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Maki Nakayama

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Barbara Davis Center

    Collapse Research 
    Collapse research activities and funding
    K99DK080885     (NAKAYAMA, MAKI)Apr 1, 2008 - Mar 31, 2010
    Structure Peptide/Conserved T-cell Receptor Determining Diabetes
    Role: Principal Investigator

    R00DK080885     (NAKAYAMA, MAKI)Apr 1, 2010 - Mar 31, 2014
    Role: Principal Investigator

    R01DK099317     (NAKAYAMA, MAKI)Aug 20, 2013 - Jun 30, 2018
    Molecular Dissection of Insulin Targeting in Anti-Islet Autoimmunity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Marrack P, Krovi SH, Silberman D, White J, Kushnir E, Nakayama M, Crooks J, Danhorn T, Leach S, Anselment R, Scott-Browne J, Gapin L, Kappler J. The somatically generated portion of the T cell receptor CDR3a contributes to the MHC allele specificity of the T cell receptor. Elife. 2017 Nov 17; 6. PMID: 29148973.
      View in: PubMed
    2. Tan S, Li Y, Xia J, Jin CH, Hu Z, Duinkerken G, Li Y, Khosravi Maharlooei M, Chavez E, Nauman G, Danzl N, Nakayama M, Roep BO, Sykes M, Yang YG. Type 1 diabetes induction in humanized mice. Proc Natl Acad Sci U S A. 2017 Oct 10; 114(41):10954-10959. PMID: 28874533.
      View in: PubMed
    3. Mitchell AM, Kaiser Y, Falta MT, Munson DJ, Landry LG, Eklund A, Nakayama M, Slansky JE, Grunewald J, Fontenot AP. Shared aß TCR Usage in Lungs of Sarcoidosis Patients with Löfgren's Syndrome. J Immunol. 2017 Oct 01; 199(7):2279-2290. PMID: 28827283.
      View in: PubMed
    4. Seay HR, Yusko E, Rothweiler SJ, Zhang L, Posgai AL, Campbell-Thompson M, Vignali M, Emerson RO, Kaddis JS, Ko D, Nakayama M, Smith MJ, Cambier JC, Pugliese A, Atkinson MA, Robins HS, Brusko TM. Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes. JCI Insight. 2016 Dec 08; 1(20):e88242. PMID: 27942583.
      View in: PubMed
    5. Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M. Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes. Diabetes. 2017 Mar; 66(3):722-734. PMID: 27920090.
      View in: PubMed
    6. Nakayama M, Simmons KM, Michels AW. Molecular Interactions Governing Autoantigen Presentation in Type 1 Diabetes. Curr Diab Rep. 2015 Dec; 15(12):113. PMID: 26458384; PMCID: PMC4807868 [Available on 12/01/16].
    7. Nakayama M, McDaniel K, Fitzgerald-Miller L, Kiekhaefer C, Snell-Bergeon JK, Davidson HW, Rewers M, Yu L, Gottlieb P, Kappler JW, Michels A. Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):4429-34. PMID: 25831495; PMCID: PMC4394309.
    8. Bettini M, Blanchfield L, Castellaw A, Zhang Q, Nakayama M, Smeltzer MP, Zhang H, Hogquist KA, Evavold BD, Vignali DA. TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential. J Immunol. 2014 Jul 15; 193(2):571-9. PMID: 24943217; PMCID: PMC4082738.
    9. Zhang L, Crawford F, Yu L, Michels A, Nakayama M, Davidson HW, Kappler JW, Eisenbarth GS. Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2656-61. PMID: 24550292; PMCID: PMC3932899.
    10. Baker RL, Delong T, Barbour G, Bradley B, Nakayama M, Haskins K. Cutting edge: CD4 T cells reactive to an islet amyloid polypeptide peptide accumulate in the pancreas and contribute to disease pathogenesis in nonobese diabetic mice. J Immunol. 2013 Oct 15; 191(8):3990-4. PMID: 24043895; PMCID: PMC3815676.
    11. Bettini ML, Bettini M, Nakayama M, Guy CS, Vignali DA. Generation of T cell receptor-retrogenic mice: improved retroviral-mediated stem cell gene transfer. Nat Protoc. 2013 Oct; 8(10):1837-40. PMID: 24008379; PMCID: PMC3832243.
    12. Ishigame H, Zenewicz LA, Sanjabi S, Licona-Limón P, Nakayama M, Leonard WJ, Flavell RA. Excessive Th1 responses due to the absence of TGF-ß signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6961-6. PMID: 23569233; PMCID: PMC3637710.
    13. Nakayama M, Eisenbarth GS. Paradigm shift or shifting paradigm for type 1 diabetes. Diabetes. 2012 May; 61(5):976-8. PMID: 22517648; PMCID: PMC3331751.
    14. Fousteri G, Jasinski J, Dave A, Nakayama M, Pagni P, Lambolez F, Juntti T, Sarikonda G, Cheng Y, Croft M, Cheroutre H, Eisenbarth G, von Herrath M. Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice. Diabetes. 2012 May; 61(5):1169-79. PMID: 22403296; PMCID: PMC3331775.
    15. Nakayama M, Castoe T, Sosinowski T, He X, Johnson K, Haskins K, Vignali DA, Gapin L, Pollock D, Eisenbarth GS. Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice. Diabetes. 2012 Apr; 61(4):857-65. PMID: 22315318; PMCID: PMC3314349.
    16. Nakayama M. Insulin as a key autoantigen in the development of type 1 diabetes. Diabetes Metab Res Rev. 2011 Nov; 27(8):773-7. PMID: 22069258.
      View in: PubMed
    17. Michels AW, Ostrov DA, Zhang L, Nakayama M, Fuse M, McDaniel K, Roep BO, Gottlieb PA, Atkinson MA, Eisenbarth GS. Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol. 2011 Dec 01; 187(11):5921-30. PMID: 22043012; PMCID: PMC3221928.
    18. Crawford F, Stadinski B, Jin N, Michels A, Nakayama M, Pratt P, Marrack P, Eisenbarth G, Kappler JW. Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16729-34. PMID: 21949373; PMCID: PMC3189014.
    19. Born WK, Zhang L, Nakayama M, Jin N, Chain JL, Huang Y, Aydintug MK, O'Brien RL. Peptide antigens for gamma/delta T cells. Cell Mol Life Sci. 2011 Jul; 68(14):2335-43. PMID: 21553233.
      View in: PubMed
    20. Michels AW, Nakayama M. The anti-insulin trimolecular complex in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2010 Aug; 17(4):329-34. PMID: 20489610; PMCID: PMC4012426.
    21. Zhang L, Jin N, Nakayama M, O'Brien RL, Eisenbarth GS, Born WK. Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23. J Autoimmun. 2010 Jun; 34(4):478-84. PMID: 20080388; PMCID: PMC2860027.
    22. Babaya N, Yu L, Miao D, Wang J, Rewers M, Nakayama M, Liu E, Barker JM, Eisenbarth GS. Comparison of insulin autoantibody: polyethylene glycol and micro-IAA 1-day and 7-day assays. Diabetes Metab Res Rev. 2009 Oct; 25(7):665-70. PMID: 19768733.
      View in: PubMed
    23. Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martínez-Llordella M, Ashby M, Nakayama M, Rosenthal W, Bluestone JA. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol. 2009 Sep; 10(9):1000-7. PMID: 19633673; PMCID: PMC2729804.
    24. Zhang L, Jasinski JM, Kobayashi M, Davenport B, Johnson K, Davidson H, Nakayama M, Haskins K, Eisenbarth GS. Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains. J Autoimmun. 2009 Aug; 33(1):42-9. PMID: 19286348; PMCID: PMC4383244.
    25. Yasuda H, Jin Z, Nakayama M, Yamada K, Kishi M, Okumachi Y, Arai T, Moriyama H, Yokono K, Nagata M. NO-mediated cytotoxicity contributes to multiple low-dose streptozotocin-induced diabetes but not to NOD diabetes. Diabetes Res Clin Pract. 2009 Feb; 83(2):200-7. PMID: 19117633.
      View in: PubMed
    26. Kobayashi M, Jasinski J, Liu E, Li M, Miao D, Zhang L, Yu L, Nakayama M, Eisenbarth GS. Conserved T cell receptor alpha-chain induces insulin autoantibodies. Proc Natl Acad Sci U S A. 2008 Jul 22; 105(29):10090-4. PMID: 18626021; PMCID: PMC2464615.
    27. Kurohara M, Yasuda H, Moriyama H, Nakayama M, Sakata M, Yamada K, Kotani R, Hara K, Yokono K, Nagata M. Low-dose warfarin functions as an immunomodulator to prevent cyclophosphamide-induced NOD diabetes. Kobe J Med Sci. 2008 May 23; 54(1):E1-13. PMID: 18772604.
      View in: PubMed
    28. Zhang L, Nakayama M, Eisenbarth GS. Insulin as an autoantigen in NOD/human diabetes. Curr Opin Immunol. 2008 Feb; 20(1):111-8. PMID: 18178393; PMCID: PMC2268871.
    29. Zhang L, Gianani R, Nakayama M, Liu E, Kobayashi M, Baschal E, Yu L, Babu S, Dawson A, Johnson K, Jahromi M, Aly T, Fain P, Barker J, Rewers M, Eisenbarth GS. Type 1 diabetes: chronic progressive autoimmune disease. Novartis Found Symp. 2008; 292:85-94; discussion 94-8, 122-9, 202-3. PMID: 19203094.
      View in: PubMed
    30. Nakayama M, Beilke JN, Jasinski JM, Kobayashi M, Miao D, Li M, Coulombe MG, Liu E, Elliott JF, Gill RG, Eisenbarth GS. Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity. J Clin Invest. 2007 Jul; 117(7):1835-43. PMID: 17607359; PMCID: PMC1904318.
    31. Liu E, Li M, Jasinski J, Kobayashi M, Gianani R, Nakayama M, Eisenbarth GS. Deleting islet autoimmunity. Cell Biochem Biophys. 2007; 48(2-3):177-82. PMID: 17709887.
      View in: PubMed
    32. Devendra D, Miao D, Nakayama M, Eisenbarth GS, Liu E. Pancreatic autoimmunity induction with insulin B:9-23 peptide and viral mimics in the NZB mouse. Ann N Y Acad Sci. 2006 Oct; 1079:135-7. PMID: 17130544.
      View in: PubMed
    33. Jasinski JM, Yu L, Nakayama M, Li MM, Lipes MA, Eisenbarth GS, Liu E. Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout. Diabetes. 2006 Jul; 55(7):1978-84. PMID: 16804066.
      View in: PubMed
    34. Devendra D, Jasinski J, Melanitou E, Nakayama M, Li M, Hensley B, Paronen J, Moriyama H, Miao D, Eisenbarth GS, Liu E. Interferon-alpha as a mediator of polyinosinic:polycytidylic acid-induced type 1 diabetes. Diabetes. 2005 Sep; 54(9):2549-56. PMID: 16123342.
      View in: PubMed
    35. Babaya N, Nakayama M, Eisenbarth GS. The stages of type 1A diabetes. Ann N Y Acad Sci. 2005 Jun; 1051:194-204. PMID: 16126959.
      View in: PubMed
    36. Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D, Yu L, Wegmann DR, Hutton JC, Elliott JF, Eisenbarth GS. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature. 2005 May 12; 435(7039):220-3. PMID: 15889095; PMCID: PMC1364531.
    37. Nakayama M, Moriyama H, Abiru N, Babu SR, Sikora K, Li M, Miao D, Hutton JC, Elliott JF, Eisenbarth GS. Establishment of native insulin-negative NOD mice and the methodology to distinguish specific insulin knockout genotypes and a B:16 alanine preproinsulin transgene. Ann N Y Acad Sci. 2004 Dec; 1037:193-8. PMID: 15699516.
      View in: PubMed
    38. Chowdhury SA, Nagata M, Yamada K, Nakayama M, Chakrabarty S, Jin Z, Kotani R, Yokono K. Tolerance mechanisms in murine autoimmune diabetes induced by anti-ICAM-1/LFA-1 mAb and anti-CD8 mAb. Kobe J Med Sci. 2002 Dec; 48(5-6):167-75. PMID: 12657834.
      View in: PubMed
    39. Kotani R, Nagata M, Moriyama H, Nakayama M, Yamada K, Chowdhury SA, Chakrabarty S, Jin Z, Yasuda H, Yokono K. Detection of GAD65-reactive T-Cells in type 1 diabetes by immunoglobulin-free ELISPOT assays. Diabetes Care. 2002 Aug; 25(8):1390-7. PMID: 12145240.
      View in: PubMed
    40. Nakayama M, Nagata M, Yasuda H, Arisawa K, Kotani R, Yamada K, Chowdhury SA, Chakrabarty S, Jin ZZ, Yagita H, Yokono K, Kasuga M. Fas/Fas ligand interactions play an essential role in the initiation of murine autoimmune diabetes. Diabetes. 2002 May; 51(5):1391-7. PMID: 11978635.
      View in: PubMed
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