Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution
Menu

Contact Us
If you have any questions or feedback please contact us.

Lori Gail Sussel

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Barbara Davis Center
Phone303/724-9119

    Collapse Research 
    Collapse research activities and funding
    F32NS010184     (SUSSEL, LORI)Dec 1, 1996
    NIH/NINDS
    GENETIC ANALYSIS OF MOUSE NKX-21 AND NKX-22 GENES
    Role: Principal Investigator
    R21DK061151     (SUSSEL, LORI)Sep 30, 2001 - Aug 31, 2003
    NIH/NIDDK
    Transcriptional regulation of exocrine development
    Role: Principal Investigator
    R21DK061422     (SUSSEL, LORI)May 15, 2002 - Apr 30, 2004
    NIH/NIDDK
    Nkx2.2 and Gata6: regulation of islet development
    Role: Principal Investigator
    R01DK064146     (SUSSEL, LORI)Jun 1, 2003 - Mar 31, 2009
    NIH/NIDDK
    The role of Gata 4 in exocrine pancreas development
    Role: Principal Investigator
    U01DK072504     (SUSSEL, LORI)Aug 1, 2005 - Jul 31, 2010
    NIH/NIDDK
    Defining the roles of Nkx2.2 and NeuroD in regulating islet cell fate
    Role: Principal Investigator
    R01DK082590     (SUSSEL, LORI)Jan 1, 2009 - Jul 31, 2022
    NIH/NIDDK
    Regulation of Pancreatic Islet Cell Fate
    Role: Principal Investigator
    R01DK087711     (SUSSEL, LORI)Sep 20, 2010 - Jun 30, 2015
    NIH/NIDDK
    Regulation of exocrine pancreas formation
    Role: Principal Investigator
    DP3DK094400     (CLYNES, RAPHAEL A)Sep 20, 2011 - Aug 31, 2015
    NIH/NIDDK
    Epigenetic events underlying Type I diabetes
    Role: Co-Principal Investigator
    R21CA188059     (SUSSEL, LORI)Sep 1, 2014 - Aug 31, 2016
    NIH/NCI
    Long non-coding RNAs in pancreatic cancer
    Role: Principal Investigator
    UC4DK108101     (ANSONG, CHARLES K)Sep 22, 2015 - Sep 21, 2019
    NIH/NIDDK
    Single Cell Resolution Omics Analysis of T1D islets
    Role: Co-Principal Investigator
    R01DK111405     (SUSSEL, LORI)Jul 1, 2017 - Jun 30, 2021
    NIH/NIDDK
    Long non-coding RNAs in Islet Cell Biology
    Role: Principal Investigator
    R01DK118155     (GADUE, PAUL J)Jul 1, 2018 - May 31, 2022
    NIH/NIDDK
    Intersection of signaling pathways and transcription factors regulating islet development
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Bartolome A, Zhu C, Sussel L, Pajvani UB. Notch signaling dynamically regulates adult ß cell proliferation and maturity. J Clin Invest. 2018 Oct 30. PMID: 30375986.
      View in: PubMed
    2. Singer RA, Sussel L. Islet Long Noncoding RNAs: A Playbook for Discovery and Characterization. Diabetes. 2018 08; 67(8):1461-1470. PMID: 29937433.
      View in: PubMed
    3. Yin R, Kyle J, Burnum-Johnson K, Bloodsworth KJ, Sussel L, Ansong C, Laskin J. High Spatial Resolution Imaging of Mouse Pancreatic Islets Using Nanospray Desorption Electrospray Ionization Mass Spectrometry. Anal Chem. 2018 Jun 05; 90(11):6548-6555. PMID: 29718662.
      View in: PubMed
    4. Arnes L, Liu Z, Wang J, Carlo Maurer H, Sagalovskiy I, Sanchez-Martin M, Bommakanti N, Garofalo DC, Balderes DA, Sussel L, Olive KP, Rabadan R. Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma. Gut. 2018 02 10. PMID: 29440233.
      View in: PubMed
    5. Cui Y, Hu D, Markillie LM, Chrisler WB, Gaffrey MJ, Ansong C, Sussel L, Orr G. Fluctuation localization imaging-based fluorescence in situ hybridization (fliFISH) for accurate detection and counting of RNA copies in single cells. Nucleic Acids Res. 2018 Jan 25; 46(2):e7. PMID: 29040675.
      View in: PubMed
    6. Lorberbaum DS, Sussel L. Gotta Have GATA for Human Pancreas Development. Cell Stem Cell. 2017 05 04; 20(5):577-579. PMID: 28475878.
      View in: PubMed
    7. Gutierrez GD, Gromada J, Sussel L. Heterogeneity of the Pancreatic Beta Cell. Front Genet. 2017; 8:22. PMID: 28321233.
      View in: PubMed
    8. Churchill AJ, Gutiérrez GD, Singer RA, Lorberbaum DS, Fischer KA, Sussel L. Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development. Elife. 2017 01 10; 6. PMID: 28071588.
      View in: PubMed
    9. Ediger BN, Lim HW, Juliana C, Groff DN, Williams LT, Dominguez G, Liu JH, Taylor BL, Walp ER, Kameswaran V, Yang J, Liu C, Hunter CS, Kaestner KH, Naji A, Li C, Sander M, Stein R, Sussel L, Won KJ, May CL, Stoffers DA. LIM domain-binding 1 maintains the terminally differentiated state of pancreatic ß cells. J Clin Invest. 2017 01 03; 127(1):215-229. PMID: 27941246.
      View in: PubMed
    10. Gutiérrez GD, Bender AS, Cirulli V, Mastracci TL, Kelly SM, Tsirigos A, Kaestner KH, Sussel L. Pancreatic ß cell identity requires continual repression of non-ß cell programs. J Clin Invest. 2017 01 03; 127(1):244-259. PMID: 27941248.
      View in: PubMed
    11. Gross S, Garofalo DC, Balderes DA, Mastracci TL, Dias JM, Perlmann T, Ericson J, Sussel L. The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2. Development. 2016 07 15; 143(14):2616-28. PMID: 27287799; PMCID: PMC4958331 [Available on 07/15/17].
      View in: PubMed, PubMed Central
    12. Xuan S, Sussel L. GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling. Development. 2016 Mar 01; 143(5):780-6. PMID: 26932670; PMCID: PMC4813334 [Available on 03/01/17].
      View in: PubMed, PubMed Central
    13. Arnes L, Akerman I, Balderes DA, Ferrer J, Sussel L. ßlinc1 encodes a long noncoding RNA that regulates islet ß-cell formation and function. Genes Dev. 2016 Mar 01; 30(5):502-7. PMID: 26944677.
      View in: PubMed
    14. Borok MJ, Papaioannou VE, Sussel L. Unique functions of Gata4 in mouse liver induction and heart development. Dev Biol. 2016 Feb 15; 410(2):213-222. PMID: 26687508; PMCID: PMC4758879 [Available on 02/15/17].
      View in: PubMed, PubMed Central
    15. Gross S, Balderes D, Liu J, Asfaha S, Gu G, Wang TC, Sussel L. Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential. Am J Physiol Gastrointest Liver Physiol. 2015 Dec 15; 309(12):G975-87. PMID: 26492922; PMCID: PMC4683302 [Available on 12/15/16].
      View in: PubMed, PubMed Central
    16. Romer AI, Sussel L. Pancreatic islet cell development and regeneration. Curr Opin Endocrinol Diabetes Obes. 2015 Aug; 22(4):255-64. PMID: 26087337; PMCID: PMC4660868.
      View in: PubMed, PubMed Central
    17. Roybon L, Mastracci TL, Li J, Stott SR, Leiter AB, Sussel L, Brundin P, Li JY. The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1. PLoS One. 2015; 10(6):e0128035. PMID: 26030886; PMCID: PMC4451148.
      View in: PubMed, PubMed Central
    18. Singer RA, Arnes L, Sussel L. Noncoding RNAs in ß cell biology. Curr Opin Endocrinol Diabetes Obes. 2015 Apr; 22(2):77-85. PMID: 25692923.
      View in: PubMed
    19. Arnes L, Sussel L. Epigenetic modifications and long noncoding RNAs influence pancreas development and function. Trends Genet. 2015 Jun; 31(6):290-9. PMID: 25812926.
      View in: PubMed
    20. Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH. Ghrelin. Mol Metab. 2015 Jun; 4(6):437-60. PMID: 26042199.
      View in: PubMed
    21. Clark JK, O'keefe A, Mastracci TL, Sussel L, Matise MP, Kucenas S. Mammalian Nkx2.2+ perineurial glia are essential for motor nerve development. Dev Dyn. 2014 Sep; 243(9):1116-29. PMID: 24979729; PMCID: PMC4180512.
      View in: PubMed, PubMed Central
    22. Sussel L, Niswander L. Editorial overview: developmental mechanisms, patterning and evolution. Curr Opin Genet Dev. 2014 Aug; 27:v-vii. PMID: 24998023.
      View in: PubMed
    23. Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC, Rhodes CJ, Sussel L, Weir GC. ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. Diabetes Care. 2014 Jun; 37(6):1751-8. PMID: 24812433; PMCID: PMC4179518.
      View in: PubMed, PubMed Central
    24. Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC, Rhodes CJ, Sussel L, Weir GC. ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. J Clin Endocrinol Metab. 2014 Jun; 99(6):1983-92. PMID: 24712577.
      View in: PubMed
    25. Nair KS, Abel ED, Adler SG, Dyck PJ, Gardner TW, Haskins KM, Hotamisligil G, Jensen MD, Krook A, Mandarino LJ, Mitchell BD, Pessin JE, Sowers JR, Sussel L, Wareham N, Vella A. Time to look back and to look forward. Diabetes. 2014 Apr; 63(4):1169-70. PMID: 24651796.
      View in: PubMed
    26. Zhu Q, Zhao X, Zheng K, Li H, Huang H, Zhang Z, Mastracci T, Wegner M, Chen Y, Sussel L, Qiu M. Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS. Development. 2014 Feb; 141(3):548-55. PMID: 24449836; PMCID: PMC3899813.
      View in: PubMed, PubMed Central
    27. Balderes DA, Magnuson MA, Sussel L. Nkx2.2:Cre knock-in mouse line: a novel tool for pancreas- and CNS-specific gene deletion. Genesis. 2013 Dec; 51(12):844-51. PMID: 23996959; PMCID: PMC3902634.
      View in: PubMed, PubMed Central
    28. Suissa Y, Magenheim J, Stolovich-Rain M, Hija A, Collombat P, Mansouri A, Sussel L, Sosa-Pineda B, McCracken K, Wells JM, Heller RS, Dor Y, Glaser B. Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas. PLoS One. 2013; 8(8):e70397. PMID: 23940571; PMCID: PMC3734289.
      View in: PubMed, PubMed Central
    29. Mastracci TL, Lin CS, Sussel L. Generation of mice encoding a conditional allele of Nkx2.2. Transgenic Res. 2013 Oct; 22(5):965-72. PMID: 23494546; PMCID: PMC3713092.
      View in: PubMed, PubMed Central
    30. Lugani F, Arora R, Papeta N, Patel A, Zheng Z, Sterken R, Singer RA, Caridi G, Mendelsohn C, Sussel L, Papaioannou VE, Gharavi AG. A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse. PLoS Genet. 2013; 9(2):e1003206. PMID: 23437001; PMCID: PMC3578747.
      View in: PubMed, PubMed Central
    31. Mastracci TL, Anderson KR, Papizan JB, Sussel L. Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas. PLoS Genet. 2013; 9(2):e1003278. PMID: 23408910.
      View in: PubMed
    32. Arnes L, Hill JT, Gross S, Magnuson MA, Sussel L. Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. PLoS One. 2012; 7(12):e52026. PMID: 23251675; PMCID: PMC3520898.
      View in: PubMed, PubMed Central
    33. Ioannou M, Serafimidis I, Arnes L, Sussel L, Singh S, Vasiliou V, Gavalas A. ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Dev Biol. 2013 Feb 01; 374(1):153-63. PMID: 23142317; PMCID: PMC3580293.
      View in: PubMed, PubMed Central
    34. Morán I, Akerman I, van de Bunt M, Xie R, Benazra M, Nammo T, Arnes L, Nakic N, García-Hurtado J, Rodríguez-Seguí S, Pasquali L, Sauty-Colace C, Beucher A, Scharfmann R, van Arensbergen J, Johnson PR, Berry A, Lee C, Harkins T, Gmyr V, Pattou F, Kerr-Conte J, Piemonti L, Berney T, Hanley N, Gloyn AL, Sussel L, Langman L, Brayman KL, Sander M, McCarthy MI, Ravassard P, Ferrer J. Human ß cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab. 2012 Oct 03; 16(4):435-48. PMID: 23040067.
      View in: PubMed
    35. Xuan S, Borok MJ, Decker KJ, Battle MA, Duncan SA, Hale MA, Macdonald RJ, Sussel L. Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest. 2012 Oct; 122(10):3516-28. PMID: 23006325; PMCID: PMC3461916.
      View in: PubMed, PubMed Central
    36. Talchai C, Xuan S, Lin HV, Sussel L, Accili D. Pancreatic ß cell dedifferentiation as a mechanism of diabetic ß cell failure. Cell. 2012 Sep 14; 150(6):1223-34. PMID: 22980982; PMCID: PMC3445031.
      View in: PubMed, PubMed Central
    37. Sussel L. Advances in pancreas development: generation informs regeneration. Semin Cell Dev Biol. 2012 Aug; 23(6):655. PMID: 22749955; PMCID: PMC3873867.
      View in: PubMed, PubMed Central
    38. Arnes L, Leclerc K, Friel JM, Hipkens SB, Magnuson MA, Sussel L. Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Genesis. 2012 Aug; 50(8):612-24. PMID: 22539496; PMCID: PMC3421046.
      View in: PubMed, PubMed Central
    39. Mastracci TL, Sussel L. The endocrine pancreas: insights into development, differentiation, and diabetes. Wiley Interdiscip Rev Dev Biol. 2012 Sep-Oct; 1(5):609-28. PMID: 23799564.
      View in: PubMed
    40. Mastracci TL, Sussel L. The Endocrine Pancreas: insights into development, differentiation and diabetes. Wiley Interdiscip Rev Membr Transp Signal. 2012 Sep; 1(5):609-628. PMID: 22905335.
      View in: PubMed
    41. Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L. Nkx2.2 repressor complex regulates islet ß-cell specification and prevents ß-to-a-cell reprogramming. Genes Dev. 2011 Nov 01; 25(21):2291-305. PMID: 22056672; PMCID: PMC3219233.
      View in: PubMed, PubMed Central
    42. Mastracci TL, Wilcox CL, Arnes L, Panea C, Golden JA, May CL, Sussel L. Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol. 2011 Nov 01; 359(1):1-11. PMID: 21856296; PMCID: PMC3192309.
      View in: PubMed, PubMed Central
    43. Anderson KR, Singer RA, Balderes DA, Hernandez-Lagunas L, Johnson CW, Artinger KB, Sussel L. The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Development. 2011 Aug; 138(15):3213-24. PMID: 21750032; PMCID: PMC3133913.
      View in: PubMed, PubMed Central
    44. Hill JT, Anderson KR, Mastracci TL, Kaestner KH, Sussel L. Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas. BMC Bioinformatics. 2011 Feb 25; 12:62. PMID: 21352540; PMCID: PMC3050729.
      View in: PubMed, PubMed Central
    45. Jeong Y, Dolson DK, Waclaw RR, Matise MP, Sussel L, Campbell K, Kaestner KH, Epstein DJ. Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity. Development. 2011 Feb; 138(3):531-41. PMID: 21205797; PMCID: PMC3014638.
      View in: PubMed, PubMed Central
    46. Lek M, Dias JM, Marklund U, Uhde CW, Kurdija S, Lei Q, Sussel L, Rubenstein JL, Matise MP, Arnold HH, Jessell TM, Ericson J. A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development. 2010 Dec; 137(23):4051-60. PMID: 21062862.
      View in: PubMed
    47. Raum JC, Hunter CS, Artner I, Henderson E, Guo M, Elghazi L, Sosa-Pineda B, Ogihara T, Mirmira RG, Sussel L, Stein R. Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Mol Cell Biol. 2010 Sep; 30(17):4234-44. PMID: 20584984; PMCID: PMC2937551.
      View in: PubMed, PubMed Central
    48. Gu C, Stein GH, Pan N, Goebbels S, Hörnberg H, Nave KA, Herrera P, White P, Kaestner KH, Sussel L, Lee JE. Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metab. 2010 Apr 07; 11(4):298-310. PMID: 20374962; PMCID: PMC2855640.
      View in: PubMed, PubMed Central
    49. Anderson KR, White P, Kaestner KH, Sussel L. Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. BMC Dev Biol. 2009 Dec 10; 9:65. PMID: 20003319; PMCID: PMC2799404.
      View in: PubMed, PubMed Central
    50. Hill JT, Chao CS, Anderson KR, Kaufman F, Johnson CW, Sussel L. Nkx2.2 activates the ghrelin promoter in pancreatic islet cells. Mol Endocrinol. 2010 Feb; 24(2):381-90. PMID: 19965928; PMCID: PMC2817598.
      View in: PubMed, PubMed Central
    51. Roybon L, Mastracci TL, Ribeiro D, Sussel L, Brundin P, Li JY. GABAergic differentiation induced by Mash1 is compromised by the bHLH proteins Neurogenin2, NeuroD1, and NeuroD2. Cereb Cortex. 2010 May; 20(5):1234-44. PMID: 19767311.
      View in: PubMed
    52. Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L. Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem. 2009 Nov 06; 284(45):31236-48. PMID: 19759004; PMCID: PMC2781522.
      View in: PubMed, PubMed Central
    53. Prakash N, Puelles E, Freude K, Trümbach D, Omodei D, Di Salvio M, Sussel L, Ericson J, Sander M, Simeone A, Wurst W. Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development. 2009 Aug; 136(15):2545-55. PMID: 19592574; PMCID: PMC2729334.
      View in: PubMed, PubMed Central
    54. Hill JT, Mastracci TL, Vinton C, Doyle ML, Anderson KR, Loomis ZL, Schrunk JM, Minic AD, Prabakar KR, Pugliese A, Sun Y, Smith RG, Sussel L. Ghrelin is dispensable for embryonic pancreatic islet development and differentiation. Regul Pept. 2009 Oct 09; 157(1-3):51-6. PMID: 19268691; PMCID: PMC2828774.
      View in: PubMed, PubMed Central
    55. Jedlicka P, Sui X, Sussel L, Gutierrez-Hartmann A. Ets transcription factors control epithelial maturation and transit and crypt-villus morphogenesis in the mammalian intestine. Am J Pathol. 2009 Apr; 174(4):1280-90. PMID: 19264912; PMCID: PMC2671360.
      View in: PubMed, PubMed Central
    56. Chao CS, Loomis ZL, Lee JE, Sussel L. Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol. 2007 Dec 15; 312(2):523-32. PMID: 17988662; PMCID: PMC2174610.
      View in: PubMed, PubMed Central
    57. Desai S, Loomis Z, Pugh-Bernard A, Schrunk J, Doyle MJ, Minic A, McCoy E, Sussel L. Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine. Dev Biol. 2008 Jan 01; 313(1):58-66. PMID: 18022152; PMCID: PMC2238176.
      View in: PubMed, PubMed Central
    58. Doyle MJ, Sussel L. Nkx2.2 regulates beta-cell function in the mature islet. Diabetes. 2007 Aug; 56(8):1999-2007. PMID: 17456846; PMCID: PMC2805073.
      View in: PubMed, PubMed Central
    59. Doyle MJ, Loomis ZL, Sussel L. Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet. Development. 2007 Feb; 134(3):515-23. PMID: 17202186; PMCID: PMC2805074.
      View in: PubMed, PubMed Central
    60. Raum JC, Gerrish K, Artner I, Henderson E, Guo M, Sussel L, Schisler JC, Newgard CB, Stein R. FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Mol Cell Biol. 2006 Aug; 26(15):5735-43. PMID: 16847327; PMCID: PMC1592775.
      View in: PubMed, PubMed Central
    61. Decker K, Goldman DC, Grasch CL, Sussel L. Gata6 is an important regulator of mouse pancreas development. Dev Biol. 2006 Oct 15; 298(2):415-29. PMID: 16887115; PMCID: PMC2824170.
      View in: PubMed, PubMed Central
    62. Prakash N, Brodski C, Naserke T, Puelles E, Gogoi R, Hall A, Panhuysen M, Echevarria D, Sussel L, Weisenhorn DM, Martinez S, Arenas E, Simeone A, Wurst W. A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development. 2006 Jan; 133(1):89-98. PMID: 16339193.
      View in: PubMed
    63. Doyle MJ, Sussel L. Engineering islets: lessons from stem cells and embryonic development. Endocrinol Metab Clin North Am. 2004 Mar; 33(1):149-62, x. PMID: 15053900.
      View in: PubMed
    64. Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L. Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):2924-9. PMID: 14970313; PMCID: PMC365721.
      View in: PubMed, PubMed Central
    65. Wang J, Elghazi L, Parker SE, Kizilocak H, Asano M, Sussel L, Sosa-Pineda B. The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Dev Biol. 2004 Feb 01; 266(1):178-89. PMID: 14729487.
      View in: PubMed
    66. Cissell MA, Zhao L, Sussel L, Henderson E, Stein R. Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. J Biol Chem. 2003 Jan 10; 278(2):751-6. PMID: 12426319.
      View in: PubMed
    67. Qi Y, Cai J, Wu Y, Wu R, Lee J, Fu H, Rao M, Sussel L, Rubenstein J, Qiu M. Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor. Development. 2001 Jul; 128(14):2723-33. PMID: 11526078.
      View in: PubMed
    68. Sander M, Sussel L, Conners J, Scheel D, Kalamaras J, Dela Cruz F, Schwitzgebel V, Hayes-Jordan A, German M. Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development. 2000 Dec; 127(24):5533-40. PMID: 11076772.
      View in: PubMed
    69. Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD, German MS. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development. 2000 Aug; 127(16):3533-42. PMID: 10903178.
      View in: PubMed
    70. Sussel L, Marin O, Kimura S, Rubenstein JL. Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development. 1999 Aug; 126(15):3359-70. PMID: 10393115.
      View in: PubMed
    71. Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM, Rubenstein JL, Ericson J. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature. 1999 Apr 15; 398(6728):622-7. PMID: 10217145.
      View in: PubMed
    72. Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI. Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese. Diabetes. 1998 Aug; 47(8):1356-8. PMID: 9703340.
      View in: PubMed
    73. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998 Jun; 125(12):2213-21. PMID: 9584121.
      View in: PubMed
    74. Qiu M, Shimamura K, Sussel L, Chen S, Rubenstein JL. Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development. Mech Dev. 1998 Mar; 72(1-2):77-88. PMID: 9533954.
      View in: PubMed
    75. Sussel L, Vannier D, Shore D. Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure. Genetics. 1995 Nov; 141(3):873-88. PMID: 8582633; PMCID: PMC1206851.
      View in: PubMed, PubMed Central
    76. Sussel L, Vannier D, Shore D. Epigenetic switching of transcriptional states: cis- and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae. Mol Cell Biol. 1993 Jul; 13(7):3919-28. PMID: 8321199; PMCID: PMC359929.
      View in: PubMed, PubMed Central
    77. Hardy CF, Sussel L, Shore D. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev. 1992 May; 6(5):801-14. PMID: 1577274.
      View in: PubMed
    78. Sussel L, Shore D. Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7749-53. PMID: 1881914; PMCID: PMC52380.
      View in: PubMed, PubMed Central
    Sussel's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (288) concept(s)
    _
    Co-Authors Expand Description
    See all (5) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department
    Physical Neighbors Expand Description
    _

    Copyright © 2017 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.10.0)