 Acetaminophen
"Acetaminophen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
| Descriptor ID |
D000082
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| MeSH Number(s) |
D02.065.199.092.040 D02.092.146.113.092.040
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| Concept/Terms |
Acetaminophen- Acetaminophen
- Acetominophen
- Hydroxyacetanilide
- APAP
- p-Acetamidophenol
- p-Hydroxyacetanilide
- Paracetamol
- N-(4-Hydroxyphenyl)acetanilide
- Acetamidophenol
- N-Acetyl-p-aminophenol
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Below are MeSH descriptors whose meaning is more general than "Acetaminophen".
Below are MeSH descriptors whose meaning is more specific than "Acetaminophen".
This graph shows the total number of publications written about "Acetaminophen" by people in this website by year, and whether "Acetaminophen" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 | | 1996 | 2 | 0 | 2 | | 1997 | 1 | 0 | 1 | | 1998 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 1 | 2 | 3 | | 2002 | 1 | 0 | 1 | | 2003 | 2 | 1 | 3 | | 2004 | 3 | 0 | 3 | | 2005 | 3 | 0 | 3 | | 2006 | 1 | 2 | 3 | | 2007 | 6 | 1 | 7 | | 2008 | 2 | 3 | 5 | | 2009 | 3 | 1 | 4 | | 2010 | 8 | 0 | 8 | | 2011 | 8 | 2 | 10 | | 2012 | 6 | 1 | 7 | | 2013 | 3 | 2 | 5 | | 2014 | 6 | 0 | 6 | | 2015 | 4 | 0 | 4 | | 2016 | 8 | 0 | 8 | | 2017 | 4 | 3 | 7 | | 2018 | 6 | 4 | 10 | | 2019 | 7 | 0 | 7 | | 2020 | 4 | 2 | 6 | | 2021 | 9 | 6 | 15 | | 2022 | 6 | 6 | 12 | | 2023 | 4 | 7 | 11 | | 2024 | 3 | 1 | 4 | | 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Acetaminophen" by people in Profiles.
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Wei Z, Boateng NKK, Schmitt LR, Cline H, Fernandes Fonseca MT, Newberry A, Taylor A, Adelmeijer J, Poole LG, Stravitz RT, Lee WM, Lisman T, Hansen KC, Luyendyk JP. Integrated cross-linking by TG2 and FXIII generates hepatoprotective fibrin(ogen) deposits in injured liver. Blood. 2025 May 22; 145(21):2507-2517.
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Ware LB, Files DC, Fowler A, Aboodi MS, Aggarwal NR, Brower RG, Chang SY, Douglas IS, Fields S, Foulkes AS, Ginde AA, Harris ES, Hendey GW, Hite RD, Huang W, Lai P, Liu KD, Thompson BT, Matthay MA. Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial. JAMA. 2024 08 06; 332(5):390-400.
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Jensen EA, DeMauro SB, Rysavy MA, Patel RM, Laughon MM, Eichenwald EC, Do BT, Das A, Wright CJ. Acetaminophen for Patent Ductus Arteriosus and Risk of Mortality and Pulmonary Morbidity. Pediatrics. 2024 Aug 01; 154(2).
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Ramachandran A, Akakpo JY, Curry SC, Rumack BH, Jaeschke H. Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure. Biochem Pharmacol. 2024 10; 228:116056.
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Bateman DN, Dart RC, Dear JW, Prescott LF, Rumack BH. Fifty years of paracetamol (acetaminophen) poisoning: the development of risk assessment and treatment 1973-2023 with particular focus on contributions published from Edinburgh and Denver. Clin Toxicol (Phila). 2023 Dec; 61(12):1020-1031.
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Akakpo JY, Ramachandran A, Rumack BH, Wallace DP, Jaeschke H. Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human kidneys: Inhibition by 4-methylpyrazole but not N-acetylcysteine. Toxicology. 2023 12; 500:153692.
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Boster JM, Adams MA, Moore HB. Commentary on "Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure". J Thromb Haemost. 2023 09; 21(9):2365-2366.
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Barber LE, Bertrand KA, Sheehy S, White LF, Roy HK, Rosenberg L, Palmer JR, Petrick JL. Aspirin and nonaspirin nonsteroidal antiinflammatory drug use and occurrence of colorectal adenoma in Black American women. Int J Cancer. 2023 12 15; 153(12):1978-1987.
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Dart RC, Mullins ME, Matoushek T, Ruha AM, Burns MM, Simone K, Beuhler MC, Heard KJ, Mazer-Amirshahi M, Stork CM, Varney SM, Funk AR, Cantrell LF, Cole JB, Banner W, Stolbach AI, Hendrickson RG, Lucyk SN, Sivilotti MLA, Su MK, Nelson LS, Rumack BH. Management of Acetaminophen Poisoning in the US and Canada: A Consensus Statement. JAMA Netw Open. 2023 08 01; 6(8):e2327739.
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Mehrpour O, Hoyte C, Al Masud A, Biswas A, Schimmel J, Nakhaee S, Nasr MS, Delva-Clark H, Goss F. Deep learning neural network derivation and testing to distinguish acute poisonings. Expert Opin Drug Metab Toxicol. 2023 Jan-Jun; 19(6):367-380.
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