Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition.

Kadgien CA, Kamesh A, Milnerwood AJ. Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition. Mol Brain. 2021 09 16; 14(1):143.

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subject areas

Animals
Cells, Cultured
Dendrites
Endosomes
Gain of Function Mutation
Gene Knock-In Techniques
Glutamic Acid
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Mice
Mice, Inbred C57BL
Miniature Postsynaptic Potentials
Mutation, Missense
Nerve Tissue Proteins
Parkinson Disease
Patch-Clamp Techniques
Point Mutation
Protein Binding
Protein Interaction Mapping
rab GTP-Binding Proteins
Receptors, AMPA
Recombinant Proteins
Synapses
Vesicular Transport Proteins

authors with profiles

Chelsie Ayn Kadgien