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Rytis Prekeris

InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Cell and Devopmental Bio

    Collapse Research 
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    T32GM008730     (PREKERIS, RYTIS)Jul 1, 1999 - Jun 30, 2020
    Predoctoral Training Program in Molecular Biology
    Role: Principal Investigator

    R01DK064380     (PREKERIS, RYTIS)Jul 1, 2002 - Aug 31, 2019
    Molecular Mechanisms of Polarized Endocytic Traffic in Epithelial Cells
    Role: Principal Investigator

    R01GM122768     (PREKERIS, RYTIS)Feb 1, 2018 - Jan 31, 2022
    The mechanisms regulating actin dynamics and polarized membrane transport during invadopodia formation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Antanaviciute I, Gibieža P, Prekeris R, Skeberdis VA. Midbody: From the Regulator of Cytokinesis to Postmitotic Signaling Organelle. Medicina (Kaunas). 2018 Jul 30; 54(4). PMID: 30344284.
      View in: PubMed
    2. Jewett CE, Prekeris R. Insane in the apical membrane: Trafficking events mediating apicobasal epithelial polarity during tube morphogenesis. Traffic. 2018 May 16. PMID: 29766620.
      View in: PubMed
    3. Das L, Gard JMC, Prekeris R, Nagle RB, Morrissey C, Knudsen BS, Miranti CK, Cress AE. Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer. Mol Cancer Res. 2018 08; 16(8):1319-1331. PMID: 29759989.
      View in: PubMed
    4. Dionne LK, Peterman E, Schiel J, Gibieža P, Skeberdis VA, Jimeno A, Wang XJ, Prekeris R. FYCO1 regulates accumulation of post-mitotic midbodies by mediating LC3-dependent midbody degradation. J Cell Sci. 2017 Dec 01; 130(23):4051-4062. PMID: 29196475.
      View in: PubMed
    5. Gibieža P, Prekeris R. Rab GTPases and cell division. Small GTPases. 2018 03 04; 9(1-2):107-115. PMID: 28471300.
      View in: PubMed
    6. Mandell MA, Jain A, Kumar S, Castleman MJ, Anwar T, Eskelinen EL, Johansen T, Prekeris R, Deretic V. Correction: TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation. J Cell Sci. 2017 03 15; 130(6):1194. PMID: 28298613.
      View in: PubMed
    7. Jacob A, Linklater E, Bayless BA, Lyons T, Prekeris R. The role and regulation of Rab40b-Tks5 complex during invadopodia formation and cancer cell invasion. J Cell Sci. 2016 12 01; 129(23):4341-4353. PMID: 27789576.
      View in: PubMed
    8. Mandell MA, Jain A, Kumar S, Castleman MJ, Anwar T, Eskelinen EL, Johansen T, Prekeris R, Deretic V. TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation. J Cell Sci. 2016 10 01; 129(19):3562-3573. PMID: 27562068.
      View in: PubMed
    9. Mangan AJ, Sietsema DV, Li D, Moore JK, Citi S, Prekeris R. Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells. Nat Commun. 2016 08 03; 7:12426. PMID: 27484926.
      View in: PubMed
    10. Peterman E, Prekeris R. Understanding post-mitotic roles of the midbody during cell differentiation and polarization. Methods Cell Biol. 2017; 137:173-186. PMID: 28065304.
      View in: PubMed
    11. Blasky AJ, Mangan A, Prekeris R. Polarized protein transport and lumen formation during epithelial tissue morphogenesis. Annu Rev Cell Dev Biol. 2015; 31:575-91. PMID: 26359775; PMCID: PMC4927002.
    12. Guo Y, Kenney SR, Muller CY, Adams S, Rutledge T, Romero E, Murray-Krezan C, Prekeris R, Sklar LA, Hudson LG, Wandinger-Ness A. R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis. Mol Cancer Ther. 2015 Oct; 14(10):2215-27. PMID: 26206334.
      View in: PubMed
    13. Prekeris R. Analyzing the functions of Rab11-effector proteins during cell division. Methods Cell Biol. 2015; 130:19-34. PMID: 26360025; PMCID: PMC4927005.
    14. Song M, Giza J, Proenca CC, Jing D, Elliott M, Dincheva I, Shmelkov SV, Kim J, Schreiner R, Huang SH, Castrén E, Prekeris R, Hempstead BL, Chao MV, Dictenberg JB, Rafii S, Chen ZY, Rodriguez-Boulan E, Lee FS. Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling. Dev Cell. 2015 Jun 22; 33(6):690-702. PMID: 26004511; PMCID: PMC4784688.
    15. Dionne LK, Wang XJ, Prekeris R. Midbody: from cellular junk to regulator of cell polarity and cell fate. Curr Opin Cell Biol. 2015 Aug; 35:51-8. PMID: 25950842; PMCID: PMC4529786.
    16. Jacob A, Prekeris R. The regulation of MMP targeting to invadopodia during cancer metastasis. Front Cell Dev Biol. 2015; 3:4. PMID: 25699257; PMCID: PMC4313772.
    17. Mangan A, Prekeris R. 3D time-lapse analysis of Rab11/FIP5 complex: spatiotemporal dynamics during apical lumen formation. Methods Mol Biol. 2015; 1298:181-6. PMID: 25800842; PMCID: PMC4479190.
    18. Prekeris R. Cut or NoCut: the role of JADE1S in regulating abscission checkpoint. Cell Cycle. 2015; 14(20):3219. PMID: 26327571; PMCID: PMC4825624.
    19. Ito Y, Correll K, Schiel JA, Finigan JH, Prekeris R, Mason RJ. Lung fibroblasts accelerate wound closure in human alveolar epithelial cells through hepatocyte growth factor/c-Met signaling. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 01; 307(1):L94-105. PMID: 24748602; PMCID: PMC4080284.
    20. Li D, Mangan A, Cicchini L, Margolis B, Prekeris R. FIP5 phosphorylation during mitosis regulates apical trafficking and lumenogenesis. EMBO Rep. 2014 Apr; 15(4):428-37. PMID: 24591568; PMCID: PMC3989674.
    21. Matsunami N, Hensel CH, Baird L, Stevens J, Otterud B, Leppert T, Varvil T, Hadley D, Glessner JT, Pellegrino R, Kim C, Thomas K, Wang F, Otieno FG, Ho K, Christensen GB, Li D, Prekeris R, Lambert CG, Hakonarson H, Leppert MF. Identification of rare DNA sequence variants in high-risk autism families and their prevalence in a large case/control population. Mol Autism. 2014 Jan 27; 5(1):5. PMID: 24467814; PMCID: PMC4098669.
    22. Li D, Kuehn EW, Prekeris R. Kinesin-2 mediates apical endosome transport during epithelial lumen formation. Cell Logist. 2014 Jan 01; 4(1):e28928. PMID: 24843830.
      View in: PubMed
    23. Nachbar J, Lázaro-Diéguez F, Prekeris R, Cohen D, Müsch A. KIFC3 promotes mitotic progression and integrity of the central spindle in cytokinesis. Cell Cycle. 2014; 13(3):426-33. PMID: 24275865; PMCID: PMC3956538.
    24. Jacob A, Jing J, Lee J, Schedin P, Gilbert SM, Peden AA, Junutula JR, Prekeris R. Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells. J Cell Sci. 2013 Oct 15; 126(Pt 20):4647-58. PMID: 23902685; PMCID: PMC3795337.
    25. Maller O, Hansen KC, Lyons TR, Acerbi I, Weaver VM, Prekeris R, Tan AC, Schedin P. Collagen architecture in pregnancy-induced protection from breast cancer. J Cell Sci. 2013 Sep 15; 126(Pt 18):4108-10. PMID: 23843613; PMCID: PMC3772386.
    26. Schiel JA, Childs C, Prekeris R. Endocytic transport and cytokinesis: from regulation of the cytoskeleton to midbody inheritance. Trends Cell Biol. 2013 Jul; 23(7):319-27. PMID: 23522622; PMCID: PMC4228945.
    27. Schiel JA, Prekeris R. Membrane dynamics during cytokinesis. Curr Opin Cell Biol. 2013 Feb; 25(1):92-8. PMID: 23177492; PMCID: PMC4228953.
    28. Schiel JA, Simon GC, Zaharris C, Weisz J, Castle D, Wu CC, Prekeris R. FIP3-endosome-dependent formation of the secondary ingression mediates ESCRT-III recruitment during cytokinesis. Nat Cell Biol. 2012 Oct; 14(10):1068-78. PMID: 23000966; PMCID: PMC4495918.
    29. Prekeris R. The art of "cut and run": the role of Rab14 GTPase in regulating N-cadherin shedding and cell motility. Dev Cell. 2012 May 15; 22(5):909-10. PMID: 22595666; PMCID: PMC3518450.
    30. Collins LL, Simon G, Matheson J, Wu C, Miller MC, Otani T, Yu X, Hayashi S, Prekeris R, Gould GW. Rab11-FIP3 is a cell cycle-regulated phosphoprotein. BMC Cell Biol. 2012 Mar 08; 13:4. PMID: 22401586; PMCID: PMC3310825.
    31. De Arras L, Yang IV, Lackford B, Riches DW, Prekeris R, Freedman JH, Schwartz DA, Alper S. Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP. J Immunol. 2012 Mar 15; 188(6):2905-13. PMID: 22312129; PMCID: PMC3293945.
    32. Willenborg C, Jing J, Wu C, Matern H, Schaack J, Burden J, Prekeris R. Interaction between FIP5 and SNX18 regulates epithelial lumen formation. J Cell Biol. 2011 Oct 03; 195(1):71-86. PMID: 21969467; PMCID: PMC3187708.
    33. Schiel JA, Prekeris R. ESCRT or endosomes?: Tales of the separation of two daughter cells. Commun Integr Biol. 2011 Sep; 4(5):606-8. PMID: 22046476; PMCID: PMC3204142.
    34. Prekeris R. Actin regulation during abscission: unexpected roles of Rab35 and endocytic transport. Cell Res. 2011 Sep; 21(9):1283-5. PMID: 21844893; PMCID: PMC3193460.
    35. Willenborg C, Prekeris R. Apical protein transport and lumen morphogenesis in polarized epithelial cells. Biosci Rep. 2011 Aug; 31(4):245-56. PMID: 21366541; PMCID: PMC4365982.
    36. Schiel JA, Park K, Morphew MK, Reid E, Hoenger A, Prekeris R. Endocytic membrane fusion and buckling-induced microtubule severing mediate cell abscission. J Cell Sci. 2011 May 01; 124(Pt 9):1411-24. PMID: 21486954.
      View in: PubMed
    37. Szperl AM, Golachowska MR, Bruinenberg M, Prekeris R, Thunnissen AM, Karrenbeld A, Dijkstra G, Hoekstra D, Mercer D, Ksiazyk J, Wijmenga C, Wapenaar MC, Rings EH, van IJzendoorn SC. Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease. J Pediatr Gastroenterol Nutr. 2011 Mar; 52(3):307-13. PMID: 21206382; PMCID: PMC3058815.
    38. Schiel JA, Prekeris R. Making the final cut - mechanisms mediating the abscission step of cytokinesis. ScientificWorldJournal. 2010 Jul 19; 10:1424-34. PMID: 20661535; PMCID: PMC4365978.
    39. Jing J, Junutula JR, Wu C, Burden J, Matern H, Peden AA, Prekeris R. FIP1/RCP binding to Golgin-97 regulates retrograde transport from recycling endosomes to the trans-Golgi network. Mol Biol Cell. 2010 Sep 01; 21(17):3041-53. PMID: 20610657; PMCID: PMC2929997.
    40. Hsu VW, Prekeris R. Transport at the recycling endosome. Curr Opin Cell Biol. 2010 Aug; 22(4):528-34. PMID: 20541925; PMCID: PMC2910225.
    41. Jing J, Prekeris R. Polarized endocytic transport: the roles of Rab11 and Rab11-FIPs in regulating cell polarity. Histol Histopathol. 2009 09; 24(9):1171-80. PMID: 19609864; PMCID: PMC4365979.
    42. Jing J, Tarbutton E, Wilson G, Prekeris R. Rab11-FIP3 is a Rab11-binding protein that regulates breast cancer cell motility by modulating the actin cytoskeleton. Eur J Cell Biol. 2009 Jun; 88(6):325-41. PMID: 19327867; PMCID: PMC2673714.
    43. Mazelova J, Astuto-Gribble L, Inoue H, Tam BM, Schonteich E, Prekeris R, Moritz OL, Randazzo PA, Deretic D. Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4. EMBO J. 2009 Feb 04; 28(3):183-92. PMID: 19153612; PMCID: PMC2637330.
    44. Schonteich E, Wilson GM, Burden J, Hopkins CR, Anderson K, Goldenring JR, Prekeris R. The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling. J Cell Sci. 2008 Nov 15; 121(Pt 22):3824-33. PMID: 18957512; PMCID: PMC4365997.
    45. Inoue H, Ha VL, Prekeris R, Randazzo PA. Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome. Mol Biol Cell. 2008 Oct; 19(10):4224-37. PMID: 18685082.
      View in: PubMed
    46. Simon GC, Prekeris R. Mechanisms regulating targeting of recycling endosomes to the cleavage furrow during cytokinesis. Biochem Soc Trans. 2008 Jun; 36(Pt 3):391-4. PMID: 18481966; PMCID: PMC4365980.
    47. Simon GC, Schonteich E, Wu CC, Piekny A, Ekiert D, Yu X, Gould GW, Glotzer M, Prekeris R. Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis. EMBO J. 2008 Jul 09; 27(13):1791-803. PMID: 18511905; PMCID: PMC2486418.
    48. Prekeris R, Gould GW. Breaking up is hard to do - membrane traffic in cytokinesis. J Cell Sci. 2008 May 15; 121(Pt 10):1569-76. PMID: 18469013; PMCID: PMC4365974.
    49. Simon GC, Prekeris R. The role of FIP3-dependent endosome transport during cytokinesis. Commun Integr Biol. 2008; 1(2):132-3. PMID: 19704869; PMCID: PMC2685998.
    50. Schonteich E, Pilli M, Simon GC, Matern HT, Junutula JR, Sentz D, Holmes RK, Prekeris R. Molecular characterization of Rab11-FIP3 binding to ARF GTPases. Eur J Cell Biol. 2007 Aug; 86(8):417-31. PMID: 17628206.
      View in: PubMed
    51. Westlake CJ, Junutula JR, Simon GC, Pilli M, Prekeris R, Scheller RH, Jackson PK, Eldridge AG. Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1236-41. PMID: 17229837; PMCID: PMC1773056.
    52. Yu X, Prekeris R, Gould GW. Role of endosomal Rab GTPases in cytokinesis. Eur J Cell Biol. 2007 Jan; 86(1):25-35. PMID: 17157409.
      View in: PubMed
    53. Eathiraj S, Mishra A, Prekeris R, Lambright DG. Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes. J Mol Biol. 2006 Nov 24; 364(2):121-35. PMID: 17007872.
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    54. Clarke M, Ewart MA, Santy LC, Prekeris R, Gould GW. ACRP30 is secreted from 3T3-L1 adipocytes via a Rab11-dependent pathway. Biochem Biophys Res Commun. 2006 Apr 21; 342(4):1361-7. PMID: 16516854.
      View in: PubMed
    55. Fielding AB, Schonteich E, Matheson J, Wilson G, Yu X, Hickson GR, Srivastava S, Baldwin SA, Prekeris R, Gould GW. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. EMBO J. 2005 Oct 05; 24(19):3389-99. PMID: 16148947; PMCID: PMC1276165.
    56. Tarbutton E, Peden AA, Junutula JR, Prekeris R. Class I FIPs, Rab11-binding proteins that regulate endocytic sorting and recycling. Methods Enzymol. 2005; 403:512-25. PMID: 16473616.
      View in: PubMed
    57. Wilson GM, Fielding AB, Simon GC, Yu X, Andrews PD, Hames RS, Frey AM, Peden AA, Gould GW, Prekeris R. The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. Mol Biol Cell. 2005 Feb; 16(2):849-60. PMID: 15601896.
      View in: PubMed
    58. Peden AA, Schonteich E, Chun J, Junutula JR, Scheller RH, Prekeris R. The RCP-Rab11 complex regulates endocytic protein sorting. Mol Biol Cell. 2004 Aug; 15(8):3530-41. PMID: 15181150.
      View in: PubMed
    59. Junutula JR, Schonteich E, Wilson GM, Peden AA, Scheller RH, Prekeris R. Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins. J Biol Chem. 2004 Aug 06; 279(32):33430-7. PMID: 15173169.
      View in: PubMed
    60. Prekeris R. Rabs, Rips, FIPs, and endocytic membrane traffic. ScientificWorldJournal. 2003 Sep 15; 3:870-80. PMID: 14532427.
      View in: PubMed
    61. Hickson GR, Matheson J, Riggs B, Maier VH, Fielding AB, Prekeris R, Sullivan W, Barr FA, Gould GW. Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout. Mol Biol Cell. 2003 Jul; 14(7):2908-20. PMID: 12857874.
      View in: PubMed
    62. Meyers JM, Prekeris R. Formation of mutually exclusive Rab11 complexes with members of the family of Rab11-interacting proteins regulates Rab11 endocytic targeting and function. J Biol Chem. 2002 Dec 13; 277(50):49003-10. PMID: 12376546.
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    63. Martinez-Menárguez JA, Prekeris R, Oorschot VM, Scheller R, Slot JW, Geuze HJ, Klumperman J. Peri-Golgi vesicles contain retrograde but not anterograde proteins consistent with the cisternal progression model of intra-Golgi transport. J Cell Biol. 2001 Dec 24; 155(7):1213-24. PMID: 11748250; PMCID: PMC2199342.
    64. Prekeris R, Davies JM, Scheller RH. Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. J Biol Chem. 2001 Oct 19; 276(42):38966-70. PMID: 11481332.
      View in: PubMed
    65. Prekeris R, Klumperman J, Scheller RH. A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes. Mol Cell. 2000 Dec; 6(6):1437-48. PMID: 11163216.
      View in: PubMed
    66. Prekeris R, Klumperman J, Scheller RH. Syntaxin 11 is an atypical SNARE abundant in the immune system. Eur J Cell Biol. 2000 Nov; 79(11):771-80. PMID: 11139139.
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    67. Steegmaier M, Lee KC, Prekeris R, Scheller RH. SNARE protein trafficking in polarized MDCK cells. Traffic. 2000 Jul; 1(7):553-60. PMID: 11208143.
      View in: PubMed
    68. Prekeris R, Foletti DL, Scheller RH. Dynamics of tubulovesicular recycling endosomes in hippocampal neurons. J Neurosci. 1999 Dec 01; 19(23):10324-37. PMID: 10575030.
      View in: PubMed
    69. Prekeris R, Yang B, Oorschot V, Klumperman J, Scheller RH. Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. Mol Biol Cell. 1999 Nov; 10(11):3891-908. PMID: 10564279.
      View in: PubMed
    70. Advani RJ, Yang B, Prekeris R, Lee KC, Klumperman J, Scheller RH. VAMP-7 mediates vesicular transport from endosomes to lysosomes. J Cell Biol. 1999 Aug 23; 146(4):765-76. PMID: 10459012; PMCID: PMC2156136.
    71. Foletti DL, Prekeris R, Scheller RH. Generation and maintenance of neuronal polarity: mechanisms of transport and targeting. Neuron. 1999 Aug; 23(4):641-4. PMID: 10482230.
      View in: PubMed
    72. Chao DS, Hay JC, Winnick S, Prekeris R, Klumperman J, Scheller RH. SNARE membrane trafficking dynamics in vivo. J Cell Biol. 1999 Mar 08; 144(5):869-81. PMID: 10085287; PMCID: PMC2148207.
    73. Yang B, Gonzalez L, Prekeris R, Steegmaier M, Advani RJ, Scheller RH. SNARE interactions are not selective. Implications for membrane fusion specificity. J Biol Chem. 1999 Feb 26; 274(9):5649-53. PMID: 10026182.
      View in: PubMed
    74. Prekeris R, Klumperman J, Chen YA, Scheller RH. Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. J Cell Biol. 1998 Nov 16; 143(4):957-71. PMID: 9817754; PMCID: PMC2132958.
    75. Prekeris R, Hernandez RM, Mayhew MW, White MK, Terrian DM. Molecular analysis of the interactions between protein kinase C-epsilon and filamentous actin. J Biol Chem. 1998 Oct 09; 273(41):26790-8. PMID: 9756923.
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    76. Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH. Seven novel mammalian SNARE proteins localize to distinct membrane compartments. J Biol Chem. 1998 Apr 24; 273(17):10317-24. PMID: 9553086.
      View in: PubMed
    77. Prekeris R, Terrian DM. Brain myosin V is a synaptic vesicle-associated motor protein: evidence for a Ca2+-dependent interaction with the synaptobrevin-synaptophysin complex. J Cell Biol. 1997 Jun 30; 137(7):1589-601. PMID: 9199173; PMCID: PMC2137828.
    78. Navin A, Prekeris R, Lisitsyn NA, Sonti MM, Grieco DA, Narayanswami S, Lander ES, Simpson EM. Mouse Y-specific repeats isolated by whole chromosome representational difference analysis. Genomics. 1996 Sep 01; 36(2):349-53. PMID: 8812464.
      View in: PubMed
    79. Prekeris R, Mayhew MW, Cooper JB, Terrian DM. Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function. J Cell Biol. 1996 Jan; 132(1-2):77-90. PMID: 8567732; PMCID: PMC2120693.
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