 Succinate Dehydrogenase
"Succinate Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A flavoprotein containing oxidoreductase that catalyzes the dehydrogenation of SUCCINATE to fumarate. In most eukaryotic organisms this enzyme is a component of mitochondrial electron transport complex II.
| Descriptor ID |
D013385
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| MeSH Number(s) |
D05.500.562.750.249.500 D08.811.600.250.500.750.500 D08.811.600.250.875.249.500 D08.811.682.660.385.500 D08.811.682.830.249.500 D12.776.157.427.374.375.909.500 D12.776.331.199.750.500 D12.776.543.277.500.750.500 D12.776.543.277.875.249.500 D12.776.556.579.374.375.141.500
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| Concept/Terms |
Succinate Dehydrogenase- Succinate Dehydrogenase
- Dehydrogenase, Succinate
- Succinic Dehydrogenase
- Dehydrogenase, Succinic
- Succinic Oxidase
- Oxidase, Succinic
- Fumarate Reductase
- Reductase, Fumarate
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Below are MeSH descriptors whose meaning is more general than "Succinate Dehydrogenase".
Below are MeSH descriptors whose meaning is more specific than "Succinate Dehydrogenase".
This graph shows the total number of publications written about "Succinate Dehydrogenase" by people in this website by year, and whether "Succinate Dehydrogenase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 2 | 2 | | 2015 | 2 | 1 | 3 | | 2016 | 0 | 1 | 1 | | 2017 | 2 | 0 | 2 | | 2018 | 0 | 1 | 1 | | 2019 | 1 | 1 | 2 | | 2020 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 | | 2022 | 0 | 4 | 4 |
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Below are the most recent publications written about "Succinate Dehydrogenase" by people in Profiles.
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Roma A, Tcheng M, Ahmed N, Walker S, Jayanth P, Minden MD, Hope K, Nekkar Rao PP, Luc J, Doxey AC, Reisz JA, Culp-Hill R, D'Alessandro A, Spagnuolo PA. Glutamine Metabolism Mediates Sensitivity to Respiratory Complex II Inhibition in Acute Myeloid Leukemia. Mol Cancer Res. 2022 11 03; 20(11):1659-1673.
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Zethoven M, Martelotto L, Pattison A, Bowen B, Balachander S, Flynn A, Rossello FJ, Hogg A, Miller JA, Frysak Z, Grimmond S, Fishbein L, Tischler AS, Gill AJ, Hicks RJ, Dahia PLM, Clifton-Bligh R, Pacak K, Tothill RW. Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment. Nat Commun. 2022 10 21; 13(1):6262.
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Dong Q, Xiu Y, Wang Y, Hodgson C, Borcherding N, Jordan C, Buchanan J, Taylor E, Wagner B, Leidinger M, Holman C, Thiele DJ, O'Brien S, Xue HH, Zhao J, Li Q, Meyerson H, Boyce BF, Zhao C. HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia. Nat Commun. 2022 10 16; 13(1):6107.
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Armstrong N, Storey CM, Noll SE, Margulis K, Soe MH, Xu H, Yeh B, Fishbein L, Kebebew E, Howitt BE, Zare RN, Sage J, Annes JP. SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas. Cell Rep. 2022 03 01; 38(9):110453.
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Vohwinkel CU, Coit EJ, Burns N, Elajaili H, Hernandez-Saavedra D, Yuan X, Eckle T, Nozik E, Tuder RM, Eltzschig HK. Targeting alveolar-specific succinate dehydrogenase A attenuates pulmonary inflammation during acute lung injury. FASEB J. 2021 04; 35(4):e21468.
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Greenberg SE, Jacobs MF, Wachtel H, Anson A, Buchmann L, Cohen DL, Bonanni M, Bennett B, Naumer A, Schaefer AM, Kohlmann W, Nathanson KL, Else T, Fishbein L. Tumor detection rates in screening of individuals with SDHx-related hereditary paraganglioma-pheochromocytoma syndrome. Genet Med. 2020 12; 22(12):2101-2107.
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Jones CL, Stevens BM, D'Alessandro A, Culp-Hill R, Reisz JA, Pei S, Gustafson A, Khan N, DeGregori J, Pollyea DA, Jordan CT. Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II. Blood. 2019 07 25; 134(4):389-394.
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Malik F, Santiago T, Bahrami A, Davis E, McCarville B, Newman S, Azzato EM, Davidoff AM, Brennan R, Ellison DW, Clay MR. Dedifferentiation in SDH-Deficient Gastrointestinal Stromal Tumor: A Report With Histologic, Immunophenotypic, and Molecular Characterization. Pediatr Dev Pathol. 2019 Oct; 22(5):492-498.
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Pollyea DA, Stevens BM, Jones CL, Winters A, Pei S, Minhajuddin M, D'Alessandro A, Culp-Hill R, Riemondy KA, Gillen AE, Hesselberth JR, Abbott D, Schatz D, Gutman JA, Purev E, Smith C, Jordan CT. Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia. Nat Med. 2018 12; 24(12):1859-1866.
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Fishbein L, Ben-Maimon S, Keefe S, Cengel K, Pryma DA, Loaiza-Bonilla A, Fraker DL, Nathanson KL, Cohen DL. SDHB mutation carriers with malignant pheochromocytoma respond better to CVD. Endocr Relat Cancer. 2017 08; 24(8):L51-L55.
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