 Factor VIIIa
"Factor VIIIa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.
| Descriptor ID |
D015944
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| MeSH Number(s) |
D12.776.124.125.350.300 D23.119.350.300
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| Concept/Terms |
Factor VIIIa- Factor VIIIa
- Factor Eight A
- Blood Coagulation Factor VIII, Activated
- Coagulation Factor VIIIa
- Factor VIIIa, Coagulation
- Factor VIII, Thrombin-Activated
- Factor VIII, Thrombin Activated
- Thrombin-Activated Factor VIII
- Factor 8A
- Factor VIII, Activated
- Activated Factor VIII
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Below are MeSH descriptors whose meaning is more general than "Factor VIIIa".
Below are MeSH descriptors whose meaning is more specific than "Factor VIIIa".
This graph shows the total number of publications written about "Factor VIIIa" by people in this website by year, and whether "Factor VIIIa" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "Factor VIIIa" by people in Profiles.
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Huang X, Ding WQ, Vaught JL, Wolf RF, Morrissey JH, Harrison RG, Lind SE. A soluble tissue factor-annexin V chimeric protein has both procoagulant and anticoagulant properties. Blood. 2006 Feb 01; 107(3):980-6.
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Chang JY, Monroe DM, Stafford DW, Brinkhous KM, Roberts HR. Replacing the first epidermal growth factor-like domain of factor IX with that of factor VII enhances activity in vitro and in canine hemophilia B. J Clin Invest. 1997 Aug 15; 100(4):886-92.
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Hoffman M, Monroe DM, Roberts HR. Platelet activation in patients with thrombotic thrombocytopenic purpura. Am J Hematol. 1993 Feb; 42(2):182-5.
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