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Raul Martin Torres

InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Immunology Microbiology

    Collapse Research 
    Collapse research activities and funding
    T32AI007405     (TORRES, RAUL MARTIN)Sep 30, 1991 - Jul 31, 2021
    Training Program in Immunology
    Role: Principal Investigator

    R01AI052157     (TORRES, RAUL M)Aug 1, 2002 - Apr 30, 2018
    Antigen and lysophospholipid receptor regulation of lymphocyte development and fu
    Role: Principal Investigator

    R21AI078468     (TORRES, RAUL MARTIN)Mar 1, 2008 - Feb 28, 2010
    Marginal Zone B Cell Response to HIV
    Role: Principal Investigator

    R01AI136534     (TORRES, RAUL MARTIN)Jul 3, 2018 - Jun 30, 2023
    Humoral Immunity by Anergic B cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Atif SM, Gibbings SL, Redente EF, Camp FA, Torres RM, Kedl RM, Henson PM, Jakubzick CV. Immune Surveillance by Natural IgM Is Required for Early Neoantigen Recognition and Initiation of Adaptive Immunity. Am J Respir Cell Mol Biol. 2018 Nov; 59(5):580-591. PMID: 29953261.
      View in: PubMed
    2. Sang A, Danhorn T, Peterson JN, Rankin AL, O'Connor BP, Leach SM, Torres RM, Pelanda R. Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus. Nat Commun. 2018 09 28; 9(1):3973. PMID: 30266981.
      View in: PubMed
    3. Greaves SA, Peterson JN, Torres RM, Pelanda R. Corrigendum: Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance. Front Immunol. 2018; 9:2218. PMID: 30323810.
      View in: PubMed
    4. Agazio AE, Pelanda R, Torres RM. Silencing of TLM B cells by chronic HIV infection. Nat Immunol. 2018 Sep; 19(9):902-903. PMID: 30104630.
      View in: PubMed
    5. Greaves SA, Peterson JN, Torres RM, Pelanda R. Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance. Front Immunol. 2018; 9:707. PMID: 29686680.
      View in: PubMed
    6. Lang J, Zhang B, Kelly M, Peterson JN, Barbee J, Freed BM, Di Santo JP, Matsuda JL, Torres RM, Pelanda R. Replacing mouse BAFF with human BAFF does not improve B-cell maturation in hematopoietic humanized mice. Blood Adv. 2017 Dec 26; 1(27):2729-2741. PMID: 29296925.
      View in: PubMed
    7. Schroeder KM, Agazio A, Torres RM. Immunological tolerance as a barrier to protective HIV humoral immunity. Curr Opin Immunol. 2017 Aug; 47:26-34. PMID: 28728075.
      View in: PubMed
    8. Schroeder KMS, Agazio A, Strauch PJ, Jones ST, Thompson SB, Harper MS, Pelanda R, Santiago ML, Torres RM. Breaching peripheral tolerance promotes the production of HIV-1-neutralizing antibodies. J Exp Med. 2017 Aug 07; 214(8):2283-2302. PMID: 28698284.
      View in: PubMed
    9. Chisholm CF, Soucie KR, Song JS, Strauch P, Torres RM, Carpenter JF, Ragheb JA, Randolph TW. Immunogenicity of Structurally Perturbed Hen Egg Lysozyme Adsorbed to Silicone Oil Microdroplets in Wild-Type and Transgenic Mouse Models. J Pharm Sci. 2017 06; 106(6):1519-1527. PMID: 28216023.
      View in: PubMed
    10. Malarkey CS, Gustafson CE, Saifee JF, Torres RM, Churchill ME, Janoff EN. Mechanism of Mitochondrial Transcription Factor A Attenuation of CpG-Induced Antibody Production. PLoS One. 2016; 11(6):e0157157. PMID: 27280778; PMCID: PMC4900672.
    11. Born WK, Huang Y, Zeng W, Torres RM, O'Brien RL. A Special Connection between ?d T Cells and Natural Antibodies? Arch Immunol Ther Exp (Warsz). 2016 Dec; 64(6):455-462. PMID: 27235134.
      View in: PubMed
    12. Chisholm CF, Baker AE, Soucie KR, Torres RM, Carpenter JF, Randolph TW. Silicone Oil Microdroplets Can Induce Antibody Responses Against Recombinant Murine Growth Hormone in Mice. J Pharm Sci. 2016 05; 105(5):1623-1632. PMID: 27020987; PMCID: PMC4846524 [Available on 05/01/17].
    13. Lang J, Ota T, Kelly M, Strauch P, Freed BM, Torres RM, Nemazee D, Pelanda R. Receptor editing and genetic variability in human autoreactive B cells. J Exp Med. 2016 Jan 11; 213(1):93-108. PMID: 26694971; PMCID: PMC4710202.
    14. Christie M, Peritt D, Torres RM, Randolph TW, Carpenter JF. The Role of Protein Excipient in Driving Antibody Responses to Erythropoietin. J Pharm Sci. 2015 Dec; 104(12):4041-4055. PMID: 26375484.
      View in: PubMed
    15. Chisholm CF, Nguyen BH, Soucie KR, Torres RM, Carpenter JF, Randolph TW. In Vivo Analysis of the Potency of Silicone Oil Microdroplets as Immunological Adjuvants in Protein Formulations. J Pharm Sci. 2015 Nov; 104(11):3681-90. PMID: 26190624; PMCID: PMC4604024 [Available on 11/01/16].
    16. Teodorovic LS, Babolin C, Rowland SL, Greaves SA, Baldwin DP, Torres RM, Pelanda R. Activation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodies. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):E2797-806. PMID: 24958853; PMCID: PMC4103347.
    17. Hu J, Oda SK, Shotts K, Donovan EE, Strauch P, Pujanauski LM, Victorino F, Al-Shami A, Fujiwara Y, Tigyi G, Oravecz T, Pelanda R, Torres RM. Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response. J Immunol. 2014 Jul 01; 193(1):85-95. PMID: 24890721; PMCID: PMC4128188.
    18. Christie M, Torres RM, Kedl RM, Randolph TW, Carpenter JF. Recombinant murine growth hormone particles are more immunogenic with intravenous than subcutaneous administration. J Pharm Sci. 2014 Jan; 103(1):128-39. PMID: 25133276; PMCID: PMC4137484.
    19. Oda SK, Strauch P, Fujiwara Y, Al-Shami A, Oravecz T, Tigyi G, Pelanda R, Torres RM. Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression. Cancer Immunol Res. 2013 Oct; 1(4):245-55. PMID: 24455753; PMCID: PMC3893823.
    20. Fuquay R, Renner B, Kulik L, McCullough JW, Amura C, Strassheim D, Pelanda R, Torres R, Thurman JM. Renal ischemia-reperfusion injury amplifies the humoral immune response. J Am Soc Nephrol. 2013 Jun; 24(7):1063-72. PMID: 23641055; PMCID: PMC3699821.
    21. Rowland SL, Tuttle K, Torres RM, Pelanda R. Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire. Immunol Res. 2013 Mar; 55(1-3):231-40. PMID: 22941591; PMCID: PMC3924590.
    22. Guan Y, Torres RM, Hartney JM. The influence of Arhgef1 on pulmonary leukocyte function. Immunol Res. 2013 Mar; 55(1-3):162-6. PMID: 22941563.
      View in: PubMed
    23. Swanson CL, Pelanda R, Torres RM. Division of labor during primary humoral immunity. Immunol Res. 2013 Mar; 55(1-3):277-86. PMID: 22945808; PMCID: PMC3997297.
    24. Lang J, Kelly M, Freed BM, McCarter MD, Kedl RM, Torres RM, Pelanda R. Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol. 2013 Mar 01; 190(5):2090-101. PMID: 23335750; PMCID: PMC3578183.
    25. Pujanauski LM, Janoff EN, McCarter MD, Pelanda R, Torres RM. Mouse marginal zone B cells harbor specificities similar to human broadly neutralizing HIV antibodies. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1422-7. PMID: 23288906; PMCID: PMC3557101.
    26. Fournier EM, Velez MG, Leahy K, Swanson CL, Rubtsov AV, Torres RM, Pelanda R. Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice. J Exp Med. 2012 Sep 24; 209(10):1797-812. PMID: 22927551.
      View in: PubMed
    27. Hartney JM, Chu H, Pelanda R, Torres RM. Sub-chronic exposure to second hand smoke induces airspace leukocyte infiltration and decreased lung elastance. Front Physiol. 2012; 3:300. PMID: 22934051; PMCID: PMC3429071.
    28. Larson JD, Thurman JM, Rubtsov AV, Claypool D, Marrack P, van Dyk LF, Torres RM, Pelanda R. Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):E1092-100. PMID: 22474381; PMCID: PMC3345002.
    29. Pelanda R, Torres RM. Central B-cell tolerance: where selection begins. Cold Spring Harb Perspect Biol. 2012 Apr 01; 4(4):a007146. PMID: 22378602; PMCID: PMC3312675.
    30. Teodorovic LS, Riccardi C, Torres RM, Pelanda R. Murine B cell development and antibody responses to model antigens are not impaired in the absence of the TNF receptor GITR. PLoS One. 2012; 7(2):e31632. PMID: 22328941; PMCID: PMC3273462.
    31. Hartney JM, Gustafson CE, Bowler RP, Pelanda R, Torres RM. Thromboxane receptor signaling is required for fibronectin-induced matrix metalloproteinase 9 production by human and murine macrophages and is attenuated by the Arhgef1 molecule. J Biol Chem. 2011 Dec 30; 286(52):44521-31. PMID: 22086927; PMCID: PMC3247948.
    32. Lang J, Weiss N, Freed BM, Torres RM, Pelanda R. Generation of hematopoietic humanized mice in the newborn BALB/c-Rag2null Il2r?null mouse model: a multivariable optimization approach. Clin Immunol. 2011 Jul; 140(1):102-16. PMID: 21536497; PMCID: PMC3115423.
    33. Rowland SL, Leahy KF, Halverson R, Torres RM, Pelanda R. BAFF receptor signaling aids the differentiation of immature B cells into transitional B cells following tonic BCR signaling. J Immunol. 2010 Oct 15; 185(8):4570-81. PMID: 20861359; PMCID: PMC2950883.
    34. Swanson CL, Wilson TJ, Strauch P, Colonna M, Pelanda R, Torres RM. Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response. J Exp Med. 2010 Jul 05; 207(7):1485-500. PMID: 20566717.
      View in: PubMed
    35. Donovan EE, Pelanda R, Torres RM. S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development. Eur J Immunol. 2010 Mar; 40(3):688-98. PMID: 20039302; PMCID: PMC2924669.
    36. Rowland SL, DePersis CL, Torres RM, Pelanda R. Ras activation of Erk restores impaired tonic BCR signaling and rescues immature B cell differentiation. J Exp Med. 2010 Mar 15; 207(3):607-21. PMID: 20176802; PMCID: PMC2839140.
    37. Hartney JM, Brown J, Chu HW, Chang LY, Pelanda R, Torres RM. Arhgef1 regulates alpha5beta1 integrin-mediated matrix metalloproteinase expression and is required for homeostatic lung immunity. Am J Pathol. 2010 Mar; 176(3):1157-68. PMID: 20093499; PMCID: PMC2832139.
    38. Rubtsov AV, Swanson CL, Troy S, Strauch P, Pelanda R, Torres RM. TLR agonists promote marginal zone B cell activation and facilitate T-dependent IgM responses. J Immunol. 2008 Mar 15; 180(6):3882-8. PMID: 18322196.
      View in: PubMed
    39. Hu J, Strauch P, Rubtsov A, Donovan EE, Pelanda R, Torres RM. Lsc activity is controlled by oligomerization and regulates integrin adhesion. Mol Immunol. 2008 Apr; 45(7):1825-36. PMID: 18157933; PMCID: PMC2315659.
    40. Velez MG, Kane M, Liu S, Gauld SB, Cambier JC, Torres RM, Pelanda R. Ig allotypic inclusion does not prevent B cell development or response. J Immunol. 2007 Jul 15; 179(2):1049-57. PMID: 17617597.
      View in: PubMed
    41. Brown JP, Taube C, Miyahara N, Koya T, Pelanda R, Gelfand EW, Torres RM. Arhgef1 is required by T cells for the development of airway hyperreactivity and inflammation. Am J Respir Crit Care Med. 2007 Jul 01; 176(1):10-9. PMID: 17463415; PMCID: PMC2049063.
    42. Wu Q, Martin RJ, Rino JG, Breed R, Torres RM, Chu HW. IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection. Microbes Infect. 2007 Jan; 9(1):78-86. PMID: 17198762; PMCID: PMC1832075.
    43. Pelanda R, Torres RM. Receptor editing for better or for worse. Curr Opin Immunol. 2006 Apr; 18(2):184-90. PMID: 16460922.
      View in: PubMed
    44. Rubtsov A, Strauch P, Digiacomo A, Hu J, Pelanda R, Torres RM. Lsc regulates marginal-zone B cell migration and adhesion and is required for the IgM T-dependent antibody response. Immunity. 2005 Nov; 23(5):527-38. PMID: 16286020.
      View in: PubMed
    45. Liu S, Velez MG, Humann J, Rowland S, Conrad FJ, Halverson R, Torres RM, Pelanda R. Receptor editing can lead to allelic inclusion and development of B cells that retain antibodies reacting with high avidity autoantigens. J Immunol. 2005 Oct 15; 175(8):5067-76. PMID: 16210610.
      View in: PubMed
    46. Halverson R, Torres RM, Pelanda R. Receptor editing is the main mechanism of B cell tolerance toward membrane antigens. Nat Immunol. 2004 Jun; 5(6):645-50. PMID: 15156139.
      View in: PubMed
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