Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

Jason Aoto

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PHARM General Operations

    Collapse Research 
    Collapse research activities and funding
    R21MH140328     (AOTO, JASON)Apr 1, 2025 - Mar 31, 2027
    NIH
    The identification and interrogation of novel intracellular proteins that underlie the distinct nanoscopic architecture of Neurexin-1 and Neurexin-3
    Role: Principal Investigator
    R21MH129620     (AOTO, JASON)Mar 4, 2022 - Feb 29, 2024
    NIH
    Control of subsynaptic domain organization and nanocolumn alignment by neurexin-3
    Role: Principal Investigator
    R01MH116901     (AOTO, JASON)Jun 1, 2018 - Apr 30, 2024
    NIH
    Functional and mechanistic interrogation of alpha neurexin extracellular domains
    Role: Principal Investigator
    R00MH103531     (AOTO, JASON)Feb 24, 2016 - Dec 31, 2019
    NIH
    Synaptic Dissection of Cell Adhesion Molecule Function within Subicular Circuits
    Role: Principal Investigator
    K99MH103531     (AOTO, JASON)Apr 1, 2014 - Mar 31, 2016
    NIH
    Synaptic Dissection of Cell Adhesion Molecule Function within Subicular Circuits
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Stokes EG, Vasquez JJ, Azouz G, Nguyen M, Tierno A, Zhuang Y, Galinato VM, Hui M, Toledano M, Tyler I, Shi X, Hunt RF, Aoto J, Beier KT. Cationic peptides cause memory loss through endophilin-mediated endocytosis. Nature. 2025 Feb; 638(8050):479-489. PMID: 39814881.
      View in: PubMed
    2. Kareemo DJ, Winborn CS, Olah SS, Miller CN, Kim J, Kadgien CA, Actor-Engel HS, Ramsay HJ, Ramsey AM, Aoto J, Kennedy MJ. Genetically encoded intrabody probes for labeling and manipulating AMPA-type glutamate receptors. Nat Commun. 2024 11 29; 15(1):10374. PMID: 39613728.
      View in: PubMed
    3. Stokes EG, Kim H, Ko J, Aoto J. A Systematic Structure-Function Characterization of a Human Mutation in Neurexin-3a Reveals an Extracellular Modulatory Sequence That Stabilizes Neuroligin-1 Binding to Enhance the Postsynaptic Properties of Excitatory Synapses. J Neurosci. 2024 Oct 09; 44(41). PMID: 39231636.
      View in: PubMed
    4. Tian G, Bartas K, Hui M, Chen L, Vasquez JJ, Azouz G, Derdeyn P, Manville RW, Ho EL, Fang AS, Li Y, Tyler I, Setola V, Aoto J, Abbott GW, Beier KT. Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity. Neuron. 2024 Oct 23; 112(20):3470-3485.e12. PMID: 39153478.
      View in: PubMed
    5. Miller CN, Li Y, Beier KT, Aoto J. Acute stress causes sex-dependent changes to ventral subiculum synapses, circuitry, and anxiety-like behavior. bioRxiv. 2024 Aug 03. PMID: 39131353.
      View in: PubMed
    6. Tian G, Bartas K, Hui M, Chen L, Vasquez JJ, Azouz G, Derdeyn P, Manville RW, Ho EL, Fang AS, Li Y, Tyler I, Setola V, Aoto J, Abbott GW, Beier KT. Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity. bioRxiv. 2024 May 30. PMID: 38853899.
      View in: PubMed
    7. Dai J, Aoto J, S?dhof TC. Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses. Neuron. 2024 Feb 07; 112(3):515-519. PMID: 38330900.
      View in: PubMed
    8. Stokes E, Zhuang Y, Toledano M, Vasquez J, Azouz G, Hui M, Tyler I, Shi X, Aoto J, Beier KT. Cationic peptides erase memories by removing synaptic AMPA receptors through endophilin-mediated endocytosis. Res Sq. 2023 Nov 21. PMID: 38045269.
      View in: PubMed
    9. Olah SS, Kareemo DJ, Buchta WC, Sinnen BL, Miller CN, Actor-Engel HS, Gookin SE, Winborn CS, Kleinjan MS, Crosby KC, Aoto J, Smith KR, Kennedy MJ. Acute reorganization of postsynaptic GABAA receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses. Cell Rep. 2023 11 28; 42(11):113331. PMID: 37910506.
      View in: PubMed
    10. Tullis JE, Larsen ME, Rumian NL, Freund RK, Boxer EE, Brown CN, Coultrap SJ, Schulman H, Aoto J, Dell'Acqua ML, Bayer KU. LTP induction by structural rather than enzymatic functions of CaMKII. Nature. 2023 Sep; 621(7977):146-153. PMID: 37648853.
      View in: PubMed
    11. Lloyd BA, Han Y, Roth R, Zhang B, Aoto J. Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus. Nat Commun. 2023 08 05; 14(1):4706. PMID: 37543682.
      View in: PubMed
    12. Boxer EE, Kim J, Dunn B, Aoto J. Ventral Subiculum Inputs to Nucleus Accumbens Medial Shell Preferentially Innervate D2R Medium Spiny Neurons and Contain Calcium Permeable AMPARs. J Neurosci. 2023 02 15; 43(7):1166-1177. PMID: 36609456.
      View in: PubMed
    13. Boxer EE, Aoto J. Neurexins and their ligands at inhibitory synapses. Front Synaptic Neurosci. 2022; 14:1087238. PMID: 36618530.
      View in: PubMed
    14. Boxer EE, Seng C, Lukacsovich D, Kim J, Schwartz S, Kennedy MJ, F?ldy C, Aoto J. Neurexin-3 defines synapse- and sex-dependent diversity of GABAergic inhibition in ventral subiculum. Cell Rep. 2021 12 07; 37(10):110098. PMID: 34879268.
      View in: PubMed
    15. Mermer F, Poliquin S, Rigsby K, Rastogi A, Shen W, Romero-Morales A, Nwosu G, McGrath P, Demerast S, Aoto J, Bilousova G, Lal D, Gama V, Kang JQ. Common molecular mechanisms of SLC6A1 variant-mediated neurodevelopmental disorders in astrocytes and neurons. Brain. 2021 09 04; 144(8):2499-2512. PMID: 34028503.
      View in: PubMed
    16. Cai Y, Nielsen BE, Boxer EE, Aoto J, Ford CP. Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments. Neuron. 2021 04 07; 109(7):1137-1149.e5. PMID: 33600762.
      View in: PubMed
    17. Restrepo S, Schwartz SL, Kennedy MJ, Aoto J. Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System. J Vis Exp. 2020 05 22; (159). PMID: 32510501.
      View in: PubMed
    18. Restrepo S, Langer NJ, Nelson KA, Aoto J. Modeling a Neurexin-3a Human Mutation in Mouse Neurons Identifies a Novel Role in the Regulation of Transsynaptic Signaling and Neurotransmitter Release at Excitatory Synapses. J Neurosci. 2019 11 13; 39(46):9065-9082. PMID: 31578233.
      View in: PubMed
    19. Meador K, Wysoczynski CL, Norris AJ, Aoto J, Bruchas MR, Tucker CL. Achieving tight control of a photoactivatable Cre recombinase gene switch: new design strategies and functional characterization in mammalian cells and rodent. Nucleic Acids Res. 2019 09 26; 47(17):e97. PMID: 31287871.
      View in: PubMed
    20. Dai J, Aoto J, S?dhof TC. Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses. Neuron. 2019 06 05; 102(5):993-1008.e5. PMID: 31005376.
      View in: PubMed
    21. Liu Q, Sinnen BL, Boxer EE, Schneider MW, Grybko MJ, Buchta WC, Gibson ES, Wysoczynski CL, Ford CP, Gottschalk A, Aoto J, Tucker CL, Kennedy MJ. A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission. Neuron. 2019 03 06; 101(5):863-875.e6. PMID: 30704911.
      View in: PubMed
    22. Purkey AM, Woolfrey KM, Crosby KC, Stich DG, Chick WS, Aoto J, Dell'Acqua ML. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP. Cell Rep. 2018 10 23; 25(4):974-987.e4. PMID: 30355502.
      View in: PubMed
    23. F?ldy C, Darmanis S, Aoto J, Malenka RC, Quake SR, S?dhof TC. Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):E5222-31. PMID: 27531958.
      View in: PubMed
    24. Pak C, Danko T, Zhang Y, Aoto J, Anderson G, Maxeiner S, Yi F, Wernig M, S?dhof TC. Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Cell Stem Cell. 2015 Sep 03; 17(3):316-28. PMID: 26279266.
      View in: PubMed
    25. Anderson GR, Aoto J, Tabuchi K, F?ldy C, Covy J, Yee AX, Wu D, Lee SJ, Chen L, Malenka RC, S?dhof TC. ?-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. Cell. 2015 Jul 30; 162(3):593-606. PMID: 26213384.
      View in: PubMed
    26. Aoto J, F?ldy C, Ilcus SM, Tabuchi K, S?dhof TC. Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses. Nat Neurosci. 2015 Jul; 18(7):997-1007. PMID: 26030848.
      View in: PubMed
    27. Chanda S, Aoto J, Lee SJ, Wernig M, S?dhof TC. Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking. Mol Psychiatry. 2016 Feb; 21(2):169-77. PMID: 25778475.
      View in: PubMed
    28. Aoto J, Martinelli DC, Malenka RC, Tabuchi K, S?dhof TC. Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking. Cell. 2013 Jul 03; 154(1):75-88. PMID: 23827676.
      View in: PubMed
    29. Anderson GR, Galfin T, Xu W, Aoto J, Malenka RC, S?dhof TC. Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):18120-5. PMID: 23074245.
      View in: PubMed
    30. Sarti F, Schroeder J, Aoto J, Chen L. Conditional RARa knockout mice reveal acute requirement for retinoic acid and RARa in homeostatic plasticity. Front Mol Neurosci. 2012; 5:16. PMID: 22419906.
      View in: PubMed
    31. Aoto J, Nam CI, Poon MM, Ting P, Chen L. Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity. Neuron. 2008 Oct 23; 60(2):308-20. PMID: 18957222.
      View in: PubMed
    32. Maghsoodi B, Poon MM, Nam CI, Aoto J, Ting P, Chen L. Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):16015-20. PMID: 18840692.
      View in: PubMed
    33. Aoto J, Ting P, Maghsoodi B, Xu N, Henkemeyer M, Chen L. Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation. J Neurosci. 2007 Jul 11; 27(28):7508-19. PMID: 17626212.
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    34. Aoto J, Chen L. Bidirectional ephrin/Eph signaling in synaptic functions. Brain Res. 2007 Dec 12; 1184:72-80. PMID: 17166489.
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    35. Sainson RC, Aoto J, Nakatsu MN, Holderfield M, Conn E, Koller E, Hughes CC. Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. FASEB J. 2005 Jun; 19(8):1027-9. PMID: 15774577.
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    36. Nakatsu MN, Sainson RC, P?rez-del-Pulgar S, Aoto JN, Aitkenhead M, Taylor KL, Carpenter PM, Hughes CC. VEGF(121) and VEGF(165) regulate blood vessel diameter through vascular endothelial growth factor receptor 2 in an in vitro angiogenesis model. Lab Invest. 2003 Dec; 83(12):1873-85. PMID: 14691306.
      View in: PubMed
    37. Nakatsu MN, Sainson RC, Aoto JN, Taylor KL, Aitkenhead M, P?rez-del-Pulgar S, Carpenter PM, Hughes CC. Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1. Microvasc Res. 2003 Sep; 66(2):102-12. PMID: 12935768.
      View in: PubMed
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