Lori Gail Sussel
Title | Professor |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-BDC Basic Research |
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Phone | 303/724-9119 |
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Research U01DK127505 (SUSSEL, LORI)Sep 15, 2020 - Jun 30, 2024 NIH Alternative RNA splicing events contribute to the onset of islet dysfunction in T1D Role: Principal Investigator |
| R01DK125360 (SUSSEL, LORI)Jul 1, 2020 - Apr 30, 2024 NIH PTPN2 mutations affect islet beta cell susceptibility in T1D Role: Principal Investigator |
| P30DK116073 (SUSSEL, LORI)Apr 1, 2020 - Mar 31, 2025 NIH UC Denver Diabetes Research Center Role: Principal Investigator |
| R01DK118155 (GADUE, PAUL J)Jul 1, 2018 - May 31, 2022 NIH Intersection of signaling pathways and transcription factors regulating islet development Role: Co-Principal Investigator |
| R01DK111405 (SUSSEL, LORI)Jul 1, 2017 - Jun 30, 2021 NIH Long non-coding RNAs in Islet Cell Biology Role: Principal Investigator |
| UC4DK108101 (ANSONG, CHARLES K)Sep 22, 2015 - Sep 21, 2019 NIH Single Cell Resolution Omics Analysis of T1D islets Role: Co-Principal Investigator |
| R21CA188059 (SUSSEL, LORI)Sep 1, 2014 - Aug 31, 2016 NIH Long non-coding RNAs in pancreatic cancer Role: Principal Investigator |
| DP3DK094400 (CLYNES, RAPHAEL A)Sep 20, 2011 - Aug 31, 2015 NIH Epigenetic events underlying Type I diabetes Role: Co-Principal Investigator |
| R01DK087711 (SUSSEL, LORI)Sep 20, 2010 - Jun 30, 2016 NIH Regulation of exocrine pancreas formation Role: Principal Investigator |
| R01DK082590 (SUSSEL, LORI)Jan 1, 2009 - Jul 31, 2022 NIH Regulation of Pancreatic Islet Cell Fate Role: Principal Investigator |
| U01DK072504 (SUSSEL, LORI)Aug 1, 2005 - Jul 31, 2010 NIH Defining the roles of Nkx2.2 and NeuroD in regulating islet cell fate Role: Principal Investigator |
| R01DK064146 (SUSSEL, LORI)Jun 1, 2003 - Mar 31, 2009 NIH The role of Gata 4 in exocrine pancreas development Role: Principal Investigator |
| R21DK061422 (SUSSEL, LORI)May 15, 2002 - Apr 30, 2004 NIH Nkx2.2 and Gata6: regulation of islet development Role: Principal Investigator |
| R21DK061151 (SUSSEL, LORI)Sep 30, 2001 - Aug 31, 2003 NIH Transcriptional regulation of exocrine development Role: Principal Investigator |
| F32NS010184 (SUSSEL, LORI)Dec 1, 1996 NIH GENETIC ANALYSIS OF MOUSE NKX-21 AND NKX-22 GENES Role: Principal Investigator |
Bibliographic
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Russ HA, Shilleh AH, Sussel L. From the dish to humans: A stem cell recipe for success. Cell Metab. 2022 02 01; 34(2):193-196. PMID: 35108510.
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Sandoval DA, Alonso LC, Gannon M, Sander M, Sussel L, Reusch JEB. Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent. Diabetes Care. 2021 08; 44(8):1744-1747. PMID: 34131046.
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Hudish LI, Bubak A, Triolo TM, Niemeyer CS, Lorberbaum DS, Sussel L, Nagel M, Taliaferro JM, Russ HA. Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System. Stem Cell Reports. 2021 Apr 13; 16(4):1009. PMID: 33852882.
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Kim YK, Sussel L, Davidson HW. Inherent Beta Cell Dysfunction Contributes to Autoimmune Susceptibility. Biomolecules. 2021 03 30; 11(4). PMID: 33808310.
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Docherty FM, Sussel L. Islet Regeneration: Endogenous and Exogenous Approaches. Int J Mol Sci. 2021 Mar 24; 22(7). PMID: 33804882.
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Li F, Hu D, Dieter C, Ansong C, Sussel L, Orr G. Single Molecule-Based fliFISH Validates Radial and Heterogeneous Gene Expression Patterns in Pancreatic Islet ß-Cells. Diabetes. 2021 05; 70(5):1117-1122. PMID: 33685924.
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Moss ND, Sussel L. mRNA Processing: An Emerging Frontier in the Regulation of Pancreatic ß Cell Function. Front Genet. 2020; 11:983. PMID: 33088281.
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Pajvani UB, Sussel L. An Ultradian Notch in Beta-Cell Development. N Engl J Med. 2020 07 02; 383(1):80-82. PMID: 32609988.
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Lorberbaum DS, Kishore S, Rosselot C, Sarbaugh D, Brooks EP, Aragon E, Xuan S, Simon O, Ghosh D, Mendelsohn C, Gadue P, Sussel L. Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human ß cell specification. Development. 2020 06 22; 147(12). PMID: 32467243.
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Hudish LI, Bubak A, Triolo TM, Niemeyer CS, Lorberbaum DS, Sussel L, Nagel M, Taliaferro JM, Russ HA. Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System. Stem Cell Reports. 2020 06 09; 14(6):1033-1043. PMID: 32386561.
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Lorberbaum DS, Docherty FM, Sussel L. Animal Models of Pancreas Development, Developmental Disorders, and Disease. Adv Exp Med Biol. 2020; 1236:65-85. PMID: 32304069.
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Hudish LI, Reusch JE, Sussel L. ß Cell dysfunction during progression of metabolic syndrome to type 2 diabetes. J Clin Invest. 2019 10 01; 129(10):4001-4008. PMID: 31424428.
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Romer AI, Singer RA, Sui L, Egli D, Sussel L. Murine Perinatal ß-Cell Proliferation and the Differentiation of Human Stem Cell-Derived Insulin-Expressing Cells Require NEUROD1. Diabetes. 2019 12; 68(12):2259-2271. PMID: 31519700.
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Hudish LI, Lorberbaum DS, Sussel L. FISHing for ß Cells. Dev Cell. 2019 01 07; 48(1):7-8. PMID: 30620904.
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Bartolome A, Zhu C, Sussel L, Pajvani UB. Notch signaling dynamically regulates adult ß cell proliferation and maturity. J Clin Invest. 2019 01 02; 129(1):268-280. PMID: 30375986.
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Font-Cunill B, Arnes L, Ferrer J, Sussel L, Beucher A. Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes. Front Genet. 2018; 9:524. PMID: 30459811.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 29718662.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 29937433.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 31607563.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 32208161.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 32864533.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 33658226.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 35381060.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 1577274.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9584121.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11526078.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 14970313.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19965928.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19767311.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 20374962.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 24449836.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 23408910.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 26030886.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25692923.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 24651796.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25812926.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 26687508.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 26492922.
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Arnes L, Liu Z, Wang J, Maurer C, Sagalovskiy I, Sanchez-Martin M, Bommakanti N, Garofalo DC, Balderes DA, Sussel L, Olive KP, Rabadan R. Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma. Gut. 2019 03; 68(3):499-511. PMID: 29440233.
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Cui Y, Hu D, Markillie LM, Chrisler WB, Gaffrey MJ, Ansong C, Sussel L, Orr G. Fluctuation localization imaging-based fluorescence in situ hybridization (fliFISH) for accurate detection and counting of RNA copies in single cells. Nucleic Acids Res. 2018 01 25; 46(2):e7. PMID: 29040675.
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Lorberbaum DS, Sussel L. Gotta Have GATA for Human Pancreas Development. Cell Stem Cell. 2017 05 04; 20(5):577-579. PMID: 28475878.
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Gutierrez GD, Gromada J, Sussel L. Heterogeneity of the Pancreatic Beta Cell. Front Genet. 2017; 8:22. PMID: 28321233.
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Churchill AJ, Gutiérrez GD, Singer RA, Lorberbaum DS, Fischer KA, Sussel L. Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development. Elife. 2017 01 10; 6. PMID: 28071588.
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Ediger BN, Lim HW, Juliana C, Groff DN, Williams LT, Dominguez G, Liu JH, Taylor BL, Walp ER, Kameswaran V, Yang J, Liu C, Hunter CS, Kaestner KH, Naji A, Li C, Sander M, Stein R, Sussel L, Won KJ, May CL, Stoffers DA. LIM domain-binding 1 maintains the terminally differentiated state of pancreatic ß cells. J Clin Invest. 2017 01 03; 127(1):215-229. PMID: 27941246.
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Gutiérrez GD, Bender AS, Cirulli V, Mastracci TL, Kelly SM, Tsirigos A, Kaestner KH, Sussel L. Pancreatic ß cell identity requires continual repression of non-ß cell programs. J Clin Invest. 2017 01 03; 127(1):244-259. PMID: 27941248.
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Gross S, Garofalo DC, Balderes DA, Mastracci TL, Dias JM, Perlmann T, Ericson J, Sussel L. The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2. Development. 2016 07 15; 143(14):2616-28. PMID: 27287799.
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Xuan S, Sussel L. GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling. Development. 2016 Mar 01; 143(5):780-6. PMID: 26932670.
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Arnes L, Akerman I, Balderes DA, Ferrer J, Sussel L. ßlinc1 encodes a long noncoding RNA that regulates islet ß-cell formation and function. Genes Dev. 2016 Mar 01; 30(5):502-7. PMID: 26944677.
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Romer AI, Sussel L. Pancreatic islet cell development and regeneration. Curr Opin Endocrinol Diabetes Obes. 2015 Aug; 22(4):255-64. PMID: 26087337.
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Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH. Ghrelin. Mol Metab. 2015 Jun; 4(6):437-60. PMID: 26042199.
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Clark JK, O'keefe A, Mastracci TL, Sussel L, Matise MP, Kucenas S. Mammalian Nkx2.2+ perineurial glia are essential for motor nerve development. Dev Dyn. 2014 Sep; 243(9):1116-29. PMID: 24979729.
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Sussel L, Niswander L. Editorial overview: developmental mechanisms, patterning and evolution. Curr Opin Genet Dev. 2014 Aug; 27:v-vii. PMID: 24998023.
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Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC, Rhodes CJ, Sussel L, Weir GC. ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. Diabetes Care. 2014 Jun; 37(6):1751-8. PMID: 24812433.
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Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC, Rhodes CJ, Sussel L, Weir GC. ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. J Clin Endocrinol Metab. 2014 Jun; 99(6):1983-92. PMID: 24712577.
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Balderes DA, Magnuson MA, Sussel L. Nkx2.2:Cre knock-in mouse line: a novel tool for pancreas- and CNS-specific gene deletion. Genesis. 2013 Dec; 51(12):844-51. PMID: 23996959.
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Suissa Y, Magenheim J, Stolovich-Rain M, Hija A, Collombat P, Mansouri A, Sussel L, Sosa-Pineda B, McCracken K, Wells JM, Heller RS, Dor Y, Glaser B. Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas. PLoS One. 2013; 8(8):e70397. PMID: 23940571.
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Mastracci TL, Lin CS, Sussel L. Generation of mice encoding a conditional allele of Nkx2.2. Transgenic Res. 2013 Oct; 22(5):965-72. PMID: 23494546.
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Lugani F, Arora R, Papeta N, Patel A, Zheng Z, Sterken R, Singer RA, Caridi G, Mendelsohn C, Sussel L, Papaioannou VE, Gharavi AG. A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse. PLoS Genet. 2013; 9(2):e1003206. PMID: 23437001.
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Arnes L, Hill JT, Gross S, Magnuson MA, Sussel L. Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. PLoS One. 2012; 7(12):e52026. PMID: 23251675.
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Ioannou M, Serafimidis I, Arnes L, Sussel L, Singh S, Vasiliou V, Gavalas A. ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Dev Biol. 2013 Feb 01; 374(1):153-63. PMID: 23142317.
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Morán I, Akerman I, van de Bunt M, Xie R, Benazra M, Nammo T, Arnes L, Nakic N, García-Hurtado J, Rodríguez-Seguí S, Pasquali L, Sauty-Colace C, Beucher A, Scharfmann R, van Arensbergen J, Johnson PR, Berry A, Lee C, Harkins T, Gmyr V, Pattou F, Kerr-Conte J, Piemonti L, Berney T, Hanley N, Gloyn AL, Sussel L, Langman L, Brayman KL, Sander M, McCarthy MI, Ravassard P, Ferrer J. Human ß cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab. 2012 Oct 03; 16(4):435-48. PMID: 23040067.
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Xuan S, Borok MJ, Decker KJ, Battle MA, Duncan SA, Hale MA, Macdonald RJ, Sussel L. Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest. 2012 Oct; 122(10):3516-28. PMID: 23006325.
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Talchai C, Xuan S, Lin HV, Sussel L, Accili D. Pancreatic ß cell dedifferentiation as a mechanism of diabetic ß cell failure. Cell. 2012 Sep 14; 150(6):1223-34. PMID: 22980982.
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Sussel L. Advances in pancreas development: generation informs regeneration. Semin Cell Dev Biol. 2012 Aug; 23(6):655. PMID: 22749955.
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Arnes L, Leclerc K, Friel JM, Hipkens SB, Magnuson MA, Sussel L. Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Genesis. 2012 Aug; 50(8):612-24. PMID: 22539496.
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Mastracci TL, Sussel L. The endocrine pancreas: insights into development, differentiation, and diabetes. Wiley Interdiscip Rev Dev Biol. 2012 Sep-Oct; 1(5):609-28. PMID: 23799564.
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Mastracci TL, Sussel L. The Endocrine Pancreas: insights into development, differentiation and diabetes. Wiley Interdiscip Rev Membr Transp Signal. 2012 Sep; 1(5):609-628. PMID: 22905335.
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Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L. Nkx2.2 repressor complex regulates islet ß-cell specification and prevents ß-to-a-cell reprogramming. Genes Dev. 2011 Nov 01; 25(21):2291-305. PMID: 22056672.
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Mastracci TL, Wilcox CL, Arnes L, Panea C, Golden JA, May CL, Sussel L. Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol. 2011 Nov 01; 359(1):1-11. PMID: 21856296.
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Anderson KR, Singer RA, Balderes DA, Hernandez-Lagunas L, Johnson CW, Artinger KB, Sussel L. The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Development. 2011 Aug; 138(15):3213-24. PMID: 21750032.
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Hill JT, Anderson KR, Mastracci TL, Kaestner KH, Sussel L. Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas. BMC Bioinformatics. 2011 Feb 25; 12:62. PMID: 21352540.
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Jeong Y, Dolson DK, Waclaw RR, Matise MP, Sussel L, Campbell K, Kaestner KH, Epstein DJ. Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity. Development. 2011 Feb; 138(3):531-41. PMID: 21205797.
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Lek M, Dias JM, Marklund U, Uhde CW, Kurdija S, Lei Q, Sussel L, Rubenstein JL, Matise MP, Arnold HH, Jessell TM, Ericson J. A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development. 2010 Dec; 137(23):4051-60. PMID: 21062862.
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Raum JC, Hunter CS, Artner I, Henderson E, Guo M, Elghazi L, Sosa-Pineda B, Ogihara T, Mirmira RG, Sussel L, Stein R. Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Mol Cell Biol. 2010 Sep; 30(17):4234-44. PMID: 20584984.
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Anderson KR, White P, Kaestner KH, Sussel L. Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. BMC Dev Biol. 2009 Dec 10; 9:65. PMID: 20003319.
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Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L. Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem. 2009 Nov 06; 284(45):31236-48. PMID: 19759004.
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Prakash N, Puelles E, Freude K, Trümbach D, Omodei D, Di Salvio M, Sussel L, Ericson J, Sander M, Simeone A, Wurst W. Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development. 2009 Aug; 136(15):2545-55. PMID: 19592574.
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Hill JT, Mastracci TL, Vinton C, Doyle ML, Anderson KR, Loomis ZL, Schrunk JM, Minic AD, Prabakar KR, Pugliese A, Sun Y, Smith RG, Sussel L. Ghrelin is dispensable for embryonic pancreatic islet development and differentiation. Regul Pept. 2009 Oct 09; 157(1-3):51-6. PMID: 19268691.
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Jedlicka P, Sui X, Sussel L, Gutierrez-Hartmann A. Ets transcription factors control epithelial maturation and transit and crypt-villus morphogenesis in the mammalian intestine. Am J Pathol. 2009 Apr; 174(4):1280-90. PMID: 19264912.
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Chao CS, Loomis ZL, Lee JE, Sussel L. Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol. 2007 Dec 15; 312(2):523-32. PMID: 17988662.
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Desai S, Loomis Z, Pugh-Bernard A, Schrunk J, Doyle MJ, Minic A, McCoy E, Sussel L. Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine. Dev Biol. 2008 Jan 01; 313(1):58-66. PMID: 18022152.
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Doyle MJ, Sussel L. Nkx2.2 regulates beta-cell function in the mature islet. Diabetes. 2007 Aug; 56(8):1999-2007. PMID: 17456846.
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Doyle MJ, Loomis ZL, Sussel L. Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet. Development. 2007 Feb; 134(3):515-23. PMID: 17202186.
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Raum JC, Gerrish K, Artner I, Henderson E, Guo M, Sussel L, Schisler JC, Newgard CB, Stein R. FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Mol Cell Biol. 2006 Aug; 26(15):5735-43. PMID: 16847327.
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Decker K, Goldman DC, Grasch CL, Sussel L. Gata6 is an important regulator of mouse pancreas development. Dev Biol. 2006 Oct 15; 298(2):415-29. PMID: 16887115.
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Prakash N, Brodski C, Naserke T, Puelles E, Gogoi R, Hall A, Panhuysen M, Echevarria D, Sussel L, Weisenhorn DM, Martinez S, Arenas E, Simeone A, Wurst W. A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development. 2006 Jan; 133(1):89-98. PMID: 16339193.
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Doyle MJ, Sussel L. Engineering islets: lessons from stem cells and embryonic development. Endocrinol Metab Clin North Am. 2004 Mar; 33(1):149-62, x. PMID: 15053900.
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Wang J, Elghazi L, Parker SE, Kizilocak H, Asano M, Sussel L, Sosa-Pineda B. The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Dev Biol. 2004 Feb 01; 266(1):178-89. PMID: 14729487.
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Cissell MA, Zhao L, Sussel L, Henderson E, Stein R. Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. J Biol Chem. 2003 Jan 10; 278(2):751-6. PMID: 12426319.
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Sander M, Sussel L, Conners J, Scheel D, Kalamaras J, Dela Cruz F, Schwitzgebel V, Hayes-Jordan A, German M. Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development. 2000 Dec; 127(24):5533-40. PMID: 11076772.
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Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD, German MS. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development. 2000 Aug; 127(16):3533-42. PMID: 10903178.
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Sussel L, Marin O, Kimura S, Rubenstein JL. Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development. 1999 Aug; 126(15):3359-70. PMID: 10393115.
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Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM, Rubenstein JL, Ericson J. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature. 1999 Apr 15; 398(6728):622-7. PMID: 10217145.
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Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI. Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese. Diabetes. 1998 Aug; 47(8):1356-8. PMID: 9703340.
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Qiu M, Shimamura K, Sussel L, Chen S, Rubenstein JL. Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development. Mech Dev. 1998 Mar; 72(1-2):77-88. PMID: 9533954.
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Sussel L, Vannier D, Shore D. Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure. Genetics. 1995 Nov; 141(3):873-88. PMID: 8582633.
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Sussel L, Vannier D, Shore D. Epigenetic switching of transcriptional states: cis- and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae. Mol Cell Biol. 1993 Jul; 13(7):3919-28. PMID: 8321199.
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Sussel L, Shore D. Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7749-53. PMID: 1881914.
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Year | Publications |
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1993 | 1 | 1995 | 1 | 1998 | 2 | 1999 | 2 | 2000 | 2 | 2002 | 1 | 2004 | 2 | 2006 | 3 | 2007 | 4 | 2009 | 5 | 2010 | 2 | 2011 | 5 | 2012 | 9 | 2013 | 4 | 2014 | 4 | 2015 | 2 | 2016 | 5 | 2017 | 3 | 2018 | 26 | 2019 | 3 | 2020 | 5 | 2021 | 5 | 2022 | 1 |
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