Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Bruce H Appel

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Address2TCH
Children's Hospital
13065 East 17th Avenue
Aurora CO 80045
Phone303/724-3465

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wang Y, Pan L, Moens CB, Appel B. Notch3 establishes brain vascular integrity by regulating pericyte number. Development. 2014 Jan; 141(2):307-17.
    View in: PubMed
  2. Hudish LI, Blasky AJ, Appel B. miR-219 Regulates Neural Precursor Differentiation by Direct Inhibition of Apical Par Polarity Proteins. Dev Cell. 2013 Nov 25; 27(4):387-98.
    View in: PubMed
  3. Langworthy MM, Appel B. Schwann cell myelination requires Dynein function. Neural Dev. 2012; 7:37.
    View in: PubMed
  4. Snyder JL, Kearns CA, Appel B. Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate. Neural Dev. 2012; 7:15.
    View in: PubMed
  5. Simmons T, Appel B. Mutation of pescadillo disrupts oligodendrocyte formation in zebrafish. PLoS One. 2012; 7(2):e32317.
    View in: PubMed
  6. Jao LE, Appel B, Wente SR. A zebrafish model of lethal congenital contracture syndrome 1 reveals Gle1 function in spinal neural precursor survival and motor axon arborization. Development. 2012 Apr; 139(7):1316-26.
    View in: PubMed
  7. Zannino DA, Sagerström CG, Appel B. olig2-Expressing hindbrain cells are required for migrating facial motor neurons. Dev Dyn. 2012 Feb; 241(2):315-26.
    View in: PubMed
  8. Tep C, Kim ML, Opincariu LI, Limpert AS, Chan JR, Appel B, Carter BD, Yoon SO. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein. J Biol Chem. 2012 Jan 6; 287(2):1600-8.
    View in: PubMed
  9. Takada N, Appel B. swap70 promotes neural precursor cell cycle exit and oligodendrocyte formation. Mol Cell Neurosci. 2011 Nov; 48(3):225-35.
    View in: PubMed
  10. Takada N, Appel B. Identification of genes expressed by zebrafish oligodendrocytes using a differential microarray screen. Dev Dyn. 2010 Jul; 239(7):2041-7.
    View in: PubMed
  11. Takada N, Kucenas S, Appel B. Sox10 is necessary for oligodendrocyte survival following axon wrapping. Glia. 2010 Jun; 58(8):996-1006.
    View in: PubMed
  12. Zhao X, He X, Han X, Yu Y, Ye F, Chen Y, Hoang T, Xu X, Mi QS, Xin M, Wang F, Appel B, Lu QR. MicroRNA-mediated control of oligodendrocyte differentiation. Neuron. 2010 Mar 11; 65(5):612-26.
    View in: PubMed
  13. Kucenas S, Wang WD, Knapik EW, Appel B. A selective glial barrier at motor axon exit points prevents oligodendrocyte migration from the spinal cord. J Neurosci. 2009 Dec 2; 29(48):15187-94.
    View in: PubMed
  14. Roberts RK, Appel B. Apical polarity protein PrkCi is necessary for maintenance of spinal cord precursors in zebrafish. Dev Dyn. 2009 Jul; 238(7):1638-48.
    View in: PubMed
  15. Zannino DA, Appel B. Olig2+ precursors produce abducens motor neurons and oligodendrocytes in the zebrafish hindbrain. J Neurosci. 2009 Feb 25; 29(8):2322-33.
    View in: PubMed
  16. Kim H, Shin J, Kim S, Poling J, Park HC, Appel B. Notch-regulated oligodendrocyte specification from radial glia in the spinal cord of zebrafish embryos. Dev Dyn. 2008 Aug; 237(8):2081-9.
    View in: PubMed
  17. Kucenas S, Snell H, Appel B. nkx2.2a promotes specification and differentiation of a myelinating subset of oligodendrocyte lineage cells in zebrafish. Neuron Glia Biol. 2008 May; 4(2):71-81.
    View in: PubMed
  18. McFarland KA, Topczewska JM, Weidinger G, Dorsky RI, Appel B. Hh and Wnt signaling regulate formation of olig2+ neurons in the zebrafish cerebellum. Dev Biol. 2008 Jun 1; 318(1):162-71.
    View in: PubMed
  19. Qu X, Jia H, Garrity DM, Tompkins K, Batts L, Appel B, Zhong TP, Baldwin HS. Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish. Dev Biol. 2008 May 15; 317(2):486-96.
    View in: PubMed
  20. Kucenas S, Takada N, Park HC, Woodruff E, Broadie K, Appel B. CNS-derived glia ensheath peripheral nerves and mediate motor root development. Nat Neurosci. 2008 Feb; 11(2):143-51.
    View in: PubMed
  21. Sarmah B, Winfrey VP, Olson GE, Appel B, Wente SR. A role for the inositol kinase Ipk1 in ciliary beating and length maintenance. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):19843-8.
    View in: PubMed
  22. Park HC, Shin J, Roberts RK, Appel B. An olig2 reporter gene marks oligodendrocyte precursors in the postembryonic spinal cord of zebrafish. Dev Dyn. 2007 Dec; 236(12):3402-7.
    View in: PubMed
  23. Shin J, Poling J, Park HC, Appel B. Notch signaling regulates neural precursor allocation and binary neuronal fate decisions in zebrafish. Development. 2007 May; 134(10):1911-20.
    View in: PubMed
  24. Kirby BB, Takada N, Latimer AJ, Shin J, Carney TJ, Kelsh RN, Appel B. In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development. Nat Neurosci. 2006 Dec; 9(12):1506-11.
    View in: PubMed
  25. Latimer AJ, Appel B. Notch signaling regulates midline cell specification and proliferation in zebrafish. Dev Biol. 2006 Oct 15; 298(2):392-402.
    View in: PubMed
  26. Ng AN, de Jong-Curtain TA, Mawdsley DJ, White SJ, Shin J, Appel B, Dong PD, Stainier DY, Heath JK. Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis. Dev Biol. 2005 Oct 1; 286(1):114-35.
    View in: PubMed
  27. Park HC, Boyce J, Shin J, Appel B. Oligodendrocyte specification in zebrafish requires notch-regulated cyclin-dependent kinase inhibitor function. J Neurosci. 2005 Jul 20; 25(29):6836-44.
    View in: PubMed
  28. Sarmah B, Latimer AJ, Appel B, Wente SR. Inositol polyphosphates regulate zebrafish left-right asymmetry. Dev Cell. 2005 Jul; 9(1):133-45.
    View in: PubMed
  29. Latimer AJ, Shin J, Appel B. her9 promotes floor plate development in zebrafish. Dev Dyn. 2005 Apr; 232(4):1098-104.
    View in: PubMed
  30. Park HC, Shin J, Appel B. Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling. Development. 2004 Dec; 131(23):5959-69.
    View in: PubMed
  31. Garg R, Geng CD, Miller JL, Callens S, Tang X, Appel B, Xu B. Molecular cloning and characterization of the catalytic domain of zebrafish homologue of the ataxia-telangiectasia mutated gene. Mol Cancer Res. 2004 Jun; 2(6):348-53.
    View in: PubMed
  32. Appel B, Marasco P, McClung LE, Latimer AJ. lunatic fringe regulates Delta-Notch induction of hypochord in zebrafish. Dev Dyn. 2003 Oct; 228(2):281-6.
    View in: PubMed
  33. Park HC, Appel B. Delta-Notch signaling regulates oligodendrocyte specification. Development. 2003 Aug; 130(16):3747-55.
    View in: PubMed
  34. Shin J, Park HC, Topczewska JM, Mawdsley DJ, Appel B. Neural cell fate analysis in zebrafish using olig2 BAC transgenics. Methods Cell Sci. 2003; 25(1-2):7-14.
    View in: PubMed
  35. Park HC, Mehta A, Richardson JS, Appel B. olig2 is required for zebrafish primary motor neuron and oligodendrocyte development. Dev Biol. 2002 Aug 15; 248(2):356-68.
    View in: PubMed
  36. Latimer AJ, Dong X, Markov Y, Appel B. Delta-Notch signaling induces hypochord development in zebrafish. Development. 2002 Jun; 129(11):2555-63.
    View in: PubMed
  37. Appel B, Chitnis A. Neurogenesis and specification of neuronal identity. Results Probl Cell Differ. 2002; 40:237-51.
    View in: PubMed
  38. Appel B, Givan LA, Eisen JS. Delta-Notch signaling and lateral inhibition in zebrafish spinal cord development. BMC Dev Biol. 2001; 1:13.
    View in: PubMed
  39. Appel B. Zebrafish neural induction and patterning. Dev Dyn. 2000 Oct; 219(2):155-68.
    View in: PubMed
  40. Appel B, Fritz A, Westerfield M, Grunwald DJ, Eisen JS, Riley BB. Delta-mediated specification of midline cell fates in zebrafish embryos. Curr Biol. 1999 Mar 11; 9(5):247-56.
    View in: PubMed
  41. Appel B, Eisen JS. Regulation of neuronal specification in the zebrafish spinal cord by Delta function. Development. 1998 Feb; 125(3):371-80.
    View in: PubMed
  42. Moens CB, Yan YL, Appel B, Force AG, Kimmel CB. valentino: a zebrafish gene required for normal hindbrain segmentation. Development. 1996 Dec; 122(12):3981-90.
    View in: PubMed
  43. Appel B, Korzh V, Glasgow E, Thor S, Edlund T, Dawid IB, Eisen JS. Motoneuron fate specification revealed by patterned LIM homeobox gene expression in embryonic zebrafish. Development. 1995 Dec; 121(12):4117-25.
    View in: PubMed
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