Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Jeffrey Scott Kieft

TitleProfessor Adjoint
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics
Phone303/724-3257

    Collapse Research 
    Collapse research activities and funding
    R24GM154192     (DE MARCO, ALEX)Jul 1, 2024 - Apr 30, 2029
    NIH
    NCCAT: National Center for CryoEM Access and Training
    Role: Co-Principal Investigator
    R21AI157244     (VICENS, QUENTIN)Dec 15, 2020 - Nov 30, 2023
    NIH
    Structural determinants of viral RNAs resistant to exoribonucleases in the alphavirus supergroup
    Role: Co-Principal Investigator
    U24GM139171     (KIEFT, JEFFREY S)Sep 15, 2020 - Aug 31, 2026
    NIH
    The National Center for In-situ Tomographic Ultramicroscopy (NCITU)
    Role: Principal Investigator
    U24GM129539     (KIEFT, JEFFREY S)May 1, 2018 - May 31, 2024
    NIH
    NCCAT: National Center for CryoEM Access and Training
    Role: Principal Investigator
    R01AI133348     (KIEFT, JEFFREY S)Jun 26, 2017 - May 31, 2027
    NIH
    Mechanisms of viral RNA maturation by co-opting cellular exonucleases
    Role: Principal Investigator
    R21AI129569     (KIEFT, JEFFREY S)Jan 1, 2017 - Dec 31, 2018
    NIH
    Understanding pathogenic noncoding RNA production in Zika Virus infection
    Role: Principal Investigator
    R35GM118070     (KIEFT, JEFFREY S)Aug 1, 2016 - Jul 31, 2026
    NIH
    Structure, function, and dynamics of viral RNAs and RNA-containing complexes
    Role: Principal Investigator
    R01GM097333     (KIEFT, JEFFREY S)Apr 1, 2012 - Feb 29, 2016
    NIH
    Manipulation of cellular translation machinery by viral RNAs
    Role: Principal Investigator
    R01GM081346     (KIEFT, JEFFREY S)Sep 1, 2008 - May 31, 2017
    NIH
    Structural basis of protein synthesis by the hepatitis C virus IRES RNA
    Role: Principal Investigator
    S10RR024632     (KIEFT, JEFFREY S)Sep 30, 2007 - Sep 29, 2008
    NIH
    Automated Macromolecular Crystallization System
    Role: Principal Investigator
    R03AI072187     (KIEFT, JEFFREY S)Jun 1, 2007 - May 31, 2009
    NIH
    Development of tools for structural genomics of viral RNA
    Role: Principal Investigator
    R01GM072560     (KIEFT, JEFFREY S)Mar 1, 2005 - Feb 28, 2011
    NIH
    Structural and biophysical analysis of a viral IRES
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sherlock ME, Langeberg CJ, Kieft JS. Diversity and modularity of tyrosine-accepting tRNA-like structures. RNA. 2024 Feb 16; 30(3):213-222. PMID: 38164607.
      View in: PubMed
    2. Eiler DR, Wimberly BT, Bilodeau DY, Taliaferro JM, Reigan P, Rissland OS, Kieft JS. The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function. Structure. 2024 Apr 04; 32(4):400-410.e4. PMID: 38242118.
      View in: PubMed
    3. Langeberg CJ, Kieft JS. A generalizable scaffold-based approach for structure determination of RNAs by cryo-EM. Nucleic Acids Res. 2023 11 10; 51(20):e100. PMID: 37791881.
      View in: PubMed
    4. Sherlock ME, Langeberg CJ, Segar KE, Kieft JS. A conserved class of viral RNA structures regulate translation reinitiation through dynamic ribosome interactions. bioRxiv. 2023 Sep 29. PMID: 37808774.
      View in: PubMed
    5. Maurina SF, O'Sullivan JP, Sharma G, Pineda Rodriguez DC, MacFadden A, Cendali F, Henen MA, V?geli B, Kieft JS, Glasgow A, Steckelberg AL. An Evolutionarily Conserved Strategy for Ribosome Binding and Host Translation Inhibition by ?-coronavirus Non-structural Protein 1. J Mol Biol. 2023 10 15; 435(20):168259. PMID: 37660941.
      View in: PubMed
    6. Eng ET, Zimanyi C, Aragon M, Chua EYD, Kopylov E, Dubbeldam C, Castello C, Kieft JS, de Marco A. The National Center for CryoEM Access and Training - Establishing a Cross-Facility-Honored Training Curriculum. Microsc Microanal. 2023 Jul 22; 29(29 Suppl 1):1042-1043. PMID: 37613291.
      View in: PubMed
    7. Langeberg CJ, Kieft JS. A Generalizable Scaffold-Based Approach for Structure Determination of RNAs by Cryo-EM. bioRxiv. 2023 Jul 06. PMID: 37461535.
      View in: PubMed
    8. Maurina SF, O'Sullivan JP, Sharma G, Pineda Rodriguez DC, MacFadden A, Cendali F, Henen MA, Kieft JS, Glasgow A, Steckelberg AL. An evolutionarily conserved strategy for ribosome binding and inhibition by ?-coronavirus non-structural protein 1. bioRxiv. 2023 Jun 08. PMID: 37333070.
      View in: PubMed
    9. Sherlock ME, Baquero Galvis L, Vicens Q, Kieft JS, Jagannathan S. Principles, mechanisms, and biological implications of translation termination-reinitiation. RNA. 2023 07; 29(7):865-884. PMID: 37024263.
      View in: PubMed
    10. Nichols PJ, Bevers S, Henen MA, Kieft JS, Vicens Q, V?geli B. Adoption of A-Z Junctions in RNAs by Binding of Za Domains. Methods Mol Biol. 2023; 2651:251-275. PMID: 36892773.
      View in: PubMed
    11. Andrysik Z, Sullivan KD, Kieft JS, Espinosa JM. PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response. Nat Commun. 2022 12 01; 13(1):7400. PMID: 36456590.
      View in: PubMed
    12. Rolband L, Beasock D, Wang Y, Shu YG, Dinman JD, Schlick T, Zhou Y, Kieft JS, Chen SJ, Bussi G, Oukhaled A, Gao X, ?ulc P, Binzel D, Bhullar AS, Liang C, Guo P, Afonin KA. Biomotors, viral assembly, and RNA nanobiotechnology: Current achievements and future directions. Comput Struct Biotechnol J. 2022; 20:6120-6137. PMID: 36420155.
      View in: PubMed
    13. Park HJ, Gregory MA, Zaberezhnyy V, Goodspeed A, Jordan CT, Kieft JS, DeGregori J. Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation. Elife. 2022 10 19; 11. PMID: 36259537.
      View in: PubMed
    14. Bonilla SL, Kieft JS. The promise of cryo-EM to explore RNA structural dynamics. J Mol Biol. 2022 09 30; 434(18):167802. PMID: 36049551.
      View in: PubMed
    15. Bonilla SL, Vicens Q, Kieft JS. Cryo-EM reveals an entangled kinetic trap in the folding of a catalytic RNA. Sci Adv. 2022 Aug 26; 8(34):eabq4144. PMID: 36026457.
      View in: PubMed
    16. Khan YA, Loughran G, Steckelberg AL, Brown K, Kiniry SJ, Stewart H, Baranov PV, Kieft JS, Firth AE, Atkins JF. Evaluating ribosomal frameshifting in CCR5 mRNA decoding. Nature. 2022 04; 604(7906):E16-E23. PMID: 35444316.
      View in: PubMed
    17. Vicens Q, Kieft JS. Thoughts on how to think (and talk) about RNA structure. Proc Natl Acad Sci U S A. 2022 04 26; 119(17):e2112677119. PMID: 35439059.
      View in: PubMed
    18. Bonilla SL, Sherlock ME, MacFadden A, Kieft JS. A viral RNA hijacks host machinery using dynamic conformational changes of a tRNA-like structure. Science. 2021 Nov 19; 374(6570):955-960. PMID: 34793227.
      View in: PubMed
    19. Llerena Cari E, Hagen-Lillevik S, Giornazi A, Post M, Komar AA, Appiah L, Bitler B, Polotsky AJ, Santoro N, Kieft J, Lai K, Johnson J. Integrated stress response control of granulosa cell translation and proliferation during normal ovarian follicle development. Mol Hum Reprod. 2021 08 07; 27(8). PMID: 34314477.
      View in: PubMed
    20. Vicens Q, Kieft JS. Shared properties and singularities of exoribonuclease-resistant RNAs in viruses. Comput Struct Biotechnol J. 2021; 19:4373-4380. PMID: 34471487.
      View in: PubMed
    21. Akiyama BM, Graham ME, O Donoghue Z, Beckham JD, Kieft JS. Three-dimensional structure of a flavivirus dumbbell RNA reveals molecular details of an RNA regulator of replication. Nucleic Acids Res. 2021 07 09; 49(12):7122-7138. PMID: 34133732.
      View in: PubMed
    22. Balas MM, Hartwick EW, Barrington C, Roberts JT, Wu SK, Bettcher R, Griffin AM, Kieft JS, Johnson AM. Establishing RNA-RNA interactions remodels lncRNA structure and promotes PRC2 activity. Sci Adv. 2021 04; 7(16). PMID: 33853770.
      View in: PubMed
    23. Langeberg CJ, Sherlock ME, MacFadden A, Kieft JS. An expanded class of histidine-accepting viral tRNA-like structures. RNA. 2021 06; 27(6):653-664. PMID: 33811147.
      View in: PubMed
    24. Nichols PJ, Bevers S, Henen M, Kieft JS, Vicens Q, V?geli B. Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions. Nat Commun. 2021 02 04; 12(1):793. PMID: 33542240.
      View in: PubMed
    25. Sparks H, Monogue B, Akiyama B, Kieft J, Beckham JD. Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication. Viruses. 2020 10 18; 12(10). PMID: 33080971.
      View in: PubMed
    26. Sherlock ME, Hartwick EW, MacFadden A, Kieft JS. Structural diversity and phylogenetic distribution of valyl tRNA-like structures in viruses. RNA. 2021 01; 27(1):27-39. PMID: 33008837.
      View in: PubMed
    27. Jones RA, Steckelberg AL, Vicens Q, Szucs MJ, Akiyama BM, Kieft JS. Different tertiary interactions create the same important 3D features in a distinct flavivirus xrRNA. RNA. 2021 01; 27(1):54-65. PMID: 33004436.
      View in: PubMed
    28. Szucs MJ, Nichols PJ, Jones RA, Vicens Q, Kieft JS. A New Subclass of Exoribonuclease-Resistant RNA Found in Multiple Genera of Flaviviridae. mBio. 2020 09 29; 11(5). PMID: 32994331.
      View in: PubMed
    29. Steckelberg AL, Vicens Q, Costantino DA, Nix JC, Kieft JS. The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold. RNA. 2020 12; 26(12):1767-1776. PMID: 32848042.
      View in: PubMed
    30. Thulson E, Hartwick EW, Cooper-Sansone A, Williams MAC, Soliman ME, Robinson LK, Kieft JS, Mouzakis KD. An RNA pseudoknot stimulates HTLV-1 pro-pol programmed -1 ribosomal frameshifting. RNA. 2020 04; 26(4):512-528. PMID: 31980578.
      View in: PubMed
    31. Yesselman JD, Eiler D, Carlson ED, Gotrik MR, d'Aquino AE, Ooms AN, Kladwang W, Carlson PD, Shi X, Costantino DA, Herschlag D, Lucks JB, Jewett MC, Kieft JS, Das R. Computational design of three-dimensional RNA structure and function. Nat Nanotechnol. 2019 09; 14(9):866-873. PMID: 31427748.
      View in: PubMed
    32. Eisenmesser EZ, Gottschlich A, Redzic JS, Paukovich N, Nix JC, Azam T, Zhang L, Zhao R, Kieft JS, The E, Meng X, Dinarello CA. Interleukin-37 monomer is the active form for reducing innate immunity. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5514-5522. PMID: 30819901.
      View in: PubMed
    33. Jaafar ZA, Kieft JS. Viral RNA structure-based strategies to manipulate translation. Nat Rev Microbiol. 2019 01; 17(2):110-123. PMID: 30514982.
      View in: PubMed
    34. Steckelberg AL, Vicens Q, Kieft JS. Exoribonuclease-Resistant RNAs Exist within both Coding and Noncoding Subgenomic RNAs. mBio. 2018 12 18; 9(6). PMID: 30563900.
      View in: PubMed
    35. Vicens Q, Kieft JS, Rissland OS. Revisiting the Closed-Loop Model and the Nature of mRNA 5'-3' Communication. Mol Cell. 2018 12 06; 72(5):805-812. PMID: 30526871.
      View in: PubMed
    36. Hartwick EW, Costantino DA, MacFadden A, Nix JC, Tian S, Das R, Kieft JS. Ribosome-induced RNA conformational changes in a viral 3'-UTR sense and regulate translation levels. Nat Commun. 2018 11 29; 9(1):5074. PMID: 30498211.
      View in: PubMed
    37. Steckelberg AL, Akiyama BM, Costantino DA, Sit TL, Nix JC, Kieft JS. A folded viral noncoding RNA blocks host cell exoribonucleases through a conformationally dynamic RNA structure. Proc Natl Acad Sci U S A. 2018 06 19; 115(25):6404-6409. PMID: 29866852.
      View in: PubMed
    38. MacFadden A, O'Donoghue Z, Silva PAGC, Chapman EG, Olsthoorn RC, Sterken MG, Pijlman GP, Bredenbeek PJ, Kieft JS. Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs. Nat Commun. 2018 01 09; 9(1):119. PMID: 29317714.
      View in: PubMed
    39. Jaafar ZA, Oguro A, Nakamura Y, Kieft JS. Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling. Elife. 2016 12 23; 5. PMID: 28009256.
      View in: PubMed
    40. Akiyama BM, Laurence HM, Massey AR, Costantino DA, Xie X, Yang Y, Shi PY, Nix JC, Beckham JD, Kieft JS. Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease. Science. 2016 12 02; 354(6316):1148-1152. PMID: 27934765.
      View in: PubMed
    41. Hussain T, Ll?cer JL, Wimberly BT, Kieft JS, Ramakrishnan V. Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation. Cell. 2016 Sep 22; 167(1):133-144.e13. PMID: 27662086.
      View in: PubMed
    42. Filbin ME, Kieft JS. Linking ? to O: diverse and dynamic RNA-based mechanisms to regulate gene expression by 5'-to-3' communication. F1000Res. 2016; 5. PMID: 27610229.
      View in: PubMed
    43. Hao Y, Kieft JS. Three-way junction conformation dictates self-association of phage packaging RNAs. RNA Biol. 2016 07 02; 13(7):635-45. PMID: 27217219.
      View in: PubMed
    44. Akiyama BM, Eiler D, Kieft JS. Structured RNAs that evade or confound exonucleases: function follows form. Curr Opin Struct Biol. 2016 Feb; 36:40-7. PMID: 26797676.
      View in: PubMed
    45. Batey RT, Kieft JS. Soaking Hexammine Cations into RNA Crystals to Obtain Derivatives for Phasing Diffraction Data. Methods Mol Biol. 2016; 1320:219-32. PMID: 26227046.
      View in: PubMed
    46. Ruehle MD, Zhang H, Sheridan RM, Mitra S, Chen Y, Gonzalez RL, Cooperman BS, Kieft JS. A dynamic RNA loop in an IRES affects multiple steps of elongation factor-mediated translation initiation. Elife. 2015 Nov 02; 4. PMID: 26523395.
      View in: PubMed
    47. Ruehle MD, Kieft JS. Molecular prejudice: RNA discrimination against purines allows response to a cellular alarm. Nat Struct Mol Biol. 2015 Oct; 22(10):754-6. PMID: 26439636.
      View in: PubMed
    48. Kieft JS, Rabe JL, Chapman EG. New hypotheses derived from the structure of a flaviviral Xrn1-resistant RNA: Conservation, folding, and host adaptation. RNA Biol. 2015; 12(11):1169-77. PMID: 26399159.
      View in: PubMed
    49. Kieft JS. Experiences gathered and lessons learned from 20 years of RNA structure. RNA. 2015 Apr; 21(4):661-3. PMID: 25780181.
      View in: PubMed
    50. Colussi TM, Costantino DA, Zhu J, Donohue JP, Korostelev AA, Jaafar ZA, Plank TD, Noller HF, Kieft JS. Initiation of translation in bacteria by a structured eukaryotic IRES RNA. Nature. 2015 Mar 05; 519(7541):110-3. PMID: 25652826.
      View in: PubMed
    51. Hao Y, Kieft JS. Diverse self-association properties within a family of phage packaging RNAs. RNA. 2014 Nov; 20(11):1759-74. PMID: 25246655.
      View in: PubMed
    52. Clayton GM, Wang Y, Crawford F, Novikov A, Wimberly BT, Kieft JS, Falta MT, Bowerman NA, Marrack P, Fontenot AP, Dai S, Kappler JW. Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity. Cell. 2014 Jul 03; 158(1):132-42. PMID: 24995984.
      View in: PubMed
    53. Colussi TM, Costantino DA, Hammond JA, Ruehle GM, Nix JC, Kieft JS. The structural basis of transfer RNA mimicry and conformational plasticity by a viral RNA. Nature. 2014 Jul 17; 511(7509):366-9. PMID: 24909993.
      View in: PubMed
    54. Chapman EG, Costantino DA, Rabe JL, Moon SL, Wilusz J, Nix JC, Kieft JS. The structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production. Science. 2014 Apr 18; 344(6181):307-10. PMID: 24744377.
      View in: PubMed
    55. Chapman EG, Moon SL, Wilusz J, Kieft JS. RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA. Elife. 2014 Apr 01; 3:e01892. PMID: 24692447.
      View in: PubMed
    56. Plank TD, Whitehurst JT, Cencic R, Pelletier J, Kieft JS. Internal translation initiation from HIV-1 transcripts is conferred by a common RNA structure. Translation (Austin). 2014; 2(1):e27694. PMID: 26779399.
      View in: PubMed
    57. Plank TD, Whitehurst JT, Kieft JS. Cell type specificity and structural determinants of IRES activity from the 5' leaders of different HIV-1 transcripts. Nucleic Acids Res. 2013 Jul; 41(13):6698-714. PMID: 23661682.
      View in: PubMed
    58. Wang H, Ru Y, Sanchez-Carbayo M, Wang X, Kieft JS, Theodorescu D. Translation initiation factor eIF3b expression in human cancer and its role in tumor growth and lung colonization. Clin Cancer Res. 2013 Jun 01; 19(11):2850-60. PMID: 23575475.
      View in: PubMed
    59. Filbin ME, Vollmar BS, Shi D, Gonen T, Kieft JS. HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation. Nat Struct Mol Biol. 2013 Feb; 20(2):150-8. PMID: 23262488.
      View in: PubMed
    60. Plank TD, Kieft JS. The structures of nonprotein-coding RNAs that drive internal ribosome entry site function. Wiley Interdiscip Rev RNA. 2012 Mar-Apr; 3(2):195-212. PMID: 22215521.
      View in: PubMed
    61. Keel AY, Jha BK, Kieft JS. Structural architecture of an RNA that competitively inhibits RNase L. RNA. 2012 Jan; 18(1):88-99. PMID: 22114318.
      View in: PubMed
    62. Liu W, Jankowska-Anyszka M, Piecyk K, Dickson L, Wallace A, Niedzwiecka A, Stepinski J, Stolarski R, Darzynkiewicz E, Kieft J, Zhao R, Jones DN, Davis RE. Structural basis for nematode eIF4E binding an m(2,2,7)G-Cap and its implications for translation initiation. Nucleic Acids Res. 2011 Nov 01; 39(20):8820-32. PMID: 21965542.
      View in: PubMed
    63. Filbin ME, Kieft JS. HCV IRES domain IIb affects the configuration of coding RNA in the 40S subunit's decoding groove. RNA. 2011 Jul; 17(7):1258-73. PMID: 21606179.
      View in: PubMed
    64. Redzic JS, Armstrong GS, Isern NG, Jones DN, Kieft JS, Eisenmesser EZ. The retinal specific CD147 Ig0 domain: from molecular structure to biological activity. J Mol Biol. 2011 Aug 05; 411(1):68-82. PMID: 21620857.
      View in: PubMed
    65. Vallejos M, Deforges J, Plank TD, Letelier A, Ramdohr P, Abraham CG, Valiente-Echeverr?a F, Kieft JS, Sargueil B, L?pez-Lastra M. Activity of the human immunodeficiency virus type 1 cell cycle-dependent internal ribosomal entry site is modulated by IRES trans-acting factors. Nucleic Acids Res. 2011 Aug; 39(14):6186-200. PMID: 21482538.
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    66. Zhu J, Korostelev A, Costantino DA, Donohue JP, Noller HF, Kieft JS. Crystal structures of complexes containing domains from two viral internal ribosome entry site (IRES) RNAs bound to the 70S ribosome. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):1839-44. PMID: 21245352.
      View in: PubMed
    67. Feser J, Truong D, Das C, Carson JJ, Kieft J, Harkness T, Tyler JK. Elevated histone expression promotes life span extension. Mol Cell. 2010 Sep 10; 39(5):724-35. PMID: 20832724.
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    68. Kieft JS, Chase E, Costantino DA, Golden BL. Identification and characterization of anion binding sites in RNA. RNA. 2010 Jun; 16(6):1118-23. PMID: 20410239.
      View in: PubMed
    69. Hammond JA, Rambo RP, Kieft JS. Multi-domain packing in the aminoacylatable 3' end of a plant viral RNA. J Mol Biol. 2010 Jun 11; 399(3):450-63. PMID: 20398674.
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    70. Constantineau J, Greason E, West M, Filbin M, Kieft JS, Carletti MZ, Christenson LK, Rodriguez A. A synonymous variant in scavenger receptor, class B, type I gene is associated with lower SR-BI protein expression and function. Atherosclerosis. 2010 May; 210(1):177-82. PMID: 20060115.
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    71. Keel AY, Easton LE, Lukavsky PJ, Kieft JS. Large-scale native preparation of in vitro transcribed RNA. Methods Enzymol. 2009; 469:3-25. PMID: 20946782.
      View in: PubMed
    72. Pfingsten JS, Castile AE, Kieft JS. Mechanistic role of structurally dynamic regions in Dicistroviridae IGR IRESs. J Mol Biol. 2010 Jan 08; 395(1):205-17. PMID: 19878683.
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    73. Liu W, Zhao R, McFarland C, Kieft J, Niedzwiecka A, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Jones DN, Davis RE. Structural insights into parasite eIF4E binding specificity for m7G and m2,2,7G mRNA caps. J Biol Chem. 2009 Nov 06; 284(45):31336-49. PMID: 19710013.
      View in: PubMed
    74. Filbin ME, Kieft JS. Toward a structural understanding of IRES RNA function. Curr Opin Struct Biol. 2009 Jun; 19(3):267-76. PMID: 19362464.
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    75. Lee SJ, Hyun S, Kieft JS, Yu J. An approach to the construction of tailor-made amphiphilic peptides that strongly and selectively bind to hairpin RNA targets. J Am Chem Soc. 2009 Feb 18; 131(6):2224-30. PMID: 19199621.
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    76. Hammond JA, Rambo RP, Filbin ME, Kieft JS. Comparison and functional implications of the 3D architectures of viral tRNA-like structures. RNA. 2009 Feb; 15(2):294-307. PMID: 19144910.
      View in: PubMed
    77. Kieft J, Martinez-Salas E. Preface: functionally critical RNA structures found in positive-sense RNA viruses. Virus Res. 2009 Feb; 139(2):135-6. PMID: 18761042.
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    78. Kieft JS. Comparing the three-dimensional structures of Dicistroviridae IGR IRES RNAs with other viral RNA structures. Virus Res. 2009 Feb; 139(2):148-56. PMID: 18672012.
      View in: PubMed
    79. Pfingsten JS, Kieft JS. RNA structure-based ribosome recruitment: lessons from the Dicistroviridae intergenic region IRESes. RNA. 2008 Jul; 14(7):1255-63. PMID: 18515544.
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    80. Kieft JS. Viral IRES RNA structures and ribosome interactions. Trends Biochem Sci. 2008 Jun; 33(6):274-83. PMID: 18468443.
      View in: PubMed
    81. Costantino DA, Pfingsten JS, Rambo RP, Kieft JS. tRNA-mRNA mimicry drives translation initiation from a viral IRES. Nat Struct Mol Biol. 2008 Jan; 15(1):57-64. PMID: 18157151.
      View in: PubMed
    82. Timmerman SL, Pfingsten JS, Kieft JS, Krushel LA. The 5' leader of the mRNA encoding the mouse neurotrophin receptor TrkB contains two internal ribosomal entry sites that are differentially regulated. PLoS One. 2007 Sep 19; 3(9):e3242. PMID: 18779873.
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    83. Keel AY, Rambo RP, Batey RT, Kieft JS. A general strategy to solve the phase problem in RNA crystallography. Structure. 2007 Jul; 15(7):761-72. PMID: 17637337.
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    84. Batey RT, Kieft JS. Improved native affinity purification of RNA. RNA. 2007 Aug; 13(8):1384-9. PMID: 17548432.
      View in: PubMed
    85. Pfingsten JS, Costantino DA, Kieft JS. Conservation and diversity among the three-dimensional folds of the Dicistroviridae intergenic region IRESes. J Mol Biol. 2007 Jul 27; 370(5):856-69. PMID: 17544444.
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    86. Kieft JS, Costantino DA, Filbin ME, Hammond J, Pfingsten JS. Structural methods for studying IRES function. Methods Enzymol. 2007; 430:333-71. PMID: 17913644.
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    87. Pfingsten JS, Costantino DA, Kieft JS. Structural basis for ribosome recruitment and manipulation by a viral IRES RNA. Science. 2006 Dec 01; 314(5804):1450-4. PMID: 17124290.
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    88. Kieft JS, Pfingsten JS. Weapons in the molecular arms race. Nat Struct Mol Biol. 2005 Nov; 12(11):938-9. PMID: 16419274.
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    89. Costantino D, Kieft JS. A preformed compact ribosome-binding domain in the cricket paralysis-like virus IRES RNAs. RNA. 2005 Mar; 11(3):332-43. PMID: 15701733.
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    90. Kieft JS, Batey RT. A general method for rapid and nondenaturing purification of RNAs. RNA. 2004 Jun; 10(6):988-95. PMID: 15146082.
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    91. Kieft JS, Zhou K, Grech A, Jubin R, Doudna JA. Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation. Nat Struct Biol. 2002 May; 9(5):370-4. PMID: 11927953.
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    92. Rijnbrand R, Bredenbeek PJ, Haasnoot PC, Kieft JS, Spaan WJ, Lemon SM. The influence of downstream protein-coding sequence on internal ribosome entry on hepatitis C virus and other flavivirus RNAs. RNA. 2001 Apr; 7(4):585-97. PMID: 11345437.
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    93. Spahn CM, Kieft JS, Grassucci RA, Penczek PA, Zhou K, Doudna JA, Frank J. Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit. Science. 2001 Mar 09; 291(5510):1959-62. PMID: 11239155.
      View in: PubMed
    94. Kieft JS, Zhou K, Jubin R, Doudna JA. Mechanism of ribosome recruitment by hepatitis C IRES RNA. RNA. 2001 Feb; 7(2):194-206. PMID: 11233977.
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    95. Kieft JS, Grech A, Adams P, Doudna JA. Mechanisms of internal ribosome entry in translation initiation. Cold Spring Harb Symp Quant Biol. 2001; 66:277-83. PMID: 12762029.
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    96. Jubin R, Vantuno NE, Kieft JS, Murray MG, Doudna JA, Lau JY, Baroudy BM. Hepatitis C virus internal ribosome entry site (IRES) stem loop IIId contains a phylogenetically conserved GGG triplet essential for translation and IRES folding. J Virol. 2000 Nov; 74(22):10430-7. PMID: 11044087.
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    97. Kieft JS, Zhou K, Jubin R, Murray MG, Lau JY, Doudna JA. The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold. J Mol Biol. 1999 Sep 24; 292(3):513-29. PMID: 10497018.
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    98. Tinoco I, Kieft JS. The ion core in RNA folding. Nat Struct Biol. 1997 Jul; 4(7):509-12. PMID: 9228937.
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    99. Kieft JS, Tinoco I. Solution structure of a metal-binding site in the major groove of RNA complexed with cobalt (III) hexammine. Structure. 1997 May 15; 5(5):713-21. PMID: 9195889.
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