Fuss B, Hinton DR, Kangas C, Macklin WB, Stohlman SA. Expression of a dominant negative IFN-gammareceptor on mouse oligodendrocytes. Glia. 2005 Jul; 51(1):22-34.
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    67. Fewou SN, Büssow H, Schaeren-Wiemers N, Vanier MT, Macklin WB, Gieselmann V, Eckhardt M. Reversal of non-hydroxy:alpha-hydroxy galactosylceramide ratio and unstable myelin in transgenic mice overexpressing UDP-galactose:ceramide galactosyltransferase. J Neurochem. 2005 Jul; 94(2):469-81.
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    68. Lin SC, Huck JH, Roberts JD, Macklin WB, Somogyi P, Bergles DE. Climbing fiber innervation of NG2-expressing glia in the mammalian cerebellum. Neuron. 2005 Jun 02; 46(5):773-85.
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    69. Zhou J, Marten NW, Bergmann CC, Macklin WB, Hinton DR, Stohlman SA. Expression of matrix metalloproteinases and their tissue inhibitor during viral encephalitis. J Virol. 2005 Apr; 79(8):4764-73.
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    70. Papay R, Gaivin R, McCune DF, Rorabaugh BR, Macklin WB, McGrath JC, Perez DM. Mouse alpha1B-adrenergic receptor is expressed in neurons and NG2 oligodendrocytes. J Comp Neurol. 2004 Oct 04; 478(1):1-10.
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    71. Duchala CS, Shick HE, Garcia J, Deweese DM, Sun X, Stewart VJ, Macklin WB. The toppler mouse: a novel mutant exhibiting loss of Purkinje cells. J Comp Neurol. 2004 Aug 16; 476(2):113-29.
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    72. Miller MJ, Haxhiu MA, Kangas CD, Georgiadis P, Gudz TI, Macklin WB. Selective alteration of the ventilatory response to hypoxia results from mutation in the myelin proteolipid protein gene. Adv Exp Med Biol. 2004; 551:85-91.
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    73. Fox MA, Colello RJ, Macklin WB, Fuss B. Phosphodiesterase-Ialpha/autotaxin: a counteradhesive protein expressed by oligodendrocytes during onset of myelination. Mol Cell Neurosci. 2003 Jul; 23(3):507-19.
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    74. Leone DP, Genoud S, Atanasoski S, Grausenburger R, Berger P, Metzger D, Macklin WB, Chambon P, Suter U. Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells. Mol Cell Neurosci. 2003 Apr; 22(4):430-40.
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    75. Miller MJ, Haxhiu MA, Georgiadis P, Gudz TI, Kangas CD, Macklin WB. Proteolipid protein gene mutation induces altered ventilatory response to hypoxia in the myelin-deficient rat. J Neurosci. 2003 Mar 15; 23(6):2265-73.
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    76. Doerflinger NH, Macklin WB, Popko B. Inducible site-specific recombination in myelinating cells. Genesis. 2003 Jan; 35(1):63-72.
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    77. Baracskay KL, Duchala CS, Miller RH, Macklin WB, Trapp BD. Oligodendrogenesis is differentially regulated in gray and white matter of jimpy mice. J Neurosci Res. 2002 Dec 01; 70(5):645-54.
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    78. Mallon BS, Macklin WB. Overexpression of the 3'-untranslated region of myelin proteolipid protein mRNA leads to reduced expression of endogenous proteolipid mRNA. Neurochem Res. 2002 Nov; 27(11):1349-60.
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    79. Gudz TI, Schneider TE, Haas TA, Macklin WB. Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes. J Neurosci. 2002 Sep 01; 22(17):7398-407.
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    80. Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C. Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes. EMBO Rep. 2002 Jun; 3(6):583-8.
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    81. Mallon BS, Shick HE, Kidd GJ, Macklin WB. Proteolipid promoter activity distinguishes two populations of NG2-positive cells throughout neonatal cortical development. J Neurosci. 2002 Feb 01; 22(3):876-85.
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    82. Fuss B, Afshari FS, Colello RJ, Macklin WB. Normal CNS myelination in transgenic mice overexpressing MHC class I H-2L(d) in oligodendrocytes. Mol Cell Neurosci. 2001 Aug; 18(2):221-34.
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    83. Flores AI, Mallon BS, Matsui T, Ogawa W, Rosenzweig A, Okamoto T, Macklin WB. Akt-mediated survival of oligodendrocytes induced by neuregulins. J Neurosci. 2000 Oct 15; 20(20):7622-30.
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    84. Jiang H, Duchala CS, Awatramani R, Shumas S, Carlock L, Kamholz J, Garbern J, Scherer SS, Shy ME, Macklin WB. Proteolipid protein mRNA stability is regulated by axonal contact in the rodent peripheral nervous system. J Neurobiol. 2000 Jul; 44(1):7-19.
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    85. Fuss B, Mallon B, Phan T, Ohlemeyer C, Kirchhoff F, Nishiyama A, Macklin WB. Purification and analysis of in vivo-differentiated oligodendrocytes expressing the green fluorescent protein. Dev Biol. 2000 Feb 15; 218(2):259-74.
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    86. das Neves L, Duchala CS, Tolentino-Silva F, Haxhiu MA, Colmenares C, Macklin WB, Campbell CE, Butz KG, Gronostajski RM, Godinho F. Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum. Proc Natl Acad Sci U S A. 1999 Oct 12; 96(21):11946-51.
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    87. Garbern JY, Cambi F, Lewis R, Shy M, Sima A, Kraft G, Vallat JM, Bosch EP, Hodes ME, Dlouhy S, Raskind W, Bird T, Macklin W, Kamholz J. Peripheral neuropathy caused by proteolipid protein gene mutations. Ann N Y Acad Sci. 1999 Sep 14; 883:351-65.
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    88. Kawczak JA, Mathisen PM, Drazba JA, Fuss B, Macklin WB, Tuohy VK. Digitized image analysis reveals diffuse abnormalities in normal-appearing white matter during acute experimental autoimmune encephalomyelitis. J Neurosci Res. 1998 Nov 01; 54(3):364-72.
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    89. Spassky N, Goujet-Zalc C, Parmantier E, Olivier C, Martinez S, Ivanova A, Ikenaka K, Macklin W, Cerruti I, Zalc B, Thomas JL. Multiple restricted origin of oligodendrocytes. J Neurosci. 1998 Oct 15; 18(20):8331-43.
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    90. Wight PA, Dobretsova A, Macklin WB. Regulation of murine myelin proteolipid protein gene expression. J Neurosci Res. 1997 Dec 15; 50(6):917-27.
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    91. Fuss B, Baba H, Phan T, Tuohy VK, Macklin WB. Phosphodiesterase I, a novel adhesion molecule and/or cytokine involved in oligodendrocyte function. J Neurosci. 1997 Dec 01; 17(23):9095-103.
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    92. Neri CL, Duchala CS, Macklin WB. Expression of molecular chaperones and vesicle transport proteins in differentiating oligodendrocytes. J Neurosci Res. 1997 Dec 01; 50(5):769-80.
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    93. Trapp BD, Nishiyama A, Cheng D, Macklin W. Differentiation and death of premyelinating oligodendrocytes in developing rodent brain. J Cell Biol. 1997 Apr 21; 137(2):459-68.
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    94. Duchala CS, Fuss B, Macklin WB. Use of Transgenic Systems to Investigate Oligodendrocyte Differentiation and Function Methods. 1996 Dec; 10(3):478-88.
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    95. Baba H, Fuss B, Urano J, Poullet P, Watson JB, Tamanoi F, Macklin WB. GapIII, a new brain-enriched member of the GTPase-activating protein family. J Neurosci Res. 1995 Aug 15; 41(6):846-58.
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    96. Duchala CS, Asotra K, Macklin WB. Expression of cell surface markers and myelin proteins in cultured oligodendrocytes from neonatal brain of rat and mouse: a comparative study. Dev Neurosci. 1995; 17(2):70-80.
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    97. Asotra K, Macklin WB. Developmental expression of protein kinase C isozymes in oligodendrocytes and their differential modulation by 4 beta-phorbol-12,13-dibutyrate. J Neurosci Res. 1994 Oct 15; 39(3):273-89.
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    98. Baba H, Fuss B, Watson JB, Zane LT, Macklin WB. Identification of novel mRNAs expressed in oligodendrocytes. Neurochem Res. 1994 Aug; 19(8):1091-9.
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    99. Wight PA, Duchala CS, Readhead C, Macklin WB. A myelin proteolipid protein-LacZ fusion protein is developmentally regulated and targeted to the myelin membrane in transgenic mice. J Cell Biol. 1993 Oct; 123(2):443-54.
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    100. Shirazi Y, Rus HG, Macklin WB, Shin ML. Enhanced degradation of messenger RNA encoding myelin proteins by terminal complement complexes in oligodendrocytes. J Immunol. 1993 May 15; 150(10):4581-90.
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    101. Asotra K, Macklin WB. Protein kinase C activity modulates myelin gene expression in enriched oligodendrocytes. J Neurosci Res. 1993 Apr 01; 34(5):571-88.
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    102. Macklin WB, Gardinier MV, Obeso ZO, King KD, Wight PA. Mutations in the myelin proteolipid protein gene alter oligodendrocyte gene expression in jimpy and jimpymsd mice. J Neurochem. 1991 Jan; 56(1):163-71.
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    103. LeVine SM, Macklin WB. Iron-enriched oligodendrocytes: a reexamination of their spatial distribution. J Neurosci Res. 1990 Aug; 26(4):508-12.
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    104. LeVine SM, Wong D, Macklin WB. Developmental expression of proteolipid protein and DM20 mRNAs and proteins in the rat brain. Dev Neurosci. 1990; 12(4-5):235-50.
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    105. Kumar S, Macklin WB, Gordon MN, Espinosa de los Monteros A, Cole R, Scully SA, de Vellis J. Transcriptional regulation studies of myelin-associated genes in myelin-deficient mutant rats. Dev Neurosci. 1990; 12(4-5):316-25.
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    106. Macklin WB, Gardinier MV, Obeso ZO. Structure and expression of the mouse myelin proteolipid protein gene. Ann N Y Acad Sci. 1990; 605:183-93.
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    107. Gardinier MV, Macklin WB. Myelin proteolipid protein gene expression in jimpy and jimpy(msd) mice. J Neurochem. 1988 Aug; 51(2):360-9.
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    108. LeVine SM, Macklin WB. Biotin enrichment in oligodendrocytes in the rat brain. Brain Res. 1988 Mar 15; 444(1):199-203.
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    109. Campagnoni AT, Macklin WB. Cellular and molecular aspects of myelin protein gene expression. Mol Neurobiol. 1988; 2(1):41-89.
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    110. Macklin WB, Gardinier MV, King KD, Kampf K. An AG----GG transition at a splice site in the myelin proteolipid protein gene in jimpy mice results in the removal of an exon. FEBS Lett. 1987 Nov 02; 223(2):417-21.
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    111. Macklin WB, Campagnoni CW, Deininger PL, Gardinier MV. Structure and expression of the mouse myelin proteolipid protein gene. J Neurosci Res. 1987; 18(3):383-94.
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    112. Kronquist KE, Crandall BF, Macklin WB, Campagnoni AT. Expression of myelin proteins in the developing human spinal cord: cloning and sequencing of human proteolipid protein cDNA. J Neurosci Res. 1987; 18(3):395-401.
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    113. Gardinier MV, Macklin WB, Diniak AJ, Deininger PL. Characterization of myelin proteolipid mRNAs in normal and jimpy mice. Mol Cell Biol. 1986 Nov; 6(11):3755-62.
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    114. Macklin WB, Weill CL, Deininger PL. Expression of myelin proteolipid and basic protein mRNAs in cultured cells. J Neurosci Res. 1986; 16(1):203-17.
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    115. Macklin WB, Weill CL. Appearance of myelin proteins during development in the chick central nervous system. Dev Neurosci. 1985; 7(3):170-8.
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    116. Cambi F, Lees MB, Williams RM, Macklin WB. Chronic experimental allergic encephalomyelitis produced by bovine proteolipid apoprotein: immunological studies in rabbits. Ann Neurol. 1983 Mar; 13(3):303-8.
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    117. Macklin WB, Oberfield E, Lees MB. Electroblot analysis of rat myelin proteolipid protein and basic protein during development. Dev Neurosci. 1983-1984; 6(3):161-8.
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    118. Williams RM, Lees MB, Cambi F, Macklin WB. Chronic experimental allergic encephalomyelitis induced in rabbits with bovine white matter proteolipid apoprotein. J Neuropathol Exp Neurol. 1982 Sep; 41(5):508-21.
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    119. Macklin WB, Lees MB. Solid-phase immunoassays for quantitation of antibody to bovine white matter proteolipid apoprotein. J Neurochem. 1982 Feb; 38(2):348-55.
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    120. Macklin WB, Braun PE, Lees MB. Electroblot analysis of the myelin proteolipid protein. J Neurosci Res. 1982; 7(1):1-10.
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    121. Lees MB, Macklin WB, Chao BH. A study of elastase peptides from bovine white matter proteolipid. Neurochem Res. 1981 Oct; 6(10):1091-104.
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    122. Macklin WB, Lees MB, Cohen SR, Ayella SB. Hydrophobic compounds interfere in radioimmunoassay for basic protein in myelin. Clin Chem. 1981 May; 27(5):742-4.
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    123. Macklin WB, Schwarting GA, Lees MB, Cohen SR. Production and purification of antibody to bovine white matter proteolipid apoprotein. J Neurochem. 1981 Jan; 36(1):101-6.
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    124. Macklin WB, Meyer DJ, Woodward DO, Erickson SK. Chloramphenicol-sensitive labelling of protein in microsomes of Neurospora crassa. Nature. 1977 Sep 29; 269(5627):447-50.
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