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Mark E Kohler

TitleAssistant Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Biography 
    Collapse education and training
    Rockhurst University, Kansas City, MOBS05/2001Biology & Chemistry
    Medical College of Wisconsin, Milwaukee, WIPhD06/2010Tumor Immunology
    Medical College of Wisconsin, Milwaukee, WIMD06/2011Medicine
    Johns Hopkins University, Baltimore, MDResidency06/2014Pediatrics
    Johns Hopkins University, Baltimore, MDFellowship06/2018Pediatric Hematology & Oncology
    National Institutes of Health, Bethesda, MDFellowship06/2018Pediatric Hematology & Oncology

    Collapse Overview 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. DeGolier KR, Danis E, D'Antonio M, Cimons J, Yarnell M, Kedl RM, Kohler ME, Scott-Browne JP, Fry TJ. Antigen experience history directs distinct functional states of CD8+ CAR T cells during the anti-leukemia response. Res Sq. 2023 Dec 21. PMID: 38196657.
      View in: PubMed
    2. Kohler ME, Fry TJ. CD4+ CAR T cells - more than helpers. Nat Cancer. 2023 07; 4(7):928-929. PMID: 37248396.
      View in: PubMed
    3. Ishii K, Pouzolles M, Chien CD, Erwin-Cohen RA, Kohler ME, Qin H, Lei H, Kuhn S, Ombrello AK, Dulau-Florea A, Eckhaus MA, Shalabi H, Yates B, Lichtenstein DA, Zimmermann VS, Kondo T, Shern JF, Young HA, Taylor N, Shah NN, Fry TJ. Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients. J Clin Invest. 2020 10 01; 130(10):5425-5443. PMID: 32925169.
      View in: PubMed
    4. Kohler ME, Fry TJ. Using erythrocyte tools to enhance CAR T cells. Blood. 2020 02 27; 135(9):595-596. PMID: 32106307.
      View in: PubMed
    5. Walsh Z, Yang Y, Kohler ME. Immunobiology of chimeric antigen receptor T cells and novel designs. Immunol Rev. 2019 07; 290(1):100-113. PMID: 31355496.
      View in: PubMed
    6. Qin H, Ishii K, Nguyen S, Su PP, Burk CR, Kim BH, Duncan BB, Tarun S, Shah NN, Kohler ME, Fry TJ. Murine pre-B-cell ALL induces T-cell dysfunction not fully reversed by introduction of a chimeric antigen receptor. Blood. 2018 11 01; 132(18):1899-1910. PMID: 30209120.
      View in: PubMed
    7. Yang Y, Kohler ME, Chien CD, Sauter CT, Jacoby E, Yan C, Hu Y, Wanhainen K, Qin H, Fry TJ. TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance. Sci Transl Med. 2017 Nov 22; 9(417). PMID: 29167392.
      View in: PubMed
    8. Long AH, Haso WM, Shern JF, Wanhainen KM, Murgai M, Ingaramo M, Smith JP, Walker AJ, Kohler ME, Venkateshwara VR, Kaplan RN, Patterson GH, Fry TJ, Orentas RJ, Mackall CL. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. Nat Med. 2015 Jun; 21(6):581-90. PMID: 25939063.
      View in: PubMed
    9. Shah NN, Baird K, Delbrook CP, Fleisher TA, Kohler ME, Rampertaap S, Lemberg K, Hurley CK, Kleiner DE, Merchant MS, Pittaluga S, Sabatino M, Stroncek DF, Wayne AS, Zhang H, Fry TJ, Mackall CL. Acute GVHD in patients receiving IL-15/4-1BBL activated NK cells following T-cell-depleted stem cell transplantation. Blood. 2015 Jan 29; 125(5):784-92. PMID: 25452614.
      View in: PubMed
    10. Kohler ME, Johnson BD, Palen K, Chen QR, Khan J, Orentas RJ. Tumor antigen analysis in neuroblastoma by serological interrogation of bioinformatic data. Cancer Sci. 2010 Nov; 101(11):2316-24. PMID: 20718755.
      View in: PubMed
    11. Kohler ME, Hallett WH, Chen QR, Khan J, Johnson BD, Orentas RJ. Early expression of stem cell-associated genes within the CD8 compartment after treatment with a tumor vaccine. Cell Immunol. 2010; 265(1):65-73. PMID: 20692654.
      View in: PubMed
    12. Zheng J, Kohler ME, Chen Q, Weber J, Khan J, Johnson BD, Orentas RJ. Serum from mice immunized in the context of Treg inhibition identifies DEK as a neuroblastoma tumor antigen. BMC Immunol. 2007 Mar 30; 8:4. PMID: 17397536.
      View in: PubMed
    13. Orentas RJ, Kohler ME, Johnson BD. Suppression of anti-cancer immunity by regulatory T cells: back to the future. Semin Cancer Biol. 2006 Apr; 16(2):137-49. PMID: 16376101.
      View in: PubMed
    14. Stephens EB, Singh DK, Kohler ME, Jackson M, Pacyniak E, Berman NE. The primary phase of infection by pathogenic simian-human immunodeficiency virus results in disruption of the blood-brain barrier. AIDS Res Hum Retroviruses. 2003 Oct; 19(10):837-46. PMID: 14585215.
      View in: PubMed
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