Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Karin A. Payne

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-ORTHO General Operations
    Other Positions
    TitleDirector-Faculty
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-ORTHO General Operations


    Collapse Biography 
    Collapse education and training
    University of Pittsburgh, Pittsburgh, PAPhD04/2007Bioengineering

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    T32AR080630     (ZUSCIK, MICHAEL J)Jul 1, 2022 - Jun 30, 2027
    NIH
    Interdisciplinary Training in Musculoskeletal Research
    Role: Co-Principal Investigator
    R21HD092109     (PAYNE, KARIN A)Dec 1, 2017 - Nov 30, 2020
    NIH
    Physeal cartilage tissue engineering using mesenchymal stem cells directed towards chondrogenesis
    Role: Principal Investigator
    R33HD090696     (PAYNE, KARIN A)Mar 1, 2017 - Feb 28, 2022
    NIH
    Treatment of pediatric physeal injuries using a 3D printed biomimetic of growth plate cartilage
    Role: Principal Investigator
    R21HD090696     (PAYNE, KARIN A)Mar 1, 2017 - Feb 28, 2019
    NIH
    Treatment of pediatric physeal injuries using a 3D printed biomimetic of growth plate cartilage
    Role: Principal Investigator
    R03AR068087     (PAYNE, KARIN A)Mar 1, 2016 - Feb 29, 2020
    NIH
    Endogenous repair of growth plate injuries by local and sequential delivery of factors that inhibit osteogenesis and promote chondrogenesis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yamamura MK, Carry PM, Gibly RF, Holmes K, Ogilvie B, Phillips A, Georgopoulos G, Miller NH, Payne KA. Epidemiology of Physeal Fractures and Clinically Significant Growth Disturbances Affecting the Distal Tibia, Proximal Tibia, and Distal Femur: A Retrospective Cohort Study. J Am Acad Orthop Surg. 2023 Jun 01; 31(11):e507-e515. PMID: 37054395.
      View in: PubMed
    2. Yu Y, Fischenich KM, Schoonraad SA, Weatherford S, Uzcategui AC, Eckstein K, Muralidharan A, Crespo-Cuevas V, Rodriguez-Fontan F, Killgore JP, Li G, McLeod RR, Miller NH, Ferguson VL, Bryant SJ, Payne KA. A 3D printed mimetic composite for the treatment of growth plate injuries in a rabbit model. NPJ Regen Med. 2022 Oct 19; 7(1):60. PMID: 36261516.
      View in: PubMed
    3. Stager MA, Thomas SM, Rotello-Kuri N, Payne KA, Krebs MD. Polyelectrolyte Complex Hydrogels with Controlled Mechanics Affect Mesenchymal Stem Cell Differentiation Relevant to Growth Plate Injuries. Macromol Biosci. 2022 09; 22(9):e2200126. PMID: 35836324.
      View in: PubMed
    4. Payne KA, Shaw NM, Erickson CB, Yarger P, Yu Y, Baldini T, Kleck CJ, Patel VV, Burger EL. Blockade of Osteoclast-Mediated Bone Resorption With a RANKL-Inhibitor Enhances Bone Formation in a Rat Spinal Fusion Model. Spine (Phila Pa 1976). 2022 Aug 15; 47(16):1165-1171. PMID: 35797625.
      View in: PubMed
    5. Fuchs JR, Gibly RF, Erickson CB, Thomas SM, Hadley Miller N, Payne KA. Analysis of Physeal Fractures from the United States National Trauma Data Bank. Children (Basel). 2022 Jun 18; 9(6). PMID: 35740851.
      View in: PubMed
    6. Stager MA, Erickson CB, Payne KA, Krebs MD. Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications. J Vis Exp. 2022 04 13; (182). PMID: 35499351.
      View in: PubMed
    7. Fischenich KM, Schneider SE, Neu CP, Payne KA, Ferguson VL. Material properties and strain distribution patterns of bovine growth plate cartilage vary with anatomic location and depth. J Biomech. 2022 03; 134:111013. PMID: 35245713.
      View in: PubMed
    8. Thomas SM, Ackert-Bicknell CL, Zuscik MJ, Payne KA. Understanding the Transcriptomic Landscape to Drive New Innovations in Musculoskeletal Regenerative Medicine. Curr Osteoporos Rep. 2022 04; 20(2):141-152. PMID: 35156183.
      View in: PubMed
    9. Eckstein KN, Thomas SM, Scott AK, Neu CP, Hadley-Miller NA, Payne KA, Ferguson VL. The heterogeneous mechanical properties of adolescent growth plate cartilage: A study in rabbit. J Mech Behav Biomed Mater. 2022 04; 128:105102. PMID: 35203020.
      View in: PubMed
    10. Erickson C, Stager M, Riederer M, Payne KA, Krebs M. Emulsion-free chitosan-genipin microgels for growth plate cartilage regeneration. J Biomater Appl. 2021 08; 36(2):289-296. PMID: 33709832.
      View in: PubMed
    11. Erickson CB, Newsom JP, Fletcher NA, Yu Y, Rodriguez-Fontan F, Weatherford SA, Hadley-Miller N, Krebs MD, Payne KA. Anti-VEGF antibody delivered locally reduces bony bar formation following physeal injury in rats. J Orthop Res. 2021 08; 39(8):1658-1668. PMID: 33179297.
      View in: PubMed
    12. Erickson CB, Newsom JP, Fletcher NA, Feuer ZM, Yu Y, Rodriguez-Fontan F, Hadley Miller N, Krebs MD, Payne KA. In vivo degradation rate of alginate-chitosan hydrogels influences tissue repair following physeal injury. J Biomed Mater Res B Appl Biomater. 2020 08; 108(6):2484-2494. PMID: 32034881.
      View in: PubMed
    13. Aisenbrey EA, Bilousova G, Payne K, Bryant SJ. Dynamic mechanical loading and growth factors influence chondrogenesis of induced pluripotent mesenchymal progenitor cells in a cartilage-mimetic hydrogel. Biomater Sci. 2019 Nov 19; 7(12):5388-5403. PMID: 31626251.
      View in: PubMed
    14. Yu Y, Rodriguez-Fontan F, Eckstein K, Muralidharan A, Uzcategui AC, Fuchs JR, Weatherford S, Erickson CB, Bryant SJ, Ferguson VL, Hadley Miller N, Li G, Payne KA. Rabbit Model of Physeal Injury for the Evaluation of Regenerative Medicine Approaches. Tissue Eng Part C Methods. 2019 12; 25(12):701-710. PMID: 31552802.
      View in: PubMed
    15. Newsom JP, Payne KA, Krebs MD. Microgels: Modular, tunable constructs for tissue regeneration. Acta Biomater. 2019 04 01; 88:32-41. PMID: 30769137.
      View in: PubMed
    16. Pascual-Garrido C, Aisenbrey EA, Rodriguez-Fontan F, Payne KA, Bryant SJ, Goodrich LR. Photopolymerizable Injectable Cartilage Mimetic Hydrogel for the Treatment of Focal Chondral Lesions: A Proof of Concept Study in a Rabbit Animal Model. Am J Sports Med. 2019 01; 47(1):212-221. PMID: 30481048.
      View in: PubMed
    17. Chu CR, Fortier LA, Williams A, Payne KA, McCarrel TM, Bowers ME, Jaramillo D. Minimally Manipulated Bone Marrow Concentrate Compared with Microfracture Treatment of Full-Thickness Chondral Defects: A One-Year Study in an Equine Model. J Bone Joint Surg Am. 2018 Jan 17; 100(2):138-146. PMID: 29342064.
      View in: PubMed
    18. Pascual-Garrido C, Rodriguez-Fontan F, Aisenbrey EA, Payne KA, Chahla J, Goodrich LR, Bryant SJ. Current and novel injectable hydrogels to treat focal chondral lesions: Properties and applicability. J Orthop Res. 2018 01; 36(1):64-75. PMID: 28975658.
      View in: PubMed
    19. Shaw N, Erickson C, Bryant SJ, Ferguson VL, Krebs MD, Hadley-Miller N, Payne KA. Regenerative Medicine Approaches for the Treatment of Pediatric Physeal Injuries. Tissue Eng Part B Rev. 2018 04; 24(2):85-97. PMID: 28830302.
      View in: PubMed
    20. Rodriguez-Fontan F, Payne KA, Chahla J, Mei-Dan O, Richards A, Uchida S, Pascual-Garrido C. Viability and Tissue Quality of Cartilage Flaps From Patients With Femoroacetabular Hip Impingement: A Matched-Control Comparison. Orthop J Sports Med. 2017 Aug; 5(8):2325967117723608. PMID: 28868322.
      View in: PubMed
    21. Erickson CB, Shaw N, Hadley-Miller N, Riederer MS, Krebs MD, Payne KA. A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies. J Vis Exp. 2017 07 04; (125). PMID: 28715376.
      View in: PubMed
    22. Riederer MS, Requist BD, Payne KA, Way JD, Krebs MD. Injectable and microporous scaffold of densely-packed, growth factor-encapsulating chitosan microgels. Carbohydr Polym. 2016 11 05; 152:792-801. PMID: 27516331.
      View in: PubMed
    23. Patel VV, Payne K. Cellular Grafts for Bone Formation. Spine (Phila Pa 1976). 2016 Apr; 41 Suppl 7:S13. PMID: 27015059.
      View in: PubMed
    24. Lee HH, O'Malley MJ, Friel NA, Payne KA, Qiao C, Xiao X, Chu CR. Persistence, localization, and external control of transgene expression after single injection of adeno-associated virus into injured joints. Hum Gene Ther. 2013 Apr; 24(4):457-66. PMID: 23496155.
      View in: PubMed
    25. Payne KA, Lee HH, Haleem AM, Martins C, Yuan Z, Qiao C, Xiao X, Chu CR. Single intra-articular injection of adeno-associated virus results in stable and controllable in vivo transgene expression in normal rat knees. Osteoarthritis Cartilage. 2011 Aug; 19(8):1058-65. PMID: 21571082.
      View in: PubMed
    26. Payne KA, Meszaros LB, Phillippi JA, Huard J. Effect of phosphatidyl inositol 3-kinase, extracellular signal-regulated kinases 1/2, and p38 mitogen-activated protein kinase inhibition on osteogenic differentiation of muscle-derived stem cells. Tissue Eng Part A. 2010 Dec; 16(12):3647-55. PMID: 20617875.
      View in: PubMed
    27. Payne KA, Didiano DM, Chu CR. Donor sex and age influence the chondrogenic potential of human femoral bone marrow stem cells. Osteoarthritis Cartilage. 2010 May; 18(5):705-13. PMID: 20171308.
      View in: PubMed
    28. Li G, Corsi-Payne K, Zheng B, Usas A, Peng H, Huard J. The dose of growth factors influences the synergistic effect of vascular endothelial growth factor on bone morphogenetic protein 4-induced ectopic bone formation. Tissue Eng Part A. 2009 Aug; 15(8):2123-33. PMID: 19215221.
      View in: PubMed
    29. Tan H, Chu CR, Payne KA, Marra KG. Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering. Biomaterials. 2009 May; 30(13):2499-506. PMID: 19167750.
      View in: PubMed
    30. Kubo S, Cooper GM, Matsumoto T, Phillippi JA, Corsi KA, Usas A, Li G, Fu FH, Huard J. Blocking vascular endothelial growth factor with soluble Flt-1 improves the chondrogenic potential of mouse skeletal muscle-derived stem cells. Arthritis Rheum. 2009 Jan; 60(1):155-65. PMID: 19116905.
      View in: PubMed
    31. Matsumoto T, Kubo S, Meszaros LB, Corsi KA, Cooper GM, Li G, Usas A, Osawa A, Fu FH, Huard J. The influence of sex on the chondrogenic potential of muscle-derived stem cells: implications for cartilage regeneration and repair. Arthritis Rheum. 2008 Dec; 58(12):3809-19. PMID: 19035511.
      View in: PubMed
    32. Deasy BM, Corsi KA, Huard J. [The sex of muscle stem cells: must it be taken into account?]. Med Sci (Paris). 2007 Oct; 23(10):798-800. PMID: 17937884.
      View in: PubMed
    33. Corsi KA, Pollett JB, Phillippi JA, Usas A, Li G, Huard J. Osteogenic potential of postnatal skeletal muscle-derived stem cells is influenced by donor sex. J Bone Miner Res. 2007 Oct; 22(10):1592-602. PMID: 17605633.
      View in: PubMed
    34. Corsi KA, Schwarz EM, Mooney DJ, Huard J. Regenerative medicine in orthopaedic surgery. J Orthop Res. 2007 Oct; 25(10):1261-8. PMID: 17551972.
      View in: PubMed
    35. Pollett JB, Corsi KA, Weiss KR, Cooper GM, Barry DA, Gharaibeh B, Huard J. Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals. Stem Cells. 2007 Sep; 25(9):2302-11. PMID: 17569791.
      View in: PubMed
    36. Kuroda R, Usas A, Kubo S, Corsi K, Peng H, Rose T, Cummins J, Fu FH, Huard J. Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells. Arthritis Rheum. 2006 Feb; 54(2):433-42. PMID: 16447218.
      View in: PubMed
    37. Li G, Peng H, Corsi K, Usas A, Olshanski A, Huard J. Differential effect of BMP4 on NIH/3T3 and C2C12 cells: implications for endochondral bone formation. J Bone Miner Res. 2005 Sep; 20(9):1611-23. PMID: 16059633.
      View in: PubMed
    38. Mansouri S, Lavigne P, Corsi K, Benderdour M, Beaumont E, Fernandes JC. Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy. Eur J Pharm Biopharm. 2004 Jan; 57(1):1-8. PMID: 14729076.
      View in: PubMed
    39. Corsi K, Chellat F, Yahia L, Fernandes JC. Mesenchymal stem cells, MG63 and HEK293 transfection using chitosan-DNA nanoparticles. Biomaterials. 2003 Mar; 24(7):1255-64. PMID: 12527266.
      View in: PubMed
    40. Demers C, Hamdy CR, Corsi K, Chellat F, Tabrizian M, Yahia L. Natural coral exoskeleton as a bone graft substitute: a review. Biomed Mater Eng. 2002; 12(1):15-35. PMID: 11847406.
      View in: PubMed
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