 GABA Modulators
"GABA Modulators" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
| Descriptor ID |
D018757
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| MeSH Number(s) |
D27.505.519.625.240.500 D27.505.696.577.240.500
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| Concept/Terms |
GABA Modulators- GABA Modulators
- Modulators, GABA
- GABAergic Modulators
- Modulators, GABAergic
- gamma-Aminobutyric Acid Modulators
- Acid Modulators, gamma-Aminobutyric
- Modulators, gamma-Aminobutyric Acid
- gamma Aminobutyric Acid Modulators
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Below are MeSH descriptors whose meaning is more general than "GABA Modulators".
Below are MeSH descriptors whose meaning is more specific than "GABA Modulators".
This graph shows the total number of publications written about "GABA Modulators" by people in this website by year, and whether "GABA Modulators" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2013 | 1 | 1 | 2 | | 2015 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "GABA Modulators" by people in Profiles.
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Ziobro JM, Eschbach K, Shellhaas RA. Novel Therapeutics for Neonatal Seizures. Neurotherapeutics. 2021 07; 18(3):1564-1581.
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Brodnik ZD, Batra A, Oleson EB, Espa?a RA. Local GABAA Receptor-Mediated Suppression of Dopamine Release within the Nucleus Accumbens. ACS Chem Neurosci. 2019 04 17; 10(4):1978-1985.
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Borghese CM, Herman M, Snell LD, Lawrence KJ, Lee HY, Backos DS, Vanderlinden LA, Harris RA, Roberto M, Hoffman PL, Tabakoff B. Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes. Sci Rep. 2017 07 24; 7(1):6230.
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Martin BS, Martinez-Botella G, Loya CM, Salituro FG, Robichaud AJ, Huntsman MM, Ackley MA, Doherty JJ, Corbin JG. Rescue of deficient amygdala tonic ?-aminobutyric acidergic currents in the Fmr-/y mouse model of fragile X syndrome by a novel ?-aminobutyric acid type A receptor-positive allosteric modulator. J Neurosci Res. 2016 Jun; 94(6):568-78.
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Fischell J, Van Dyke AM, Kvarta MD, LeGates TA, Thompson SM. Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors. Neuropsychopharmacology. 2015 Oct; 40(11):2499-509.
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Obradovic ALj, Joksimovic S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinic B, Radulovic T, Markovic B, Roth BL, Sieghart W, Cook JM, Savic MM. Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects. Brain Res. 2014 Mar 20; 1554:36-48.
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Mellion SA, Bennett KS, Ellsworth GL, Moore K, Riva-Cambrin J, Metzger RR, Bratton SL. High-dose barbiturates for refractory intracranial hypertension in children with severe traumatic brain injury. Pediatr Crit Care Med. 2013 Mar; 14(3):239-47.
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Schacht JP, Anton RF, Randall PK, Li X, Henderson S, Myrick H. Effects of a GABA-ergic medication combination and initial alcohol withdrawal severity on cue-elicited brain activation among treatment-seeking alcoholics. Psychopharmacology (Berl). 2013 Jun; 227(4):627-37.
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Timic T, Joksimovic S, Milic M, Divljakovic J, Batinic B, Savic MM. Midazolam impairs acquisition and retrieval, but not consolidation of reference memory in the Morris water maze. Behav Brain Res. 2013 Mar 15; 241:198-205.
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Joksimovic S, Divljakovic J, Van Linn ML, Varagic Z, Brajkovic G, Milinkovic MM, Yin W, Timic T, Sieghart W, Cook JM, Savic MM. Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of a1 GABA(A) receptors. Eur Neuropsychopharmacol. 2013 May; 23(5):390-9.
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