 Nicotinic Agonists
"Nicotinic Agonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that bind to and activate nicotinic cholinergic receptors (RECEPTORS, NICOTINIC). Nicotinic agonists act at postganglionic nicotinic receptors, at neuroeffector junctions in the peripheral nervous system, and at nicotinic receptors in the central nervous system. Agents that function as neuromuscular depolarizing blocking agents are included here because they activate nicotinic receptors, although they are used clinically to block nicotinic transmission.
| Descriptor ID |
D018722
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| MeSH Number(s) |
D27.505.519.625.120.140.700 D27.505.696.577.120.140.700
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| Concept/Terms |
Nicotinic Agonists- Nicotinic Agonists
- Agonists, Nicotinic
- Cholinergic Agonists, Nicotinic
- Agonists, Nicotinic Cholinergic
- Nicotinic Cholinergic Agonists
- Nicotinic Agonist
- Agonist, Nicotinic
- Cholinergic Agonist, Nicotinic
- Agonist, Nicotinic Cholinergic
- Nicotinic Cholinergic Agonist
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Below are MeSH descriptors whose meaning is more general than "Nicotinic Agonists".
Below are MeSH descriptors whose meaning is more specific than "Nicotinic Agonists".
This graph shows the total number of publications written about "Nicotinic Agonists" by people in this website by year, and whether "Nicotinic Agonists" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1999 | 2 | 0 | 2 | | 2000 | 3 | 2 | 5 | | 2001 | 2 | 0 | 2 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2004 | 2 | 2 | 4 | | 2005 | 1 | 0 | 1 | | 2006 | 2 | 2 | 4 | | 2007 | 2 | 3 | 5 | | 2008 | 4 | 0 | 4 | | 2009 | 5 | 0 | 5 | | 2010 | 2 | 1 | 3 | | 2011 | 3 | 1 | 4 | | 2012 | 7 | 1 | 8 | | 2013 | 3 | 1 | 4 | | 2014 | 4 | 0 | 4 | | 2015 | 4 | 2 | 6 | | 2016 | 2 | 1 | 3 | | 2017 | 5 | 3 | 8 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Nicotinic Agonists" by people in Profiles.
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Mineur YS, Cahuzac EL, Mose TN, Bentham MP, Plantenga ME, Thompson DC, Picciotto MR. Interaction between noradrenergic and cholinergic signaling in amygdala regulates anxiety- and depression-related behaviors in mice. Neuropsychopharmacology. 2018 09; 43(10):2118-2125.
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Lewis AS, Olincy A, Buchanan RW, Kem WR, Picciotto MR, Freedman R. Effects of a nicotinic agonist on the Brief Psychiatric Rating Scale five-factor subscale model in schizophrenia. Schizophr Res. 2018 05; 195:568-569.
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Littlewood RA, Claus ED, Wilcox CE, Mickey J, Arenella PB, Bryan AD, Hutchison KE. Moderators of smoking cessation outcomes in a randomized-controlled trial of varenicline versus placebo. Psychopharmacology (Berl). 2017 Dec; 234(23-24):3417-3429.
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Kem WR, Olincy A, Johnson L, Harris J, Wagner BD, Buchanan RW, Christians U, Freedman R. Pharmacokinetic Limitations on Effects of an Alpha7-Nicotinic Receptor Agonist in Schizophrenia: Randomized Trial with an Extended-Release Formulation. Neuropsychopharmacology. 2018 02; 43(3):583-589.
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Wilcox CE, Calhoun VD, Rachakonda S, Claus ED, Littlewood RA, Mickey J, Arenella PB, Hutchison KE. Functional network connectivity predicts treatment outcome during treatment of nicotine use disorder. Psychiatry Res Neuroimaging. 2017 Jul 30; 265:45-53.
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Smucny J, Tregellas JR. Targeting neuronal dysfunction in schizophrenia with nicotine: Evidence from neurophysiology to neuroimaging. J Psychopharmacol. 2017 07; 31(7):801-811.
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Gee KW, Olincy A, Kanner R, Johnson L, Hogenkamp D, Harris J, Tran M, Edmonds SA, Sauer W, Yoshimura R, Johnstone T, Freedman R. First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288. J Psychopharmacol. 2017 04; 31(4):434-441.
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Smucny J, Wylie KP, Kronberg E, Legget KT, Tregellas JR. Nicotinic modulation of salience network connectivity and centrality in schizophrenia. J Psychiatr Res. 2017 06; 89:85-96.
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Koukouli F, Rooy M, Tziotis D, Sailor KA, O'Neill HC, Levenga J, Witte M, Nilges M, Changeux JP, Hoeffer CA, Stitzel JA, Gutkin BS, DiGregorio DA, Maskos U. Nicotine reverses hypofrontality in animal models of addiction and schizophrenia. Nat Med. 2017 Mar; 23(3):347-354.
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Olincy A, Blakeley-Smith A, Johnson L, Kem WR, Freedman R. Brief Report: Initial Trial of Alpha7-Nicotinic Receptor Stimulation in Two Adult Patients with Autism Spectrum Disorder. J Autism Dev Disord. 2016 Dec; 46(12):3812-3817.
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