 Pentacyclic Triterpenes
"Pentacyclic Triterpenes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Five-ring derivatives of dammarane having a chair-chair-chair-boat configuration. They include the lupanes, oleananes, amyrins, GLYCYRRHIZIC ACID, and soyasaponins.
| Descriptor ID |
D053978
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| MeSH Number(s) |
D02.455.849.919.530
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pentacyclic Triterpenes".
Below are MeSH descriptors whose meaning is more specific than "Pentacyclic Triterpenes".
This graph shows the total number of publications written about "Pentacyclic Triterpenes" by people in this website by year, and whether "Pentacyclic Triterpenes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 1 | 2 | | 2014 | 1 | 1 | 2 | | 2015 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 1 | 2 | | 2020 | 1 | 0 | 1 | | 2025 | 1 | 0 | 1 | | 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pentacyclic Triterpenes" by people in Profiles.
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Schiavon A, Evaristo C, Saba L, Petiti J, Pignochino Y, Puglisi S, Perotti P, Messina E, Giachino C, Terzolo M, Lo Iacono M. Targeting ER stress in adrenocortical carcinoma: Celastrol as a novel therapeutic candidate. Biomed Pharmacother. 2026 Apr; 197:119156.
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Alula KM, Collins CB, Nguyen TT, Aherne CM, Jedlicka P, de Zoeten EF. Celastrol Activates HSF1 to Enhance Regulatory T Cells Function and Ameliorate Intestinal Inflammation. Biomolecules. 2025 12 31; 16(1).
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Pereira Beserra F, Sérgio Gushiken LF, Vieira AJ, Augusto Bérgamo D, Luísa Bérgamo P, Oliveira de Souza M, Alberto Hussni C, Kiomi Takahira R, Henrique Nóbrega R, Monteiro Martinez ER, John Jackson C, Lemos de Azevedo Maia G, Leite Rozza A, Helena Pellizzon C. From Inflammation to Cutaneous Repair: Topical Application of Lupeol Improves Skin Wound Healing in Rats by Modulating the Cytokine Levels, NF-?B, Ki-67, Growth Factor Expression, and Distribution of Collagen Fibers. Int J Mol Sci. 2020 Jul 13; 21(14).
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Beserra FP, Vieira AJ, Gushiken LFS, de Souza EO, Hussni MF, Hussni CA, Nóbrega RH, Martinez ERM, Jackson CJ, de Azevedo Maia GL, Rozza AL, Pellizzon CH. Lupeol, a Dietary Triterpene, Enhances Wound Healing in Streptozotocin-Induced Hyperglycemic Rats with Modulatory Effects on Inflammation, Oxidative Stress, and Angiogenesis. Oxid Med Cell Longev. 2019; 2019:3182627.
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Zhang C, Wang R, Liu Z, Bunker E, Lee S, Giuntini M, Chapnick D, Liu X. The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1's association with the mitochondrial protein TOM20. J Biol Chem. 2019 05 03; 294(18):7472-7487.
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Pereira Beserra F, Xue M, Maia GLA, Leite Rozza A, Helena Pellizzon C, Jackson CJ. Lupeol, a Pentacyclic Triterpene, Promotes Migration, Wound Closure, and Contractile Effect In Vitro: Possible Involvement of PI3K/Akt and p38/ERK/MAPK Pathways. Molecules. 2018 Oct 30; 23(11).
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McMillin M, Frampton G, Tobin R, Dusio G, Smith J, Shin H, Newell-Rogers K, Grant S, DeMorrow S. TGR5 signaling reduces neuroinflammation during hepatic encephalopathy. J Neurochem. 2015 Nov; 135(3):565-76.
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Sharma S, Mishra R, Walker BL, Deshmukh S, Zampino M, Patel J, Anamalai M, Simpson D, Singh IS, Kaushal S, Kaushal S. Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death. Cell Stress Chaperones. 2015 Jan; 20(1):185-201.
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Kavitha CV, Jain AK, Agarwal C, Pierce A, Keating A, Huber KM, Serkova NJ, Wempe MF, Agarwal R, Deep G. Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo. Mol Carcinog. 2015 Nov; 54(11):1417-29.
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Safe SH, Prather PL, Brents LK, Chadalapaka G, Jutooru I. Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs. Anticancer Agents Med Chem. 2012 Dec; 12(10):1211-20.
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