Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Trevor J. Williams

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSDM-Craniofacial Biology
Phone303/724-4571

    Collapse Research 
    Collapse research activities and funding
    R01GM046770     (WILLIAMS, TREVOR J)Feb 1, 1992 - Nov 30, 1997
    NIH/NIGMS
    TRANSCRIPTION FACTOR REGULATION DURING DEVELOPMENT
    Role: Principal Investigator

    R01CA077833     (WILLIAMS, TREVOR J)May 1, 1998 - Feb 29, 2004
    NIH/NCI
    TRANSCRIPTION FACTOR AP-2 IN MAMMARY GLAND DEVELOPMENT
    Role: Principal Investigator

    R01DE012728     (WILLIAMS, TREVOR J)Aug 1, 1998 - Mar 31, 2014
    NIH/NIDCR
    The Role of AP-2 in Craniofacial Development
    Role: Principal Investigator

    R21DE018005     (WILLIAMS, TREVOR J)Sep 1, 2007 - Aug 31, 2010
    NIH/NIDCR
    FUNCTIONAL ANALYSIS OF GENES INVOLVED IN VERTEBRATE CRANIOFACIAL DEVELOPMENT
    Role: Principal Investigator

    R01DE019843     (WILLIAMS, TREVOR J)Jul 1, 2009 - Jun 30, 2014
    NIH/NIDCR
    Role of Ectodermal Signals in Facial Prominence Outgrowth and Development
    Role: Principal Investigator

    R01HD060882     (WILLIAMS, TREVOR J)Jul 17, 2009 - Jun 30, 2012
    NIH/NICHD
    Role of Ectodermal Signals in Limb Bud Outgrowth and Development
    Role: Principal Investigator

    U01DE024429     (HOOPER, JOAN E)Jul 3, 2014 - Apr 30, 2019
    NIH/NIDCR
    RNA dynamics in the developing mouse face
    Role: Principal Investigator

    R01HD081562     (WILLIAMS, TREVOR J)Sep 20, 2014 - Jun 30, 2019
    NIH/NICHD
    Phenotyping Embryonic Lethal Knockout mice with neural crest and neural defects
    Role: Principal Investigator

    R01EY025789     (WEST-MAYS, JUDITH A)Sep 30, 2015 - Aug 31, 2019
    NIH/NEI
    Role of AP-2beta in Anterior Segment Development
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hooper JE, Feng W, Li H, Leach SM, Phang T, Siska C, Jones KL, Spritz RA, Hunter LE, Williams T. Systems biology of facial development: contributions of ectoderm and mesenchyme. Dev Biol. 2017 Jun 01; 426(1):97-114. PMID: 28363736.
      View in: PubMed
    2. Schock EN, Struve JN, Chang CF, Williams TJ, Snedeker J, Attia AC, Stottmann RW, Brugmann SA. A tissue-specific role for intraflagellar transport genes during craniofacial development. PLoS One. 2017; 12(3):e0174206. PMID: 28346501.
      View in: PubMed
    3. Seberg HE, Van Otterloo E, Loftus SK, Liu H, Bonde G, Sompallae R, Gildea DE, Santana JF, Manak JR, Pavan WJ, Williams T, Cornell RA. TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF. PLoS Genet. 2017 Mar; 13(3):e1006636. PMID: 28249010.
      View in: PubMed
    4. Snell GI, Holsworth L, Khorramnia S, Westall GP, Williams TJ, Marasco S, Gooi JH. Feasibility and Safety of a Transthoracic Pneumostoma Airway Bypass in Severe Emphysema Patients. Respiration. 2017; 93(4):236-246. PMID: 28142136.
      View in: PubMed
    5. Khorramnia S, Holsworth L, Mestitz H, Westall GP, Williams TJ, Gooi JH, Snell GI. Sequential unilateral lung volume reduction for emphysema - Stretching the benefit. Respir Med Case Rep. 2017; 20:120-122. PMID: 28180065.
      View in: PubMed
    6. Calderone A, Stevens W, Prior D, Nandurkar H, Gabbay E, Proudman SM, Williams T, Celermajer D, Sahhar J, Wong PK, Thakkar V, Dwyer N, Wrobel J, Chin W, Liew D, Staples M, Buchbinder R, Nikpour M. Multicentre randomised placebo-controlled trial of oral anticoagulation with apixaban in systemic sclerosis-related pulmonary arterial hypertension: the SPHInX study protocol. BMJ Open. 2016 Dec 08; 6(12):e011028. PMID: 27932335.
      View in: PubMed
    7. Prior DL, Adams H, Williams TJ. Update on pharmacotherapy for pulmonary hypertension. Med J Aust. 2016 Sep 19; 205(6):271-6. PMID: 27627939.
      View in: PubMed
    8. Denton EJ, Rischin A, McGiffin D, Williams TJ, Paraskeva MA, Westall GP, Snell G. Refractory Pulmonary Edema Caused by Late Pulmonary Vein Thrombosis After Lung Transplantation: A Rare Adverse Event. Ann Thorac Surg. 2016 Sep; 102(3):e197-9. PMID: 27549541.
      View in: PubMed
    9. Cole JB, Manyama M, Kimwaga E, Mathayo J, Larson JR, Liberton DK, Lukowiak K, Ferrara TM, Riccardi SL, Li M, Mio W, Prochazkova M, Williams T, Li H, Jones KL, Klein OD, Santorico SA, Hallgrimsson B, Spritz RA. Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape. PLoS Genet. 2016 Aug; 12(8):e1006174. PMID: 27560698; PMCID: PMC4999243.
    10. Zhang L, Ferreyros M, Feng W, Hupe M, Crumrine DA, Chen J, Elias PM, Holleran WM, Niswander L, Hohl D, Williams T, Torchia EC, Roop DR. Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis. PLoS One. 2016; 11(8):e0161465. PMID: 27551807; PMCID: PMC4994956.
    11. Williams T, Gulack BC, Kim S, Fernandez FG, Ferguson MK. Operative Risk for Major Lung Resection Increases at Extremes of Body Mass Index. Ann Thorac Surg. 2017 Jan; 103(1):296-302. PMID: 27476820.
      View in: PubMed
    12. Martino VB, Sabljic T, Deschamps P, Green RM, Akula M, Peacock E, Ball A, Williams T, West-Mays JA. Conditional deletion of AP-2ß in mouse cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma. Dis Model Mech. 2016 Aug 01; 9(8):849-61. PMID: 27483349; PMCID: PMC5007979.
    13. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J, Chai Y. The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development. 2016 Jul 15; 143(14):2677-88. PMID: 27287806; PMCID: PMC4958338.
    14. Chen L, Martino V, Dombkowski A, Williams T, West-Mays J, Gage PJ. AP-2ß Is a Downstream Effector of PITX2 Required to Specify Endothelium and Establish Angiogenic Privilege During Corneal Development. Invest Ophthalmol Vis Sci. 2016 Mar; 57(3):1072-81. PMID: 26968737; PMCID: PMC4790471.
    15. Van Otterloo E, Williams T, Artinger KB. The old and new face of craniofacial research: How animal models inform human craniofacial genetic and clinical data. Dev Biol. 2016 Jul 15; 415(2):171-187. PMID: 26808208; PMCID: PMC4914413 [Available on 07/15/17].
    16. Van Otterloo E, Feng W, Jones KL, Hynes NE, Clouthier DE, Niswander L, Williams T. MEMO1 drives cranial endochondral ossification and palatogenesis. Dev Biol. 2016 Jul 15; 415(2):278-295. PMID: 26746790; PMCID: PMC4914435 [Available on 07/15/17].
    17. Fok A, Williams T, McLean CA, Butler E. Interferon beta-1a long-term therapy related to pulmonary arterial hypertension in multiple sclerosis patients. Mult Scler. 2016 Oct; 22(11):1495-1498. PMID: 26564996.
      View in: PubMed
    18. Williams T, Duraid H, Watson S, Durkin A, Todd K, Kindler HL, Vigneswaran WT. Extended Pleurectomy and Decortication for Malignant Pleural Mesothelioma Is an Effective and Safe Cytoreductive Surgery in the Elderly. Ann Thorac Surg. 2015 Nov; 100(5):1868-74. PMID: 26319490.
      View in: PubMed
    19. Ellender CM, McLean C, Williams TJ, Snell GI, Whitford HM. Autoimmune disease leading to pulmonary AL amyloidosis and pulmonary hypertension. Respirol Case Rep. 2015 Jun; 3(2):78-81. PMID: 26090118; PMCID: PMC4469147.
    20. Ellender CM, Williams TJ, Gooi J, Snell GI, Whitford HM. Management of refractory chylothorax in pulmonary lymphangioleiomyomatosis. Respirol Case Rep. 2015 Jun; 3(2):72-4. PMID: 26090116; PMCID: PMC4469145.
    21. Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, Lazic S, Burrows JT, Wong MD, Li D, Deimling S, Ciruna B, Scott I, Simmons C, Henkelman RM, Williams T, Hadjantonakis AK, Fernandez-Gonzalez R, Sun Y, Hopyan S. Anisotropic stress orients remodelling of mammalian limb bud ectoderm. Nat Cell Biol. 2015 May; 17(5):569-79. PMID: 25893915; PMCID: PMC4955842.
    22. Otani S, Levvey BJ, Westall GP, Paraskeva M, Whitford H, Williams T, McGiffin DC, Walker R, Menahem S, Snell GI. Long-term successful outcomes from kidney transplantation after lung and heart-lung transplantation. Ann Thorac Surg. 2015 Mar; 99(3):1032-8. PMID: 25624053.
      View in: PubMed
    23. Wrobel JP, Thompson BR, Stuart-Andrews CR, Kee K, Snell GI, Buckland M, Williams TJ. Intermittent positive pressure ventilation increases diastolic pulmonary arterial pressure in advanced COPD. Heart Lung. 2015 Jan-Feb; 44(1):50-6. PMID: 25453391.
      View in: PubMed
    24. Green RM, Feng W, Phang T, Fish JL, Li H, Spritz RA, Marcucio RS, Hooper J, Jamniczky H, Hallgrímsson B, Williams T. Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage. Dis Model Mech. 2015 Jan; 8(1):31-43. PMID: 25381013; PMCID: PMC4283648.
    25. Kerr CL, Zaveri MA, Robinson ML, Williams T, West-Mays JA. AP-2a is required after lens vesicle formation to maintain lens integrity. Dev Dyn. 2014 Oct; 243(10):1298-309. PMID: 24753151.
      View in: PubMed
    26. Kurosaka H, Iulianella A, Williams T, Trainor PA. Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis. J Clin Invest. 2014 Apr; 124(4):1660-71. PMID: 24590292; PMCID: PMC3973078.
    27. Goodnough LH, Dinuoscio GJ, Ferguson JW, Williams T, Lang RA, Atit RP. Distinct requirements for cranial ectoderm and mesenchyme-derived wnts in specification and differentiation of osteoblast and dermal progenitors. PLoS Genet. 2014 Feb; 10(2):e1004152. PMID: 24586192; PMCID: PMC3930509.
    28. Paraskeva MA, Westall GP, Pilcher D, McGiffin D, Levvey BJ, Williams TJ, Snell GI. The Alfred Hospital Lung Transplant Experience. Clin Transpl. 2014; 99-108. PMID: 26281133.
      View in: PubMed
    29. Wrobel JP, McLean CA, Thompson BR, Stuart-Andrews CR, Paul E, Snell GI, Williams TJ. Pulmonary arterial remodeling in chronic obstructive pulmonary disease is lobe dependent. Pulm Circ. 2013 Sep; 3(3):665-74. PMID: 24618551; PMCID: PMC4070801.
    30. Simón O, Williams T, Cerutti M, Caballero P, López-Ferber M. Expression of a peroral infection factor determines pathogenicity and population structure in an insect virus. PLoS One. 2013; 8(11):e78834. PMID: 24223853; PMCID: PMC3818493.
    31. Wang J, Bai Y, Li H, Greene SB, Klysik E, Yu W, Schwartz RJ, Williams TJ, Martin JF. MicroRNA-17-92, a direct Ap-2a transcriptional target, modulates T-box factor activity in orofacial clefting. PLoS Genet. 2013; 9(9):e1003785. PMID: 24068957; PMCID: PMC3777996.
    32. van Empel VP, Lee J, Williams TJ, Kaye DM. Iron deficiency in patients with idiopathic pulmonary arterial hypertension. Heart Lung Circ. 2014 Mar; 23(3):287-92. PMID: 24094431.
      View in: PubMed
    33. Feng W, Choi I, Clouthier DE, Niswander L, Williams T. The Ptch1(DL) mouse: a new model to study lambdoid craniosynostosis and basal cell nevus syndrome-associated skeletal defects. Genesis. 2013 Oct; 51(10):677-89. PMID: 23897749; PMCID: PMC3918964.
    34. Melvin VS, Feng W, Hernandez-Lagunas L, Artinger KB, Williams T. A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Dev Dyn. 2013 Jul; 242(7):817-31. PMID: 23559552; PMCID: PMC4027977.
    35. Li H, Williams T. Separation of mouse embryonic facial ectoderm and mesenchyme. J Vis Exp. 2013 Apr 12; (74). PMID: 23603693; PMCID: PMC3654862.
    36. Li H, Sheridan R, Williams T. Analysis of TFAP2A mutations in Branchio-Oculo-Facial Syndrome indicates functional complexity within the AP-2a DNA-binding domain. Hum Mol Genet. 2013 Aug 15; 22(16):3195-206. PMID: 23578821; PMCID: PMC3723307.
    37. Dennis JF, Kurosaka H, Iulianella A, Pace J, Thomas N, Beckham S, Williams T, Trainor PA. Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects. PLoS Genet. 2012; 8(10):e1002927. PMID: 23055936; PMCID: PMC3464201.
    38. Tavares AL, Garcia EL, Kuhn K, Woods CM, Williams T, Clouthier DE. Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch. Dev Biol. 2012 Nov 01; 371(1):47-56. PMID: 22902530; PMCID: PMC3470875.
    39. Kerr CL, Huang J, Williams T, West-Mays JA. Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation. Invest Ophthalmol Vis Sci. 2012 Jun 05; 53(7):3316-30. PMID: 22491411; PMCID: PMC3385968.
    40. Bassett EA, Korol A, Deschamps PA, Buettner R, Wallace VA, Williams T, West-Mays JA. Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina. Dev Dyn. 2012 Apr; 241(4):814-29. PMID: 22411557; PMCID: PMC3700368.
    41. Ferretti E, Li B, Zewdu R, Wells V, Hebert JM, Karner C, Anderson MJ, Williams T, Dixon J, Dixon MJ, Depew MJ, Selleri L. A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis. Dev Cell. 2011 Oct 18; 21(4):627-41. PMID: 21982646; PMCID: PMC3199312.
    42. Johnson CW, Hernandez-Lagunas L, Feng W, Melvin VS, Williams T, Artinger KB. Vgll2a is required for neural crest cell survival during zebrafish craniofacial development. Dev Biol. 2011 Sep 01; 357(1):269-81. PMID: 21741961; PMCID: PMC3519931.
    43. Forni PE, Taylor-Burds C, Melvin VS, Williams T, Williams T, Wray S. Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells. J Neurosci. 2011 May 04; 31(18):6915-27. PMID: 21543621; PMCID: PMC3101109.
    44. Schmidt M, Huber L, Majdazari A, Schütz G, Williams T, Rohrer H. The transcription factors AP-2ß and AP-2a are required for survival of sympathetic progenitors and differentiated sympathetic neurons. Dev Biol. 2011 Jul 01; 355(1):89-100. PMID: 21539825.
      View in: PubMed
    45. Harlow DE, Yang H, Williams T, Barlow LA. Epibranchial placode-derived neurons produce BDNF required for early sensory neuron development. Dev Dyn. 2011 Feb; 240(2):309-23. PMID: 21246648; PMCID: PMC3070660.
    46. Reid BS, Yang H, Melvin VS, Taketo MM, Williams T. Ectodermal Wnt/ß-catenin signaling shapes the mouse face. Dev Biol. 2011 Jan 15; 349(2):261-9. PMID: 21087601; PMCID: PMC3057077.
    47. Reid BS, Sargent TD, Williams T. Generation and characterization of a novel neural crest marker allele, Inka1-LacZ, reveals a role for Inka1 in mouse neural tube closure. Dev Dyn. 2010 Apr; 239(4):1188-96. PMID: 20175189; PMCID: PMC2927325.
    48. Bassett EA, Williams T, Zacharias AL, Gage PJ, Fuhrmann S, West-Mays JA. AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis. Hum Mol Genet. 2010 May 01; 19(9):1791-804. PMID: 20150232; PMCID: PMC2850623.
    49. Feng W, Leach SM, Tipney H, Phang T, Geraci M, Spritz RA, Hunter LE, Williams T. Spatial and temporal analysis of gene expression during growth and fusion of the mouse facial prominences. PLoS One. 2009 Dec 16; 4(12):e8066. PMID: 20016822; PMCID: PMC2789411.
    50. Feng W, Simoes-de-Souza F, Finger TE, Restrepo D, Williams T. Disorganized olfactory bulb lamination in mice deficient for transcription factor AP-2epsilon. Mol Cell Neurosci. 2009 Nov; 42(3):161-71. PMID: 19580868; PMCID: PMC2745980.
    51. Leach SM, Tipney H, Feng W, Baumgartner WA, Kasliwal P, Schuyler RP, Williams T, Spritz RA, Hunter L. Biomedical discovery acceleration, with applications to craniofacial development. PLoS Comput Biol. 2009 Mar; 5(3):e1000215. PMID: 19325874; PMCID: PMC2653649.
    52. Tipney HJ, Leach SM, Feng W, Spritz R, Williams T, Hunter L. Leveraging existing biological knowledge in the identification of candidate genes for facial dysmorphology. BMC Bioinformatics. 2009 Feb 05; 10 Suppl 2:S12. PMID: 19208187; PMCID: PMC2646237.
    53. Reid DW, Wen Y, Johns DP, Williams TJ, Ward C, Walters EH. Bronchodilator reversibility, airway eosinophilia and anti-inflammatory effects of inhaled fluticasone in COPD are not related. Respirology. 2008 Nov; 13(6):799-809. PMID: 18811878.
      View in: PubMed
    54. Wang X, Pasolli HA, Williams T, Fuchs E. AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis. J Cell Biol. 2008 Oct 06; 183(1):37-48. PMID: 18824566; PMCID: PMC2557040.
    55. Williams T. Animal models of ventral body wall closure defects: a personal perspective on gastroschisis. Am J Med Genet C Semin Med Genet. 2008 Aug 15; 148C(3):186-91. PMID: 18655100.
      View in: PubMed
    56. Pontoriero GF, Deschamps P, Ashery-Padan R, Wong R, Yang Y, Zavadil J, Cvekl A, Sullivan S, Williams T, West-Mays JA. Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype. Dev Dyn. 2008 Mar; 237(3):602-17. PMID: 18224708; PMCID: PMC2517426.
    57. Guttormsen J, Koster MI, Stevens JR, Roop DR, Williams T, Winger QA. Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice. Dev Biol. 2008 May 01; 317(1):187-95. PMID: 18353300; PMCID: PMC2435508.
    58. Feng W, Huang J, Zhang J, Williams T. Identification and analysis of a conserved Tcfap2a intronic enhancer element required for expression in facial and limb bud mesenchyme. Mol Cell Biol. 2008 Jan; 28(1):315-25. PMID: 17984226; PMCID: PMC2223317.
    59. Bassett EA, Pontoriero GF, Feng W, Marquardt T, Fini ME, Williams T, West-Mays JA. Conditional deletion of activating protein 2alpha (AP-2alpha) in the developing retina demonstrates non-cell-autonomous roles for AP-2alpha in optic cup development. Mol Cell Biol. 2007 Nov; 27(21):7497-510. PMID: 17724084; PMCID: PMC2169054.
    60. Makhani LF, Williams T, West-Mays JA. Genetic analysis indicates that transcription factors AP-2alpha and Pax6 cooperate in the normal patterning and morphogenesis of the lens. Mol Vis. 2007 Jul 19; 13:1215-25. PMID: 17679940.
      View in: PubMed
    61. Winger Q, Huang J, Auman HJ, Lewandoski M, Williams T. Analysis of transcription factor AP-2 expression and function during mouse preimplantation development. Biol Reprod. 2006 Sep; 75(3):324-33. PMID: 16672719.
      View in: PubMed
    62. Donner AL, Williams T. Frontal nasal prominence expression driven by Tcfap2a relies on a conserved binding site for STAT proteins. Dev Dyn. 2006 May; 235(5):1358-70. PMID: 16502414; PMCID: PMC2738421.
    63. Wang X, Bolotin D, Chu DH, Polak L, Williams T, Fuchs E. AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis. J Cell Biol. 2006 Jan 30; 172(3):409-21. PMID: 16449191; PMCID: PMC2063650.
    64. Koster MI, Kim S, Huang J, Williams T, Roop DR. TAp63alpha induces AP-2gamma as an early event in epidermal morphogenesis. Dev Biol. 2006 Jan 01; 289(1):253-61. PMID: 16324689.
      View in: PubMed
    65. Li C, Xu X, Nelson DK, Williams T, Kuehn MR, Deng CX. FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis. Development. 2005 Nov; 132(21):4755-64. PMID: 16207751.
      View in: PubMed
    66. Dwivedi DJ, Pontoriero GF, Ashery-Padan R, Sullivan S, Williams T, West-Mays JA. Targeted deletion of AP-2alpha leads to disruption in corneal epithelial cell integrity and defects in the corneal stroma. Invest Ophthalmol Vis Sci. 2005 Oct; 46(10):3623-30. PMID: 16186342; PMCID: PMC2517422.
    67. Lim JH, Booker AB, Luo T, Williams T, Furuta Y, Lagutin O, Oliver G, Sargent TD, Fallon JR. AP-2alpha selectively regulates fragile X mental retardation-1 gene transcription during embryonic development. Hum Mol Genet. 2005 Jul 15; 14(14):2027-34. PMID: 15930016.
      View in: PubMed
    68. Brewer S, Williams T. Finally, a sense of closure? Animal models of human ventral body wall defects. Bioessays. 2004 Dec; 26(12):1307-21. PMID: 15551266.
      View in: PubMed
    69. Sumigama S, Ito T, Kajiyama H, Shibata K, Tamakoshi K, Kikkawa F, Williams T, Tainsky MA, Nomura S, Mizutani S. Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha. Oncogene. 2004 Jul 15; 23(32):5496-504. PMID: 15146170.
      View in: PubMed
    70. Ahituv N, Erven A, Fuchs H, Guy K, Ashery-Padan R, Williams T, de Angelis MH, Avraham KB, Steel KP. An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice. Mamm Genome. 2004 Jun; 15(6):424-32. PMID: 15181535.
      View in: PubMed
    71. Brewer S, Williams T. Loss of AP-2alpha impacts multiple aspects of ventral body wall development and closure. Dev Biol. 2004 Mar 15; 267(2):399-417. PMID: 15013802.
      View in: PubMed
    72. Douglas DB, Akiyama Y, Carraway H, Belinsky SA, Esteller M, Gabrielson E, Weitzman S, Williams T, Herman JG, Baylin SB. Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2alpha expression during progression of breast cancer. Cancer Res. 2004 Mar 01; 64(5):1611-20. PMID: 14996719.
      View in: PubMed
    73. Brewer S, Feng W, Huang J, Sullivan S, Williams T. Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects. Dev Biol. 2004 Mar 01; 267(1):135-52. PMID: 14975722.
      View in: PubMed
    74. Sivak JM, West-Mays JA, Yee A, Williams T, Fini ME. Transcription Factors Pax6 and AP-2alpha Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase B. Mol Cell Biol. 2004 Jan; 24(1):245-57. PMID: 14673159; PMCID: PMC303332.
    75. Feng W, Williams T. Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb. Mol Cell Neurosci. 2003 Oct; 24(2):460-75. PMID: 14572467.
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    76. West-Mays JA, Sivak JM, Papagiotas SS, Kim J, Nottoli T, Williams T, Fini ME. Positive influence of AP-2alpha transcription factor on cadherin gene expression and differentiation of the ocular surface. Differentiation. 2003 Apr; 71(3):206-16. PMID: 12694203; PMCID: PMC2517417.
    77. Zhang J, Brewer S, Huang J, Williams T. Overexpression of transcription factor AP-2alpha suppresses mammary gland growth and morphogenesis. Dev Biol. 2003 Apr 01; 256(1):127-45. PMID: 12654297.
      View in: PubMed
    78. Kennedy B, Enns R, Nelson D, Williams T, Bao X, Ziegler MG. Reduction of adrenal and kidney epinephrine and phenylethanolamine N-methyltransferase in AP-2 knockout mouse fetuses. Ann N Y Acad Sci. 2002 Oct; 971:92-4. PMID: 12438097.
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    79. Auman HJ, Nottoli T, Lakiza O, Winger Q, Donaldson S, Williams T. Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development. Development. 2002 Jun; 129(11):2733-47. PMID: 12015300.
      View in: PubMed
    80. Brewer S, Jiang X, Donaldson S, Williams T, Sucov HM. Requirement for AP-2alpha in cardiac outflow tract morphogenesis. Mech Dev. 2002 Jan; 110(1-2):139-49. PMID: 11744375.
      View in: PubMed
    81. Mazina OM, Phillips MA, Williams T, Vines CA, Cherr GN, Rice RH. Redistribution of transcription factor AP-2alpha in differentiating cultured human epidermal cells. J Invest Dermatol. 2001 Oct; 117(4):864-70. PMID: 11676824.
      View in: PubMed
    82. Beger M, Butz K, Denk C, Williams T, Hurst HC, Hoppe-Seyler F. Expression pattern of AP-2 transcription factors in cervical cancer cells and analysis of their influence on human papillomavirus oncogene transcription. J Mol Med (Berl). 2001 Jun; 79(5-6):314-20. PMID: 11485026.
      View in: PubMed
    83. Pena P, Reutens AT, Albanese C, D'Amico M, Watanabe G, Donner A, Shu IW, Williams T, Pestell RG. Activator protein-2 mediates transcriptional activation of the CYP11A1 gene by interaction with Sp1 rather than binding to DNA. Mol Endocrinol. 1999 Aug; 13(8):1402-16. PMID: 10446912.
      View in: PubMed
    84. Mohibullah N, Donner A, Ippolito JA, Williams T. SELEX and missing phosphate contact analyses reveal flexibility within the AP-2[alpha] protein: DNA binding complex. Nucleic Acids Res. 1999 Jul 01; 27(13):2760-9. PMID: 10373594; PMCID: PMC148486.
    85. West-Mays JA, Zhang J, Nottoli T, Hagopian-Donaldson S, Libby D, Strissel KJ, Williams T. AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle. Dev Biol. 1999 Feb 01; 206(1):46-62. PMID: 9918694.
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    86. Turner BC, Zhang J, Gumbs AA, Maher MG, Kaplan L, Carter D, Glazer PM, Hurst HC, Haffty BG, Williams T. Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways. Cancer Res. 1998 Dec 01; 58(23):5466-72. PMID: 9850080.
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    87. Nottoli T, Hagopian-Donaldson S, Zhang J, Perkins A, Williams T. AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13714-9. PMID: 9811866; PMCID: PMC24885.
    88. Shen H, Wilke T, Ashique AM, Narvey M, Zerucha T, Savino E, Williams T, Richman JM. Chicken transcription factor AP-2: cloning, expression and its role in outgrowth of facial prominences and limb buds. Dev Biol. 1997 Aug 15; 188(2):248-66. PMID: 9268573.
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    89. Johnson W, Albanese C, Handwerger S, Williams T, Pestell RG, Jameson JL. Regulation of the human chorionic gonadotropin alpha- and beta-subunit promoters by AP-2. J Biol Chem. 1997 Jun 13; 272(24):15405-12. PMID: 9182571.
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    90. Bosher JM, Totty NF, Hsuan JJ, Williams T, Hurst HC. A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma. Oncogene. 1996 Oct 17; 13(8):1701-7. PMID: 8895516.
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    91. Creaser PC, D'Argenio DA, Williams T. Comparative and functional analysis of the AP2 promoter indicates that conserved octamer and initiator elements are critical for activity. Nucleic Acids Res. 1996 Jul 01; 24(13):2597-605. PMID: 8692702; PMCID: PMC145978.
    92. Williamson JA, Bosher JM, Skinner A, Sheer D, Williams T, Hurst HC. Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors. Genomics. 1996 Jul 01; 35(1):262-4. PMID: 8661133.
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    93. Zhang J, Hagopian-Donaldson S, Serbedzija G, Elsemore J, Plehn-Dujowich D, McMahon AP, Flavell RA, Williams T. Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature. 1996 May 16; 381(6579):238-41. PMID: 8622766.
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    94. Somasundaram K, Jayaraman G, Williams T, Moran E, Frisch S, Thimmapaya B. Repression of a matrix metalloprotease gene by E1A correlates with its ability to bind to cell type-specific transcription factor AP-2. Proc Natl Acad Sci U S A. 1996 Apr 02; 93(7):3088-93. PMID: 8610173; PMCID: PMC39766.
    95. Warren G, Gordon M, Siracusa LD, Buchberg AM, Williams T. Physical and genetic localization of the gene encoding the AP-2 transcription factor to mouse chromosome 13. Genomics. 1996 Jan 15; 31(2):234-7. PMID: 8824807.
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    96. Bosher JM, Williams T, Hurst HC. The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):744-7. PMID: 7846046; PMCID: PMC42696.
    97. Mellentin-Michelotti J, John S, Pennie WD, Williams T, Hager GL. The 5' enhancer of the mouse mammary tumor virus long terminal repeat contains a functional AP-2 element. J Biol Chem. 1994 Dec 16; 269(50):31983-90. PMID: 7989375.
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    98. Lafyatis R, Denhez F, Williams T, Sporn M, Roberts A. Sequence specific protein binding to and activation of the TGF-beta 3 promoter through a repeated TCCC motif. Nucleic Acids Res. 1991 Dec 11; 19(23):6419-25. PMID: 1754378; PMCID: PMC329187.
    99. Williams T, Tjian R. Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes Dev. 1991 Apr; 5(4):670-82. PMID: 2010091.
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    100. Williams T, Tjian R. Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins. Science. 1991 Mar 01; 251(4997):1067-71. PMID: 1998122.
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    101. Lüscher B, Mitchell PJ, Williams T, Tjian R. Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers. Genes Dev. 1989 Oct; 3(10):1507-17. PMID: 2482225.
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    102. Williams T, Admon A, Lüscher B, Tjian R. Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes Dev. 1988 Dec; 2(12A):1557-69. PMID: 3063603.
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