 Semaphorin-3A
"Semaphorin-3A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The prototypical and most well-studied member of the semaphorin family. Semaphorin-3A is an axon-repulsive guidance cue for migrating neurons in the developing nervous system. It has so far been found only in vertebrates, and binds to NEUROPILIN-1/plexin complex receptors on growth cones. Like other class 3 semaphorins, it is a secreted protein.
| Descriptor ID |
D040121
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| MeSH Number(s) |
D12.644.276.923.374 D12.776.467.923.374 D23.529.923.374
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| Concept/Terms |
Semaphorin-3A- Semaphorin-3A
- Sem D
- Semaphorin D
- Collapsin-1
- Collapsin 1
- Sema3A
- Semaphorin 3A
- Collapsing Factor
- Collapsin
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Below are MeSH descriptors whose meaning is more general than "Semaphorin-3A".
Below are MeSH descriptors whose meaning is more specific than "Semaphorin-3A".
This graph shows the total number of publications written about "Semaphorin-3A" by people in this website by year, and whether "Semaphorin-3A" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Semaphorin-3A" by people in Profiles.
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Sanford SD, Yun BG, Leslie CC, Murphy RC, Pfenninger KH. Group IVA phospholipase A2 is necessary for growth cone repulsion and collapse. J Neurochem. 2012 Mar; 120(6):974-84.
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Atkinson-Leadbeater K, Bertolesi GE, Hehr CL, Webber CA, Cechmanek PB, McFarlane S. Dynamic expression of axon guidance cues required for optic tract development is controlled by fibroblast growth factor signaling. J Neurosci. 2010 Jan 13; 30(2):685-93.
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Roffers-Agarwal J, Gammill LS. Neuropilin receptors guide distinct phases of sensory and motor neuronal segmentation. Development. 2009 Jun; 136(11):1879-88.
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Gatlin JC, Estrada-Bernal A, Sanford SD, Pfenninger KH. Myristoylated, alanine-rich C-kinase substrate phosphorylation regulates growth cone adhesion and pathfinding. Mol Biol Cell. 2006 Dec; 17(12):5115-30.
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Eastwood SL, Law AJ, Everall IP, Harrison PJ. The axonal chemorepellant semaphorin 3A is increased in the cerebellum in schizophrenia and may contribute to its synaptic pathology. Mol Psychiatry. 2003 Feb; 8(2):148-55.
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