 ADAMTS4 Protein
"ADAMTS4 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may also be involved in the destruction of aggrecan in ARTHRITIS.
| Descriptor ID |
D000071121
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| MeSH Number(s) |
D08.811.277.656.675.374.102.500.844 D09.400.430.500.500.844 D12.776.395.033.500.844 D12.776.860.300.085.844
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| Concept/Terms |
ADAMTS4 Protein- ADAMTS4 Protein
- Aggrecanase-1
- Aggrecanase 1
- A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein
- ADAMTS-4 Protein
- ADAMTS 4 Protein
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Below are MeSH descriptors whose meaning is more general than "ADAMTS4 Protein".
Below are MeSH descriptors whose meaning is more specific than "ADAMTS4 Protein".
This graph shows the total number of publications written about "ADAMTS4 Protein" by people in this website by year, and whether "ADAMTS4 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "ADAMTS4 Protein" by people in Profiles.
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Ambardekar AV, Stratton MS, Dobrinskikh E, Hunter KS, Tatman PD, Lemieux ME, Cleveland JC, Tuder RM, Weiser-Evans MCM, Moulton KS, McKinsey TA. Matrix-Degrading Enzyme Expression and Aortic Fibrosis During Continuous-Flow Left Ventricular Mechanical Support. J Am Coll Cardiol. 2021 11 02; 78(18):1782-1795.
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McCreery KP, Xu X, Scott AK, Fajrial AK, Calve S, Ding X, Neu CP. Nuclear Stiffness Decreases with Disruption of the Extracellular Matrix in Living Tissues. Small. 2021 02; 17(6):e2006699.
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Boyd DF, Allen EK, Randolph AG, Guo XJ, Weng Y, Sanders CJ, Bajracharya R, Lee NK, Guy CS, Vogel P, Guan W, Li Y, Liu X, Novak T, Newhams MM, Fabrizio TP, Wohlgemuth N, Mourani PM, Wight TN, Schultz-Cherry S, Cormier SA, Shaw-Saliba K, Pekosz A, Rothman RE, Chen KF, Yang Z, Webby RJ, Zhong N, Crawford JC, Thomas PG. Exuberant fibroblast activity compromises lung function via ADAMTS4. Nature. 2020 11; 587(7834):466-471.
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Steele MP, Luna LG, Coldren CD, Murphy E, Hennessy CE, Heinz D, Evans CM, Groshong S, Cool C, Cosgrove GP, Brown KK, Fingerlin TE, Schwarz MI, Schwartz DA, Yang IV. Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias. BMC Genomics. 2015 Oct 26; 16:869.
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