 Physostigmine
"Physostigmine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
| Descriptor ID |
D010830
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| MeSH Number(s) |
D02.241.081.251.583.682 D03.132.436.545 D03.633.100.473.402.545
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Physostigmine".
Below are MeSH descriptors whose meaning is more specific than "Physostigmine".
This graph shows the total number of publications written about "Physostigmine" by people in this website by year, and whether "Physostigmine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Physostigmine" by people in Profiles.
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Wang GS, Baker K, Ng P, Janis GC, Leonard J, Mistry RD, Heard K. A randomized trial comparing physostigmine vs lorazepam for treatment of antimuscarinic (anticholinergic) toxidrome. Clin Toxicol (Phila). 2021 Aug; 59(8):698-704.
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Myers TM, Hamilton LR. Delayed match-to-sample performance in African green monkeys (Chlorocebus aethiops sabaeus): effects of benzodiazepine, cholinergic, and anticholinergic drugs. Behav Pharmacol. 2011 Dec; 22(8):814-23.
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Fekonja O, Zorec-Karlovsek M, El Kharbili M, Fournier D, Stojan J. Inhibition and protection of cholinesterases by methanol and ethanol. J Enzyme Inhib Med Chem. 2007 Aug; 22(4):407-15.
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Arciniegas DB, Topkoff JL. Applications of the P50 evoked response to the evaluation of cognitive impairments after traumatic brain injury. Phys Med Rehabil Clin N Am. 2004 Feb; 15(1):177-203, viii.
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Arnold SM, Arnholz D, Garyfallou GT, Heard K. Two siblings poisoned with diphenhydramine: a case of factitious disorder by proxy. Ann Emerg Med. 1998 Aug; 32(2):256-9.
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Moye TB, Vanderryn J. Physostigmine accelerates the development of associative memory processes in the infant rat. Psychopharmacology (Berl). 1988; 95(3):401-6.
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Linden CH, Mitchiner JC, Lindzon RD, Rumack BH. Cyclobenzaprine overdosage. J Toxicol Clin Toxicol. 1983 May; 20(3):281-8.
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Kulig K, Rumack BH. Physostigmine and asystole. Ann Emerg Med. 1981 Apr; 10(4):228-20.
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Hooper RG, Conner CS, Rumack BH. Acute poisoning from over-the-counter sleep preparations. JACEP. 1979 Mar; 8(3):98-100.
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Rumack BH. Editorial: Physostigmine: rational use. JACEP. 1976 Jul; 5(7):541-2.
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