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Elan Zohar Eisenmesser

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics

    Collapse Research 
    Collapse research activities and funding
    R01GM096019     (EISENMESSER, ELAN Z)Apr 1, 2011 - Mar 31, 2016
    EMMPRIN: from biology to molecular mechanism
    Role: Principal Investigator

    R01GM107262     (EISENMESSER, ELAN Z)May 1, 2014 - Apr 30, 2018
    Combining chemical shift-based and experimental approaches to study enzyme dynami
    Role: Principal Investigator

    R03CA219743     (EISENMESSER, ELAN Z)Aug 1, 2017 - Jul 31, 2019
    Interleukin-37: The molecular basis of the atypical interleukin-1 family dimer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mercurio L, Morelli M, Scarponi C, Eisenmesser EZ, Doti N, Pagnanelli G, Gubinelli E, Mazzanti C, Cavani A, Ruvo M, Dinarello CA, Albanesi C, Madonna S. IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment. Cell Death Dis. 2018 Oct 30; 9(11):1104. PMID: 30377293.
      View in: PubMed
    2. Reisz JA, Nemkov T, Dzieciatkowska M, Culp-Hill R, Stefanoni D, Hill RC, Yoshida T, Dunham A, Kanias T, Dumont LJ, Busch M, Eisenmesser EZ, Zimring JC, Hansen KC, D'Alessandro A. Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells. Transfusion. 2018 Oct 12. PMID: 30312994.
      View in: PubMed
    3. Paukovich N, Xue M, Elder JR, Redzic JS, Blue A, Pike H, Miller BG, Pitts TM, Pollock DD, Hansen K, D'Alessandro A, Eisenmesser EZ. Biliverdin Reductase B Dynamics Are Coupled to Coenzyme Binding. J Mol Biol. 2018 Sep 14; 430(18 Pt B):3234-3250. PMID: 29932944.
      View in: PubMed
    4. Salmon L, Stull F, Sayle S, Cato C, Akgül S, Foit L, Ahlstrom LS, Eisenmesser EZ, Al-Hashimi HM, Bardwell JCA, Horowitz S. The Mechanism of HdeA Unfolding and Chaperone Activation. J Mol Biol. 2018 Jan 05; 430(1):33-40. PMID: 29138002.
      View in: PubMed
    5. Rajiv C, Jackson SR, Cocklin S, Eisenmesser EZ, Davis TL. The spliceosomal proteins PPIH and PRPF4 exhibit bi-partite binding. Biochem J. 2017 10 25; 474(21):3689-3704. PMID: 28935721.
      View in: PubMed
    6. Chi YC, Rahkola JT, Kendrick AA, Holliday MJ, Paukovich N, Roberts TS, Janoff EN, Eisenmesser EZ. Streptococcus pneumoniae IgA1 protease: A metalloprotease that can catalyze in a split manner in vitro. Protein Sci. 2017 03; 26(3):600-610. PMID: 28028839.
      View in: PubMed
    7. Cavalli G, Justice JN, Boyle KE, D'Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Seals DR, Dagna L, Joosten LA, Ballak DB, Dinarello CA. Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2313-2318. PMID: 28193888.
      View in: PubMed
    8. Kendrick AA, Schafer J, Dzieciatkowska M, Nemkov T, D'Alessandro A, Neelakantan D, Ford HL, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ. CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming. Oncotarget. 2017 Jan 24; 8(4):6742-6762. PMID: 28039486.
      View in: PubMed
    9. Holliday MJ, Camilloni C, Armstrong GS, Vendruscolo M, Eisenmesser EZ. Networks of Dynamic Allostery Regulate Enzyme Function. Structure. 2017 02 07; 25(2):276-286. PMID: 28089447.
      View in: PubMed
    10. Doshi U, Holliday MJ, Eisenmesser EZ, Hamelberg D. Dynamical network of residue-residue contacts reveals coupled allosteric effects in recognition, catalysis, and mutation. Proc Natl Acad Sci U S A. 2016 Apr 26; 113(17):4735-40. PMID: 27071107; PMCID: PMC4855540.
    11. Holliday MJ, Armstrong GS, Eisenmesser EZ. Determination of the Full Catalytic Cycle among Multiple Cyclophilin Family Members and Limitations on the Application of CPMG-RD in Reversible Catalytic Systems. Biochemistry. 2015 Sep 29; 54(38):5815-27. PMID: 26335054; PMCID: PMC4801485.
    12. Holliday MJ, Camilloni C, Armstrong GS, Isern NG, Zhang F, Vendruscolo M, Eisenmesser EZ. Structure and Dynamics of GeoCyp: A Thermophilic Cyclophilin with a Novel Substrate Binding Mechanism That Functions Efficiently at Low Temperatures. Biochemistry. 2015 May 26; 54(20):3207-17. PMID: 25923019; PMCID: PMC4475676.
    13. Eisenmesser EZ, Capodagli GC, Armstrong GS, Holliday MJ, Isern NG, Zhang F, Pegan SD. Inherent dynamics within the Crimean-Congo Hemorrhagic fever virus protease are localized to the same region as substrate interactions. Protein Sci. 2015 May; 24(5):651-60. PMID: 25564798; PMCID: PMC4420516.
    14. Camilloni C, Sahakyan AB, Holliday MJ, Isern NG, Zhang F, Eisenmesser EZ, Vendruscolo M. Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10203-8. PMID: 24982184; PMCID: PMC4104850.
    15. Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, Southall N, Reigan P, Marugan J, Ford HL, Zhao R. Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration. J Biol Chem. 2014 Jun 06; 289(23):16349-61. PMID: 24755226.
      View in: PubMed
    16. Chi YC, Armstrong GS, Jones DN, Eisenmesser EZ, Liu CW. Residue histidine 50 plays a key role in protecting a-synuclein from aggregation at physiological pH. J Biol Chem. 2014 May 30; 289(22):15474-81. PMID: 24742669; PMCID: PMC4140903.
    17. Kendrick AA, Holliday MJ, Isern NG, Zhang F, Camilloni C, Huynh C, Vendruscolo M, Armstrong G, Eisenmesser EZ. The dynamics of interleukin-8 and its interaction with human CXC receptor I peptide. Protein Sci. 2014 Apr; 23(4):464-80. PMID: 24442768; PMCID: PMC3970897.
    18. Redzic JS, Kendrick AA, Bahmed K, Dahl KD, Pearson CG, Robinson WA, Robinson SE, Graner MW, Eisenmesser EZ. Extracellular vesicles secreted from cancer cell lines stimulate secretion of MMP-9, IL-6, TGF-ß1 and EMMPRIN. PLoS One. 2013; 8(8):e71225. PMID: 23936495; PMCID: PMC3731303.
    19. Holliday MJ, Zhang F, Isern NG, Armstrong GS, Eisenmesser EZ. 1H, 13C, and 15N backbone and side chain resonance assignments of thermophilic Geobacillus kaustophilus cyclophilin-A. Biomol NMR Assign. 2014 Apr; 8(1):23-7. PMID: 23138858; PMCID: PMC4084936.
    20. Bahmed K, Henry C, Holliday M, Redzic J, Ciobanu M, Zhang F, Weekes C, Sclafani R, Degregori J, Eisenmesser E. Extracellular cyclophilin-A stimulates ERK1/2 phosphorylation in a cell-dependent manner but broadly stimulates nuclear factor kappa B. Cancer Cell Int. 2012 Jul 04; 12(1):19. PMID: 22631225; PMCID: PMC3390265.
    21. Redzic JS, Armstrong GS, Isern NG, Jones DN, Kieft JS, Eisenmesser EZ. The retinal specific CD147 Ig0 domain: from molecular structure to biological activity. J Mol Biol. 2011 Aug 05; 411(1):68-82. PMID: 21620857; PMCID: PMC3143262.
    22. Bosco DA, Eisenmesser EZ, Clarkson MW, Wolf-Watz M, Labeikovsky W, Millet O, Kern D. Dissecting the microscopic steps of the cyclophilin A enzymatic cycle on the biological HIV-1 capsid substrate by NMR. J Mol Biol. 2010 Nov 12; 403(5):723-38. PMID: 20708627.
      View in: PubMed
    23. Davis TL, Walker JR, Campagna-Slater V, Finerty PJ, Paramanathan R, Bernstein G, MacKenzie F, Tempel W, Ouyang H, Lee WH, Eisenmesser EZ, Dhe-Paganon S. Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. PLoS Biol. 2010 Jul 27; 8(7):e1000439. PMID: 20676357; PMCID: PMC2911226.
    24. Kovacs JM, Hannan JP, Eisenmesser EZ, Holers VM. Biophysical investigations of complement receptor 2 (CD21 and CR2)-ligand interactions reveal amino acid contacts unique to each receptor-ligand pair. J Biol Chem. 2010 Aug 27; 285(35):27251-8. PMID: 20558730; PMCID: PMC2930724.
    25. Yurchenko V, Constant S, Eisenmesser E, Bukrinsky M. Cyclophilin-CD147 interactions: a new target for anti-inflammatory therapeutics. Clin Exp Immunol. 2010 Jun; 160(3):305-17. PMID: 20345978; PMCID: PMC2883100.
    26. Gardino AK, Villali J, Kivenson A, Lei M, Liu CF, Steindel P, Eisenmesser EZ, Labeikovsky W, Wolf-Watz M, Clarkson MW, Kern D. Transient non-native hydrogen bonds promote activation of a signaling protein. Cell. 2009 Dec 11; 139(6):1109-18. PMID: 20005804; PMCID: PMC2891250.
    27. Clarkson MW, Lei M, Eisenmesser EZ, Labeikovsky W, Redfield A, Kern D. Mesodynamics in the SARS nucleocapsid measured by NMR field cycling. J Biomol NMR. 2009 Sep; 45(1-2):217-25. PMID: 19641854; PMCID: PMC2728245.
    28. Schlegel J, Redzic JS, Porter CC, Yurchenko V, Bukrinsky M, Labeikovsky W, Armstrong GS, Zhang F, Isern NG, DeGregori J, Hodges R, Eisenmesser EZ. Solution characterization of the extracellular region of CD147 and its interaction with its enzyme ligand cyclophilin A. J Mol Biol. 2009 Aug 21; 391(3):518-35. PMID: 19500591; PMCID: PMC2940942.
    29. Schlegel J, Armstrong GS, Redzic JS, Zhang F, Eisenmesser EZ. Characterizing and controlling the inherent dynamics of cyclophilin-A. Protein Sci. 2009 Apr; 18(4):811-24. PMID: 19319933; PMCID: PMC2762593.
    30. Kovacs JM, Hannan JP, Eisenmesser EZ, Holers VM. Mapping of the C3d ligand binding site on complement receptor 2 (CR2/CD21) using nuclear magnetic resonance and chemical shift analysis. J Biol Chem. 2009 Apr 03; 284(14):9513-20. PMID: 19164292; PMCID: PMC2666603.
    31. Davis TL, Walker JR, Ouyang H, MacKenzie F, Butler-Cole C, Newman EM, Eisenmesser EZ, Dhe-Paganon S. The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1). FEBS J. 2008 May; 275(9):2283-95. PMID: 18397323.
      View in: PubMed
    32. Thai V, Renesto P, Fowler CA, Brown DJ, Davis T, Gu W, Pollock DD, Kern D, Raoult D, Eisenmesser EZ. Structural, biochemical, and in vivo characterization of the first virally encoded cyclophilin from the Mimivirus. J Mol Biol. 2008 Apr 18; 378(1):71-86. PMID: 18342330; PMCID: PMC2884007.
    33. Labeikovsky W, Eisenmesser EZ, Bosco DA, Kern D. Structure and dynamics of pin1 during catalysis by NMR. J Mol Biol. 2007 Apr 13; 367(5):1370-81. PMID: 17316687; PMCID: PMC2975599.
    34. Eisenmesser EZ, Millet O, Labeikovsky W, Korzhnev DM, Wolf-Watz M, Bosco DA, Skalicky JJ, Kay LE, Kern D. Intrinsic dynamics of an enzyme underlies catalysis. Nature. 2005 Nov 03; 438(7064):117-21. PMID: 16267559.
      View in: PubMed
    35. Kern D, Eisenmesser EZ, Wolf-Watz M. Enzyme dynamics during catalysis measured by NMR spectroscopy. Methods Enzymol. 2005; 394:507-24. PMID: 15808235.
      View in: PubMed
    36. Wolf-Watz M, Thai V, Henzler-Wildman K, Hadjipavlou G, Eisenmesser EZ, Kern D. Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair. Nat Struct Mol Biol. 2004 Oct; 11(10):945-9. PMID: 15334070.
      View in: PubMed
    37. Bosco DA, Eisenmesser EZ, Pochapsky S, Sundquist WI, Kern D. Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5247-52. PMID: 11929983; PMCID: PMC122755.
    38. Eisenmesser EZ, Bosco DA, Akke M, Kern D. Enzyme dynamics during catalysis. Science. 2002 Feb 22; 295(5559):1520-3. PMID: 11859194.
      View in: PubMed
    39. Eisenmesser EZ, Horita DA, Altieri AS, Byrd RA. Solution structure of interleukin-13 and insights into receptor engagement. J Mol Biol. 2001 Jun 29; 310(1):231-41. PMID: 11419949.
      View in: PubMed
    40. Eisenmesser EZ, Horita DA, Byrd RA. Secondary structure and backbone resonance assignments for human interleukin-13. J Biomol NMR. 2001 Jan; 19(1):93-4. PMID: 11246865.
      View in: PubMed
    41. Eisenmesser EZ, Kapust RB, Nawrocki JP, Mazzulla MJ, Pannell LK, Waugh DS, Byrd RA. Expression, purification, refolding, and characterization of recombinant human interleukin-13: utilization of intracellular processing. Protein Expr Purif. 2000 Nov; 20(2):186-95. PMID: 11049743.
      View in: PubMed
    42. Kingston RL, Fitzon-Ostendorp T, Eisenmesser EZ, Schatz GW, Vogt VM, Post CB, Rossmann MG. Structure and self-association of the Rous sarcoma virus capsid protein. Structure. 2000 Jun 15; 8(6):617-28. PMID: 10873863.
      View in: PubMed
    43. Eisenmesser EZ, Zabell AP, Post CB. Accuracy of bound peptide structures determined by exchange transferred nuclear Overhauser data: a simulation study. J Biomol NMR. 2000 May; 17(1):17-32. PMID: 10909863.
      View in: PubMed
    44. Post CB, Gaul BS, Eisenmesser EZ, Schneider ML. NMR structure of phospho-tyrosine signaling complexes. Med Res Rev. 1999 Jul; 19(4):295-305. PMID: 10398926.
      View in: PubMed
    45. Eisenmesser EZ, Post CB. Insights into tyrosine phosphorylation control of protein-protein association from the NMR structure of a band 3 peptide inhibitor bound to glyceraldehyde-3-phosphate dehydrogenase. Biochemistry. 1998 Jan 20; 37(3):867-77. PMID: 9454576.
      View in: PubMed
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