 Tankyrases
"Tankyrases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of telomere associated proteins that interact with TRF1 PROTEIN, contain ANKYRIN REPEATS and have poly(ADP-ribose) polymerase activity.
| Descriptor ID |
D038501
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| MeSH Number(s) |
D08.811.913.400.725.115.690.840
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| Concept/Terms |
Tankyrases- Tankyrases
- TRF-1 Interacting, Ankyrin-Related, ADP-Ribose Polymerases
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Below are MeSH descriptors whose meaning is more general than "Tankyrases".
Below are MeSH descriptors whose meaning is more specific than "Tankyrases".
This graph shows the total number of publications written about "Tankyrases" by people in this website by year, and whether "Tankyrases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 1 | 0 | 1 | | 2016 | 2 | 0 | 2 | | 2020 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tankyrases" by people in Profiles.
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Clements CM, Shellman SX, Shellman MH, Shellman YG. TBM Hunter: Identify and Score Canonical, Extended, and Unconventional Tankyrase-Binding Motifs in Any Protein. Int J Mol Sci. 2023 Nov 30; 24(23).
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Miglani M, Pasha Q, Gupta A, Priyadarshini A, Pati Pandey R, Vibhuti A. Seeding drug discovery: Telomeric tankyrase as a pharmacological target for the pathophysiology of high-altitude hypoxia. Drug Discov Today. 2021 11; 26(11):2774-2781.
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Miglani M, Rain M, Pasha Q, Raj VS, Thinlas T, Mohammad G, Gupta A, Pandey RP, Vibhuti A. Shorter telomere length, higher telomerase activity in association with tankyrase gene polymorphism contribute to high-altitude pulmonary edema. Hum Mol Genet. 2020 11 04; 29(18):3094-3106.
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Scarborough HA, Helfrich BA, Cas?s-Selves M, Schuller AG, Grosskurth SE, Kim J, Tan AC, Chan DC, Zhang Z, Zaberezhnyy V, Bunn PA, DeGregori J. AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non-Small Cell Lung Cancer Cells Following EGFR Inhibition. Clin Cancer Res. 2017 Mar 15; 23(6):1531-1541.
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Quackenbush KS, Bagby S, Tai WM, Messersmith WA, Schreiber A, Greene J, Kim J, Wang G, Purkey A, Pitts TM, Nguyen A, Gao D, Blatchford P, Capasso A, Schuller AG, Eckhardt SG, Arcaroli JJ. The novel tankyrase inhibitor (AZ1366) enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance. Oncotarget. 2016 May 10; 7(19):28273-85.
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Cas?s-Selves M, Kim J, Zhang Z, Helfrich BA, Gao D, Porter CC, Scarborough HA, Bunn PA, Chan DC, Tan AC, DeGregori J. Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition. Cancer Res. 2012 Aug 15; 72(16):4154-64.
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