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Search Results to Rebecca E Schweppe

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Schweppe, Rebecca

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The investigation of molecular mechanisms and targeted therapies is critical to help us understand the causes of thyroid cancer, how the tumor grows and spreads, and how we can find new ways to treat advanced disease for which there is currently no cure. The deregulation of protein kinases plays a major role in promoting tumorigenesis in the majority of human cancers, including thyroid cancer, and targeting this deregulated activity has led to major breakthroughs in cancer therapy. The goals of Dr. Rebecca Schweppe’s lab are to understand the regulation and function of deregulated kinase pathways in thyroid cancer in order to develop more effective therapies. We use translational approaches using cell lines derived from thyroid tumors to understand why some tumors are sensitive or resistant to different kinase-directed therapies, with the goal of identifying predictive biomarkers of response, and improving clinical responses. Ultimately, these studies will identify rational and more specific therapies for patients with advanced thyroid cancer.

One or more keywords matched the following items that are connected to Schweppe, Rebecca

Item Type	Name
Academic Article	Inhibition of Src with AZD0530 reveals the Src-Focal Adhesion kinase complex as a novel therapeutic target in papillary and anaplastic thyroid cancer.
Academic Article	Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells.
Academic Article	Functional components of fibroblast growth factor (FGF) signal transduction in pituitary cells. Identification of FGF response elements in the prolactin gene.
Academic Article	Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5-mediated responses.
Academic Article	Monitoring post-translational modification of proteins with allosteric ribozymes.
Academic Article	Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma.
Academic Article	Distinct genetic alterations in the mitogen-activated protein kinase pathway dictate sensitivity of thyroid cancer cells to mitogen-activated protein kinase kinase 1/2 inhibition.
Academic Article	Targeted inhibition of Src kinase with dasatinib blocks thyroid cancer growth and metastasis.
Concept	MAP Kinase Signaling System
Concept	MAP Kinase Kinase 2
Concept	Protein-Tyrosine Kinases
Concept	Cyclin-Dependent Kinase 6
Concept	Calcium-Calmodulin-Dependent Protein Kinases
Concept	Mitogen-Activated Protein Kinase 7
Concept	Protein Kinase Inhibitors
Concept	Mitogen-Activated Protein Kinase 1
Concept	src-Family Kinases
Concept	Extracellular Signal-Regulated MAP Kinases
Concept	Focal Adhesion Protein-Tyrosine Kinases
Concept	Cyclin-Dependent Kinase 4
Concept	Mitogen-Activated Protein Kinase 3
Concept	Focal Adhesion Kinase 1
Concept	MAP Kinase Kinase 1
Academic Article	mTOR Inhibition promotes TTF1-dependent redifferentiation and restores iodine uptake in thyroid carcinoma cell lines.
Academic Article	Yes-mediated phosphorylation of focal adhesion kinase at tyrosine 861 increases metastatic potential of prostate cancer cells.
Academic Article	The Mitogen-Activated Protein Kinase Pathway Facilitates Resistance to the Src Inhibitor Dasatinib in Thyroid Cancer.
Academic Article	FAK Expression, Not Kinase Activity, Is a Key Mediator of Thyroid Tumorigenesis and Protumorigenic Processes.
Academic Article	Cytostatic Activity of Adenosine Triphosphate-Competitive Kinase Inhibitors in BRAF Mutant Thyroid Carcinoma Cells.
Grant	Targeting Focal Adhesion Kinase in Thyroid Cancer
Grant	The Regulation of the MAP Kinase Pathway and DNA Repair
Academic Article	Sustained activation of the AKT/mTOR and MAP kinase pathways mediate resistance to the Src inhibitor, dasatinib, in thyroid cancer.
Grant	Targeting FAK and Src in thyroid cancer
Academic Article	Resistance to Src inhibition alters the BRAF-mutant tumor secretome to promote an invasive phenotype and therapeutic escape through a FAK>p130Cas>c-Jun signaling axis.
Academic Article	Establishment and Characterization of Four Novel Thyroid Cancer Cell Lines and PDX Models Expressing the RET/PTC1 Rearrangement, BRAFV600E, or RASQ61R as Drivers.
Concept	Class I Phosphatidylinositol 3-Kinases
Concept	TOR Serine-Threonine Kinases
Grant	Targeting the Src Kinase Pathway in Thyroid Cancer
Academic Article	Molecular therapeutics for anaplastic thyroid cancer.
Academic Article	Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor-Resistant Melanoma.
Academic Article	Dasatinib and Trametinib Promote Anti-Tumor Metabolic Activity.
Academic Article	Fibronectin Contributes to a BRAF Inhibitor-driven Invasive Phenotype in Thyroid Cancer through EGR1, Which Can Be Blocked by Inhibition of ERK1/2.
Academic Article	AKT-independent signaling in PIK3CA-mutant thyroid cancer mediates resistance to dual SRC and MEK1/2 inhibition.

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