Dideoxyadenosine
"Dideoxyadenosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.
| Descriptor ID |
D016048
|
| MeSH Number(s) |
D03.633.100.759.590.138.325.105 D13.570.230.229.105 D13.570.230.500.105 D13.570.583.138.325.105
|
| Concept/Terms |
Dideoxyadenosine- Dideoxyadenosine
- 2',3'-Dideoxyadenosine
- 2',3' Dideoxyadenosine
- ddA (Antiviral)
|
Below are MeSH descriptors whose meaning is more general than "Dideoxyadenosine".
Below are MeSH descriptors whose meaning is more specific than "Dideoxyadenosine".
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Below are the most recent publications written about "Dideoxyadenosine" by people in Profiles.
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Teitelbaum I, Strasheim A. AVP stimulates adenylyl cyclase and phospholipase C in reciprocal fashion in cultured RIMCT cells. Am J Physiol. 1990 Oct; 259(4 Pt 1):C693-6.