Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
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Katharine R. Smith

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PHARM General Operations

    Collapse Research 
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    R01MH128199     (SMITH, KATHARINE RACHEL)Aug 1, 2022 - Jul 31, 2027
    NIH
    Local translation mechanisms to control inhibitory synaptic plasticity
    Role: Principal Investigator
    R01MH119154     (SMITH, KATHARINE RACHEL)Dec 1, 2019 - Oct 31, 2024
    NIH
    Nanoscale organization of the inhibitory synapse during synaptic plasticity
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Welle TM, Smith KR. Release your inhibitions: The cell biology of GABAergic postsynaptic plasticity. Curr Opin Neurobiol. 2025 Feb; 90:102952. PMID: 39721557.
      View in: PubMed
    2. Welle TM, Rajgor D, Kareemo DJ, Garcia JD, Zych SM, Wolfe SE, Gookin SE, Martinez TP, Dell'Acqua ML, Ford CP, Kennedy MJ, Smith KR. miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity. EMBO Rep. 2024 Nov; 25(11):5141-5168. PMID: 39294503.
      View in: PubMed
    3. Burch AM, Garcia JD, O'Leary H, Haas A, Orfila JE, Tiemeier E, Chalmers N, Smith KR, Quillinan N, Herson PS. TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia. J Neurosci. 2024 May 08; 44(19). PMID: 38565288.
      View in: PubMed
    4. Welle TM, Rajgor D, Garcia JD, Kareemo D, Zych SM, Gookin SE, Martinez TP, Dell'Acqua ML, Ford CP, Kennedy MJ, Smith KR. miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity. bioRxiv. 2023 Dec 12. PMID: 38168421.
      View in: PubMed
    5. Olah SS, Kareemo DJ, Buchta WC, Sinnen BL, Miller CN, Actor-Engel HS, Gookin SE, Winborn CS, Kleinjan MS, Crosby KC, Aoto J, Smith KR, Kennedy MJ. Acute reorganization of postsynaptic GABAA receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses. Cell Rep. 2023 11 28; 42(11):113331. PMID: 37910506.
      View in: PubMed
    6. Garcia JD, Wolfe SE, Stewart AR, Tiemeier E, Gookin SE, Guerrero MB, Quillinan N, Smith KR. Distinct mechanisms drive sequential internalization and degradation of GABAARs during global ischemia and reperfusion injury. iScience. 2023 Oct 20; 26(10):108061. PMID: 37860758.
      View in: PubMed
    7. Ramsay HJ, Gookin SE, Ramsey AM, Kareemo DJ, Crosby KC, Stich DG, Olah SS, Actor-Engel HS, Smith KR, Kennedy MJ. AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release. Front Mol Neurosci. 2023; 16:1232795. PMID: 37602191.
      View in: PubMed
    8. Piguel NH, Sanders SS, De Simone FI, Martin-de-Saavedra MD, McCoig E, Dionisio LE, Smith KR, Thomas GM, Penzes P. Palmitoylation controls the stability of 190 kDa ankyrin-G in dendritic spines and is regulated by ZDHHC8 and lithium. Front Mol Neurosci. 2023; 16:1144066. PMID: 36969554.
      View in: PubMed
    9. Piguel NH, Yoon S, Gao R, Horan KE, Garza JC, Petryshen TL, Smith KR, Penzes P. Lithium rescues dendritic abnormalities in Ank3 deficiency models through the synergic effects of GSK3ß and cyclic AMP signaling pathways. Neuropsychopharmacology. 2023 06; 48(7):1000-1010. PMID: 36376465.
      View in: PubMed
    10. Gookin SE, Taylor MR, Schwartz SL, Kennedy MJ, Dell'Acqua ML, Crosby KC, Smith KR. Complementary Use of Super-Resolution Imaging Modalities to Study the Nanoscale Architecture of Inhibitory Synapses. Front Synaptic Neurosci. 2022; 14:852227. PMID: 35463850.
      View in: PubMed
    11. Garcia JD, Gookin SE, Crosby KC, Schwartz SL, Tiemeier E, Kennedy MJ, Dell'Acqua ML, Herson PS, Quillinan N, Smith KR. Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity. Cell Rep. 2021 12 21; 37(12):110142. PMID: 34936876.
      View in: PubMed
    12. Actor-Engel HS, Schwartz SL, Crosby KC, Sinnen BL, Prikhodko O, Ramsay HJ, Bourne JN, Winborn CS, Lucas A, Smith KR, Dell'Acqua ML, Kennedy MJ. Precision Mapping of Amyloid-ß Binding Reveals Perisynaptic Localization and Spatially Restricted Plasticity Deficits. eNeuro. 2021 Nov-Dec; 8(6). PMID: 34789478.
      View in: PubMed
    13. Rajgor D, Welle TM, Smith KR. The Coordination of Local Translation, Membranous Organelle Trafficking, and Synaptic Plasticity in Neurons. Front Cell Dev Biol. 2021; 9:711446. PMID: 34336865.
      View in: PubMed
    14. Towers CG, Wodetzki DK, Thorburn J, Smith KR, Caino MC, Thorburn A. Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy. Dev Cell. 2021 07 26; 56(14):2029-2042.e5. PMID: 34171288.
      View in: PubMed
    15. Rajgor D, Purkey AM, Sanderson JL, Welle TM, Garcia JD, Dell'Acqua ML, Smith KR. Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation. Cell Rep. 2020 06 23; 31(12):107785. PMID: 32579917.
      View in: PubMed
    16. Guthman EM, Garcia JD, Ma M, Chu P, Baca SM, Smith KR, Restrepo D, Huntsman MM. Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition. Elife. 2020 Jan 09; 9. PMID: 31916940.
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    17. Crosby KC, Gookin SE, Garcia JD, Hahm KM, Dell'Acqua ML, Smith KR. Nanoscale Subsynaptic Domains Underlie the Organization of the Inhibitory Synapse. Cell Rep. 2019 03 19; 26(12):3284-3297.e3. PMID: 30893601.
      View in: PubMed
    18. Oh WC, Smith KR. Activity-dependent development of GABAergic synapses. Brain Res. 2019 03 15; 1707:18-26. PMID: 30439352.
      View in: PubMed
    19. Smith KR, Penzes P. Ankyrins: Roles in synaptic biology and pathology. Mol Cell Neurosci. 2018 09; 91:131-139. PMID: 29730177.
      View in: PubMed
    20. Hiester BG, Bourke AM, Sinnen BL, Cook SG, Gibson ES, Smith KR, Kennedy MJ. L-Type Voltage-Gated Ca2+ Channels Regulate Synaptic-Activity-Triggered Recycling Endosome Fusion in Neuronal Dendrites. Cell Rep. 2017 Nov 21; 21(8):2134-2146. PMID: 29166605.
      View in: PubMed
    21. Smith KR, Rajgor D, Hanley JG. Differential regulation of the Rac1 GTPase-activating protein (GAP) BCR during oxygen/glucose deprivation in hippocampal and cortical neurons. J Biol Chem. 2017 12 08; 292(49):20173-20183. PMID: 29046349.
      View in: PubMed
    22. Smith KR, Jones KA, Kopeikina KJ, Burette AC, Copits BA, Yoon S, Forrest MP, Fawcett-Patel JM, Hanley JG, Weinberg RJ, Swanson GT, Penzes P. Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins. J Neurosci. 2017 11 15; 37(46):11127-11139. PMID: 29030434.
      View in: PubMed
    23. Smith KR, Davenport EC, Wei J, Li X, Pathania M, Vaccaro V, Yan Z, Kittler JT. GIT1 and ßPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission. Cell Rep. 2014 Oct 09; 9(1):298-310. PMID: 25284783.
      View in: PubMed
    24. Duffney LJ, Wei J, Cheng J, Liu W, Smith KR, Kittler JT, Yan Z. Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism. J Neurosci. 2013 Oct 02; 33(40):15767-78. PMID: 24089484.
      View in: PubMed
    25. Srivastava DP, Woolfrey KM, Jones KA, Anderson CT, Smith KR, Russell TA, Lee H, Yasvoina MV, Wokosin DL, Ozdinler PH, Shepherd GM, Penzes P. An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice. PLoS Biol. 2012; 10(6):e1001350. PMID: 22745599.
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    26. Smith KR, Muir J, Rao Y, Browarski M, Gruenig MC, Sheehan DF, Haucke V, Kittler JT. Stabilization of GABA(A) receptors at endocytic zones is mediated by an AP2 binding motif within the GABA(A) receptor ß3 subunit. J Neurosci. 2012 Feb 15; 32(7):2485-98. PMID: 22396422.
      View in: PubMed
    27. Muir J, Arancibia-Carcamo IL, MacAskill AF, Smith KR, Griffin LD, Kittler JT. NMDA receptors regulate GABAA receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the ?2 subunit. Proc Natl Acad Sci U S A. 2010 Sep 21; 107(38):16679-84. PMID: 20823221.
      View in: PubMed
    28. Smith KR, Kittler JT. The cell biology of synaptic inhibition in health and disease. Curr Opin Neurobiol. 2010 Oct; 20(5):550-6. PMID: 20650630.
      View in: PubMed
    29. Smith KR, Oliver PL, Lumb MJ, Arancibia-Carcamo IL, Revilla-Sanchez R, Brandon NJ, Moss SJ, Kittler JT. Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons. Mol Cell Neurosci. 2010 Aug; 44(4):330-41. PMID: 20417281.
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    30. Smith KR, McAinsh K, Chen G, Arancibia-Carcamo IL, Haucke V, Yan Z, Moss SJ, Kittler JT. Regulation of inhibitory synaptic transmission by a conserved atypical interaction of GABA(A) receptor beta- and gamma-subunits with the clathrin AP2 adaptor. Neuropharmacology. 2008 Oct; 55(5):844-50. PMID: 18662706.
      View in: PubMed
    31. Kittler JT, Chen G, Kukhtina V, Vahedi-Faridi A, Gu Z, Tretter V, Smith KR, McAinsh K, Arancibia-Carcamo IL, Saenger W, Haucke V, Yan Z, Moss SJ. Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit. Proc Natl Acad Sci U S A. 2008 Mar 04; 105(9):3616-21. PMID: 18305175.
      View in: PubMed
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