 Locus Coeruleus
"Locus Coeruleus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Bluish-colored region in the superior angle of the FOURTH VENTRICLE floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the PERIAQUEDUCTAL GRAY.
| Descriptor ID |
D008125
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| MeSH Number(s) |
A08.186.211.132.659.473 A08.186.211.132.810.428.600.650.437
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| Concept/Terms |
Locus Coeruleus- Locus Coeruleus
- Nucleus Pigmentosus Pontis
- Pontis, Nucleus Pigmentosus
- Locus Ceruleus Complex
- Ceruleus Complex, Locus
- Ceruleus Complices, Locus
- Complex, Locus Ceruleus
- Complices, Locus Ceruleus
- Locus Ceruleus Complices
- Locus Coeruleus Complex
- Coeruleus Complex, Locus
- Coeruleus Complices, Locus
- Complex, Locus Coeruleus
- Complices, Locus Coeruleus
- Locus Coeruleus Complices
- Locus Caeruleus
- Locus Ceruleus
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Below are MeSH descriptors whose meaning is more general than "Locus Coeruleus".
Below are MeSH descriptors whose meaning is more specific than "Locus Coeruleus".
This graph shows the total number of publications written about "Locus Coeruleus" by people in this website by year, and whether "Locus Coeruleus" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 | | 1998 | 2 | 0 | 2 | | 2005 | 0 | 1 | 1 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 0 | 1 | | 2011 | 0 | 2 | 2 | | 2015 | 1 | 1 | 2 | | 2016 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 1 | 2 | | 2024 | 1 | 0 | 1 | | 2025 | 3 | 0 | 3 |
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Below are the most recent publications written about "Locus Coeruleus" by people in Profiles.
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Ogg MC, Lansdell BJ, Franks HT, Hughes AC, Lee J, Nolen HG, Shirinifard A, Schwarz LA. Locus coeruleus norepinephrine neurons facilitate orbitofrontal cortex remapping and behavioral flexibility. Cell Rep. 2025 Dec 23; 44(12):116687.
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Becker LJ, Martin MM, Hughes AC, Mulvey B, Kuo CC, Piantadosi SC, Bruchas MR, Martinowich K, Meye FJ, Schwarz LA, Weinshenker D, McCall JG, Riga D. Neuropeptides as transmitters and regulators of the locus coeruleus noradrenergic system. Pharmacol Rev. 2025 Sep; 77(5):100081.
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Luskin AT, Li L, Fu X, Martin MM, Barcomb K, Girven KS, Blackburn T, Wells BA, Thai ST, Li EM, Rana AN, Simon RC, Sun L, Gao L, Murry AD, Golden SA, Stuber GD, Ford CP, Gu L, Bruchas MR. Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours. Nature. 2025 07; 643(8071):437-447.
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Hughes AC, Pittman BG, Xu B, Gammons JW, Webb CM, Nolen HG, Chapman P, Bikoff JB, Schwarz LA. A single-vector intersectional AAV strategy for interrogating cellular diversity and brain function. Nat Neurosci. 2024 Jul; 27(7):1400-1410.
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Saternos H, Hamlett ED, Guzman S, Head E, Granholm AC, Ledreux A. Unique Pathology in the Locus Coeruleus of Individuals with Down Syndrome. J Alzheimers Dis. 2024; 101(2):541-561.
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Bell TR, Elman JA, Beck A, Fennema-Notestine C, Gustavson DE, Hagler DJ, Jack AJ, Lyons MJ, Puckett OK, Toomey R, Franz CE, Kremen WS. Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age. J Int Neuropsychol Soc. 2023 10; 29(8):763-774.
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Barcomb K, Olah SS, Kennedy MJ, Ford CP. Properties and modulation of excitatory inputs to the locus coeruleus. J Physiol. 2022 11; 600(22):4897-4916.
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Burnham NW, Chaimowitz CN, Vis CC, Segantine Dornellas AP, Navarro M, Thiele TE. Lateral hypothalamus-projecting noradrenergic locus coeruleus pathway modulates binge-like ethanol drinking in male and female TH-ires-cre mice. Neuropharmacology. 2021 09 15; 196:108702.
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Elman JA, Puckett OK, Beck A, Fennema-Notestine C, Cross LK, Dale AM, Eglit GML, Eyler LT, Gillespie NA, Granholm EL, Gustavson DE, Hagler DJ, Hatton SN, Hauger R, Jak AJ, Logue MW, McEvoy LK, McKenzie RE, Neale MC, Panizzon MS, Reynolds CA, Sanderson-Cimino M, Toomey R, Tu XM, Whitsel N, Williams ME, Xian H, Lyons MJ, Franz CE, Kremen WS. MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction. Alzheimers Dement. 2021 06; 17(6):1017-1025.
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Hamlett ED, Ledreux A, Gilmore A, Vazey EM, Aston-Jones G, Boger HA, Paredes D, Granholm AE. Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome. Neurobiol Dis. 2020 02; 134:104616.
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