 Mingxia Huang
| Title | Associate Professor |
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| Institution | University of Colorado Denver - Anschutz Medical Campus |
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| Department | SOM-DERM General Operations |
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| Phone | 303/724-3204 |
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ORCID
.gif) | 0000-0003-4241-8723  |
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 Research 1RF1NS128739-01 (Mingxia Huang/Huntington Potter/Kelly Sullivan)Sep 7, 2022 - Aug 31, 2025 NIH/NINDS
Neurovascular unit dysfunction in Down syndrome revealed by TBI
Role Description: The goal of this study is to use mild traumatic brain injury (mTBI) as a sensitizing probe to visualize the subtle and hard-to-detect Down syndrome (DS) associated cellular and molecular alterations with the overarching goal of discovering new therapeutic strategies for people with DS.
Role: Contact PI |
| GM081393 (JoAnne Stubbe)Feb 1, 2013 - Dec 31, 2016 NIH/NIGMS
(MeIII)2-Y (Me = Fe, Mn) Cluster Assembly/Maintenance in Ribonucleotide Reductase
Role: Co-Investigator |
| R01CA125574 (HUANG, MINGXIA)Aug 1, 2008 - Jul 31, 2014 NIH
In Vivo Regulation and Inhibition of Ribonucleotide Reductase
Role: Principal Investigator |
| R01GM081393 (JoAnne Stubbe)Jul 1, 2008 - Apr 30, 2012 NIH/NIGMS
Ribonucleotide Reductase Regulation: Diferric Y• assembly/maintenance and Sml1
Role: Co-Investigator |
| R01CA095207 (HUANG, MINGXIA)Mar 1, 2003 - Feb 28, 2010 NIH
Function and Regulation of DNA Damage Response Genes
Role: Principal Investigator |
| RSG0305001-GMC (Mingxia Huang)Jan 1, 2003 - Dec 31, 2006 American Cancer Society
Regulation of Deoxyribonucleotide Synthesis by the DNA Damage Checkpoint
Role: Principal Investigator |
Bibliographic
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Epperson CN, Rubinow DR, Meltzer-Brody S, Deligiannidis KM, Riesenberg R, Krystal AD, Bankole K, Huang MY, Li H, Brown C, Kanes SJ, Lasser R. Effect of brexanolone on depressive symptoms, anxiety, and insomnia in women with postpartum depression: Pooled analyses from 3 double-blind, randomized, placebo-controlled clinical trials in the HUMMINGBIRD clinical program. J Affect Disord. 2023 01 01; 320:353-359. PMID: 36191643.
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Li H, Zhang C, Bian L, Deng H, Blevins M, Han G, Fan B, Yang C, Zhao R, High W, Norris D, Fujita M, Wang XJ, Huang M. Inhibition of CtBP-Regulated Proinflammatory Gene Transcription Attenuates Psoriatic Skin Inflammation. J Invest Dermatol. 2022 02; 142(2):390-401. PMID: 34293351.
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Li H, Zhang C, Yang C, Blevins M, Norris D, Zhao R, Huang M. C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment. Int J Biol Sci. 2020; 16(7):1107-1120. PMID: 32174788.
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Blevins MA, Zhang C, Zhang L, Li H, Li X, Norris DA, Huang M, Zhao R. CPP-E1A fusion peptides inhibit CtBP-mediated transcriptional repression. Mol Oncol. 2018 08; 12(8):1358-1373. PMID: 29879296.
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Blevins MA, Huang M, Zhao R. The Role of CtBP1 in Oncogenic Processes and Its Potential as a Therapeutic Target. Mol Cancer Ther. 2017 06; 16(6):981-990. PMID: 28576945.
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Li H, St?mpfig M, Zhang C, An X, Stubbe J, Lill R, Huang M. The diferric-tyrosyl radical cluster of ribonucleotide reductase and cytosolic iron-sulfur clusters have distinct and similar biogenesis requirements. J Biol Chem. 2017 07 07; 292(27):11445-11451. PMID: 28515324.
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Huang M, Parker MJ, Stubbe J. Choosing the right metal: case studies of class I ribonucleotide reductases. J Biol Chem. 2014 Oct 10; 289(41):28104-11. PMID: 25160629.
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Zhang Y, Li H, Zhang C, An X, Liu L, Stubbe J, Huang M. Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):E1695-704. PMID: 24733891.
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Zhang C, Liu G, Huang M. Ribonucleotide reductase metallocofactor: assembly, maintenance and inhibition. Front Biol (Beijing). 2014 Jan 02; 9(2):104-113. PMID: 24899886.
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Zhang Y, An X, Stubbe J, Huang M. Investigation of in vivo roles of the C-terminal tails of the small subunit (??') of Saccharomyces cerevisiae ribonucleotide reductase: contribution to cofactor formation and intersubunit association within the active holoenzyme. J Biol Chem. 2013 May 17; 288(20):13951-13959. PMID: 23532842.
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Wu X, Huang M. Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit. Mol Cell Biol. 2008 Dec; 28(23):7156-67. PMID: 18838542.
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Zhang Z, Yang K, Chen CC, Feser J, Huang M. Role of the C terminus of the ribonucleotide reductase large subunit in enzyme regeneration and its inhibition by Sml1. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2217-22. PMID: 17277086.
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An X, Zhang Z, Yang K, Huang M. Cotransport of the heterodimeric small subunit of the Saccharomyces cerevisiae ribonucleotide reductase between the nucleus and the cytoplasm. Genetics. 2006 May; 173(1):63-73. PMID: 16489218.
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Zhang Z, An X, Yang K, Perlstein DL, Hicks L, Kelleher N, Stubbe J, Huang M. Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1422-7. PMID: 16432237.
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Yao R, Zhang Z, An X, Bucci B, Perlstein DL, Stubbe J, Huang M. Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6628-33. PMID: 12732713.
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Cho RJ, Huang M, Campbell MJ, Dong H, Steinmetz L, Sapinoso L, Hampton G, Elledge SJ, Davis RW, Lockhart DJ. Transcriptional regulation and function during the human cell cycle. Nat Genet. 2001 Jan; 27(1):48-54. PMID: 11137997.
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Matsuoka S, Huang M, Elledge SJ. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science. 1998 Dec 04; 282(5395):1893-7. PMID: 9836640.
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Huang M, Zhou Z, Elledge SJ. The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell. 1998 Sep 04; 94(5):595-605. PMID: 9741624.
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Huang M, Gu G, Ferguson EL, Chalfie M. A stomatin-like protein necessary for mechanosensation in C. elegans. Nature. 1995 Nov 16; 378(6554):292-5. PMID: 7477350.
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Huang M, Chalfie M. Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans. Nature. 1994 Feb 03; 367(6462):467-70. PMID: 7509039.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 1994 | 1 | | 1995 | 1 | | 1998 | 2 | | 2001 | 1 | | 2003 | 1 | | 2006 | 2 | | 2007 | 1 | | 2008 | 1 | | 2013 | 1 | | 2014 | 3 | | 2017 | 2 | | 2018 | 1 | | 2020 | 1 | | 2021 | 1 | | 2022 | 1 |
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