Off-Label Use
"Off-Label Use" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The practice of prescribing or using a drug outside the scope of the drug's official approved label as designated by a regulatory agency concerning the treatment of a particular disease or condition.
Descriptor ID |
D056687
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MeSH Number(s) |
E02.319.307.500
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Concept/Terms |
Off-Label Use- Off-Label Use
- Off Label Use
- Off-Label Uses
- Use, Off-Label
- Uses, Off-Label
- Off-Label Prescribing
- Off Label Prescribing
- Off-Label Prescribings
- Prescribing, Off-Label
- Prescribings, Off-Label
- Unlabeled Indication
- Indication, Unlabeled
- Indications, Unlabeled
- Unlabeled Indications
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Below are MeSH descriptors whose meaning is more general than "Off-Label Use".
Below are MeSH descriptors whose meaning is more specific than "Off-Label Use".
This graph shows the total number of publications written about "Off-Label Use" by people in this website by year, and whether "Off-Label Use" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2009 | 2 | 1 | 3 | 2011 | 1 | 0 | 1 | 2012 | 2 | 1 | 3 | 2013 | 0 | 2 | 2 | 2014 | 2 | 0 | 2 | 2015 | 1 | 2 | 3 | 2016 | 0 | 1 | 1 | 2017 | 2 | 5 | 7 | 2018 | 2 | 0 | 2 | 2019 | 1 | 3 | 4 | 2020 | 1 | 1 | 2 | 2021 | 1 | 1 | 2 | 2022 | 0 | 1 | 1 | 2023 | 1 | 2 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "Off-Label Use" by people in Profiles.
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Sandhu A, Kaltenbach LA, Chiswell K, Shimoga V, Ashur C, Pribish A, Fonarow GC, Piccini JP, Ho PM, Varosy PD, Hess PL. Off-Label Dosing of Direct Oral Anticoagulants Among Inpatients With Atrial Fibrillation in the United States. Circ Cardiovasc Qual Outcomes. 2023 Dec; 16(12):e010062.
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Gazarian M, Horton DB, Carleton B, Kinlaw AC, Bushnell GA, Czaja AS, Durrieu G, Gorman EF, Titievsky L, Zito J, Slaughter JL, dosReis S. Optimizing therapeutic decision-making for off-label medicines use: A scoping review and consensus recommendations for improving practice and research. Pharmacoepidemiol Drug Saf. 2023 11; 32(11):1200-1222.
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Szmuilowicz ED, Levy CJ, Buschur EO, Polsky S. Expert Guidance on Off-Label Use of Hybrid Closed-Loop Therapy in Pregnancies Complicated by Diabetes. Diabetes Technol Ther. 2023 05; 25(5):363-373.
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Kelsey MM, Zeitler PS, Nadeau KJ, Shah AS. Type 2 diabetes in youth: Rationale for use of off-label antidiabetic agents. Pediatr Diabetes. 2022 09; 23(6):615-619.
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Hughes MS, Bailey R, Calhoun P, Shah VN, Lyons SK, DeSalvo DJ. Off-label use of sodium glucose co-transporter inhibitors among adults in type 1 diabetes exchange registry. Diabetes Obes Metab. 2022 01; 24(1):171-173.
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San Giovanni CB, Sweeney B, Skelton JA, Kelsey MM, Kelly AS. Aversion to Off-label Prescribing in Clinical Pediatric Weight Management: The Quintessential Double Standard. J Clin Endocrinol Metab. 2021 06 16; 106(7):2103-2113.
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Boguniewicz M. Biologics for Atopic Dermatitis. Immunol Allergy Clin North Am. 2020 11; 40(4):593-607.
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Kisor DF, Monte AA, M?ller DJ. Pharmacogenetic associations and evidence-based pharmacogenomics guidelines: supporting label and off-label use of drug-gene interaction data. Pharmacogenomics. 2020 05; 21(7):427-430.
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Oleszek JL, Kanallakan AS, Powell AJ. Out of the spasticity box: Off-label uses of botulinum toxin in children. J Pediatr Rehabil Med. 2020; 13(2):205-207.
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Wipf A, Lofgreen S, Miller DD, Farah RS. Novel Use of Deoxycholic Acid for Adiposis Dolorosa (Dercum Disease). Dermatol Surg. 2019 12; 45(12):1718-1720.
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