 Quinacrine
"Quinacrine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
| Descriptor ID |
D011796
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| MeSH Number(s) |
D03.633.300.046.250.760
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Quinacrine".
Below are MeSH descriptors whose meaning is more specific than "Quinacrine".
This graph shows the total number of publications written about "Quinacrine" by people in this website by year, and whether "Quinacrine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 2004 | 1 | 1 | 2 |
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Below are the most recent publications written about "Quinacrine" by people in Profiles.
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Yoon-yub P, Hybertson B, Wright R, Fini M, Elkins N, Repine J. Serum ferritin elevation and acute lung injury in rats subjected to hemorrhage: reduction by mepacrine treatment. Exp Lung Res. 2004 Oct-Nov; 30(7):571-84.
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Kwiek JJ, Haystead TA, Rudolph J. Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines. Biochemistry. 2004 Apr 20; 43(15):4538-47.
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Lee YM, Hybertson BM, Terada LS, Repine AJ, Cho HG, Repine JE. Mepacrine decreases lung leak in rats given interleukin-1 intratracheally. Am J Respir Crit Care Med. 1997 May; 155(5):1624-8.
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Bunnachak D, Almeida AR, Wetzels JF, Gengaro P, Nemenoff RA, Burke TJ, Schrier RW. Ca2+ uptake, fatty acid, and LDH release during proximal tubule hypoxia: effects of mepacrine and dibucaine. Am J Physiol. 1994 Feb; 266(2 Pt 2):F196-201.
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Canham EM, Shoemaker SA, Tate RM, Harada RN, McMurtry IF, Repine JE. Mepacrine but not methylprednisolone decreases acute edematous lung injury after injection of phorbol myristate acetate in rabbits. Am Rev Respir Dis. 1983 May; 127(5):594-8.
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Sokol RJ, Lichtenstein PK, Farrell MK. Quinacrine hydrochloride-induced yellow discoloration of the skin in children. Pediatrics. 1982 Feb; 69(2):232-3.
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Newburger PE, Cohen HJ, Rothchild SB, Hobbins JC, Malawista SE, Mahoney MJ. Prenatal diagnosis of chronic granulomatous disease. N Engl J Med. 1979 Jan 25; 300(4):178-81.
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