 RNA Interference
"RNA Interference" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
| Descriptor ID |
D034622
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| MeSH Number(s) |
G05.308.203.374.790
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| Concept/Terms |
RNA Interference- RNA Interference
- Interference, RNA
- Gene Silencing, Post-Transcriptional
- Gene Silencing, Post Transcriptional
- RNA Silencing
- Post-Transcriptional Gene Silencing
- Post Transcriptional Gene Silencing
- Post-Transcriptional Gene Silencings
- Silencing, Post-Transcriptional Gene
- RNAi
- Posttranscriptional Gene Silencing
- Gene Silencing, Posttranscriptional
- Gene Silencings, Posttranscriptional
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Below are MeSH descriptors whose meaning is more general than "RNA Interference".
Below are MeSH descriptors whose meaning is more specific than "RNA Interference".
This graph shows the total number of publications written about "RNA Interference" by people in this website by year, and whether "RNA Interference" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 8 | 8 | | 2004 | 1 | 7 | 8 | | 2005 | 4 | 8 | 12 | | 2006 | 0 | 14 | 14 | | 2007 | 0 | 7 | 7 | | 2008 | 1 | 13 | 14 | | 2009 | 3 | 18 | 21 | | 2010 | 2 | 11 | 13 | | 2011 | 3 | 17 | 20 | | 2012 | 4 | 19 | 23 | | 2013 | 3 | 29 | 32 | | 2014 | 3 | 24 | 27 | | 2015 | 1 | 16 | 17 | | 2016 | 4 | 23 | 27 | | 2017 | 1 | 13 | 14 | | 2018 | 0 | 5 | 5 | | 2019 | 2 | 9 | 11 | | 2020 | 0 | 8 | 8 | | 2021 | 2 | 2 | 4 |
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Below are the most recent publications written about "RNA Interference" by people in Profiles.
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Shah VN, Pyle L. Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1. N Engl J Med. 2021 11 11; 385(20):e69.
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Haswell JR, Mattioli K, Gerhardinger C, Maass PG, Foster DJ, Peinado P, Wang X, Medina PP, Rinn JL, Slack FJ. Genome-wide CRISPR interference screen identifies long non-coding RNA loci required for differentiation and pluripotency. PLoS One. 2021; 16(11):e0252848.
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Vaughan OR, Maksym K, Silva E, Barentsen K, Anthony RV, Brown TL, Hillman SL, Spencer R, David AL, Rosario FJ, Powell TL, Jansson T. Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice. Clin Sci (Lond). 2021 09 17; 135(17):2049-2066.
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Tanner AR, Lynch CS, Kennedy VC, Ali A, Winger QA, Rozance PJ, Anthony RV. CSH RNA Interference Reduces Global Nutrient Uptake and Umbilical Blood Flow Resulting in Intrauterine Growth Restriction. Int J Mol Sci. 2021 Jul 29; 22(15).
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Jillson LK, Rider LC, Rodrigues LU, Romero L, Karimpour-Fard A, Nieto C, Gillette C, Torkko K, Danis E, Smith EE, Nolley R, Peehl DM, Lucia MS, Costello JC, Cramer SD. MAP3K7 Loss Drives Enhanced Androgen Signaling and Independently Confers Risk of Recurrence in Prostate Cancer with Joint Loss of CHD1. Mol Cancer Res. 2021 07; 19(7):1123-1136.
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Niemiec SM, Louiselle AE, Liechty KW, Zgheib C. Role of microRNAs in Pressure Ulcer Immune Response, Pathogenesis, and Treatment. Int J Mol Sci. 2020 Dec 23; 22(1).
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Zou M, Zhang X, Jiang D, Zhao Y, Wu T, Gong Q, Su H, Wu D, Moreland L, Li G. Transcriptional Regulation of CD40 Expression by 4 Ribosomal Proteins via a Functional SNP on a Disease-Associated CD40 Locus. Genes (Basel). 2020 12 21; 11(12).
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Ali A, Swanepoel CM, Winger QA, Rozance PJ, Anthony RV. Chorionic somatomammotropin RNA interference alters fetal liver glucose utilization. J Endocrinol. 2020 12; 247(3):251-262.
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Tanner AR, Lynch CS, Ali A, Winger QA, Rozance PJ, Anthony RV. Impact of chorionic somatomammotropin RNA interference on uterine blood flow and placental glucose uptake in the absence of intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2021 02 01; 320(2):R138-R148.
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Mahesh G, Rivas GBS, Caster C, Ost EB, Amunugama R, Jones R, Allen DL, Hardin PE. Proteomic analysis of Drosophila CLOCK complexes identifies rhythmic interactions with SAGA and Tip60 complex component NIPPED-A. Sci Rep. 2020 10 21; 10(1):17951.
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