 Pyruvate Kinase
"Pyruvate Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.
| Descriptor ID |
D011770
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| MeSH Number(s) |
D08.811.913.696.620.695
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| Concept/Terms |
Pyruvate Kinase L- Pyruvate Kinase L
- L-Type Pyruvate Kinase
- L Type Pyruvate Kinase
- Pyruvate Kinase, L-Type
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Below are MeSH descriptors whose meaning is more general than "Pyruvate Kinase".
Below are MeSH descriptors whose meaning is more specific than "Pyruvate Kinase".
This graph shows the total number of publications written about "Pyruvate Kinase" by people in this website by year, and whether "Pyruvate Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 2 | 2 | | 2017 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pyruvate Kinase" by people in Profiles.
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van de Wetering C, Manuel AM, Sharafi M, Aboushousha R, Qian X, Erickson C, MacPherson M, Chan G, Adcock IM, ZounematKermani N, Schleich F, Louis R, Bohrnsen E, D'Alessandro A, Wouters EF, Reynaert NL, Li J, Wolf CR, Henderson CJ, Lundblad LKA, Poynter ME, Dixon AE, Irvin CG, van der Vliet A, van der Velden JL, Janssen-Heininger YM. Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2. Redox Biol. 2021 11; 47:102160.
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Moreno-Fernandez ME, Giles DA, Oates JR, Chan CC, Damen MSMA, Doll JR, Stankiewicz TE, Chen X, Chetal K, Karns R, Weirauch MT, Romick-Rosendale L, Xanthakos SA, Sheridan R, Szabo S, Shah AS, Helmrath MA, Inge TH, Deshmukh H, Salomonis N, Divanovic S. PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease. Cell Metab. 2021 06 01; 33(6):1187-1204.e9.
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Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW. Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2. Circulation. 2017 Dec 19; 136(25):2451-2467.
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Lupi R, Marselli L, Dionisi S, Del Guerra S, Boggi U, Del Chiaro M, Lencioni C, Bugliani M, Mosca F, Di Mario U, Del Prato S, Dotta F, Marchetti P. Improved insulin secretory function and reduced chemotactic properties after tissue culture of islets from type 1 diabetic patients. Diabetes Metab Res Rev. 2004 May-Jun; 20(3):246-51.
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Magnusson AL, Powell T, Wennergren M, Jansson T. Glucose metabolism in the human preterm and term placenta of IUGR fetuses. Placenta. 2004 Apr; 25(4):337-46.
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Ghidini A, Sirtori M, Romero R, Yarkoni S, Solomon L, Hobbins JC. Hepatosplenomegaly as the only prenatal finding in a fetus with pyruvate kinase deficiency anemia. Am J Perinatol. 1991 Jan; 8(1):44-6.
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