 Intercalating Agents
"Intercalating Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.
| Descriptor ID |
D007364
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| MeSH Number(s) |
D27.720.470.410.360
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| Concept/Terms |
Intercalating Agents- Intercalating Agents
- Agents, Intercalating
- Intercalating Ligands
- Ligands, Intercalating
- Intercalators
- Intercalative Compounds
- Compounds, Intercalative
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Below are MeSH descriptors whose meaning is more general than "Intercalating Agents".
Below are MeSH descriptors whose meaning is more specific than "Intercalating Agents".
This graph shows the total number of publications written about "Intercalating Agents" by people in this website by year, and whether "Intercalating Agents" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2011 | 2 | 0 | 2 |
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Below are the most recent publications written about "Intercalating Agents" by people in Profiles.
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Vann KR, Erg?n Y, Zencir S, Oncuoglu S, Osheroff N, Topcu Z. Inhibition of human DNA topoisomerase IIa by two novel ellipticine derivatives. Bioorg Med Chem Lett. 2016 Apr 01; 26(7):1809-12.
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Bouffier L, Wang BS, Roget A, Livache T, Demeunynck M, Mailley P. Electrochemical transduction of DNA hybridization at modified electrodes by using an electroactive pyridoacridone intercalator. Anal Bioanal Chem. 2014 Feb; 406(4):1163-72.
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Wilhelm M, Mukherjee A, Bouvier B, Zakrzewska K, Hynes JT, Lavery R. Multistep drug intercalation: molecular dynamics and free energy studies of the binding of daunomycin to DNA. J Am Chem Soc. 2012 May 23; 134(20):8588-96.
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Paik DH, Perkins TT. Dynamics and multiple stable binding modes of DNA intercalators revealed by single-molecule force spectroscopy. Angew Chem Int Ed Engl. 2012 Feb 20; 51(8):1811-5.
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Eshkourfu R, Cobeljic B, Vujcic M, Turel I, Pevec A, Sepcic K, Zec M, Radulovic S, Srdic-Radic T, Mitic D, Andjelkovic K, Sladic D. Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide. J Inorg Biochem. 2011 Sep; 105(9):1196-203.
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Mukherjee A, Lavery R, Bagchi B, Hynes JT. On the molecular mechanism of drug intercalation into DNA: a simulation study of the intercalation pathway, free energy, and DNA structural changes. J Am Chem Soc. 2008 Jul 30; 130(30):9747-55.
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Podell ER, Harrington DJ, Taatjes DJ, Koch TH. Crystal structure of epidoxorubicin-formaldehyde virtual crosslink of DNA and evidence for its formation in human breast-cancer cells. Acta Crystallogr D Biol Crystallogr. 1999 Sep; 55(Pt 9):1516-23.
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Barnes NR, Schreiner AF, Dolan MA. Measurement and interpretation of Q0 and Q1 band property changes of two cationic metalloporphyrins upon binding with B-DNA: electronic MCD, CD, and optical absorption. J Inorg Biochem. 1998 Oct; 72(1-2):1-12.
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Tanner NK, Cech TR. Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by intercalating dyes. Nucleic Acids Res. 1985 Nov 11; 13(21):7741-58.
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