 Wnt Signaling Pathway
"Wnt Signaling Pathway" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, and the vertebrate INT gene. The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN.
| Descriptor ID |
D060449
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| MeSH Number(s) |
G02.111.820.925 G04.835.925
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| Concept/Terms |
Wnt Signaling Pathway- Wnt Signaling Pathway
- Pathway, Wnt Signaling
- Pathways, Wnt Signaling
- Signaling Pathway, Wnt
- Signaling Pathways, Wnt
- Wnt Signaling Pathways
- Wnt Pathway
- Pathway, Wnt
- Pathways, Wnt
- Wnt Pathways
Wnt beta-Catenin Signaling Pathway- Wnt beta-Catenin Signaling Pathway
- Wnt beta Catenin Signaling Pathway
- Wnt Pathway, Canonical
- Canonical Wnt Pathway
- Canonical Wnt Pathways
- Pathway, Canonical Wnt
- Pathways, Canonical Wnt
- Wnt Pathways, Canonical
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Below are MeSH descriptors whose meaning is more general than "Wnt Signaling Pathway".
Below are MeSH descriptors whose meaning is more specific than "Wnt Signaling Pathway".
This graph shows the total number of publications written about "Wnt Signaling Pathway" by people in this website by year, and whether "Wnt Signaling Pathway" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2011 | 1 | 1 | 2 | | 2012 | 2 | 2 | 4 | | 2013 | 3 | 3 | 6 | | 2014 | 2 | 1 | 3 | | 2015 | 5 | 3 | 8 | | 2016 | 2 | 5 | 7 | | 2017 | 5 | 4 | 9 | | 2018 | 5 | 2 | 7 | | 2019 | 7 | 2 | 9 | | 2020 | 8 | 5 | 13 | | 2021 | 3 | 3 | 6 | | 2022 | 1 | 0 | 1 | | 2023 | 2 | 2 | 4 | | 2024 | 2 | 3 | 5 |
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Below are the most recent publications written about "Wnt Signaling Pathway" by people in Profiles.
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Rutt LN, Orlicky DJ, McCullough RL. Investigating the role of Wnt3a and Wnt5a as critical factors of hepatic stellate cell activation in acute toxicant-induced liver injury. Cell Biol Toxicol. 2024 12 21; 41(1):5.
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Kim TO, Geris JM, Flanagan JM, Grace RF, Lambert MP, O'Farrell C, Rose MJ, Shimano KA, Niss O, Neunert C, Nakano TA, MacMath D, Dinu B, Kirk SE, Neufeld EJ, Despotovic JM, Scheurer ME, Grimes AB. Genetic variants in canonical Wnt signaling pathway associated with pediatric immune thrombocytopenia. Blood Adv. 2024 11 12; 8(21):5529-5538.
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Shirai R, Biebighauser T, Walker D, Oviedo J, Nelson-Taylor S, Bodlak A, Porfilio T, Oike N, Goodspeed A, Hayashi M. Cadherin-11 contributes to the heterogenous and dynamic Wnt-Wnt-?-catenin pathway activation in Ewing sarcoma. PLoS One. 2024; 19(6):e0305490.
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Hawkins HJ, Yacob BW, Brown ME, Goldstein BR, Arcaroli JJ, Bagby SM, Hartman SJ, Macbeth M, Goodspeed A, Danhorn T, Lentz RW, Lieu CH, Leal AD, Messersmith WA, Dempsey PJ, Pitts TM. Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL). PLoS One. 2024; 19(4):e0298808.
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Goldstein NB, Steel A, Tomb L, Berk Z, Hu J, Balaya V, Hoaglin L, Ganuthula K, Patel M, Mbika E, Robinson WA, Roop DR, Norris DA, Birlea SA. Vitiligo non-responding lesions to narrow band UVB have intriguing cellular and molecular abnormalities that may prevent epidermal repigmentation. Pigment Cell Melanoma Res. 2024 05; 37(3):378-390.
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Mason EC, Menon S, Schneider BR, Gaskill CF, Dawson MM, Moore CM, Armstrong LC, Cho O, Richmond BW, Kropski JA, West JD, Geraghty P, Gomperts BN, Ess KC, Gally F, Majka SM. Activation of mTOR signaling in adult lung microvascular progenitor cells accelerates lung aging. J Clin Invest. 2023 12 15; 133(24).
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Dinarello A, May M, Amo-Aparicio J, Azam T, Gaballa JM, Marchetti C, Tesoriere A, Ghirardo R, Redzic JS, Webber WS, Atif SM, Li S, Eisenmesser EZ, de Graaf DM, Dinarello CA. IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1? secretion. Proc Natl Acad Sci U S A. 2023 Nov 07; 120(45):e2306476120.
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Cooney RA, Saal ML, Geraci KP, Maynard C, Cleaver O, Hoang ON, Moore TT, Hwang RF, Axelrod JD, Vladar EK. A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis. J Cell Sci. 2023 08 15; 136(16).
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Baxi A, Jourdeuil K, Cox TC, Clouthier DE, Tavares ALP. Transcriptomic analysis reveals the role of SIX1 in mouse cranial neural crest patterning and bone development. Dev Dyn. 2023 Oct; 252(10):1303-1315.
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Shull LC, Lencer ES, Kim HM, Goyama S, Kurokawa M, Costello JC, Jones K, Artinger KB. PRDM paralogs antagonistically balance Wnt/?-catenin activity during craniofacial chondrocyte differentiation. Development. 2022 02 15; 149(4).
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