 E-Box Elements
"E-Box Elements" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA locations with the consensus sequence CANNTG. ENHANCER ELEMENTS may contain multiple copies of this element. E-boxes play a regulatory role in the control of transcription. They bind with basic helix-loop-helix (bHLH) type TRANSCRIPTION FACTORS. Binding specificity is determined by the specific bHLH heterodimer or homodimer combination and by the specific nucleotides at the 3rd and 4th position of the E-box sequence.
| Descriptor ID |
D024721
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| MeSH Number(s) |
G02.111.570.080.689.330.240 G05.360.080.689.330.240 G05.360.340.024.340.137.750.249.240
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| Concept/Terms |
E-Box Elements- E-Box Elements
- E Box Elements
- E-Box Element
- Element, E-Box
- Elements, E-Box
- E-Box Sequences
- E Box Sequences
- E-Box Sequence
- Sequence, E-Box
- Sequences, E-Box
- E-Box Sites
- E Box Sites
- E-Box Site
- Site, E-Box
- Sites, E-Box
- E-Box Motifs
- E Box Motifs
- E-Box Motif
- Motif, E-Box
- Motifs, E-Box
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Below are MeSH descriptors whose meaning is more general than "E-Box Elements".
Below are MeSH descriptors whose meaning is more specific than "E-Box Elements".
This graph shows the total number of publications written about "E-Box Elements" by people in this website by year, and whether "E-Box Elements" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 2 | 2 | | 2015 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "E-Box Elements" by people in Profiles.
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Kaufman ML, Goodson NB, Park KU, Schwanke M, Office E, Schneider SR, Abraham J, Hensley A, Jones KL, Brzezinski JA. Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity. Development. 2021 06 15; 148(12).
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Nagalingam RS, Safi HA, Al-Hattab DS, Bagchi RA, Landry NM, Dixon IMC, Wigle JT, Czubryt MP. Regulation of cardiac fibroblast MMP2 gene expression by scleraxis. J Mol Cell Cardiol. 2018 07; 120:64-73.
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Bagchi RA, Lin J, Wang R, Czubryt MP. Regulation of fibronectin gene expression in cardiac fibroblasts by scleraxis. Cell Tissue Res. 2016 Nov; 366(2):381-391.
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Cruickshank MN, Dods J, Taylor RL, Karimi M, Fenwick EJ, Quail EA, Rea AJ, Holers VM, Abraham LJ, Ulgiati D. Analysis of tandem E-box motifs within human Complement receptor 2 (CR2/CD21) promoter reveals cell specific roles for RP58, E2A, USF and localized chromatin accessibility. Int J Biochem Cell Biol. 2015 Jul; 64:107-19.
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Kim K, Petrova YM, Scott BL, Nigam R, Agrawal A, Evans CM, Azzegagh Z, Gomez A, Rodarte EM, Olkkonen VM, Bagirzadeh R, Piccotti L, Ren B, Yoon JH, McNew JA, Adachi R, Tuvim MJ, Dickey BF. Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells. Biochem J. 2012 Sep 15; 446(3):383-94.
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Bagchi RA, Czubryt MP. Synergistic roles of scleraxis and Smads in the regulation of collagen 1a2 gene expression. Biochim Biophys Acta. 2012 Oct; 1823(10):1936-44.
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Yeung F, Chung E, Guess MG, Bell ML, Leinwand LA. Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos. Nucleic Acids Res. 2012 Aug; 40(15):7303-18.
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