 Apoprotein(a)
"Apoprotein(a)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large and highly glycosylated protein constituent of LIPOPROTEIN (A). It has very little affinity for lipids but forms disulfide-linkage to APOLIPOPROTEIN B-100. Apoprotein(a) has SERINE PROTEINASE activity and can be of varying sizes from 400- to 800-kDa. It is homologous to PLASMINOGEN and is known to modulate THROMBOSIS and FIBRINOLYSIS.
| Descriptor ID |
D053241
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| MeSH Number(s) |
D10.532.350.500 D12.776.521.400.500
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| Concept/Terms |
Apoprotein(a)- Apoprotein(a)
- Apo Lp(a)
- Apolipoprotein (a)
- Apoprotein (a)
- Apolipoprotein Lp(a+)
- Apolipoprotein(a)
- Antiangiogenic AK38 Protein
- Protein, Antiangiogenic AK38
- Apolipoprotein Lp(a)
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Below are MeSH descriptors whose meaning is more general than "Apoprotein(a)".
Below are MeSH descriptors whose meaning is more specific than "Apoprotein(a)".
This graph shows the total number of publications written about "Apoprotein(a)" by people in this website by year, and whether "Apoprotein(a)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 | | 1999 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Apoprotein(a)" by people in Profiles.
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Goldenberg NA, Bernard TJ, Hillhouse J, Armstrong-Wells J, Galinkin J, Knapp-Clevenger R, Jacobson L, Marcovina SM, Manco-Johnson MJ. Elevated lipoprotein (a), small apolipoprotein (a), and the risk of arterial ischemic stroke in North American children. Haematologica. 2013 May; 98(5):802-7.
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Edelstein C, Shapiro SD, Klezovitch O, Scanu AM. Macrophage metalloelastase, MMP-12, cleaves human apolipoprotein(a) in the linker region between kringles IV-4 and IV-5. Potential relevance to lipoprotein(a) biology. J Biol Chem. 1999 Apr 09; 274(15):10019-23.
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Edelstein C, Italia JA, Klezovitch O, Scanu AM. Functional and metabolic differences between elastase-generated fragments of human lipoprotein[a] and apolipoprotein[a]. J Lipid Res. 1996 Aug; 37(8):1786-801.
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Klezovitch O, Edelstein C, Scanu AM. Evidence that the fibrinogen binding domain of Apo(a) is outside the lysine binding site of kringle IV-10: a study involving naturally occurring lysine binding defective lipoprotein(a) phenotypes. J Clin Invest. 1996 Jul 01; 98(1):185-91.
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