 ELAV-Like Protein 1
"ELAV-Like Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An RRM protein that binds to the 3'-UTR region of mRNAs and increases their stability. In EMBRYONIC STEM CELLS, it binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs and preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), to stabilize them and promote differentiation.
| Descriptor ID |
D000067780
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| MeSH Number(s) |
D12.776.157.725.813.500.250 D12.776.664.962.813.500.250
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| Concept/Terms |
ELAV-Like Protein 1- ELAV-Like Protein 1
- ELAV Like Protein 1
- HuR Paraneoplastic Encephalomyelitis Antigen
- HuR Protein
- Protein, HuR
- ELAVL1 protein
- protein, ELAVL1
- HuR Antigen
- Antigen, HuR
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Below are MeSH descriptors whose meaning is more general than "ELAV-Like Protein 1".
Below are MeSH descriptors whose meaning is more specific than "ELAV-Like Protein 1".
This graph shows the total number of publications written about "ELAV-Like Protein 1" by people in this website by year, and whether "ELAV-Like Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2000 | 0 | 2 | 2 | | 2002 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2009 | 0 | 2 | 2 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 2 | 0 | 2 | | 2017 | 4 | 0 | 4 | | 2021 | 2 | 0 | 2 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "ELAV-Like Protein 1" by people in Profiles.
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Vujovic A, de Rooij L, Chahi AK, Chen HT, Yee BA, Loganathan SK, Liu L, Chan DCH, Tajik A, Tsao E, Moreira S, Joshi P, Xu J, Wong N, Balde Z, Jahangiri S, Zandi S, Aigner S, Dick JE, Minden MD, Schramek D, Yeo GW, Hope KJ. In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target. Blood Cancer Discov. 2023 05 01; 4(3):180-207.
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Rothamel K, Arcos S, Kim B, Reasoner C, Lisy S, Mukherjee N, Ascano M. ELAVL1 primarily couples mRNA stability with the 3' UTRs of interferon-stimulated genes. Cell Rep. 2021 05 25; 35(8):109178.
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Lee S, Wei L, Zhang B, Goering R, Majumdar S, Wen J, Taliaferro JM, Lai EC. ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing. PLoS Genet. 2021 04; 17(4):e1009439.
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Ripin N, Boudet J, Duszczyk MM, Hinniger A, Faller M, Krepl M, Gadi A, Schneider RJ, ?poner J, Meisner-Kober NC, Allain FH. Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):2935-2944.
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Muralidharan R, Babu A, Amreddy N, Srivastava A, Chen A, Zhao YD, Kompella UB, Munshi A, Ramesh R. Tumor-targeted Nanoparticle Delivery of HuR siRNA Inhibits Lung Tumor Growth In Vitro and In Vivo By Disrupting the Oncogenic Activity of the RNA-binding Protein HuR. Mol Cancer Ther. 2017 08; 16(8):1470-1486.
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Bhandare S, Goldberg DS, Dowell R. Discriminating between HuR and TTP binding sites using the k-spectrum kernel method. PLoS One. 2017; 12(3):e0174052.
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Matsye P, Zheng L, Si Y, Kim S, Luo W, Crossman DK, Bratcher PE, King PH. HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseases. Glia. 2017 06; 65(6):945-963.
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Hoffman O, Burns N, Vad?sz I, Eltzschig HK, Edwards MG, Vohwinkel CU. Detrimental ELAVL-1/HuR-dependent GSK3? mRNA stabilization impairs resolution in acute respiratory distress syndrome. PLoS One. 2017; 12(2):e0172116.
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Muralidharan R, Babu A, Amreddy N, Basalingappa K, Mehta M, Chen A, Zhao YD, Kompella UB, Munshi A, Ramesh R. Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration. J Nanobiotechnology. 2016 Jun 21; 14(1):47.
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Huang YH, Peng W, Furuuchi N, Gerhart J, Rhodes K, Mukherjee N, Jimbo M, Gonye GE, Brody JR, Getts RC, Sawicki JA. Delivery of Therapeutics Targeting the mRNA-Binding Protein HuR Using 3DNA Nanocarriers Suppresses Ovarian Tumor Growth. Cancer Res. 2016 Mar 15; 76(6):1549-59.
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