 Phosphatidylcholine-Sterol O-Acyltransferase
"Phosphatidylcholine-Sterol O-Acyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma.
| Descriptor ID |
D007862
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| MeSH Number(s) |
D08.811.913.050.625
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| Concept/Terms |
Phosphatidylcholine-Sterol O-Acyltransferase- Phosphatidylcholine-Sterol O-Acyltransferase
- O-Acyltransferase, Phosphatidylcholine-Sterol
- Phosphatidylcholine Sterol O Acyltransferase
- Lecithin Cholesterol Acyltransferase
- Acyltransferase, Lecithin Cholesterol
- Cholesterol Acyltransferase, Lecithin
- Lecithin Acyltransferase
- Acyltransferase, Lecithin
- Cholesterol Ester Lysolecithin Acyltransferase
- Phosophatidylcholine-Sterol Acyltransferase
- Acyltransferase, Phosophatidylcholine-Sterol
- Phosophatidylcholine Sterol Acyltransferase
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Below are MeSH descriptors whose meaning is more general than "Phosphatidylcholine-Sterol O-Acyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Phosphatidylcholine-Sterol O-Acyltransferase".
This graph shows the total number of publications written about "Phosphatidylcholine-Sterol O-Acyltransferase" by people in this website by year, and whether "Phosphatidylcholine-Sterol O-Acyltransferase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 1 | 0 | 1 | | 2022 | 1 | 2 | 3 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Phosphatidylcholine-Sterol O-Acyltransferase" by people in Profiles.
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Coleman B, Bedi S, Hill JH, Morris J, Manthei KA, Hart RC, He Y, Shah AS, Jerome WG, Vaisar T, Bornfeldt KE, Song H, Segrest JP, Heinecke JW, Aller SG, Tesmer JJG, Davidson WS. Lecithin:cholesterol acyltransferase binds a discontinuous binding site on adjacent apolipoprotein A-I belts in HDL. J Lipid Res. 2025 05; 66(5):100786.
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Bonaca MP, Morrow DA, Bergmark BA, Berg DD, Lima JAC, Hoffmann U, Kato Y, Lu MT, Kuder J, Murphy SA, Spinar J, Oude Ophuis T, Kiss RG, Lopez-Sendon J, Averkov O, Wheatcroft SB, Kubica J, Carlos Nicolau J, Furtado RHM, Abuhatzira L, Hirshberg B, Omar SA, Vavere AL, Chang YT, George RT, Sabatine MS. Randomized, Placebo-Controlled Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Lecithin Cholesterol Acyltransferase in Acute ST-Segment-Elevation Myocardial Infarction: Results of REAL-TIMI 63B. Circulation. 2022 09 20; 146(12):907-916.
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Bonaca MP, George RT, Morrow DA, Bergmark BA, Park JG, Abuhatzira L, Vavere AL, Karathanasis SK, Jin C, She D, Hirshberg B, Hsia J, Sabatine MS. Recombinant human lecithin-cholesterol acyltransferase in patients with atherosclerosis: phase 2a primary results and phase 2b design. Eur Heart J Cardiovasc Pharmacother. 2022 05 05; 8(3):243-252.
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Bedi S, Morris J, Shah A, Hart RC, Jerome WG, Aller SG, Tang C, Vaisar T, Bornfeldt KE, Segrest JP, Heinecke JW, Davidson WS. Conformational flexibility of apolipoprotein A-I amino- and carboxy-termini is necessary for lipid binding but not cholesterol efflux. J Lipid Res. 2022 03; 63(3):100168.
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Cooke AL, Morris J, Melchior JT, Street SE, Jerome WG, Huang R, Herr AB, Smith LE, Segrest JP, Remaley AT, Shah AS, Thompson TB, Davidson WS. A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL. J Lipid Res. 2018 07; 59(7):1244-1255.
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Schauer UJ, Schauer I, Hummel S, Thielmann K. Inhibition of lecithin: cholesterol acyl transfer by propranolol treatment in man. Biomed Biochim Acta. 1985; 44(5):685-93.
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Schauer UJ, Schauer I, Rühling K, Thielmann K. Stimulation of lecithin:cholesterol acyl transfer by intravenous injection of heparin. Biomed Biochim Acta. 1984; 43(10):1165-72.
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Schauer I, Schauer U, Rühling K, Thielmann K. The effect of propranolol treatment on total cholesterol, HDL cholesterol, triglycerides. Postheparin lipolytic activity and lecithin:cholesterol acyltransferase in hypertensive individuals. Artery. 1980; 8(2):146-50.
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