 Holoprosencephaly
"Holoprosencephaly" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Anterior midline brain, cranial, and facial malformations resulting from the failure of the embryonic prosencephalon to undergo segmentation and cleavage. Alobar prosencephaly is the most severe form and features anophthalmia; cyclopia; severe INTELLECTUAL DISABILITY; CLEFT LIP; CLEFT PALATE; SEIZURES; and microcephaly. Semilobar holoprosencepaly is characterized by hypotelorism, microphthalmia, coloboma, nasal malformations, and variable degrees of INTELLECTUAL DISABILITY. Lobar holoprosencephaly is associated with mild (or absent) facial malformations and intellectual abilities that range from mild INTELLECTUAL DISABILITY to normal. Holoprosencephaly is associated with CHROMOSOME ABNORMALITIES.
| Descriptor ID |
D016142
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| MeSH Number(s) |
C05.660.207.410 C10.500.034.875 C16.131.077.410 C16.131.260.380 C16.131.621.207.410 C16.131.666.034.875 C16.320.180.380
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| Concept/Terms |
Semilobar Holoprosencephaly- Semilobar Holoprosencephaly
- Holoprosencephalies, Semilobar
- Holoprosencephaly, Semilobar
- Semilobar Holoprosencephalies
Lobar Holoprosencephaly- Lobar Holoprosencephaly
- Holoprosencephalies, Lobar
- Holoprosencephaly, Lobar
- Lobar Holoprosencephalies
Alobar Holoprosencephaly- Alobar Holoprosencephaly
- Alobar Holoprosencephalies
- Holoprosencephalies, Alobar
- Holoprosencephaly, Alobar
- Holoprosencephaly, Familial Alobar
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Below are MeSH descriptors whose meaning is more general than "Holoprosencephaly".
Below are MeSH descriptors whose meaning is more specific than "Holoprosencephaly".
This graph shows the total number of publications written about "Holoprosencephaly" by people in this website by year, and whether "Holoprosencephaly" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Holoprosencephaly" by people in Profiles.
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Hu T, Kruszka P, Martinez AF, Ming JE, Shabason EK, Raam MS, Shaikh TH, Pineda-Alvarez DE, Muenke M. Cytogenetics and holoprosencephaly: A chromosomal microarray study of 222 individuals with holoprosencephaly. Am J Med Genet C Semin Med Genet. 2018 06; 178(2):175-186.
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Larson A, Nokoff NJ, Meeks NJ. Genetic causes of pituitary hormone deficiencies. Discov Med. 2015 Mar; 19(104):175-83.
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Dennis JF, Kurosaka H, Iulianella A, Pace J, Thomas N, Beckham S, Williams T, Trainor PA. Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects. PLoS Genet. 2012; 8(10):e1002927.
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McCabe MJ, Gaston-Massuet C, Tziaferi V, Gregory LC, Alatzoglou KS, Signore M, Puelles E, Gerrelli D, Farooqi IS, Raza J, Walker J, Kavanaugh SI, Tsai PS, Pitteloud N, Martinez-Barbera JP, Dattani MT. Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction. J Clin Endocrinol Metab. 2011 Oct; 96(10):E1709-18.
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El-Jaick KB, Powers SE, Bartholin L, Myers KR, Hahn J, Orioli IM, Ouspenskaia M, Lacbawan F, Roessler E, Wotton D, Muenke M. Functional analysis of mutations in TGIF associated with holoprosencephaly. Mol Genet Metab. 2007 Jan; 90(1):97-111.
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Rubinstein D, Cajade-Law AG, Youngman V, Hise JM, Baganz M. The development of the corpus callosum in semilobar and lobar holoprosencephaly. Pediatr Radiol. 1996 Dec; 26(12):839-44.
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