A study of sirolimus and mTOR kinase inhibitor in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease.

Holditch SJ, Brown CN, Atwood DJ, Lombardi AM, Nguyen KN, Toll HW, Hopp K, Edelstein CL. A study of sirolimus and mTOR kinase inhibitor in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease. Am J Physiol Renal Physiol. 2019 07 01; 317(1):F187-F196.

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subject areas

Adaptor Proteins, Signal Transducing
Animals
Apoptosis
Cell Cycle Proteins
Cell Proliferation
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Humans
Kidney Tubules
Male
Mice, Inbred C57BL
Mice, Mutant Strains
Mutation
Naphthyridines
Phosphorylation
Polycystic Kidney, Autosomal Dominant
Protein Kinase Inhibitors
Proto-Oncogene Proteins c-akt
Ribosomal Protein S6 Kinases
Signal Transduction
Sirolimus
TOR Serine-Threonine Kinases
TRPP Cation Channels

authors with profiles

Charles Louis Edelstein
Katharina Hopp