 Cyclin-Dependent Kinase 2
"Cyclin-Dependent Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A key regulator of CELL CYCLE progression. It partners with CYCLIN E to regulate entry into S PHASE and also interacts with CYCLIN A to phosphorylate RETINOBLASTOMA PROTEIN. Its activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P27 and CYCLIN-DEPENDENT KINASE INHIBITOR P21.
| Descriptor ID |
D051357
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| MeSH Number(s) |
D08.811.913.696.620.682.700.646.500.750 D12.644.360.250.323 D12.776.167.200.323 D12.776.476.250.323
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| Concept/Terms |
Cyclin-Dependent Kinase 2- Cyclin-Dependent Kinase 2
- Cyclin Dependent Kinase 2
- Cdk2 Protein Kinase
- Cdc2-Related Protein Kinase
- Cdc2 Related Protein Kinase
- p33cdk2 Kinase
- CDK2 Protein
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Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase 2".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase 2".
This graph shows the total number of publications written about "Cyclin-Dependent Kinase 2" by people in this website by year, and whether "Cyclin-Dependent Kinase 2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1997 | 0 | 2 | 2 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2001 | 0 | 2 | 2 | | 2002 | 0 | 2 | 2 | | 2004 | 0 | 2 | 2 | | 2005 | 0 | 4 | 4 | | 2007 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2017 | 2 | 2 | 4 | | 2018 | 2 | 1 | 3 | | 2019 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cyclin-Dependent Kinase 2" by people in Profiles.
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Yang C, Tian C, Hoffman TE, Jacobsen NK, Spencer SL. Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling. Nat Commun. 2021 03 19; 12(1):1747.
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Min M, Spencer SL. Spontaneously slow-cycling subpopulations of human cells originate from activation of stress-response pathways. PLoS Biol. 2019 03; 17(3):e3000178.
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Mishra SK, Stephenson DJ, Chalfant CE, Brown RE. Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 02; 1864(2):158-167.
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Vladar EK, Stratton MB, Saal ML, Salazar-De Simone G, Wang X, Wolgemuth D, Stearns T, Axelrod JD. Cyclin-dependent kinase control of motile ciliogenesis. Elife. 2018 08 28; 7.
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Moser J, Miller I, Carter D, Spencer SL. Control of the Restriction Point by Rb and p21. Proc Natl Acad Sci U S A. 2018 08 28; 115(35):E8219-E8227.
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Garcia TB, Fosmire SP, Porter CC. Increased activity of both CDK1 and CDK2 is necessary for the combinatorial activity of WEE1 inhibition and cytarabine. Leuk Res. 2018 01; 64:30-33.
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Gookin S, Min M, Phadke H, Chung M, Moser J, Miller I, Carter D, Spencer SL. A map of protein dynamics during cell-cycle progression and cell-cycle exit. PLoS Biol. 2017 Sep; 15(9):e2003268.
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Song K, Liu X, Huang W, Lu S, Shen Q, Zhang L, Zhang J. Improved Method for the Identification and Validation of Allosteric Sites. J Chem Inf Model. 2017 09 25; 57(9):2358-2363.
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Arora M, Moser J, Phadke H, Basha AA, Spencer SL. Endogenous Replication Stress in Mother Cells Leads to Quiescence of Daughter Cells. Cell Rep. 2017 05 16; 19(7):1351-1364.
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Coxon CR, Anscombe E, Harnor SJ, Martin MP, Carbain B, Golding BT, Hardcastle IR, Harlow LK, Korolchuk S, Matheson CJ, Newell DR, Noble ME, Sivaprakasam M, Tudhope SJ, Turner DM, Wang LZ, Wedge SR, Wong C, Griffin RJ, Endicott JA, Cano C. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem. 2017 03 09; 60(5):1746-1767.
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