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James Tucker Nichols

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSDM-Craniofacial Biology

    Collapse Research 
    Collapse research activities and funding
    R01DE029193     (NICHOLS, JAMES TUCKER)Apr 1, 2021 - Feb 28, 2026
    NIH
    Mechanisms of developmental buffering
    Role: Principal Investigator

    R56DE027955     (NICHOLS, JAMES TUCKER)Aug 1, 2019 - Jul 31, 2021
    NIH
    Mechanisms underlying the incomplete penetrance of craniofacial anomalies
    Role: Principal Investigator

    R00DE024190     (NICHOLS, JAMES TUCKER)Apr 1, 2017 - Mar 31, 2020
    NIH
    Cell Fate Choices in the Skeleton
    Role: Principal Investigator

    K99DE024190     (NICHOLS, JAMES TUCKER)Apr 1, 2014 - Mar 31, 2017
    NIH
    Cell Fate Choices in the Skeleton
    Role: Principal Investigator

    F32GM086027     (NICHOLS, JAMES TUCKER)Feb 1, 2009 - Jan 31, 2012
    NIH
    The Molecular Genetics and Cell Biology of Jaw Joint Morphogenesis
    Role: Principal Investigator

    F31EB006278     (NICHOLS, JAMES T)Mar 1, 2007 - Feb 28, 2009
    NIH
    Imaging Delta-Induced Activation of Notch
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bailon-Zambrano R, Sucharov J, Mumme-Monheit A, Murry M, Stenzel A, Pulvino AT, Mitchell JM, Colborn KL, Nichols JT. Variable paralog expression underlies phenotype variation. Elife. 2022 09 22; 11. PMID: 36134886.
      View in: PubMed
    2. Desvignes T, Robbins AE, Carey AZ, Bailon-Zambrano R, Nichols JT, Postlethwait JH, Stankunas K. Coordinated patterning of zebrafish caudal fin symmetry by a central and two peripheral organizers. Dev Dyn. 2022 08; 251(8):1306-1321. PMID: 35403297.
      View in: PubMed
    3. Mitchell JM, Sucharov J, Pulvino AT, Brooks EP, Gillen AE, Nichols JT. The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing. Development. 2021 04 01; 148(7). PMID: 33741714.
      View in: PubMed
    4. Tessadori F, de Bakker DEM, Barske L, Nelson N, Algra HA, Willekers S, Nichols JT, Crump JG, Bakkers J. Zebrafish prrx1a mutants have normal hearts. Nature. 2020 09; 585(7826):E14-E16. PMID: 32968253.
      View in: PubMed
    5. Kimmel CB, Wind AL, Oliva W, Ahlquist SD, Walker C, Dowd J, Blanco-Sánchez B, Titus TA, Batzel P, Talbot JC, Postlethwait JH, Nichols JT. Transgene-mediated skeletal phenotypic variation in zebrafish. J Fish Biol. 2021 Apr; 98(4):956-970. PMID: 32112658.
      View in: PubMed
    6. Sucharov J, Ray K, Brooks EP, Nichols JT. Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway. PLoS Genet. 2019 12; 15(12):e1008507. PMID: 31790396.
      View in: PubMed
    7. Brooks EP, Nichols JT. Shifting Zebrafish Lethal Skeletal Mutant Penetrance by Progeny Testing. J Vis Exp. 2017 09 01; (127). PMID: 28892034.
      View in: PubMed
    8. Nichols JT, Blanco-Sánchez B, Brooks EP, Parthasarathy R, Dowd J, Subramanian A, Nachtrab G, Poss KD, Schilling TF, Kimmel CB. Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. Development. 2016 12 01; 143(23):4430-4440. PMID: 27789622.
      View in: PubMed
    9. Talbot JC, Nichols JT, Yan YL, Leonard IF, BreMiller RA, Amacher SL, Postlethwait JH, Kimmel CB. Pharyngeal morphogenesis requires fras1-itga8-dependent epithelial-mesenchymal interaction. Dev Biol. 2016 08 01; 416(1):136-148. PMID: 27265864.
      View in: PubMed
    10. Barske L, Askary A, Zuniga E, Balczerski B, Bump P, Nichols JT, Crump JG. Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face. PLoS Genet. 2016 Apr; 12(4):e1005967. PMID: 27058748.
      View in: PubMed
    11. Gore AV, Athans B, Iben JR, Johnson K, Russanova V, Castranova D, Pham VN, Butler MG, Williams-Simons L, Nichols JT, Bresciani E, Feldman B, Kimmel CB, Liu PP, Weinstein BM. Epigenetic regulation of hematopoiesis by DNA methylation. Elife. 2016 Jan 27; 5:e11813. PMID: 26814702.
      View in: PubMed
    12. Kimmel CB, Watson S, Couture RB, McKibben NS, Nichols JT, Richardson SE, Noakes DL. Patterns of variation and covariation in the shapes of mandibular bones of juvenile salmonids in the genus Oncorhynchus. Evol Dev. 2015 Sep-Oct; 17(5):302-14. PMID: 26372063.
      View in: PubMed
    13. DeLaurier A, Huycke TR, Nichols JT, Swartz ME, Larsen A, Walker C, Dowd J, Pan L, Moens CB, Kimmel CB. Role of mef2ca in developmental buffering of the zebrafish larval hyoid dermal skeleton. Dev Biol. 2014 Jan 15; 385(2):189-99. PMID: 24269905.
      View in: PubMed
    14. Sasaki MM, Nichols JT, Kimmel CB. edn1 and hand2 Interact in early regulation of pharyngeal arch outgrowth during zebrafish development. PLoS One. 2013; 8(6):e67522. PMID: 23826316.
      View in: PubMed
    15. Eames BF, DeLaurier A, Ullmann B, Huycke TR, Nichols JT, Dowd J, McFadden M, Sasaki MM, Kimmel CB. FishFace: interactive atlas of zebrafish craniofacial development at cellular resolution. BMC Dev Biol. 2013 May 28; 13:23. PMID: 23714426.
      View in: PubMed
    16. Nichols JT, Pan L, Moens CB, Kimmel CB. barx1 represses joints and promotes cartilage in the craniofacial skeleton. Development. 2013 Jul; 140(13):2765-75. PMID: 23698351.
      View in: PubMed
    17. Nichols JT, Miyamoto A, Weinmaster G. Notch signaling--constantly on the move. Traffic. 2007 Aug; 8(8):959-69. PMID: 17547700.
      View in: PubMed
    18. Nichols JT, Miyamoto A, Olsen SL, D'Souza B, Yao C, Weinmaster G. DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur. J Cell Biol. 2007 Feb 12; 176(4):445-58. PMID: 17296795.
      View in: PubMed
    19. Ladi E, Nichols JT, Ge W, Miyamoto A, Yao C, Yang LT, Boulter J, Sun YE, Kintner C, Weinmaster G. The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands. J Cell Biol. 2005 Sep 12; 170(6):983-92. PMID: 16144902.
      View in: PubMed
    20. Yang LT, Nichols JT, Yao C, Manilay JO, Robey EA, Weinmaster G. Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol Biol Cell. 2005 Feb; 16(2):927-42. PMID: 15574878.
      View in: PubMed
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