 Pregnanolone
"Pregnanolone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.
| Descriptor ID |
D011280
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| MeSH Number(s) |
D04.210.500.745.640
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| Concept/Terms |
Pregnanolone- Pregnanolone
- 3 alpha-Hydroxy-5 beta-pregnan-20-one
- 3 alpha Hydroxy 5 beta pregnan 20 one
- alpha-Hydroxy-5 beta-pregnan-20-one, 3
- beta-pregnan-20-one, 3 alpha-Hydroxy-5
- 3-Hydroxypregnan-20-one
- 3 Hydroxypregnan 20 one
- Pregnanolone, (3alpha,5beta)-isomer
- Eltanolone
- Pregnan-3alpha-ol-20-one
- Pregnan 3alpha ol 20 one
- 3 alpha, 5 beta-Tetrahydroprogesterone
- 3 alpha, 5 beta Tetrahydroprogesterone
Sepranolone- Sepranolone
- Allopregnanolone
- 3 alpha-Hydroxy-5 alpha-pregnan-20-one
- 3 alpha Hydroxy 5 alpha pregnan 20 one
- alpha-Hydroxy-5 alpha-pregnan-20-one, 3
- alpha-pregnan-20-one, 3 alpha-Hydroxy-5
- Pregnanolone, (3alpha,5alpha)-isomer
Pregnanolone, (3beta, 5alpha)-isomer- Pregnanolone, (3beta, 5alpha)-isomer
- Allopregnan-3 beta-ol-20-one
- Allopregnan 3 beta ol 20 one
- beta-ol-20-one, Allopregnan-3
- 3beta-Hydroxy-5alpha-pregnan-20-one
- 3beta Hydroxy 5alpha pregnan 20 one
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Below are MeSH descriptors whose meaning is more general than "Pregnanolone".
Below are MeSH descriptors whose meaning is more specific than "Pregnanolone".
This graph shows the total number of publications written about "Pregnanolone" by people in this website by year, and whether "Pregnanolone" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 | | 2008 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2021 | 3 | 1 | 4 | | 2022 | 1 | 1 | 2 | | 2023 | 1 | 2 | 3 | | 2024 | 0 | 1 | 1 | | 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pregnanolone" by people in Profiles.
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Osborne LM, Etyemez S, Pinna G, Alemani R, Standeven LR, Wang XQ, Payne JL. Neuroactive steroid biosynthesis during pregnancy predicts future postpartum depression: a role for the 3a and/or 3?-HSD neurosteroidogenic enzymes? Neuropsychopharmacology. 2025 May; 50(6):904-912.
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Downs J, Jacoby P, Specchio N, Cross H, Amin S, Bahi-Buisson N, Rajaraman R, Suter B, Devinsky O, Aimetti A, Busse G, Olson HE, Demarest S, Benke TA, Pestana-Knight E. Effects of ganaxolone on non-seizure outcomes in CDKL5 Deficiency Disorder: Double-blind placebo-controlled randomized trial. Eur J Paediatr Neurol. 2024 Jul; 51:140-146.
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Miller KN, Standeven L, Morrow AL, Payne JL, Epperson CN, Hantsoo L. GABAergic neuroactive steroid response to sertraline in premenstrual dysphoric disorder. Psychoneuroendocrinology. 2024 Feb; 160:106684.
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Olson HE, Amin S, Bahi-Buisson N, Devinsky O, Marsh ED, Pestana-Knight E, Rajaraman RR, Aimetti AA, Rybak E, Kong F, Miller I, Hulihan J, Demarest S. Long-term treatment with ganaxolone for seizures associated with cyclin-dependent kinase-like 5 deficiency disorder: Two-year open-label extension follow-up. Epilepsia. 2024 Jan; 65(1):37-45.
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Etyemez S, Miller KN, Voegtline KM, ?zdemir I, Standeven LR, Santovito LS, Pinna G, Payne JL, Osborne LM. Metabolites of progesterone in pregnancy: Associations with perinatal anxiety. Psychoneuroendocrinology. 2023 10; 156:106327.
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Novick AM, Duffy KA, Johnson RL, Sammel MD, Cao W, Strasser AA, Sofuoglu M, Kuzma A, Loughead J, Morrow AL, Epperson CN. Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone. Biol Sex Differ. 2022 10 23; 13(1):60.
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Knight EMP, Amin S, Bahi-Buisson N, Benke TA, Cross JH, Demarest ST, Olson HE, Specchio N, Fleming TR, Aimetti AA, Gasior M, Devinsky O. Safety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder: results from the double-blind phase of a randomised, placebo-controlled, phase 3 trial. Lancet Neurol. 2022 05; 21(5):417-427.
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Standeven LR, Osborne LM, Betz JF, Yenokyan G, Voegtline K, Hantsoo L, Payne JL. Allopregnanolone and depression and anxiety symptoms across the peripartum: an exploratory study. Arch Womens Ment Health. 2022 04; 25(2):521-526.
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B?ckstr?m T, Ekberg K, Hirschberg AL, Bixo M, Epperson CN, Briggs P, Panay N, O'Brien S. A randomized, double-blind study on efficacy and safety of sepranolone in premenstrual dysphoric disorder. Psychoneuroendocrinology. 2021 11; 133:105426.
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Coulter I, Timic Stamenic T, Eggan P, Fine BR, Corrigan T, Covey DF, Yang L, Pan JQ, Todorovic SM. Different roles of T-type calcium channel isoforms in hypnosis induced by an endogenous neurosteroid epipregnanolone. Neuropharmacology. 2021 10 01; 197:108739.
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