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Wendy Macklin

TitleDistinguished Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Cell and Devopmental Bio
Phone303/724-3426

    Collapse Research 
    Collapse research activities and funding
    R21NS135041     (MACKLIN, WENDY B)Jul 1, 2024 - Jun 30, 2026
    NIH
    Axonal signaling regulating oligodendrocyte differentiation
    Role: Principal Investigator
    R01NS115488     (MACKLIN, WENDY B)Jun 15, 2020 - Mar 31, 2025
    NIH
    Microglial impact on remyelination
    Role: Principal Investigator
    R01NS105788     (MACKLIN, WENDY B)Jan 1, 2019 - Dec 31, 2024
    NIH
    Oligodendrocyte responses to stresses
    Role: Principal Investigator
    R21NS102705     (MACKLIN, WENDY B)May 1, 2017 - Apr 30, 2019
    NIH
    The role of orphan nuclear receptor Nur77/NR4A1 in oligodendrocyte development
    Role: Principal Investigator
    R37NS082203     (MACKLIN, WENDY B)Sep 30, 2012 - Jul 31, 2024
    NIH
    The role of mTOR signaling in oligodendrocyte differentiation and CNS myelination
    Role: Principal Investigator
    R01NS082203     (MACKLIN, WENDY B)Sep 30, 2012 - Sep 29, 2017
    NIH
    The role of mTOR signaling in oligodendrocyte differentiation and CNS myelination
    Role: Principal Investigator
    R21NS078386     (MACKLIN, WENDY B)Apr 1, 2012 - Mar 31, 2015
    NIH
    Development of zebrafish as a screening tool for remyelination drugs
    Role: Principal Investigator
    R13NS067696     (MACKLIN, WENDY B)Jan 27, 2010 - Dec 31, 2010
    NIH
    2010 Myelin Gordon Research Conference
    Role: Principal Investigator
    R13NS061503     (MACKLIN, WENDY B)Sep 30, 2007 - Aug 31, 2008
    NIH
    2008 Myelin Gordon Research Conference
    Role: Principal Investigator
    R01NS056417     (MACKLIN, WENDY B)Apr 1, 2007 - Mar 31, 2013
    NIH
    Signaling pathways controlling myelination
    Role: Principal Investigator
    R13NS055474     (MACKLIN, WENDY B)Mar 3, 2006 - Feb 28, 2007
    NIH
    American Society for Neurochemistry: Cellular and Molecular Mechanisms of Neural
    Role: Principal Investigator
    R01NS038171     (MACKLIN, WENDY B)Sep 30, 1999 - Aug 31, 2005
    NIH
    EFFECTS OF NEURONAL DEGENERATION ON OLIGODENDROCYTES
    Role: Principal Investigator
    R01NS025304     (MACKLIN, WENDY B)Jul 1, 1987 - Dec 31, 2014
    NIH
    Myelin Protein Gene Expression in Dysmyelinating Mutants
    Role: Principal Investigator
    K04NS001089     (MACKLIN, WENDY B)Dec 1, 1985 - Nov 30, 1989
    NIH
    INVESTIGATIONS ON OLIGODENDROCYTE DIFFERENTATION
    Role: Principal Investigator
    R01NS023715     (MACKLIN, WENDY B)Dec 1, 1985 - Aug 31, 1989
    NIH
    ACYLATION OF MYELIN PROTEOLIPID AND OTHER BRAIN PROTEINS
    Role: Principal Investigator
    K04NS000971     (MACKLIN, WENDY B)Apr 1, 1985 - Jun 30, 1985
    NIH
    INVESTIGATIONS ON OLIGODENDROCYTE DIFFERENTIATION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Owens GP, Fellin TJ, Matschulat A, Salas V, Schaller KL, Given KS, Ritchie AM, Navarro A, Blauth K, Hughes EG, Macklin WB, Bennett JL. Pathogenic myelin-specific antibodies in multiple sclerosis target conformational proteolipid protein 1-anchored membrane domains. J Clin Invest. 2023 10 02; 133(19). PMID: 37561592.
      View in: PubMed
    2. Almeida AR, Macklin WB. Early myelination involves the dynamic and repetitive ensheathment of axons which resolves through a low and consistent stabilization rate. Elife. 2023 04 20; 12. PMID: 37078701.
      View in: PubMed
    3. Frazier AP, Mitchell DN, Given KS, Hunn G, Burch AM, Childs CR, Moreno-Garcia M, Corigilano MR, Quillinan N, Macklin WB, Herson PS, Dingman AL. Chronic changes in oligodendrocyte sub-populations after middle cerebral artery occlusion in neonatal mice. Glia. 2023 06; 71(6):1429-1450. PMID: 36794545.
      View in: PubMed
    4. Jewett CE, McCurdy BL, O'Toole ET, Stemm-Wolf AJ, Given KS, Lin CH, Olsen V, Martin W, Reinholdt L, Espinosa JM, Sullivan KD, Macklin WB, Prekeris R, Pearson CG. Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development. Elife. 2023 01 19; 12. PMID: 36656118.
      View in: PubMed
    5. Woods C, Flockton AR, Wallace LE, Keenan CM, Macklin WB, Sharkey KA, Belkind-Gerson J. Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse. Am J Physiol Gastrointest Liver Physiol. 2023 02 01; 324(2):G115-G130. PMID: 36511517.
      View in: PubMed
    6. Bubak AN, Merle L, Niemeyer CS, Baxter BD, Gentile Polese A, Ramakrishnan V, Gomez J, Madrigal L, Villegas-Lanau A, Lopera F, Macklin W, Frietze S, Nagel MA, Restrepo D. Signatures for viral infection and inflammation in the proximal olfactory system in familial Alzheimer's disease. Neurobiol Aging. 2023 03; 123:75-82. PMID: 36638683.
      View in: PubMed
    7. Dahl KD, Almeida AR, Hathaway HA, Bourne J, Brown TL, Finseth LT, Wood TL, Macklin WB. mTORC2 Loss in Oligodendrocyte Progenitor Cells Results in Regional Hypomyelination in the Central Nervous System. J Neurosci. 2023 01 25; 43(4):540-558. PMID: 36460463.
      View in: PubMed
    8. Mendiola AS, Church KA, Cardona SM, Vanegas D, Garcia SA, Macklin W, Lira SA, Ransohoff RM, Kokovay E, Lin CA, Cardona AE. Defective fractalkine-CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone-induced demyelination. J Neurochem. 2022 09; 162(5):430-443. PMID: 35560167.
      View in: PubMed
    9. Khandker L, Jeffries MA, Chang YJ, Mather ML, Evangelou AV, Bourne JN, Tafreshi AK, Ornelas IM, Bozdagi-Gunal O, Macklin WB, Wood TL. Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord. Cell Rep. 2022 03 01; 38(9):110423. PMID: 35235799.
      View in: PubMed
    10. Benardais K, Ornelas IM, Fauveau M, Brown TL, Finseth LT, Panic R, Deboux C, Macklin WB, Wood TL, Nait-Oumesmar B. p70S6 kinase regulates oligodendrocyte differentiation and is active in remyelinating lesions. Brain Commun. 2022; 4(1):fcac025. PMID: 35224490.
      View in: PubMed
    11. George NM, Gentile Polese A, Merle L, Macklin WB, Restrepo D. Excitable Axonal Domains Adapt to Sensory Deprivation in the Olfactory System. J Neurosci. 2022 02 23; 42(8):1491-1509. PMID: 35022219.
      View in: PubMed
    12. Vicentini FA, Keenan CM, Wallace LE, Woods C, Cavin JB, Flockton AR, Macklin WB, Belkind-Gerson J, Hirota SA, Sharkey KA. Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia. Microbiome. 2021 10 26; 9(1):210. PMID: 34702353.
      View in: PubMed
    13. Jeffries MA, McLane LE, Khandker L, Mather ML, Evangelou AV, Kantak D, Bourne JN, Macklin WB, Wood TL. mTOR Signaling Regulates Metabolic Function in Oligodendrocyte Precursor Cells and Promotes Efficient Brain Remyelination in the Cuprizone Model. J Neurosci. 2021 10 06; 41(40):8321-8337. PMID: 34417330.
      View in: PubMed
    14. Kohnke S, Buller S, Nuzzaci D, Ridley K, Lam B, Pivonkova H, Bentsen MA, Alonge KM, Zhao C, Tadross J, Holmqvist S, Shimizu T, Hathaway H, Li H, Macklin W, Schwartz MW, Richardson WD, Yeo GSH, Franklin RJM, Karadottir RT, Rowitch DH, Blouet C. Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence. Cell Rep. 2021 07 13; 36(2):109362. PMID: 34260928.
      View in: PubMed
    15. Kapitza C, Chunder R, Scheller A, Given KS, Macklin WB, Enders M, Kuerten S, Neuhuber WL, W?rl J. Murine Esophagus Expresses Glial-Derived Central Nervous System Antigens. Int J Mol Sci. 2021 Mar 22; 22(6). PMID: 33810144.
      View in: PubMed
    16. Brown TL, Hashimoto H, Finseth LT, Wood TL, Macklin WB. PAK1 Positively Regulates Oligodendrocyte Morphology and Myelination. J Neurosci. 2021 03 03; 41(9):1864-1877. PMID: 33478987.
      View in: PubMed
    17. Bargagna-Mohan P, Schultz G, Rheaume B, Trakhtenberg EF, Robson P, Pal-Ghosh S, Stepp MA, Given KS, Macklin WB, Mohan R. Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers. J Neurosci Res. 2021 03; 99(3):731-749. PMID: 33197966.
      View in: PubMed
    18. Adams KL, Dahl KD, Gallo V, Macklin WB. Intrinsic and extrinsic regulators of oligodendrocyte progenitor proliferation and differentiation. Semin Cell Dev Biol. 2021 08; 116:16-24. PMID: 34110985.
      View in: PubMed
    19. Musah AS, Brown TL, Jeffries MA, Shang Q, Hashimoto H, Evangelou AV, Kowalski A, Batish M, Macklin WB, Wood TL. Mechanistic Target of Rapamycin Regulates the Oligodendrocyte Cytoskeleton during Myelination. J Neurosci. 2020 04 08; 40(15):2993-3007. PMID: 32139584.
      View in: PubMed
    20. Ornelas IM, Khandker L, Wahl SE, Hashimoto H, Macklin WB, Wood TL. The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation. Glia. 2020 06; 68(6):1274-1290. PMID: 31904150.
      View in: PubMed
    21. Liu Y, Given KS, Dickson EL, Owens GP, Macklin WB, Bennett JL. Concentration-dependent effects of CSF1R inhibitors on oligodendrocyte progenitor cells ex vivo and in vivo. Exp Neurol. 2019 08; 318:32-41. PMID: 31029597.
      View in: PubMed
    22. Dingman AL, Rodgers KM, Dietz RM, Hickey SP, Frazier AP, Clevenger AC, Yonchek JC, Traystman RJ, Macklin WB, Herson PS. Oligodendrocyte Progenitor Cell Proliferation and Fate after White Matter Stroke in Juvenile and Adult Mice. Dev Neurosci. 2019 Mar 12; 1-16. PMID: 30861520.
      View in: PubMed
    23. Brown TL, Macklin WB. The Actin Cytoskeleton in Myelinating Cells. Neurochem Res. 2020 Mar; 45(3):684-693. PMID: 30847860.
      View in: PubMed
    24. Ishii A, Furusho M, Macklin W, Bansal R. Independent and cooperative roles of the Mek/ERK1/2-MAPK and PI3K/Akt/mTOR pathways during developmental myelination and in adulthood. Glia. 2019 07; 67(7):1277-1295. PMID: 30761608.
      View in: PubMed
    25. Preston MA, Finseth LT, Bourne JN, Macklin WB. A novel myelin protein zero transgenic zebrafish designed for rapid readout of in vivo myelination. Glia. 2019 04; 67(4):650-667. PMID: 30623975.
      View in: PubMed
    26. Liu Y, Given KS, Owens GP, Macklin WB, Bennett JL. Distinct patterns of glia repair and remyelination in antibody-mediated demyelination models of multiple sclerosis and neuromyelitis optica. Glia. 2018 12; 66(12):2575-2588. PMID: 30240044.
      View in: PubMed
    27. Rodgers KM, Ahrendsen JT, Patsos OP, Strnad FA, Yonchek JC, Traystman RJ, Macklin WB, Herson PS. Endogenous Neuronal Replacement in the Juvenile Brain Following Cerebral Ischemia. Neuroscience. 2018 06 01; 380:1-13. PMID: 29649514.
      View in: PubMed
    28. Bruce KD, Gorkhali S, Given K, Coates AM, Boyle KE, Macklin WB, Eckel RH. Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination. Front Mol Neurosci. 2018; 11:57. PMID: 29599706.
      View in: PubMed
    29. Gould EA, Busquet N, Shepherd D, Dietz RM, Herson PS, Simoes de Souza FM, Li A, George NM, Restrepo D, Macklin WB. Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone. Elife. 2018 02 13; 7. PMID: 29436368.
      View in: PubMed
    30. Orfila JE, Grewal H, Dietz RM, Strnad F, Shimizu T, Moreno M, Schroeder C, Yonchek J, Rodgers KM, Dingman A, Bernard TJ, Quillinan N, Macklin WB, Traystman RJ, Herson PS. Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke. J Cereb Blood Flow Metab. 2019 06; 39(6):1005-1014. PMID: 29283314.
      View in: PubMed
    31. Ahrendsen JT, Harlow DE, Finseth LT, Bourne JN, Hickey SP, Gould EA, Culp CM, Macklin WB. The Protein Tyrosine Phosphatase Shp2 Regulates Oligodendrocyte Differentiation and Early Myelination and Contributes to Timely Remyelination. J Neurosci. 2018 01 24; 38(4):787-802. PMID: 29217681.
      View in: PubMed
    32. Abi Ghanem C, Degerny C, Hussain R, Liere P, Pianos A, Tourpin S, Habert R, Macklin WB, Schumacher M, Ghoumari AM. Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor. PLoS Genet. 2017 Nov; 13(11):e1007049. PMID: 29107990.
      View in: PubMed
    33. Peschl P, Schanda K, Zeka B, Given K, B?hm D, Ruprecht K, Saiz A, Lutterotti A, Rost?sy K, H?ftberger R, Berger T, Macklin W, Lassmann H, Bradl M, Bennett JL, Reindl M. Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination. J Neuroinflammation. 2017 Oct 25; 14(1):208. PMID: 29070051.
      View in: PubMed
    34. Ryan DP, Gould EA, Seedorf GJ, Masihzadeh O, Abman SH, Vijayaraghavan S, Macklin WB, Restrepo D, Shepherd DP. Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy. Nat Commun. 2017 09 20; 8(1):612. PMID: 28931809.
      View in: PubMed
    35. McLane LE, Bourne JN, Evangelou AV, Khandker L, Macklin WB, Wood TL. Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination. J Neurosci. 2017 08 02; 37(31):7534-7546. PMID: 28694334.
      View in: PubMed
    36. Liu Y, Given KS, Harlow DE, Matschulat AM, Macklin WB, Bennett JL, Owens GP. Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination. Acta Neuropathol Commun. 2017 03 24; 5(1):25. PMID: 28340598.
      View in: PubMed
    37. Hussain R, Macklin WB. Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle. J Neurosci. 2017 01 11; 37(2):397-412. PMID: 28077718.
      View in: PubMed
    38. Liu Y, Harlow DE, Given KS, Owens GP, Macklin WB, Bennett JL. Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica. J Neuroinflammation. 2016 12 01; 13(1):301. PMID: 27905992.
      View in: PubMed
    39. Verden D, Macklin WB. Neuroprotection by central nervous system remyelination: Molecular, cellular, and functional considerations. J Neurosci Res. 2016 12; 94(12):1411-1420. PMID: 27618492.
      View in: PubMed
    40. Turcotte R, Rutledge DJ, B?langer E, Dill D, Macklin WB, C?t? DC. Intravital assessment of myelin molecular order with polarimetric multiphoton microscopy. Sci Rep. 2016 08 19; 6:31685. PMID: 27538357.
      View in: PubMed
    41. Ahrendsen JT, Grewal HS, Hickey SP, Culp CM, Gould EA, Shimizu T, Strnad FA, Traystman RJ, Herson PS, Macklin WB. Juvenile striatal white matter is resistant to ischemia-induced damage. Glia. 2016 11; 64(11):1972-86. PMID: 27463063.
      View in: PubMed
    42. Bai CB, Sun S, Roholt A, Benson E, Edberg D, Medicetty S, Dutta R, Kidd G, Macklin WB, Trapp B. A mouse model for testing remyelinating therapies. Exp Neurol. 2016 09; 283(Pt A):330-40. PMID: 27384502.
      View in: PubMed
    43. Li Y, Dunphy JM, Pedraza CE, Lynch CR, Cardona SM, Macklin WB, Lynch WP. Ecotropic Murine Leukemia Virus Infection of Glial Progenitors Interferes with Oligodendrocyte Differentiation: Implications for Neurovirulence. J Virol. 2016 Jan 13; 90(7):3385-99. PMID: 26764005.
      View in: PubMed
    44. Dai J, Bercury KK, Jin W, Macklin WB. Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development. J Neurosci. 2015 Dec 02; 35(48):15875-93. PMID: 26631469.
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    45. Novgorodov SA, Riley CL, Keffler JA, Yu J, Kindy MS, Macklin WB, Lombard DB, Gudz TI. SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY. J Biol Chem. 2016 Jan 22; 291(4):1957-1973. PMID: 26620563.
      View in: PubMed
    46. Harlow DE, Saul KE, Komuro H, Macklin WB. Myelin Proteolipid Protein Complexes with av Integrin and AMPA Receptors In Vivo and Regulates AMPA-Dependent Oligodendrocyte Progenitor Cell Migration through the Modulation of Cell-Surface GluR2 Expression. J Neurosci. 2015 Aug 26; 35(34):12018-32. PMID: 26311781.
      View in: PubMed
    47. Dai J, Bercury KK, Ahrendsen JT, Macklin WB. Olig1 function is required for oligodendrocyte differentiation in the mouse brain. J Neurosci. 2015 Mar 11; 35(10):4386-402. PMID: 25762682.
      View in: PubMed
    48. Bercury KK, Macklin WB. Dynamics and mechanisms of CNS myelination. Dev Cell. 2015 Feb 23; 32(4):447-58. PMID: 25710531.
      View in: PubMed
    49. Sachs HH, Bercury KK, Popescu DC, Narayanan SP, Macklin WB. A new model of cuprizone-mediated demyelination/remyelination. ASN Neuro. 2014; 6(5). PMID: 25290063.
      View in: PubMed
    50. Preston MA, Macklin WB. Zebrafish as a model to investigate CNS myelination. Glia. 2015 Feb; 63(2):177-93. PMID: 25263121.
      View in: PubMed
    51. Dai J, Bercury KK, Macklin WB. Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation. Glia. 2014 Dec; 62(12):2096-109. PMID: 25060812.
      View in: PubMed
    52. Greenberg ML, Weinger JG, Matheu MP, Carbajal KS, Parker I, Macklin WB, Lane TE, Cahalan MD. Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):E2349-55. PMID: 24843159.
      View in: PubMed
    53. Chen L, Coleman R, Leang R, Tran H, Kopf A, Walsh CM, Sears-Kraxberger I, Steward O, Macklin WB, Loring JF, Lane TE. Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis. Stem Cell Reports. 2014 Jun 03; 2(6):825-37. PMID: 24936469.
      View in: PubMed
    54. Bercury KK, Dai J, Sachs HH, Ahrendsen JT, Wood TL, Macklin WB. Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination. J Neurosci. 2014 Mar 26; 34(13):4466-80. PMID: 24671993.
      View in: PubMed
    55. Wahl SE, McLane LE, Bercury KK, Macklin WB, Wood TL. Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination. J Neurosci. 2014 Mar 26; 34(13):4453-65. PMID: 24671992.
      View in: PubMed
    56. Zhao X, Dai J, Ma Y, Mi Y, Cui D, Ju G, Macklin WB, Jin W. Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation. Glia. 2014 Jun; 62(6):914-26. PMID: 24615693.
      View in: PubMed
    57. Harlow DE, Saul KE, Culp CM, Vesely EM, Macklin WB. Expression of proteolipid protein gene in spinal cord stem cells and early oligodendrocyte progenitor cells is dispensable for normal cell migration and myelination. J Neurosci. 2014 Jan 22; 34(4):1333-43. PMID: 24453324.
      View in: PubMed
    58. Harlow DE, Macklin WB. Inhibitors of myelination: ECM changes, CSPGs and PTPs. Exp Neurol. 2014 Jan; 251:39-46. PMID: 24200549.
      View in: PubMed
    59. Jaini R, Popescu DC, Flask CA, Macklin WB, Tuohy VK. Myelin antigen load influences antigen presentation and severity of central nervous system autoimmunity. J Neuroimmunol. 2013 Jun 15; 259(1-2):37-46. PMID: 23601904.
      View in: PubMed
    60. Dutta R, Chomyk AM, Chang A, Ribaudo MV, Deckard SA, Doud MK, Edberg DD, Bai B, Li M, Baranzini SE, Fox RJ, Staugaitis SM, Macklin WB, Trapp BD. Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors. Ann Neurol. 2013 May; 73(5):637-45. PMID: 23595422.
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    61. Ahrendsen JT, Macklin W. Signaling mechanisms regulating myelination in the central nervous system. Neurosci Bull. 2013 Apr; 29(2):199-215. PMID: 23558589.
      View in: PubMed
    62. Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB. mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development. ASN Neuro. 2013 Mar 19; 5(1):e00108. PMID: 23421405.
      View in: PubMed
    63. Hu X, Schlanger R, He W, Macklin WB, Yan R. Reversing hypomyelination in BACE1-null mice with Akt-DD overexpression. FASEB J. 2013 May; 27(5):1868-73. PMID: 23335052.
      View in: PubMed
    64. Hussain R, Ghoumari AM, Bielecki B, Steibel J, Boehm N, Liere P, Macklin WB, Kumar N, Habert R, Mhaouty-Kodja S, Tronche F, Sitruk-Ware R, Schumacher M, Ghandour MS. The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination. Brain. 2013 Jan; 136(Pt 1):132-46. PMID: 23365095.
      View in: PubMed
    65. Inamura N, Sugio S, Macklin WB, Tomita K, Tanaka KF, Ikenaka K. Gene induction in mature oligodendrocytes with a PLP-tTA mouse line. Genesis. 2012 May; 50(5):424-8. PMID: 21953949.
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    66. Hussain R, El-Etr M, Gaci O, Rakotomamonjy J, Macklin WB, Kumar N, Sitruk-Ware R, Schumacher M, Ghoumari AM. Progesterone and Nestorone facilitate axon remyelination: a role for progesterone receptors. Endocrinology. 2011 Oct; 152(10):3820-31. PMID: 21828184.
      View in: PubMed
    67. Zhao L, Spassieva SD, Jucius TJ, Shultz LD, Shick HE, Macklin WB, Hannun YA, Obeid LM, Ackerman SL. A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet. 2011 May; 7(5):e1002063. PMID: 21625621.
      View in: PubMed
    68. Wang C, Wu C, Popescu DC, Zhu J, Macklin WB, Miller RH, Wang Y. Longitudinal near-infrared imaging of myelination. J Neurosci. 2011 Feb 16; 31(7):2382-90. PMID: 21325505.
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    69. Yu M, Narayanan SP, Wang F, Morse E, Macklin WB, Peachey NS. Visual abnormalities associated with enhanced optic nerve myelination. Brain Res. 2011 Feb 16; 1374:36-42. PMID: 21172315.
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    70. Wu C, Wang C, Popescu DC, Zhu W, Somoza EA, Zhu J, Condie AG, Flask CA, Miller RH, Macklin W, Wang Y. A novel PET marker for in vivo quantification of myelination. Bioorg Med Chem. 2010 Dec 15; 18(24):8592-9. PMID: 21071233.
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    71. Macklin WB. The myelin brake: when enough is enough. Sci Signal. 2010 Sep 21; 3(140):pe32. PMID: 20858865.
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    72. Wang C, Popescu DC, Wu C, Zhu J, Macklin W, Wang Y. In situ fluorescence imaging of myelination. J Histochem Cytochem. 2010 Jul; 58(7):611-21. PMID: 20354147.
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    73. Rasband M, Bansal R, Macklin W, de Vellis J. Editorial. J Neurosci Res. 2009 Nov 15; 87(15):3239-40. PMID: 19806674.
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    74. Tsai HH, Macklin WB, Miller RH. Distinct modes of migration position oligodendrocyte precursors for localized cell division in the developing spinal cord. J Neurosci Res. 2009 Nov 15; 87(15):3320-30. PMID: 19301427.
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    75. Mayer CA, Macklin WB, Avishai N, Balan K, Wilson CG, Miller MJ. Mutation in the myelin proteolipid protein gene alters BK and SK channel function in the caudal medulla. Respir Physiol Neurobiol. 2009 Dec 31; 169(3):303-14. PMID: 19808102.
      View in: PubMed
    76. Miller MJ, Kangas CD, Macklin WB. Neuronal expression of the proteolipid protein gene in the medulla of the mouse. J Neurosci Res. 2009 Oct; 87(13):2842-53. PMID: 19479988.
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    77. Jacobs EC, Reyes SD, Campagnoni CW, Irene Givogri M, Kampf K, Handley V, Spreuer V, Fisher R, Macklin W, Campagnoni AT. Targeted overexpression of a golli-myelin basic protein isoform to oligodendrocytes results in aberrant oligodendrocyte maturation and myelination. ASN Neuro. 2009 Sep 23; 1(4). PMID: 19715557.
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    78. Narayanan SP, Flores AI, Wang F, Macklin WB. Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination. J Neurosci. 2009 May 27; 29(21):6860-70. PMID: 19474313.
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    79. Paez PM, Fulton DJ, Spreuer V, Handley V, Campagnoni CW, Macklin WB, Colwell C, Campagnoni AT. Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca2+ influx. J Neurosci. 2009 May 20; 29(20):6663-76. PMID: 19458236.
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    80. Pedraza CE, Monk R, Lei J, Hao Q, Macklin WB. Production, characterization, and efficient transfection of highly pure oligodendrocyte precursor cultures from mouse embryonic neural progenitors. Glia. 2008 Sep; 56(12):1339-52. PMID: 18512250.
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    81. Flores AI, Narayanan SP, Morse EN, Shick HE, Yin X, Kidd G, Avila RL, Kirschner DA, Macklin WB. Constitutively active Akt induces enhanced myelination in the CNS. J Neurosci. 2008 Jul 09; 28(28):7174-83. PMID: 18614687.
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    82. Duncan ID, Goldman S, Macklin WB, Rao M, Weiner LP, Reingold SC. Stem cell therapy in multiple sclerosis: promise and controversy. Mult Scler. 2008 May; 14(4):541-6. PMID: 18562508.
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    83. Hu X, He W, Diaconu C, Tang X, Kidd GJ, Macklin WB, Trapp BD, Yan R. Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves. FASEB J. 2008 Aug; 22(8):2970-80. PMID: 18413858.
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    84. Dy P, Penzo-M?ndez A, Wang H, Pedraza CE, Macklin WB, Lefebvre V. The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties. Nucleic Acids Res. 2008 May; 36(9):3101-17. PMID: 18403418.
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    85. Malone KE, Stohlman SA, Ramakrishna C, Macklin W, Bergmann CC. Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitis. Glia. 2008 Mar; 56(4):426-35. PMID: 18205173.
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    86. Murtie JC, Macklin WB, Corfas G. Morphometric analysis of oligodendrocytes in the adult mouse frontal cortex. J Neurosci Res. 2007 Aug 01; 85(10):2080-6. PMID: 17492793.
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    87. Wight PA, Duchala CS, Shick HE, Gudz TI, Macklin WB. Expression of a myelin proteolipid protein (Plp)-lacZ transgene is reduced in both the CNS and PNS of Plp(jp) mice. Neurochem Res. 2007 Feb; 32(2):343-51. PMID: 17191136.
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    88. Hu X, Hicks CW, He W, Wong P, Macklin WB, Trapp BD, Yan R. Bace1 modulates myelination in the central and peripheral nervous system. Nat Neurosci. 2006 Dec; 9(12):1520-5. PMID: 17099708.
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    89. Zhao L, Tian D, Xia M, Macklin WB, Feng Y. Rescuing qkV dysmyelination by a single isoform of the selective RNA-binding protein QKI. J Neurosci. 2006 Nov 01; 26(44):11278-86. PMID: 17079655.
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    90. Lee KK, de Repentigny Y, Saulnier R, Rippstein P, Macklin WB, Kothary R. Dominant-negative beta1 integrin mice have region-specific myelin defects accompanied by alterations in MAPK activity. Glia. 2006 Jun; 53(8):836-44. PMID: 16575886.
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    91. Morris JK, Maklad A, Hansen LA, Feng F, Sorensen C, Lee KF, Macklin WB, Fritzsch B. A disorganized innervation of the inner ear persists in the absence of ErbB2. Brain Res. 2006 May 26; 1091(1):186-99. PMID: 16630588.
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    92. Dutta R, McDonough J, Yin X, Peterson J, Chang A, Torres T, Gudz T, Macklin WB, Lewis DA, Fox RJ, Rudick R, Mirnics K, Trapp BD. Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Ann Neurol. 2006 Mar; 59(3):478-89. PMID: 16392116.
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    93. Gudz TI, Komuro H, Macklin WB. Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex. J Neurosci. 2006 Mar 01; 26(9):2458-66. PMID: 16510724.
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    94. Gonz?lez JM, Bergmann CC, Ramakrishna C, Hinton DR, Atkinson R, Hoskin J, Macklin WB, Stohlman SA. Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination. Am J Pathol. 2006 Mar; 168(3):796-804. PMID: 16507895.
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    95. Tsai HH, Macklin WB, Miller RH. Netrin-1 is required for the normal development of spinal cord oligodendrocytes. J Neurosci. 2006 Feb 15; 26(7):1913-22. PMID: 16481423.
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    96. Yin X, Baek RC, Kirschner DA, Peterson A, Fujii Y, Nave KA, Macklin WB, Trapp BD. Evolution of a neuroprotective function of central nervous system myelin. J Cell Biol. 2006 Jan 30; 172(3):469-78. PMID: 16449196.
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    97. Gao L, Macklin W, Gerson J, Miller RH. Intrinsic and extrinsic inhibition of oligodendrocyte development by rat retina. Dev Biol. 2006 Feb 15; 290(2):277-86. PMID: 16388796.
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    98. Sherman DL, Tait S, Melrose S, Johnson R, Zonta B, Court FA, Macklin WB, Meek S, Smith AJ, Cottrell DF, Brophy PJ. Neurofascins are required to establish axonal domains for saltatory conduction. Neuron. 2005 Dec 08; 48(5):737-42. PMID: 16337912.
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    99. Hindinger C, Gonzalez JM, Bergmann CC, Fuss B, Hinton DR, Atkinson RD, Macklin WB, Stohlman SA. Astrocyte expression of a dominant-negative interferon-gamma receptor. J Neurosci Res. 2005 Oct 01; 82(1):20-31. PMID: 16118798.
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    100. Yoshida M, Macklin WB. Oligodendrocyte development and myelination in GFP-transgenic zebrafish. J Neurosci Res. 2005 Jul 01; 81(1):1-8. PMID: 15920740.
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    101. Gonz?lez JM, Bergmann CC, Fuss B, Hinton DR, Kangas C, Macklin WB, Stohlman SA. Expression of a dominant negative IFN-gammareceptor on mouse oligodendrocytes. Glia. 2005 Jul; 51(1):22-34. PMID: 15779088.
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    102. Fewou SN, B?ssow H, Schaeren-Wiemers N, Vanier MT, Macklin WB, Gieselmann V, Eckhardt M. Reversal of non-hydroxy:alpha-hydroxy galactosylceramide ratio and unstable myelin in transgenic mice overexpressing UDP-galactose:ceramide galactosyltransferase. J Neurochem. 2005 Jul; 94(2):469-81. PMID: 15998297.
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    103. Lin SC, Huck JH, Roberts JD, Macklin WB, Somogyi P, Bergles DE. Climbing fiber innervation of NG2-expressing glia in the mammalian cerebellum. Neuron. 2005 Jun 02; 46(5):773-85. PMID: 15924863.
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    104. Zhou J, Marten NW, Bergmann CC, Macklin WB, Hinton DR, Stohlman SA. Expression of matrix metalloproteinases and their tissue inhibitor during viral encephalitis. J Virol. 2005 Apr; 79(8):4764-73. PMID: 15795262.
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    105. Papay R, Gaivin R, McCune DF, Rorabaugh BR, Macklin WB, McGrath JC, Perez DM. Mouse alpha1B-adrenergic receptor is expressed in neurons and NG2 oligodendrocytes. J Comp Neurol. 2004 Oct 04; 478(1):1-10. PMID: 15334645.
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    106. Duchala CS, Shick HE, Garcia J, Deweese DM, Sun X, Stewart VJ, Macklin WB. The toppler mouse: a novel mutant exhibiting loss of Purkinje cells. J Comp Neurol. 2004 Aug 16; 476(2):113-29. PMID: 15248193.
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    107. Miller MJ, Haxhiu MA, Kangas CD, Georgiadis P, Gudz TI, Macklin WB. Selective alteration of the ventilatory response to hypoxia results from mutation in the myelin proteolipid protein gene. Adv Exp Med Biol. 2004; 551:85-91. PMID: 15602948.
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    108. Fox MA, Colello RJ, Macklin WB, Fuss B. Phosphodiesterase-Ialpha/autotaxin: a counteradhesive protein expressed by oligodendrocytes during onset of myelination. Mol Cell Neurosci. 2003 Jul; 23(3):507-19. PMID: 12837632.
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    109. Leone DP, Genoud S, Atanasoski S, Grausenburger R, Berger P, Metzger D, Macklin WB, Chambon P, Suter U. Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells. Mol Cell Neurosci. 2003 Apr; 22(4):430-40. PMID: 12727441.
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    110. Miller MJ, Haxhiu MA, Georgiadis P, Gudz TI, Kangas CD, Macklin WB. Proteolipid protein gene mutation induces altered ventilatory response to hypoxia in the myelin-deficient rat. J Neurosci. 2003 Mar 15; 23(6):2265-73. PMID: 12657685.
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    111. Doerflinger NH, Macklin WB, Popko B. Inducible site-specific recombination in myelinating cells. Genesis. 2003 Jan; 35(1):63-72. PMID: 12481300.
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    112. Baracskay KL, Duchala CS, Miller RH, Macklin WB, Trapp BD. Oligodendrogenesis is differentially regulated in gray and white matter of jimpy mice. J Neurosci Res. 2002 Dec 01; 70(5):645-54. PMID: 12424732.
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    113. Mallon BS, Macklin WB. Overexpression of the 3'-untranslated region of myelin proteolipid protein mRNA leads to reduced expression of endogenous proteolipid mRNA. Neurochem Res. 2002 Nov; 27(11):1349-60. PMID: 12512940.
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    114. Gudz TI, Schneider TE, Haas TA, Macklin WB. Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes. J Neurosci. 2002 Sep 01; 22(17):7398-407. PMID: 12196561.
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    115. Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C. Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes. EMBO Rep. 2002 Jun; 3(6):583-8. PMID: 12034752.
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    116. Mallon BS, Shick HE, Kidd GJ, Macklin WB. Proteolipid promoter activity distinguishes two populations of NG2-positive cells throughout neonatal cortical development. J Neurosci. 2002 Feb 01; 22(3):876-85. PMID: 11826117.
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    117. Fuss B, Afshari FS, Colello RJ, Macklin WB. Normal CNS myelination in transgenic mice overexpressing MHC class I H-2L(d) in oligodendrocytes. Mol Cell Neurosci. 2001 Aug; 18(2):221-34. PMID: 11520182.
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    118. Flores AI, Mallon BS, Matsui T, Ogawa W, Rosenzweig A, Okamoto T, Macklin WB. Akt-mediated survival of oligodendrocytes induced by neuregulins. J Neurosci. 2000 Oct 15; 20(20):7622-30. PMID: 11027222.
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    119. Jiang H, Duchala CS, Awatramani R, Shumas S, Carlock L, Kamholz J, Garbern J, Scherer SS, Shy ME, Macklin WB. Proteolipid protein mRNA stability is regulated by axonal contact in the rodent peripheral nervous system. J Neurobiol. 2000 Jul; 44(1):7-19. PMID: 10880128.
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    120. Fuss B, Mallon B, Phan T, Ohlemeyer C, Kirchhoff F, Nishiyama A, Macklin WB. Purification and analysis of in vivo-differentiated oligodendrocytes expressing the green fluorescent protein. Dev Biol. 2000 Feb 15; 218(2):259-74. PMID: 10656768.
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    121. das Neves L, Duchala CS, Tolentino-Silva F, Haxhiu MA, Colmenares C, Macklin WB, Campbell CE, Butz KG, Gronostajski RM, Godinho F. Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum. Proc Natl Acad Sci U S A. 1999 Oct 12; 96(21):11946-51. PMID: 10518556.
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    122. Garbern JY, Cambi F, Lewis R, Shy M, Sima A, Kraft G, Vallat JM, Bosch EP, Hodes ME, Dlouhy S, Raskind W, Bird T, Macklin W, Kamholz J. Peripheral Neuropathy Caused by Proteolipid Protein Gene Mutations. Ann N Y Acad Sci. 1999 Oct; 883(1):351-365. PMID: 29086946.
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    123. Garbern JY, Cambi F, Lewis R, Shy M, Sima A, Kraft G, Vallat JM, Bosch EP, Hodes ME, Dlouhy S, Raskind W, Bird T, Macklin W, Kamholz J. Peripheral neuropathy caused by proteolipid protein gene mutations. Ann N Y Acad Sci. 1999 Sep 14; 883:351-65. PMID: 10586260.
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    124. Kawczak JA, Mathisen PM, Drazba JA, Fuss B, Macklin WB, Tuohy VK. Digitized image analysis reveals diffuse abnormalities in normal-appearing white matter during acute experimental autoimmune encephalomyelitis. J Neurosci Res. 1998 Nov 01; 54(3):364-72. PMID: 9819141.
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    125. Spassky N, Goujet-Zalc C, Parmantier E, Olivier C, Martinez S, Ivanova A, Ikenaka K, Macklin W, Cerruti I, Zalc B, Thomas JL. Multiple restricted origin of oligodendrocytes. J Neurosci. 1998 Oct 15; 18(20):8331-43. PMID: 9763477.
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    126. Wight PA, Dobretsova A, Macklin WB. Regulation of murine myelin proteolipid protein gene expression. J Neurosci Res. 1997 Dec 15; 50(6):917-27. PMID: 9452006.
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    127. Fuss B, Baba H, Phan T, Tuohy VK, Macklin WB. Phosphodiesterase I, a novel adhesion molecule and/or cytokine involved in oligodendrocyte function. J Neurosci. 1997 Dec 01; 17(23):9095-103. PMID: 9364056.
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    128. Neri CL, Duchala CS, Macklin WB. Expression of molecular chaperones and vesicle transport proteins in differentiating oligodendrocytes. J Neurosci Res. 1997 Dec 01; 50(5):769-80. PMID: 9418964.
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    129. Trapp BD, Nishiyama A, Cheng D, Macklin W. Differentiation and death of premyelinating oligodendrocytes in developing rodent brain. J Cell Biol. 1997 Apr 21; 137(2):459-68. PMID: 9128255.
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    130. Duchala CS, Fuss B, Macklin WB. Use of Transgenic Systems to Investigate Oligodendrocyte Differentiation and Function Methods. 1996 Dec; 10(3):478-88. PMID: 8954858.
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    131. Baba H, Fuss B, Urano J, Poullet P, Watson JB, Tamanoi F, Macklin WB. GapIII, a new brain-enriched member of the GTPase-activating protein family. J Neurosci Res. 1995 Aug 15; 41(6):846-58. PMID: 7500386.
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    132. Duchala CS, Asotra K, Macklin WB. Expression of cell surface markers and myelin proteins in cultured oligodendrocytes from neonatal brain of rat and mouse: a comparative study. Dev Neurosci. 1995; 17(2):70-80. PMID: 7555740.
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    133. Asotra K, Macklin WB. Developmental expression of protein kinase C isozymes in oligodendrocytes and their differential modulation by 4 beta-phorbol-12,13-dibutyrate. J Neurosci Res. 1994 Oct 15; 39(3):273-89. PMID: 7869420.
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    134. Baba H, Fuss B, Watson JB, Zane LT, Macklin WB. Identification of novel mRNAs expressed in oligodendrocytes. Neurochem Res. 1994 Aug; 19(8):1091-9. PMID: 7800118.
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    135. Wight PA, Duchala CS, Readhead C, Macklin WB. A myelin proteolipid protein-LacZ fusion protein is developmentally regulated and targeted to the myelin membrane in transgenic mice. J Cell Biol. 1993 Oct; 123(2):443-54. PMID: 8408224.
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    136. Shirazi Y, Rus HG, Macklin WB, Shin ML. Enhanced degradation of messenger RNA encoding myelin proteins by terminal complement complexes in oligodendrocytes. J Immunol. 1993 May 15; 150(10):4581-90. PMID: 7683324.
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    137. Asotra K, Macklin WB. Protein kinase C activity modulates myelin gene expression in enriched oligodendrocytes. J Neurosci Res. 1993 Apr 01; 34(5):571-88. PMID: 7683060.
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    138. Macklin WB, Gardinier MV, Obeso ZO, King KD, Wight PA. Mutations in the myelin proteolipid protein gene alter oligodendrocyte gene expression in jimpy and jimpymsd mice. J Neurochem. 1991 Jan; 56(1):163-71. PMID: 1702830.
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    139. LeVine SM, Macklin WB. Iron-enriched oligodendrocytes: a reexamination of their spatial distribution. J Neurosci Res. 1990 Aug; 26(4):508-12. PMID: 1700140.
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    140. LeVine SM, Wong D, Macklin WB. Developmental expression of proteolipid protein and DM20 mRNAs and proteins in the rat brain. Dev Neurosci. 1990; 12(4-5):235-50. PMID: 1705207.
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    141. Kumar S, Macklin WB, Gordon MN, Espinosa de los Monteros A, Cole R, Scully SA, de Vellis J. Transcriptional regulation studies of myelin-associated genes in myelin-deficient mutant rats. Dev Neurosci. 1990; 12(4-5):316-25. PMID: 1705212.
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    142. Macklin WB, Gardinier MV, Obeso ZO. Structure and expression of the mouse myelin proteolipid protein gene. Ann N Y Acad Sci. 1990; 605:183-93. PMID: 1702596.
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    143. Gardinier MV, Macklin WB. Myelin proteolipid protein gene expression in jimpy and jimpy(msd) mice. J Neurochem. 1988 Aug; 51(2):360-9. PMID: 2455772.
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    144. LeVine SM, Macklin WB. Biotin enrichment in oligodendrocytes in the rat brain. Brain Res. 1988 Mar 15; 444(1):199-203. PMID: 3359289.
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    145. Campagnoni AT, Macklin WB. Cellular and molecular aspects of myelin protein gene expression. Mol Neurobiol. 1988; 2(1):41-89. PMID: 3077065.
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    146. Macklin WB, Gardinier MV, King KD, Kampf K. An AG----GG transition at a splice site in the myelin proteolipid protein gene in jimpy mice results in the removal of an exon. FEBS Lett. 1987 Nov 02; 223(2):417-21. PMID: 2444462.
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    147. Macklin WB, Campagnoni CW, Deininger PL, Gardinier MV. Structure and expression of the mouse myelin proteolipid protein gene. J Neurosci Res. 1987; 18(3):383-94. PMID: 2449535.
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    148. Kronquist KE, Crandall BF, Macklin WB, Campagnoni AT. Expression of myelin proteins in the developing human spinal cord: cloning and sequencing of human proteolipid protein cDNA. J Neurosci Res. 1987; 18(3):395-401. PMID: 2449536.
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    149. Gardinier MV, Macklin WB, Diniak AJ, Deininger PL. Characterization of myelin proteolipid mRNAs in normal and jimpy mice. Mol Cell Biol. 1986 Nov; 6(11):3755-62. PMID: 2432393.
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    150. Macklin WB, Weill CL, Deininger PL. Expression of myelin proteolipid and basic protein mRNAs in cultured cells. J Neurosci Res. 1986; 16(1):203-17. PMID: 2427736.
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    151. Macklin WB, Weill CL. Appearance of myelin proteins during development in the chick central nervous system. Dev Neurosci. 1985; 7(3):170-8. PMID: 2416527.
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    152. Cambi F, Lees MB, Williams RM, Macklin WB. Chronic experimental allergic encephalomyelitis produced by bovine proteolipid apoprotein: immunological studies in rabbits. Ann Neurol. 1983 Mar; 13(3):303-8. PMID: 6189448.
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    153. Macklin WB, Oberfield E, Lees MB. Electroblot analysis of rat myelin proteolipid protein and basic protein during development. Dev Neurosci. 1983-1984; 6(3):161-8. PMID: 6680099.
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    154. Williams RM, Lees MB, Cambi F, Macklin WB. Chronic experimental allergic encephalomyelitis induced in rabbits with bovine white matter proteolipid apoprotein. J Neuropathol Exp Neurol. 1982 Sep; 41(5):508-21. PMID: 7108565.
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    155. Macklin WB, Lees MB. Solid-phase immunoassays for quantitation of antibody to bovine white matter proteolipid apoprotein. J Neurochem. 1982 Feb; 38(2):348-55. PMID: 7108542.
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    156. Macklin WB, Braun PE, Lees MB. Electroblot analysis of the myelin proteolipid protein. J Neurosci Res. 1982; 7(1):1-10. PMID: 6175769.
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    157. Lees MB, Macklin WB, Chao BH. A study of elastase peptides from bovine white matter proteolipid. Neurochem Res. 1981 Oct; 6(10):1091-104. PMID: 6917041.
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    158. Macklin WB, Lees MB, Cohen SR, Ayella SB. Hydrophobic compounds interfere in radioimmunoassay for basic protein in myelin. Clin Chem. 1981 May; 27(5):742-4. PMID: 6164508.
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    159. Macklin WB, Schwarting GA, Lees MB, Cohen SR. Production and purification of antibody to bovine white matter proteolipid apoprotein. J Neurochem. 1981 Jan; 36(1):101-6. PMID: 7463040.
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    160. Macklin WB, Meyer DJ, Woodward DO, Erickson SK. Chloramphenicol-sensitive labelling of protein in microsomes of Neurospora crassa. Nature. 1977 Sep 29; 269(5627):447-50. PMID: 143619.
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