 Drug Antagonism
"Drug Antagonism" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Phenomena and pharmaceutics of compounds that inhibit the function of agonists (DRUG AGONISM) and inverse agonists (DRUG INVERSE AGONISM) for a specific receptor. On their own, antagonists produce no effect by themselves to a receptor, and are said to have neither intrinsic activity nor efficacy.
| Descriptor ID |
D004336
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| MeSH Number(s) |
G07.690.773.968.310
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| Concept/Terms |
Drug Antagonism- Drug Antagonism
- Antagonism, Drug
- Antagonisms, Drug
- Drug Antagonisms
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Below are MeSH descriptors whose meaning is more general than "Drug Antagonism".
Below are MeSH descriptors whose meaning is more specific than "Drug Antagonism".
This graph shows the total number of publications written about "Drug Antagonism" by people in this website by year, and whether "Drug Antagonism" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "Drug Antagonism" by people in Profiles.
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Mailankot M, Howell S, Nagaraj RH. Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells. Biochim Biophys Acta. 2010 Jul-Aug; 1802(7-8):609-20.
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Ho GY, Xue X, Cushman M, McKeown-Eyssen G, Sandler RS, Ahnen DJ, Barry EL, Saibil F, Bresalier RS, Rohan TE, Baron JA. Antagonistic effects of aspirin and folic acid on inflammation markers and subsequent risk of recurrent colorectal adenomas. J Natl Cancer Inst. 2009 Dec 02; 101(23):1650-4.
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Heard KJ, Cleveland NR, Krier S. The effect of olanzapine pretreatment on acute cocaine toxicity in mice. Clin Toxicol (Phila). 2009 Jul; 47(6):542-4.
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Barron MA, Doyle J, Zlotkin S. Vitamin K deficiency in children pre-bone marrow transplantation. Bone Marrow Transplant. 2006 Jan; 37(2):151-4.
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DeWitt CR, Cleveland N, Dart RC, Heard K. The effect of amiodarone pretreatment on survival of mice with cocaine toxicity. J Med Toxicol. 2005 Dec; 1(1):11-8.
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Baker RK, Kurz EU, Pyatt DW, Irons RD, Kroll DJ. Benzene metabolites antagonize etoposide-stabilized cleavable complexes of DNA topoisomerase IIalpha. Blood. 2001 Aug 01; 98(3):830-3.
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Pott WA, Benjamin SA, Yang RS. Antagonistic interactions of an arsenic-containing mixture in a multiple organ carcinogenicity bioassay. Cancer Lett. 1998 Nov 27; 133(2):185-90.
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Sokol RJ, McKim JM, Goff MC, Ruyle SZ, Devereaux MW, Han D, Packer L, Everson G. Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat. Gastroenterology. 1998 Jan; 114(1):164-74.
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Deterding RR, Havill AM, Yano T, Middleton SC, Jacoby CR, Shannon JM, Simonet WS, Mason RJ. Prevention of bleomycin-induced lung injury in rats by keratinocyte growth factor. Proc Assoc Am Physicians. 1997 May; 109(3):254-68.
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Meyer FA, Yaron I, Yaron M. Synergistic, additive, and antagonistic effects of interleukin-1 beta, tumor necrosis factor alpha, and gamma-interferon on prostaglandin E, hyaluronic acid, and collagenase production by cultured synovial fibroblasts. Arthritis Rheum. 1990 Oct; 33(10):1518-25.
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