 Drug Substitution
"Drug Substitution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The practice of replacing one prescribed drug with another that is expected to have the same clinical or psychological effect.
| Descriptor ID |
D057915
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| MeSH Number(s) |
E02.319.307.312 N02.421.668.778.500.312
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| Concept/Terms |
Drug Substitution- Drug Substitution
- Drug Substitutions
- Substitution, Drug
- Substitutions, Drug
- Therapeutic Substitution
- Substitution, Therapeutic
- Substitutions, Therapeutic
- Therapeutic Substitutions
- Drug Switching
- Drug Switchings
- Switching, Drug
- Switchings, Drug
Generic Substitution- Generic Substitution
- Generic Substitutions
- Substitution, Generic
- Substitutions, Generic
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Below are MeSH descriptors whose meaning is more general than "Drug Substitution".
Below are MeSH descriptors whose meaning is more specific than "Drug Substitution".
This graph shows the total number of publications written about "Drug Substitution" by people in this website by year, and whether "Drug Substitution" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 4 | 0 | 4 | | 2013 | 2 | 1 | 3 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 2 | 3 | | 2016 | 1 | 3 | 4 | | 2017 | 2 | 3 | 5 | | 2018 | 1 | 1 | 2 | | 2019 | 2 | 3 | 5 | | 2020 | 1 | 3 | 4 | | 2021 | 1 | 1 | 2 | | 2024 | 0 | 4 | 4 |
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Below are the most recent publications written about "Drug Substitution" by people in Profiles.
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Gibbons JB, Hermosilla M, Trujillo A. On the motivation for pharmaceutical manufacturer coupons: Brand loyalty or customer acquisition? Health Serv Res. 2025 Apr; 60(2):e14379.
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Hwang YJ, Lesko CR, Brown TT, Alexander GC, Zalla LC, Keruly JC, Snow LN, Pytell JD, Falade-Nwulia O, Jones JL, Moore RD, Fojo AT. Association between switching to integrase strand transfer inhibitors and incident diabetes in people with HIV. AIDS. 2024 Sep 01; 38(11):1696-1702.
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Kousari AE, Wilson MP, Hawkins KL, Bandali MM, Henao-Mart?nez AF, Gardner EM, Erlandson KM. Weight change with antiretroviral switch from integrase inhibitor or tenofovir alafenamide-based to Doravirine-Based regimens in people with HIV. HIV Res Clin Pract. 2024 12; 25(1):2339576.
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Patel N, Morris S, Burke L, Chow K, Pacheco D, Anderson P, Stancyzk F, Blumenthal J. No observed bidirectional effect between tenofovir diphosphate concentrations and gender-affirming hormone concentrations among transgender persons switching from tenofovir disoproxil fumarate/emtricitabine to tenofovir alafenamide/emtricitabine for HIV pre-exposure prophylaxis. Br J Clin Pharmacol. 2024 Oct; 90(10):2360-2365.
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Sauer BC, Chen W, Shen J, Accortt NA, Collier DH, Cannon GW. Potential for Major Therapeutic Changes to Produce Significant Clinical Response Across a Broad Range of Disease Activity: An Observational Study of US Veterans With Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2021 07; 73(7):964-974.
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Dagenais GR, Dyal L, Bosch JJ, Leong DP, Aboyans V, Berkowitz SD, Bhatt DL, Connolly SJ, Fox KAA, Muehlhofer E, Probstfield JL, Widimsky P, Winkelmann BR, Yusuf S, Eikelboom JW. Cardiovascular consequences of discontinuing low-dose rivaroxaban in people with chronic coronary or peripheral artery disease. Heart. 2021 07; 107(14):1130-1137.
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Kuemmerle-Deschner JB, Welzel T, Hoertnagel K, Tsiflikas I, Hospach A, Liu X, Schlipf S, Hansmann S, Samba SD, Griesinger A, Benseler SM, Weber AN. New variant in the IL1RN-gene (DIRA) associated with late-onset, CRMO-like presentation. Rheumatology (Oxford). 2020 Nov 01; 59(11):3259-3263.
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Salehi Omran S, Parikh NS, Zambrano Espinoza M, Lerario MP, Levine SR, Kamel H, Marshall R, Willey J. Managing Ischemic Stroke in Patients Already on Anticoagulation for Atrial Fibrillation: A Nationwide Practice Survey. J Stroke Cerebrovasc Dis. 2020 Dec; 29(12):105291.
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Cochrane AB, Lyster H, Lindenfeld J, Doligalski C, Baran D, Yost C, Shullo M, Schweiger M, Weill D, Stuckey L, Ivulich S, Scheel J, Peters L, Colvin M, Dawson K, Girgis R, Weeks P, Tse T, Russell S, Flattery M, Jennings D, Kittleson M, Miller T, Khuu T, Claridge T, Uber P, Ford K, Ensor CR, Simpson K, Dipchand A, Page RL. Report from the 2018 consensus conference on immunomodulating agents in thoracic transplantation: Access, formulations, generics, therapeutic drug monitoring, and special populations. J Heart Lung Transplant. 2020 10; 39(10):1050-1069.
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Becker WC, Frank JW, Edens EL. Switching From High-Dose, Long-Term Opioids to Buprenorphine: A Case Series. Ann Intern Med. 2020 07 07; 173(1):70-71.
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