 RNA Interference
"RNA Interference" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
| Descriptor ID |
D034622
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| MeSH Number(s) |
G05.308.203.374.790
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| Concept/Terms |
RNA Interference- RNA Interference
- Interference, RNA
- Gene Silencing, Post-Transcriptional
- Gene Silencing, Post Transcriptional
- RNA Silencing
- Post-Transcriptional Gene Silencing
- Post Transcriptional Gene Silencing
- Post-Transcriptional Gene Silencings
- Silencing, Post-Transcriptional Gene
- RNAi
- Posttranscriptional Gene Silencing
- Gene Silencing, Posttranscriptional
- Gene Silencings, Posttranscriptional
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Below are MeSH descriptors whose meaning is more general than "RNA Interference".
Below are MeSH descriptors whose meaning is more specific than "RNA Interference".
This graph shows the total number of publications written about "RNA Interference" by people in this website by year, and whether "RNA Interference" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2003 | 0 | 10 | 10 | | 2004 | 1 | 8 | 9 | | 2005 | 5 | 8 | 13 | | 2006 | 0 | 16 | 16 | | 2007 | 2 | 12 | 14 | | 2008 | 1 | 18 | 19 | | 2009 | 4 | 21 | 25 | | 2010 | 2 | 17 | 19 | | 2011 | 3 | 19 | 22 | | 2012 | 4 | 24 | 28 | | 2013 | 4 | 32 | 36 | | 2014 | 6 | 23 | 29 | | 2015 | 2 | 16 | 18 | | 2016 | 2 | 30 | 32 | | 2017 | 0 | 13 | 13 | | 2018 | 0 | 9 | 9 | | 2019 | 0 | 4 | 4 |
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Below are the most recent publications written about "RNA Interference" by people in Profiles.
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George LF, Pradhan SJ, Mitchell D, Josey M, Casey J, Belus MT, Fedder KN, Dahal GR, Bates EA. Ion Channel Contributions to Wing Development in Drosophila melanogaster. G3 (Bethesda). 2019 04 09; 9(4):999-1008.
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Ressel S, Rosca A, Gordon K, Buck AH. Extracellular RNA in viral-host interactions: Thinking outside the cell. Wiley Interdiscip Rev RNA. 2019 07; 10(4):e1535.
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Charkoftaki G, Thompson DC, Golla JP, Garcia-Milian R, Lam TT, Engel J, Vasiliou V. Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cells. Chem Biol Interact. 2019 May 01; 304:88-96.
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Chang KC, Shieh B, Petrash JM. Role of aldose reductase in diabetes-induced retinal microglia activation. Chem Biol Interact. 2019 Apr 01; 302:46-52.
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Menzel P, McCorkindale AL, Stefanov SR, Zinzen RP, Meyer IM. Transcriptional dynamics of microRNAs and their targets during Drosophila neurogenesis. RNA Biol. 2019 01; 16(1):69-81.
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Zabel MD, Mollnow L, Bender H. Lipopeptide Delivery of siRNA to the Central Nervous System. Methods Mol Biol. 2019; 1943:389-403.
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Zhang Y, Knight W, Chen S, Mohan A, Yan C. Multiprotein Complex With TRPC (Transient Receptor Potential-Canonical) Channel, PDE1C (Phosphodiesterase 1C), and A2R (Adenosine A2 Receptor) Plays a Critical Role in Regulating Cardiomyocyte cAMP and Survival. Circulation. 2018 10 30; 138(18):1988-2002.
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Du T, Sikora MJ, Levine KM, Tasdemir N, Riggins RB, Wendell SG, Van Houten B, Oesterreich S. Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer. Breast Cancer Res. 2018 09 04; 20(1):106.
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Suda K, Murakami I, Yu H, Kim J, Tan AC, Mizuuchi H, Rozeboom L, Ellison K, Rivard CJ, Mitsudomi T, Hirsch FR. CD44 Facilitates Epithelial-to-Mesenchymal Transition Phenotypic Change at Acquisition of Resistance to EGFR Kinase Inhibitors in Lung Cancer. Mol Cancer Ther. 2018 10; 17(10):2257-2265.
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Saldi TK, Gonzales P, Garrido-Lecca A, Dostal V, Roberts CM, Petrucelli L, Link CD. The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2. Mol Cell Biol. 2018 08 01; 38(15).
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