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Eric D. Larson

TitleAsst Professor-Clinical
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Cell and Devopmental Bio

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    R21DC018864     (LARSON, ERIC D.)Jun 12, 2020 - May 31, 2024
    NIH
    Investigating chemosensory cell heterogeneity in the upper airway epithelium with single cell RNA sequencing and high resolution light sheet microscopy
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Campa?a MB, Perkins MR, McCabe MC, Neumann A, Larson ED, Fantauzzo KA. PDGFRa/? heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation. bioRxiv. 2023 Dec 27. PMID: 38234806.
      View in: PubMed
    2. Shechtman LA, Scott JK, Larson ED, Isner TJ, Johnson BJ, Gaillard D, Dempsey PJ, Barlow LA. High Sox2 expression predicts taste lineage competency of lingual progenitors in vitro. Development. 2023 02 15; 150(4). PMID: 36794954.
      View in: PubMed
    3. Elling CL, Scholes MA, Streubel SO, Larson ED, Wine TM, Bootpetch TC, Yoon PJ, Kofonow JM, Gubbels SP, Cass SP, Robertson CE, Jenkins HA, Prager JD, Frank DN, Chan KH, Friedman NR, Ryan AF, Santos-Cortez RLP. The FUT2 Variant c.461G>A (p.Trp154*) Is Associated With Differentially Expressed Genes and Nasopharyngeal Microbiota Shifts in Patients With Otitis Media. Front Cell Infect Microbiol. 2021; 11:798246. PMID: 35096646.
      View in: PubMed
    4. Dennison BJC, Larson ED, Fu R, Mo J, Fantauzzo KA. Srsf3 mediates alternative RNA splicing downstream of PDGFRa signaling in the facial mesenchyme. Development. 2021 07 15; 148(14). PMID: 34184034.
      View in: PubMed
    5. Golden EJ, Larson ED, Shechtman LA, Trahan GD, Gaillard D, Fellin TJ, Scott JK, Jones KL, Barlow LA. Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function. Elife. 2021 05 19; 10. PMID: 34009125.
      View in: PubMed
    6. Baxter BD, Larson ED, Merle L, Feinstein P, Polese AG, Bubak AN, Niemeyer CS, Hassell J, Shepherd D, Ramakrishnan VR, Nagel MA, Restrepo D. Transcriptional profiling reveals potential involvement of microvillous TRPM5-expressing cells in viral infection of the olfactory epithelium. BMC Genomics. 2021 Mar 30; 22(1):224. PMID: 33781205.
      View in: PubMed
    7. Larson ED, Vandenbeuch A, Anderson CB, Kinnamon SC. GAD65Cre Drives Reporter Expression in Multiple Taste Cell Types. Chem Senses. 2021 01 01; 46. PMID: 34160573.
      View in: PubMed
    8. Baxter BD, Larson ED, Merle L, Feinstein P, Polese AG, Bubak AN, Niemeyer CS, Hassell J, Shepherd D, Ramakrishnan VR, Nagel MA, Restrepo D. Transcriptional profiling reveals potential involvement of microvillous TRPM5-expressing cells in viral infection of the olfactory epithelium. bioRxiv. 2020 Dec 01. PMID: 32511400.
      View in: PubMed
    9. Bootpetch TC, Hafr?n L, Elling CL, Baschal EE, Manichaikul AW, Pine HS, Szeremeta W, Scholes MA, Cass SP, Larson ED, Chan KH, Ishaq R, Prager JD, Shaikh RS, Gubbels SP, Yousaf A, Wine TM, Bamshad MJ, Yoon PJ, Jenkins HA, Nickerson DA, Streubel SO, Friedman NR, Frank DN, Einarsdottir E, Kere J, Riazuddin S, Daly KA, Leal SM, Ryan AF, Mattila PS, Ahmed ZM, Sale MM, Chonmaitree T, Santos-Cortez RLP. Multi-omic studies on missense PLG variants in families with otitis media. Sci Rep. 2020 09 14; 10(1):15035. PMID: 32929111.
      View in: PubMed
    10. Cooper KW, Brann DH, Farruggia MC, Bhutani S, Pellegrino R, Tsukahara T, Weinreb C, Joseph PV, Larson ED, Parma V, Albers MW, Barlow LA, Datta SR, Di Pizio A. COVID-19 and the Chemical Senses: Supporting Players Take Center Stage. Neuron. 2020 07 22; 107(2):219-233. PMID: 32640192.
      View in: PubMed
    11. Larson ED, Vandenbeuch A, Anderson CB, Kinnamon SC. Function, Innervation, and Neurotransmitter Signaling in Mice Lacking Type-II Taste Cells. eNeuro. 2020 Jan/Feb; 7(1). PMID: 31988217.
      View in: PubMed
    12. Baschal EE, Larson ED, Bootpetch Roberts TC, Pathak S, Frank G, Handley E, Dinwiddie J, Moloney M, Yoon PJ, Gubbels SP, Scholes MA, Cass SP, Jenkins HA, Frank DN, Yang IV, Schwartz DA, Ramakrishnan VR, Santos-Cortez RLP. Identification of Novel Genes and Biological Pathways That Overlap in Infectious and Nonallergic Diseases of the Upper and Lower Airways Using Network Analyses. Front Genet. 2019; 10:1352. PMID: 32010199.
      View in: PubMed
    13. Larson ED, Pathak S, Ramakrishnan VR, Finger TE. A Subset of Olfactory Sensory Neurons Express Forkhead Box J1-Driven eGFP. Chem Senses. 2019 10 26; 44(9):663-671. PMID: 31504289.
      View in: PubMed
    14. Chen J, Larson ED, Anderson CB, Agarwal P, Frank DN, Kinnamon SC, Ramakrishnan VR. Expression of Bitter Taste Receptors and Solitary Chemosensory Cell Markers in the Human Sinonasal Cavity. Chem Senses. 2019 09 07; 44(7):483-495. PMID: 31231752.
      View in: PubMed
    15. Kennel C, Gould EA, Larson ED, Salcedo E, Vickery T, Restrepo D, Ramakrishnan VR. Differential Expression of Mucins in Murine Olfactory Versus Respiratory Epithelium. Chem Senses. 2019 09 07; 44(7):511-521. PMID: 31300812.
      View in: PubMed
    16. Larson ED, Magno JPM, Steritz MJ, Llanes EGDV, Cardwell J, Pedro M, Roberts TB, Einarsdottir E, Rosanes RAQ, Greenlee C, Santos RAP, Yousaf A, Streubel SO, Santos ATR, Ruiz AG, Lagrana-Villagracia SM, Ray D, Yarza TKL, Scholes MA, Anderson CB, Acharya A, Gubbels SP, Bamshad MJ, Cass SP, Lee NR, Shaikh RS, Nickerson DA, Mohlke KL, Prager JD, Cruz TLG, Yoon PJ, Abes GT, Schwartz DA, Chan AL, Wine TM, Cutiongco-de la Paz EM, Friedman N, Kechris K, Kere J, Leal SM, Yang IV, Patel JA, Tantoco MLC, Riazuddin S, Chan KH, Mattila PS, Reyes-Quintos MRT, Ahmed ZM, Jenkins HA, Chonmaitree T, Hafr?n L, Chiong CM, Santos-Cortez RLP. A2ML1 and otitis media: novel variants, differential expression, and relevant pathways. Hum Mutat. 2019 08; 40(8):1156-1171. PMID: 31009165.
      View in: PubMed
    17. Ramakrishnan VR, Gonzalez JR, Cooper SE, Barham HP, Anderson CB, Larson ED, Cool CD, Diller JD, Jones K, Kinnamon SC. RNA sequencing and pathway analysis identify tumor necrosis factor alpha driven small proline-rich protein dysregulation in chronic rhinosinusitis. Am J Rhinol Allergy. 2017 Sep 01; 31(5):283-288. PMID: 28859701.
      View in: PubMed
    18. St Clair JR, Larson ED, Sharpe EJ, Liao Z, Proenza C. Phosphodiesterases 3 and 4 Differentially Regulate the Funny Current, If, in Mouse Sinoatrial Node Myocytes. J Cardiovasc Dev Dis. 2017 Sep; 4(3). PMID: 28868308.
      View in: PubMed
    19. Stratford JM, Larson ED, Yang R, Salcedo E, Finger TE. 5-HT3A -driven green fluorescent protein delineates gustatory fibers innervating sour-responsive taste cells: A labeled line for sour taste? J Comp Neurol. 2017 Jul 01; 525(10):2358-2375. PMID: 28316078.
      View in: PubMed
    20. Bhattarai Y, Schmidt BA, Linden DR, Larson ED, Grover M, Beyder A, Farrugia G, Kashyap PC. Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT3 receptor expression via acetate production. Am J Physiol Gastrointest Liver Physiol. 2017 Jul 01; 313(1):G80-G87. PMID: 28408644.
      View in: PubMed
    21. Sharpe EJ, Larson ED, Proenza C. Cyclic AMP reverses the effects of aging on pacemaker activity and If in sinoatrial node myocytes. J Gen Physiol. 2017 Feb; 149(2):237-247. PMID: 28057842.
      View in: PubMed
    22. Larson ED, Vandenbeuch A, Voigt A, Meyerhof W, Kinnamon SC, Finger TE. The Role of 5-HT3 Receptors in Signaling from Taste Buds to Nerves. J Neurosci. 2015 Dec 02; 35(48):15984-95. PMID: 26631478.
      View in: PubMed
    23. Vandenbeuch A, Larson ED, Anderson CB, Smith SA, Ford AP, Finger TE, Kinnamon SC. Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice. J Physiol. 2015 Mar 01; 593(5):1113-25. PMID: 25524179.
      View in: PubMed
    24. Groenke S, Larson ED, Alber S, Zhang R, Lamp ST, Ren X, Nakano H, Jordan MC, Karagueuzian HS, Roos KP, Nakano A, Proenza C, Philipson KD, Goldhaber JI. Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity. PLoS One. 2013; 8(11):e81633. PMID: 24278453.
      View in: PubMed
    25. Larson ED, St Clair JR, Sumner WA, Bannister RA, Proenza C. Depressed pacemaker activity of sinoatrial node myocytes contributes to the age-dependent decline in maximum heart rate. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):18011-6. PMID: 24128759.
      View in: PubMed
    26. St Clair JR, Liao Z, Larson ED, Proenza C. PKA-independent activation of I(f) by cAMP in mouse sinoatrial myocytes. Channels (Austin). 2013 Jul-Aug; 7(4):318-21. PMID: 23756695.
      View in: PubMed
    27. Liao Z, Lockhead D, St Clair JR, Larson ED, Wilson CE, Proenza C. Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: ligand-independent relief of autoinhibition in HCN4. J Gen Physiol. 2012 Nov; 140(5):557-66. PMID: 23109717.
      View in: PubMed
    28. Liao Z, St Clair JR, Larson ED, Proenza C. Myristoylated peptides potentiate the funny current (I(f)) in sinoatrial myocytes. Channels (Austin). 2011 Mar-Apr; 5(2):115-9. PMID: 21150293.
      View in: PubMed
    29. Liao Z, Lockhead D, Larson ED, Proenza C. Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial node. J Gen Physiol. 2010 Sep; 136(3):247-58. PMID: 20713547.
      View in: PubMed
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